Host Genetic Variation Influences Gene Expression Response to Rhinovirus Infection

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Rhinovirus (RV) is the predominant cause of the common cold. However, infections with RV result in a broad spectrum of effects ranging from asymptomatic infections to severe lower respiratory illnesses. We hypothesized that diversity in response to RV-infections is, at least in part, due to variation in the host genome. To address this, we mapped the genetic variations that are associated with gene expression response (reQTLs) to RV-infection in PBMCs. Here, we report local reQTLs for 38 genes including those with known functions in viral response such as UBA7, OAS1, IRF5 and those that have been previously associated with immune and RV-related diseases (e.g., ITGA2, MSR1, GSTM3). We also show that reQTL regions are enriched for binding sites of the virus-activated STAT2 transcription factor, suggesting a potential mechanism of action for five of the reQTLs identified. Overall, the reQTLs we identified represent promising candidates to affect individual’s immune response to RV infections and further targeted studies of the reQTL regions might lead to improved control and treatment of RV-associated immune and respiratory diseases.

Vyšlo v časopise: Host Genetic Variation Influences Gene Expression Response to Rhinovirus Infection. PLoS Genet 11(4): e32767. doi:10.1371/journal.pgen.1005111
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.pgen.1005111

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