Papillomavirus E6 Oncoproteins Take Common Structural Approaches to Solve Different Biological Problems

1. Rector A, Van Ranst M (2013) Animal papillomaviruses. Virology 445: 213–223. doi: 10.1016/j.virol.2013.05.007 23711385

2. Van Doorslaer K (2013) Evolution of the papillomaviridae. Virology 445: 11–20. doi: 10.1016/j.virol.2013.05.012 23769415

3. Vande Pol SB, Klingelhutz AJ (2013) Papillomavirus E6 oncoproteins. Virology 445: 115–137. doi: 10.1016/j.virol.2013.04.026 23711382

4. Moody CA, Laimins LA (2009) Human papillomaviruses activate the ATM DNA damage pathway for viral genome amplification upon differentiation. PLoS Pathog 5: e1000605. doi: 10.1371/journal.ppat.1000605 19798429

5. Roman A, Munger K (2013) The papillomavirus E7 proteins. Virology 445: 138–168. doi: 10.1016/j.virol.2013.04.013 23731972

6. Scheffner M, Werness BA, Huibregtse JM, Levine AJ, Howley PM (1990) The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53. Cell 63: 1129–1136. 2175676

7. Huibregtse JM, Scheffner M, Howley PM (1993) Localization of the E6-AP regions that direct human papillomavirus E6 binding, association with p53, and ubiquitination of associated proteins. Mol Cell Biol 13: 4918–4927. 8393140

8. Ansari T, Brimer N, Vande Pol SB (2012) Peptide interactions stabilize and restructure human papillomavirus type 16 E6 to interact with p53. J Virol 86: 11386–11391. 22896608

9. Pim D, Bergant M, Boon SS, Ganti K, Kranjec C, et al. (2012) Human papillomaviruses and the specificity of PDZ domain targeting. FEBS J 279: 3530–3537. doi: 10.1111/j.1742-4658.2012.08709.x 22805590

10. Oh ST, Longworth MS, Laimins LA (2004) Roles of the E6 and E7 proteins in the life cycle of low-risk human papillomavirus type 11. J Virol 78: 2620–2626. 14963169

11. White EA, Kramer RE, Tan MJ, Hayes SD, Harper JW, et al. (2012) Comprehensive analysis of host cellular interactions with human papillomavirus E6 proteins identifies new E6 binding partners and reflects viral diversity. J Virol 86: 13174–13186. doi: 10.1128/JVI.02172-12 23015706

12. Brimer N, Lyons C, Wallberg AE, Vande Pol SB (2012) Cutaneous papillomavirus E6 oncoproteins associate with MAML1 to repress transactivation and NOTCH signaling. Oncogene 31: 4639–4646. doi: 10.1038/onc.2011.589 22249263

13. Rozenblatt-Rosen O, Deo RC, Padi M, Adelmant G, Calderwood MA, et al. (2012) Interpreting cancer genomes using systematic host network perturbations by tumour virus proteins. Nature 487: 491–495. doi: 10.1038/nature11288 22810586

14. Tan MJ, White EA, Sowa ME, Harper JW, Aster JC, et al. (2012) Cutaneous beta-human papillomavirus E6 proteins bind Mastermind-like coactivators and repress Notch signaling. Proc Natl Acad Sci U S A 109: E1473–1480. doi: 10.1073/pnas.1205991109 22547818

15. Nicolas M, Wolfer A, Raj K, Kummer JA, Mill P, et al. (2003) Notch1 functions as a tumor suppressor in mouse skin. Nat Genet 33: 416–421. 12590261

16. Ramoz N, Rueda LA, Bouadjar B, Montoya LS, Orth G, et al. (2002) Mutations in two adjacent novel genes are associated with epidermodysplasia verruciformis. Nat Genet 32: 579–581. 12426567

17. Wallace NA, Robinson K, Howie HL, Galloway DA (2012) HPV 5 and 8 E6 abrogate ATR activity resulting in increased persistence of UVB induced DNA damage. PLoS Pathog 8: e1002807. doi: 10.1371/journal.ppat.1002807 22807682

18. Wade R, Brimer N, Vande Pol S (2008) Transformation by bovine papillomavirus type 1 E6 requires paxillin. J Virol 82: 5962–5966. doi: 10.1128/JVI.02747-07 18385245

19. Bohl J, Das K, Dasgupta B, Vande Pol SB (2000) Competitive binding to a charged leucine motif represses transformation by a papillomavirus E6 oncoprotein. Virology 271: 163–170. 10814581

20. Zanier K, Charbonnier S, Sidi AO, McEwen AG, Ferrario MG, et al. (2013) Structural basis for hijacking of cellular LxxLL motifs by papillomavirus E6 oncoproteins. Science 339: 694–698. doi: 10.1126/science.1229934 23393263