#PAGE_PARAMS# #ADS_HEAD_SCRIPTS# #MICRODATA#

The Role of Iron in Prion Disease and Other Neurodegenerative Diseases


article has not abstract


Vyšlo v časopise: The Role of Iron in Prion Disease and Other Neurodegenerative Diseases. PLoS Pathog 10(9): e32767. doi:10.1371/journal.ppat.1004335
Kategorie: Pearls
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.ppat.1004335

Souhrn

article has not abstract


Zdroje

1. SinghN, HaldarS, TripathiAK, HorbackK, WongJ, et al. (2014) Brain iron homeostasis: from molecular mechanisms to clinical significance and therapeutic opportunities. Antioxid Redox Signal 20: 1324–1363.

2. HaldarS, BeveridgeJ, WongJ, SinghA, GalimbertiD, et al. (2013) A low-molecular-weight ferroxidase is increased in the CSF of sCJD cases: CSF ferroxidase and transferrin as diagnostic biomarkers for sCJD. Antioxid Redox Signal 19: 1662–1675.

3. OlivieriS, ContiA, IannacconeS, CannistraciCV, CampanellaA, et al. (2011) Ceruloplasmin oxidation, a feature of Parkinson's disease CSF, inhibits ferroxidase activity and promotes cellular iron retention. J Neurosci 31: 18568–18577.

4. SinghA, IsaacAO, LuoX, MohanML, CohenML, et al. (2009) Abnormal brain iron homeostasis in human and animal prion disorders. PLoS Pathog 5: e1000336.

5. GreenoughMA, CamakarisJ, BushAI (2013) Metal dyshomeostasis and oxidative stress in Alzheimer's disease. Neurochem Int 62: 540–555.

6. AndersenHH, JohnsenKB, MoosT (2014) Iron deposits in the chronically inflamed central nervous system and contributes to neurodegeneration. Cell Mol Life Sci 71: 1607–1622.

7. SinghA, HaldarS, HorbackK, TomC, ZhouL, et al. (2013) Prion protein regulates iron transport by functioning as a ferrireductase. J Alzheimers Dis 35: 541–552.

8. OhgamiRS, CampagnaDR, McDonaldA, FlemingMD (2006) The Steap proteins are metalloreductases. Blood 108: 1388–1394.

9. SinghA, QingL, KongQ, SinghN (2012) Change in the characteristics of ferritin induces iron imbalance in prion disease affected brains. Neurobiol Dis 45: 930–938.

10. HwangD, LeeIY, YooH, GehlenborgN, ChoJH, et al. (2009) A systems approach to prion disease. Mol Syst Biol 5: 252.

11. KimBH, JunYC, JinJK, KimJI, KimNH, et al. (2007) Alteration of iron regulatory proteins (IRP1 and IRP2) and ferritin in the brains of scrapie-infected mice. Neurosci Lett 422: 158–163.

12. HuzarewichRL, MedinaS, RobertsonC, ParchaliukD, BoothSA (2011) Transcriptional modulation in a leukocyte-depleted splenic cell population during prion disease. J Toxicol Environ Health A 74: 1504–1520.

13. FernaeusS, HalldinJ, BedecsK, LandT (2005) Changed iron regulation in scrapie-infected neuroblastoma cells. Brain Res Mol Brain Res 133: 266–273.

14. BasuS, MohanML, LuoX, KunduB, KongQ, et al. (2007) Modulation of proteinase K-resistant prion protein in cells and infectious brain homogenate by redox iron: implications for prion replication and disease pathogenesis. Mol Biol Cell 18: 3302–3312.

15. MishraRS, BasuS, GuY, LuoX, ZouWQ, et al. (2004) Protease-resistant human prion protein and ferritin are cotransported across Caco-2 epithelial cells: implications for species barrier in prion uptake from the intestine. J Neurosci 24: 11280–11290.

16. SinghA, KongQ, LuoX, PetersenRB, MeyersonH, et al. (2009) Prion protein (PrP) knock-out mice show altered iron metabolism: a functional role for PrP in iron uptake and transport. PLoS ONE 4: e6115.

17. PushieMJ, PickeringIJ, MartinGR, TsutsuiS, JirikFR, et al. (2011) Prion protein expression level alters regional copper, iron and zinc content in the mouse brain. Metallomics 3: 206–214.

18. BandyopadhyayS, CahillC, BalleidierA, HuangC, LahiriDK, et al. (2013) Novel 5′ untranslated region directed blockers of iron-regulatory protein-1 dependent amyloid precursor protein translation: implications for down syndrome and Alzheimer's disease. PLoS ONE 8: e65978.

19. WongBX, DuceJA (2014) The iron regulatory capability of the major protein participants in prevalent neurodegenerative disorders. Front Pharmacol 5: 81.

20. SalazarJ, MenaN, HunotS, PrigentA, Alvarez-FischerD, et al. (2008) Divalent metal transporter 1 (DMT1) contributes to neurodegeneration in animal models of Parkinson's disease. Proc Natl Acad Sci U S A 105: 18578–18583.

Štítky
Hygiena a epidemiológia Infekčné lekárstvo Laboratórium

Článok vyšiel v časopise

PLOS Pathogens


2014 Číslo 9
Najčítanejšie tento týždeň
Najčítanejšie v tomto čísle
Kurzy

Zvýšte si kvalifikáciu online z pohodlia domova

Aktuální možnosti diagnostiky a léčby litiáz
nový kurz
Autori: MUDr. Tomáš Ürge, PhD.

Všetky kurzy
Prihlásenie
Zabudnuté heslo

Zadajte e-mailovú adresu, s ktorou ste vytvárali účet. Budú Vám na ňu zasielané informácie k nastaveniu nového hesla.

Prihlásenie

Nemáte účet?  Registrujte sa

#ADS_BOTTOM_SCRIPTS#