Hematopoietic but Not Endothelial Cell MyD88 Contributes to Host Defense during Gram-negative Pneumonia Derived Sepsis

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Klebsiella pneumoniae is an important causative pathogen in hospital acquired or health care associated pneumonia and sepsis. Toll-like receptors recognize conserved motifs expressed by pathogens and thereby initiate the innate immune response. Myeloid differentiation primary response gene (MyD)88 is a common adapter for multiple Toll-like receptors that is important for protective immunity during Klebsiella infections. The contribution of different cell types to MyD88 mediated protection is not known. We used a model of Klebsiella pneumonia and secondary sepsis in mice that were selectively deficient for MyD88 in specific cell-types that are implicated to be important for host defense mechanisms by use of a tissue specific gene recombination system and bone marrow transfer. We demonstrate that MyD88 in myeloid cells, but not in endothelial cells, is important for host defense during pneumonia derived sepsis caused by Klebsiella pneumoniae.

Vyšlo v časopise: Hematopoietic but Not Endothelial Cell MyD88 Contributes to Host Defense during Gram-negative Pneumonia Derived Sepsis. PLoS Pathog 10(9): e32767. doi:10.1371/journal.ppat.1004368
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.ppat.1004368

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