The Genetic Legacy of the Expansion of Turkic-Speaking Nomads across Eurasia
Centuries of nomadic migrations have ultimately resulted in the distribution of Turkic languages over a large area ranging from Siberia, across Central Asia to Eastern Europe and the Middle East. Despite the profound cultural impact left by these nomadic peoples, little is known about their prehistoric origins. Moreover, because contemporary Turkic speakers tend to genetically resemble their geographic neighbors, it is not clear whether their nomadic ancestors left an identifiable genetic trace. In this study, we show that Turkic-speaking peoples sampled across the Middle East, Caucasus, East Europe, and Central Asia share varying proportions of Asian ancestry that originate in a single area, southern Siberia and Mongolia. Mongolic- and Turkic-speaking populations from this area bear an unusually high number of long chromosomal tracts that are identical by descent with Turkic peoples from across west Eurasia. Admixture induced linkage disequilibrium decay across chromosomes in these populations indicates that admixture occurred during the 9th–17th centuries, in agreement with the historically recorded Turkic nomadic migrations and later Mongol expansion. Thus, our findings reveal genetic traces of recent large-scale nomadic migrations and map their source to a previously hypothesized area of Mongolia and southern Siberia.
Vyšlo v časopise:
The Genetic Legacy of the Expansion of Turkic-Speaking Nomads across Eurasia. PLoS Genet 11(4): e32767. doi:10.1371/journal.pgen.1005068
Kategorie:
Research Article
prolekare.web.journal.doi_sk:
https://doi.org/10.1371/journal.pgen.1005068
Souhrn
Centuries of nomadic migrations have ultimately resulted in the distribution of Turkic languages over a large area ranging from Siberia, across Central Asia to Eastern Europe and the Middle East. Despite the profound cultural impact left by these nomadic peoples, little is known about their prehistoric origins. Moreover, because contemporary Turkic speakers tend to genetically resemble their geographic neighbors, it is not clear whether their nomadic ancestors left an identifiable genetic trace. In this study, we show that Turkic-speaking peoples sampled across the Middle East, Caucasus, East Europe, and Central Asia share varying proportions of Asian ancestry that originate in a single area, southern Siberia and Mongolia. Mongolic- and Turkic-speaking populations from this area bear an unusually high number of long chromosomal tracts that are identical by descent with Turkic peoples from across west Eurasia. Admixture induced linkage disequilibrium decay across chromosomes in these populations indicates that admixture occurred during the 9th–17th centuries, in agreement with the historically recorded Turkic nomadic migrations and later Mongol expansion. Thus, our findings reveal genetic traces of recent large-scale nomadic migrations and map their source to a previously hypothesized area of Mongolia and southern Siberia.
Zdroje
1. Renfrew C. Archaeogenetics—towards a 'new synthesis'? Curr Biol. 2010;20(4):R162–5. doi: 10.1016/j.cub.2009.11.056 20178762
2. Sinor D. The establishment and dissolution of the Turk empire. In: Sinor D, editor. The Cambridge History of Early Inner Asia. Cambridge: Cambridge University Press 1990. p. 285–316.
3. Findley CV. The Turks in world history. New York: Oxford University Press; 2004. 320 p.
4. Golden PB. Central Asia in World History: Oxford University Press; 2011. 176 p.
5. Johanson L. The Structure of Turkic. In: Johanson L, Csató EA, editors. The Turkic languages. London & New York: Routledge & Chapman & Hall; 1998. p. 67–80.
6. Dybo AV. Chronology of Türkic languages and linguistic contacts of early Türks. Moscow: Academia Publishers; 2004.
7. Rona-Tas A. The Reconstruction of Proto-Turkic and the Genetic Question. In: Johanson L, Csató EA, editors. The Turkic languages. London & New York: Routledge & Chapman & Hall; 1998. p. 67–80.
8. Dybo AV. Linguistic contacts of early Turks. Lexical fund. Pre-Turkic period. Moscow: «Vostochnaya Literatura» Publishers; 2007.
9. Golden PB. Some Thoughts on the Origins of the Turks and the Shaping of the Turkic Peoples. In: Mair V, editor. Contact and Exchange in the Ancient World Honolulu: University of Hawaii Press; 2006. p. 136–57.
10. Bermisheva M, Tambets K, Villems R, Khusnutdinova E. Diversity of mitochondrial DNA haplotypes in ethnic populations of the Volga-Ural region of Russia. Mol Biol (Mosk). 2002;36(6):990–1001. 12500536
11. Nasidze I, Sarkisian T, Kerimov A, Stoneking M. Testing hypotheses of language replacement in the Caucasus: evidence from the Y-chromosome. Hum Genet. 2003;112(3):255–61. 12596050
12. Cinnioglu C, King R, Kivisild T, Kalfoglu E, Atasoy S, Cavalleri GL, et al. Excavating Y-chromosome haplotype strata in Anatolia. Hum Genet. 2004;114(2):127–48. 14586639
13. Varzari A, Kharkov V, Stephan W, Dergachev V, Puzyrev V, Weiss EH, et al. Searching for the origin of Gagauzes: inferences from Y-chromosome analysis. Am J Hum Biol. 2009;21(3):326–36. doi: 10.1002/ajhb.20863 19107901
14. Malyarchuk B, Derenko M, Denisova G, Kravtsova O. Mitogenomic diversity in Tatars from the Volga-Ural region of Russia. Mol Biol Evol. 2010;27(10):2220–6. doi: 10.1093/molbev/msq065 20457583
15. Yunusbayev B, Metspalu M, Jarve M, Kutuev I, Rootsi S, Metspalu E, et al. The Caucasus as an Asymmetric Semipermeable Barrier to Ancient Human Migrations. Mol Biol Evol. 2012;29(1):359–65. doi: 10.1093/molbev/msr221 21917723
16. Comas D, Plaza S, Wells RS, Yuldaseva N, Lao O, Calafell F, et al. Admixture, migrations, and dispersals in Central Asia: evidence from maternal DNA lineages. Eur J Hum Genet. 2004;12(6):495–504. 14872198
17. Quintana-Murci L, Chaix R, Wells S, Behar D, Sayar H, Scozzari R, et al. Where West meets East: The complex mtDNA landscape of the Southwest and Central Asian corridor. Am J Hum Genet. 2004;74:827–45. 15077202
18. Derenko M, Malyarchuk B, Denisova GA, Wozniak M, Dambueva I, Dorzhu C, et al. Contrasting patterns of Y-chromosome variation in south Siberian populations from Baikal and Altai-Sayan regions. Hum Genet. 2006;118(5):591–604. 16261343
19. Derenko M, Malyarchuk B, Grzybowski T, Denisova G, Dambueva I, Perkova M, et al. Phylogeographic analysis of mitochondrial DNA in northern Asian Populations. Am J Hum Genet. 2007;81(5):1025–41. 17924343
20. Li JZ, Absher DM, Tang H, Southwick AM, Casto AM, Ramachandran S, et al. Worldwide human relationships inferred from genome-wide patterns of variation. Science. 2008;319(5866):1100–4. doi: 10.1126/science.1153717 18292342
21. Rasmussen M, Li Y, Lindgreen S, Pedersen JS, Albrechtsen A, Moltke I, et al. Ancient human genome sequence of an extinct Palaeo-Eskimo. Nature. 2010;463(7282):757–62. doi: 10.1038/nature08835 20148029
22. Behar DM, Yunusbayev B, Metspalu M, Metspalu E, Rosset S, Parik J, et al. The genome-wide structure of the Jewish people. Nature. 2010;466(7303):238–42. doi: 10.1038/nature09103 20531471
23. Fedorova SA, Reidla M, Metspalu E, Metspalu M, Rootsi S, Tambets K, et al. Autosomal and uniparental portraits of the native populations of Sakha (Yakutia): implications for the peopling of Northeast Eurasia. BMC evolutionary biology. 2013;13(1):127.
24. Di Cristofaro J, Pennarun E, Mazieres S, Myres NM, Lin AA, Temori SA, et al. Afghan Hindu Kush: where Eurasian sub-continent gene flows converge. PLoS One. 2013;8(10):e76748. doi: 10.1371/journal.pone.0076748 24204668
25. Hodoglugil U, Mahley RW. Turkish population structure and genetic ancestry reveal relatedness among Eurasian populations. Ann Hum Genet. 2012;76(2):128–41. doi: 10.1111/j.1469-1809.2011.00701.x 22332727
26. Hellenthal G, Busby GB, Band G, Wilson JF, Capelli C, Falush D, et al. A genetic atlas of human admixture history. Science. 2014;343(6172):747–51. doi: 10.1126/science.1243518 24531965
27. Pritchard JK, Stephens M, Rosenberg NA, Donnelly P. Association mapping in structured populations. Am J Hum Genet. 2000;67(1):170–81. 10827107
28. Alexander DH, Novembre J, Lange K. Fast model-based estimation of ancestry in unrelated individuals. Genome Research. 2009;19(9):1655–64. doi: 10.1101/gr.094052.109 19648217
29. Metspalu M, Romero IG, Yunusbayev B, Chaubey G, Mallick CB, Hudjashov G, et al. Shared and Unique Components of Human Population Structure and Genome-Wide Signals of Positive Selection in South Asia. Am J Hum Genet. 2011;89(6):731–44. doi: 10.1016/j.ajhg.2011.11.010 22152676
30. Reich D, Thangaraj K, Patterson N, Price AL, Singh L. Reconstructing Indian population history. Nature. 2009;461(7263):489–U50. doi: 10.1038/nature08365 19779445
31. Patterson N, Moorjani P, Luo Y, Mallick S, Rohland N, Zhan Y, et al. Ancient admixture in human history. Genetics. 2012;192(3):1065–93. doi: 10.1534/genetics.112.145037 22960212
32. Ralph P, Coop G. The Geography of Recent Genetic Ancestry across Europe. PLoS Biol. 2013;11(5).
33. Browning SR. Estimation of pairwise identity by descent from dense genetic marker data in a population sample of haplotypes. Genetics. 2008;178(4):2123–32. doi: 10.1534/genetics.107.084624 18430938
34. Loh PR, Lipson M, Patterson N, Moorjani P, Pickrell JK, Reich D, et al. Inferring admixture histories of human populations using linkage disequilibrium. Genetics. 2013;193(4):1233–54. doi: 10.1534/genetics.112.147330 23410830
35. Pugach I, Matveyev R, Wollstein A, Kayser M, Stoneking M. Dating the age of admixture via wavelet transform analysis of genome-wide data. Genome Biology. 2011;12(2):R19. doi: 10.1186/gb-2011-12-2-r19 21352535
36. Williams AL, Patterson N, Glessner J, Hakonarson H, Reich D. Phasing of many thousands of genotyped samples. Am J Hum Genet. 2012;91(2):238–51. doi: 10.1016/j.ajhg.2012.06.013 22883141
37. Grousset R. The Empire of the Steppes: A History of Central Asia. New Brunswick: Rutgers University Press; 1970.
38. Schönig C. Turko-Mongolic Relations. Janhunen J, editor. London: Routledge; 2003.
39. Saunders JJ. The history of the Mongol conquests: Routledge; 1971. 275 p.
40. Mako G. The Islamization of the Volga Bulghars: A Question Reconsidered. Archivum Eurasiae Medii Aevi. 2011;18:199–223.
41. Raghavan M, Skoglund P, Graf KE, Metspalu M, Albrechtsen A, Moltke I, et al. Upper Palaeolithic Siberian genome reveals dual ancestry of Native Americans. Nature 2014;505:87–91. doi: 10.1038/nature12736 24256729
42. Behar DM, Metspalu M, Baran Y, Kopelman NM, Yunusbayev B, Gladstein A, et al. No Evidence from Genome-Wide Data of a Khazar Origin for the Ashkenazi Jews. Human Biology. 2013;85(6):859–900. 25079123
43. Manichaikul A, Mychaleckyj JC, Rich SS, Daly K, Sale M, Chen WM. Robust relationship inference in genome-wide association studies. Bioinformatics. 2010;26(22):2867–73. doi: 10.1093/bioinformatics/btq559 20926424
44. Frazer KA, Ballinger DG, Cox DR, Hinds DA, Stuve LL, Gibbs RA, et al. A second generation human haplotype map of over 3.1 million SNPs. Nature. 2007;449(7164):851–61. 17943122
45. Browning BL, Browning SR. A fast, powerful method for detecting identity by descent. Am J Hum Genet. 2011;88(2):173–82. doi: 10.1016/j.ajhg.2011.01.010 21310274
46. Banerjee S. On geodetic distance computations in spatial modelling. Biometrics. 2005;61:617–25. 16011712
47. Cann HM, de Toma C, Cazes L, Legrand MF, Morel V, Piouffre L, et al. A human genome diversity cell line panel. Science. 2002;296(5566):261–2. 11954565
48. Ma J, Amos CI. Principal components analysis of population admixture. Plos One. 2012;7(7):e40115. doi: 10.1371/journal.pone.0040115 22808102
49. Chen GK, Marjoram P, Wall JD. Fast and flexible simulation of DNA sequence data. Genome Research. 2009;19(1):136–42. doi: 10.1101/gr.083634.108 19029539
50. Schaffner SF, Foo C, Gabriel S, Reich D, Daly MJ, Altshuler D. Calibrating a coalescent simulation of human genome sequence variation. Genome Research. 2005;15(11):1576–83. 16251467
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Genetika Reprodukčná medicínaČlánok vyšiel v časopise
PLOS Genetics
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