THY-1 Cell Surface Antigen (CD90) Has an Important Role in the Initial Stage of Human Cytomegalovirus Infection

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Human cytomegalovirus (HCMV) is an important human pathogen that infects about half the US population and is a major cause of birth defects and morbidity in transplant recipients. Despite extensive research, much is still unknown regarding how the virus enters cells. We identified THY-1, a protein on the surface of many different cell types susceptible to CMV infection, as having an important role for facilitating virus infection. We found that antibody to THY-1 or soluble THY-1 protein blocked HCMV infection in multiple cell types, suggesting that THY-1 might serve as a potential therapeutic target to reduce infection. Expression of exogenous THY-1 increased susceptibility of cells to HCMV infection. We showed that THY-1 has an important role in a host signaling pathway that is initiated when HCMV infects cells. Furthermore, we found that THY-1 interacted with HCMV glycoproteins that initiate entry of virus into the cell. THY-1 is known to interact with several host cell proteins important for infection and is expressed on numerous types of cells that can be infected by HCMV. Thus, we have identified THY-1 as a molecule that has an important role in the initial stage of HCMV infection.

Vyšlo v časopise: THY-1 Cell Surface Antigen (CD90) Has an Important Role in the Initial Stage of Human Cytomegalovirus Infection. PLoS Pathog 11(7): e32767. doi:10.1371/journal.ppat.1004999
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.ppat.1004999

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