N-acetylglucosamine Regulates Virulence Properties in Microbial Pathogens

1. Kombrink A, Thomma BP. LysM effectors: secreted proteins supporting fungal life. PLoS Pathog. 2013;9(12):e1003769. doi: 10.1371/journal.ppat.1003769 24348247

2. Bueter CL, Specht CA, Levitz SM. Innate sensing of chitin and chitosan. PLoS Pathog. 2013;9(1):e1003080. doi: 10.1371/journal.ppat.1003080 23326227

3. Wheeler R, Chevalier G, Eberl G, Gomperts Boneca I. The biology of bacterial peptidoglycans and their impact on host immunity and physiology. Cell Microbiol. 2014;16(7):1014–23. doi: 10.1111/cmi.12304 24779390

4. Sohanpal BK, El-Labany S, Lahooti M, Plumbridge JA, Blomfield IC. Integrated regulatory responses of fimB to N-acetylneuraminic (sialic) acid and GlcNAc in Escherichia coli K-12. Proc Natl Acad Sci U S A. 2004;101(46):16322–7. 15534208

5. Konopka JB. N-acetylglucosamine (GlcNAc) functions in cell signaling. Scientifica. 2012;2012:489208. 23350039

6. Korgaonkar A, Trivedi U, Rumbaugh KP, Whiteley M. Community surveillance enhances Pseudomonas aeruginosa virulence during polymicrobial infection. Proc Natl Acad Sci U S A. 2013;110(3):1059–64. doi: 10.1073/pnas.1214550110 23277552

7. Simonetti N, Strippoli V, Cassone A. Yeast-mycelial conversion induced by N-acetyl-D-glucosamine in Candida albicans. Nature. 1974;250(464):344–6. 4605454

8. Sudbery PE. Growth of Candida albicans hyphae. Nat Rev Microbiol. 2011;9(10):737–48. Epub 2011/08/17. doi: 10.1038/nrmicro2636 21844880

9. Pande K, Chen C, Noble SM. Passage through the mammalian gut triggers a phenotypic switch that promotes Candida albicans commensalism. Nat Genet. 2013;45(9):1088–91. doi: 10.1038/ng.2710 23892606

10. Huang G, Yi S, Sahni N, Daniels KJ, Srikantha T, Soll DR. N-acetylglucosamine induces white to opaque switching, a mating prerequisite in Candida albicans. PLoS Pathog. 2010;6(3):e1000806. Epub 2010/03/20. doi: 10.1371/journal.ppat.1000806 20300604

11. Alvarez FJ, Konopka JB. Identification of an N-acetylglucosamine transporter that mediates hyphal induction in Candida albicans. Mol Biol Cell. 2007;18:965–75. 17192409

12. Gilmore SA, Naseem S, Konopka JB, Sil A. N-acetylglucosamine (GlcNAc) Triggers a Rapid, Temperature-Responsive Morphogenetic Program in Thermally Dimorphic Fungi. PLoS Genet. 2013;9(9):e1003799. doi: 10.1371/journal.pgen.1003799 24068964

13. Naseem S, Gunasekera A, Araya E, Konopka JB. N-acetylglucosamine (GlcNAc) induction of hyphal morphogenesis and transcriptional responses in Candida albicans are not dependent on its metabolism. J Biol Chem. 2011;286(33):28671–80. doi: 10.1074/jbc.M111.249854 21700702

14. Hart GW, Slawson C, Ramirez-Correa G, Lagerlof O. Cross talk between O-GlcNAcylation and phosphorylation: roles in signaling, transcription, and chronic disease. Annu Rev Biochem. 2011;80:825–58. Epub 2011/03/12. doi: 10.1146/annurev-biochem-060608-102511 21391816

15. Gunasekera A, Alvarez FJ, Douglas LM, Wang HX, Rosebrock AP, Konopka JB. Identification of GIG1, a GlcNAc-induced gene in Candida albicans needed for normal sensitivity to the chitin synthase inhibitor nikkomycin Z. Eukaryot Cell. 2010;9(10):1476–83. Epub 2010/08/03. doi: 10.1128/EC.00178-10 20675577

16. Naseem S, Araya E, Konopka JB. Hyphal growth in Candida albicans does not require induction of hyphal-specific gene expression. Mol Biol Cell. 2015;26(6):1174–87. doi: 10.1091/mbc.E14-08-1312 25609092

17. Vylkova S, Carman AJ, Danhof HA, Collette JR, Zhou H, Lorenz MC. The fungal pathogen Candida albicans autoinduces hyphal morphogenesis by raising extracellular pH. MBio. 2011;2(3):e00055–11. Epub 2011/05/19. doi: 10.1128/mBio.00055-11 21586647

18. Moye ZD, Burne RA, Zeng L. Uptake and metabolism of N-acetylglucosamine and glucosamine by Streptococcus mutans. Appl Environ Microbiol. 2014;80(16):5053–67. doi: 10.1128/AEM.00820-14 24928869

19. Park JT, Uehara T. How bacteria consume their own exoskeletons (turnover and recycling of cell wall peptidoglycan). Microbiol Mol Biol Rev. 2008;72(2):211–27. Epub 2008/06/07. doi: 10.1128/MMBR.00027-07 18535144

20. Plumbridge J. Co-ordinated regulation of amino sugar biosynthesis and degradation: the NagC repressor acts as both an activator and a repressor for the transcription of the glmUS operon and requires two separated NagC binding sites. EMBO J. 1995;14(16):3958–65. Epub 1995/08/15. 7545108

21. Chang DE, Smalley DJ, Tucker DL, Leatham MP, Norris WE, Stevenson SJ, et al. Carbon nutrition of Escherichia coli in the mouse intestine. Proc Natl Acad Sci U S A. 2004;101(19):7427–32. 15123798

22. Ghosh S, Rao KH, Sengupta M, Bhattacharya SK, Datta A. Two gene clusters co-ordinate for a functional N-acetylglucosamine catabolic pathway in Vibrio cholerae. Mol Microbiol. 2011;80(6):1549–60. doi: 10.1111/j.1365-2958.2011.07664.x 21488982

23. Kawada-Matsuo M, Mazda Y, Oogai Y, Kajiya M, Kawai T, Yamada S, et al. GlmS and NagB regulate amino sugar metabolism in opposing directions and affect Streptococcus mutans virulence. PloS one. 2012;7(3):e33382. doi: 10.1371/journal.pone.0033382 22438919

24. Nothaft H, Rigali S, Boomsma B, Swiatek M, McDowall KJ, van Wezel GP, et al. The permease gene nagE2 is the key to N-acetylglucosamine sensing and utilization in Streptomyces coelicolor and is subject to multi-level control. Mol Microbiol. 2010;75(5):1133–44. Epub 2010/05/22. doi: 10.1111/j.1365-2958.2009.07020.x 20487300

25. Korgaonkar AK, Whiteley M. Pseudomonas aeruginosa enhances production of an antimicrobial in response to N-acetylglucosamine and peptidoglycan. J Bacteriol. 2011;193(4):909–17. Epub 2010/12/21. doi: 10.1128/JB.01175-10 21169497

26. Barnhart MM, Lynem J, Chapman MR. GlcNAc-6P levels modulate the expression of Curli fibers by Escherichia coli. J Bacteriol. 2006;188(14):5212–9. 16816193

27. Shen A, Kamp HD, Grundling A, Higgins DE. A bifunctional O-GlcNAc transferase governs flagellar motility through anti-repression. Genes Dev. 2006;20(23):3283–95. Epub 2006/12/13. 17158746

28. Li S, Zhang L, Yao Q, Li L, Dong N, Rong J, et al. Pathogen blocks host death receptor signalling by arginine GlcNAcylation of death domains. Nature. 2013;501(7466):242–6. doi: 10.1038/nature12436 23955153

29. Jank T, Bogdanovic X, Wirth C, Haaf E, Spoerner M, Bohmer KE, et al. A bacterial toxin catalyzing tyrosine glycosylation of Rho and deamidation of Gq and Gi proteins. Nat Struct Mol Biol. 2013;20(11):1273–80. doi: 10.1038/nsmb.2688 24141704

30. Milewski S, Gabriel I, Olchowy J. Enzymes of UDP-GlcNAc biosynthesis in yeast. Yeast. 2006;23(1):1–14. 16408321

31. Dennis JW, Nabi IR, Demetriou M. Metabolism, cell surface organization, and disease. Cell. 2009;139(7):1229–41. Epub 2010/01/13. doi: 10.1016/j.cell.2009.12.008 20064370

32. Wiesner DL, Specht CA, Lee CK, Smith KD, Mukaremera L, Lee ST, et al. Chitin Recognition via Chitotriosidase Promotes Pathologic Type-2 Helper T Cell Responses to Cryptococcal Infection. PLoS Pathog. 2015;11(3):e1004701. doi: 10.1371/journal.ppat.1004701 25764512

33. Grigorian A, Araujo L, Naidu NN, Place DJ, Choudhury B, Demetriou M. N-acetylglucosamine inhibits T-helper 1 (Th1)/T-helper 17 (Th17) cell responses and treats experimental autoimmune encephalomyelitis. J Biol Chem. 2011;286(46):40133–41. Epub 2011/10/04. doi: 10.1074/jbc.M111.277814 21965673

34. Naderer T, Heng J, McConville MJ. Evidence that intracellular stages of Leishmania major utilize amino sugars as a major carbon source. PLoS Pathog. 2010;6(12):e1001245. Epub 2011/01/05. doi: 10.1371/journal.ppat.1001245 21203480

35. Shank EA, Kolter R. New developments in microbial interspecies signaling. Curr Opin Microbiol. 2009;12(2):205–14. Epub 2009/03/03. doi: 10.1016/j.mib.2009.01.003 19251475

36. Nicholson JK, Holmes E, Kinross J, Burcelin R, Gibson G, Jia W, et al. Host-gut microbiota metabolic interactions. Science. 2012;336(6086):1262–7. Epub 2012/06/08. doi: 10.1126/science.1223813 22674330