Genomic Location of the Major Ribosomal Protein Gene Locus Determines Global Growth and Infectivity

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Increasing evidence indicates that nucleoid spatiotemporal organization is crucial for bacterial physiology since these microorganism lack compartmentalized nucleus. However, it is still unclear how gene order within the chromosome can influence cell physiology. Here, by systematically relocating ribosomal protein genes to different genomic positions in Vibrio cholerae, we revealed drastic differences in growth rate and infectivity of this isogenic strain set. We show that genomic positioning of ribosomal protein genes is crucial for physiology by providing replication-dependent higher dosage. Therefore it might play a key role in genome evolution of bacterial species. This work will contribute to discover genomic rules governing cell physiology which will be essential in the context of the creation of new artificial life forms.

Vyšlo v časopise: Genomic Location of the Major Ribosomal Protein Gene Locus Determines Global Growth and Infectivity. PLoS Genet 11(4): e32767. doi:10.1371/journal.pgen.1005156
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.pgen.1005156

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