Symbionts Commonly Provide Broad Spectrum Resistance to Viruses in Insects: A Comparative Analysis of Strains

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In recent years it has been discovered that many organisms are infected with bacterial symbionts that protect them against pathogens. Wolbachia is a bacterial symbiont that is found in many species of insects, and several strains are known to protect the insects against viral infection. We took 19 strains of Wolbachia from different species of Drosophila fruit flies, transferred them into Drosophila simulans, and then infected these flies with two different viruses. We found that about half of the strains slowed the death of flies after viral infection. Given that 40% of terrestrial arthropods may be infected with Wolbachia, this suggests that many species may benefit from this protection. These increases in survival were tightly linked to reductions in the levels of the virus in the insect, suggesting that Wolbachia is reducing the viruses' ability to replicate. Despite the two viruses we used being very different, the level of protection that a Wolbachia strain provided against the two viruses tended to be very similar, suggesting that a single general mechanism underlies the antiviral effects. The extent to which a Wolbachia strain provides protection against viral infection depends largely on the bacterial density— the more Wolbachia, the greater the protection.

Vyšlo v časopise: Symbionts Commonly Provide Broad Spectrum Resistance to Viruses in Insects: A Comparative Analysis of Strains. PLoS Pathog 10(9): e32767. doi:10.1371/journal.ppat.1004369
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.ppat.1004369

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