The Autophagy Receptor TAX1BP1 and the Molecular Motor Myosin VI Are Required for Clearance of Salmonella Typhimurium by Autophagy

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One of the most common causes of food poisoning is the pathogen Salmonella enterica serovar Typhimurium. This pathogen enters the cells of the body through the intestine and after invasion of these cells it survives and multiplies due to its own ability to evade the immune system, thus causing infection. Understanding how this pathogen evades the natural protective mechanisms present within the cell that normally degrade a foreign body is an important area of current research. Here, we describe a process by which the control of infection is mediated by a cellular self-degradation pathway called autophagy. This pathway requires specific adaptor proteins within the cell that identify the foreign pathogen and target it for degradation. We define the function of a specific adaptor protein required for this process of pathogen recognition and show how this adaptor links to and utilises other cellular machinery, the actin cytoskeleton and associated motor proteins to accomplish this function and restrict pathogen proliferation. Our work thus demonstrates that this specialised autophagy pathway requires the coordination of multiple proteins and we identify novel machinery that is essential to efficiently degrade Salmonella Typhimurium within cells.

Vyšlo v časopise: The Autophagy Receptor TAX1BP1 and the Molecular Motor Myosin VI Are Required for Clearance of Salmonella Typhimurium by Autophagy. PLoS Pathog 11(10): e32767. doi:10.1371/journal.ppat.1005174
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.ppat.1005174

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