#PAGE_PARAMS# #ADS_HEAD_SCRIPTS# #MICRODATA#

Controlling Pre-leukemic Thymocyte Self-Renewal

English version České info

article has not abstract

Vyšlo v časopise: Controlling Pre-leukemic Thymocyte Self-Renewal. PLoS Genet 10(12): e32767. doi:10.1371/journal.pgen.1004881
Kategorie: Perspective
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.pgen.1004881

Souhrn

article has not abstract

Zdroje

1. Van VlierbergheP, FerrandoA (2012) The molecular basis of T cell acute lymphoblastic leukemia. J Clin Invest 122: 3398–3406.

2. TremblayCS, HoangT, HoangT (2010) Early T cell differentiation lessons from T cell acute lymphoblastic leukemia. Prog Mol Biol Transl Sci 92: 121–156.

3. PandolfiA, BarreyroL, SteidlU (2013) Concise review: preleukemic stem cells: molecular biology and clinical implications of the precursors to leukemia stem cells. Stem Cells Transl Med 2: 143–150.

4. Corces-Zimmerman MR, Majeti R (2014) Pre-leukemic evolution of hematopoietic stem cells: the importance of early mutations in leukemogenesis. Leukemia. E-pub ahead of print. doi:10.1038/leu.2014.211.

5. Corces-ZimmermanMR, HongWJ, WeissmanIL, MedeirosBC, MajetiR (2014) Preleukemic mutations in human acute myeloid leukemia affect epigenetic regulators and persist in remission. Proc Natl Acad Sci U S A 111: 2548–2553.

6. ShlushLI, ZandiS, MitchellA, ChenWC, BrandweinJM, et al. (2014) Identification of pre-leukaemic haematopoietic stem cells in acute leukaemia. Nature 506: 328–333.

7. TremblayCS, CurtisDJ (2014) The clonal evolution of leukemic stem cells in T cell acute lymphoblastic leukemia. Curr Opin Hematol 21: 320–325.

8. GerbyB, TremblayM, Rojas-SutterlinS, HébertJ, SauvageauG, et al. (2014) SCL, LMO1 and Notch1 reprogram thymocytes into self-renewing cells. PLoS Genet 10: e1004768 doi:10.1371/journal.pgen.1004768

9. TremblayM, TremblayCS, HerblotS, AplanPD, HebertJ, et al. (2010) Modeling T cell acute lymphoblastic leukemia induced by the SCL and LMO1 oncogenes. Genes Dev 24: 1093–1105.

10. McCormackMP, ShieldsBJ, JacksonJT, NasaC, ShiW, et al. (2013) Requirement for Lyl1 in a model of Lmo2-driven early T cell precursor ALL. Blood 122: 2093–2103.

11. DelmoreJE, IssaGC, LemieuxME, RahlPB, ShiJ, et al. (2011) BET bromodomain inhibition as a therapeutic strategy to target c-Myc. Cell 146: 904–917.

12. HerblotS, SteffAM, HugoP, AplanPD, HoangT (2000) SCL and LMO1 alter thymocyte differentiation: inhibition of E2A-HEB function and pre-T alpha chain expression. Nat Immunol 1: 138–144.

13. MatthewsJM, LesterK, JosephS, CurtisDJ (2013) LIM-domain-only proteins in cancer. Nat Rev Cancer 13: 111–122.

14. HayduJE, FerrandoAA (2013) Early T cell precursor acute lymphoblastic leukaemia. Curr Opin Hematol 20: 369–373.

Štítky

Genetika Reprodukčná medicína

Článek Stratification by Smoking Status Reveals an Association of Genotype with Body Mass Index in Never Smokers

Článek Genome Wide Meta-analysis Highlights the Role of Genetic Variation in in the Regulation of Circulating Serum Chemerin

Článek Occupancy of Mitochondrial Single-Stranded DNA Binding Protein Supports the Strand Displacement Mode of DNA Replication

Článek Distinct Genealogies for Plasmids and Chromosome

Článek Large-scale Metabolomic Profiling Identifies Novel Biomarkers for Incident Coronary Heart Disease

Článek Non-coding RNAs Prevent the Binding of the MSL-complex to Heterochromatic Regions

Článek Plasmid Flux in ST131 Sublineages, Analyzed by Plasmid Constellation Network (PLACNET), a New Method for Plasmid Reconstruction from Whole Genome Sequences

Článek Epigenome-Guided Analysis of the Transcriptome of Plaque Macrophages during Atherosclerosis Regression Reveals Activation of the Wnt Signaling Pathway

Článek The Inventiveness of Nature: An Interview with Werner Arber

Článek Mediation Analysis Demonstrates That -eQTLs Are Often Explained by -Mediation: A Genome-Wide Analysis among 1,800 South Asians

Článek Generation of Antigenic Diversity in by Structured Rearrangement of Genes During Mitosis

Článek A Massively Parallel Pipeline to Clone DNA Variants and Examine Molecular Phenotypes of Human Disease Mutations

Článek Genetic Analysis of the Cardiac Methylome at Single Nucleotide Resolution in a Model of Human Cardiovascular Disease

Článek Genetic Analysis of Circadian Responses to Low Frequency Electromagnetic Fields in

Článek The Dissection of Meiotic Chromosome Movement in Mice Using an Electroporation Technique

Článek Altered Chromatin Occupancy of Master Regulators Underlies Evolutionary Divergence in the Transcriptional Landscape of Erythroid Differentiation

Článek Syd/JIP3 and JNK Signaling Are Required for Myonuclear Positioning and Muscle Function

Článek Notch Signaling Mediates the Age-Associated Decrease in Adhesion of Germline Stem Cells to the Niche

Článek Mutation of Leads to Blurred Tonotopic Organization of Central Auditory Circuits in Mice

Článek The IKAROS Interaction with a Complex Including Chromatin Remodeling and Transcription Elongation Activities Is Required for Hematopoiesis

Článek RAN-Binding Protein 9 is Involved in Alternative Splicing and is Critical for Male Germ Cell Development and Male Fertility

Článek Enhanced Longevity by Ibuprofen, Conserved in Multiple Species, Occurs in Yeast through Inhibition of Tryptophan Import

Článek Phosphorylation of Mitochondrial Polyubiquitin by PINK1 Promotes Parkin Mitochondrial Tethering

Článek Recurrent Loss of Specific Introns during Angiosperm Evolution

Článek Natural Variation Is Associated With Genome-Wide Methylation Changes and Temperature Seasonality

Článek SEEDSTICK is a Master Regulator of Development and Metabolism in the Arabidopsis Seed Coat

Článek Overlapping and Non-overlapping Functions of Condensins I and II in Neural Stem Cell Divisions

Článek Unisexual Reproduction Drives Meiotic Recombination and Phenotypic and Karyotypic Plasticity in

Článek Tetraspanin (TSP-17) Protects Dopaminergic Neurons against 6-OHDA-Induced Neurodegeneration in

Článek ABA-Mediated ROS in Mitochondria Regulate Root Meristem Activity by Controlling Expression in

Článek Mutations in Global Regulators Lead to Metabolic Selection during Adaptation to Complex Environments

Článek Global Analysis of Photosynthesis Transcriptional Regulatory Networks

Článek Mucolipin Co-deficiency Causes Accelerated Endolysosomal Vacuolation of Enterocytes and Failure-to-Thrive from Birth to Weaning

Článek How Malaria Parasites Avoid Running Out of Ammo

Článek Echoes of the Past: Hereditarianism and

Článek Deep Reads: Strands in the History of Molecular Genetics

Článek Keep on Laying Eggs Mama, RNAi My Reproductive Aging Blues Away

Článek Analysis of a Plant Complex Resistance Gene Locus Underlying Immune-Related Hybrid Incompatibility and Its Occurrence in Nature

Článek Epistatic Adaptive Evolution of Human Color Vision

Článek Increased and Imbalanced dNTP Pools Symmetrically Promote Both Leading and Lagging Strand Replication Infidelity

Článek Genetic Basis of Haloperidol Resistance in Is Complex and Dose Dependent

Článek Genome-Wide Analysis of DNA Methylation Dynamics during Early Human Development

Článek Interaction between Conjugative and Retrotransposable Elements in Horizontal Gene Transfer

Článek The Evolution of Sex Ratio Distorter Suppression Affects a 25 cM Genomic Region in the Butterfly

Článek is Required for Adult Maintenance of Dopaminergic Neurons in the Ventral Substantia Nigra

Článek PRL1, an RNA-Binding Protein, Positively Regulates the Accumulation of miRNAs and siRNAs in Arabidopsis

Článek Genetic Control of Contagious Asexuality in the Pea Aphid

Článek Early Mesozoic Coexistence of Amniotes and Hepadnaviridae

Článek Local and Systemic Regulation of Plant Root System Architecture and Symbiotic Nodulation by a Receptor-Like Kinase

Článek Gene Pathways That Delay Reproductive Senescence

Článek The Evolution of Fungal Metabolic Pathways

Článek Maf1 Is a Novel Target of PTEN and PI3K Signaling That Negatively Regulates Oncogenesis and Lipid Metabolism

Článek Formation of Linear Amplicons with Inverted Duplications in Requires the MRE11 Nuclease

Článek Identification of Rare Causal Variants in Sequence-Based Studies: Methods and Applications to , a Gene Involved in Cohen Syndrome and Autism

Článek Rrp12 and the Exportin Crm1 Participate in Late Assembly Events in the Nucleolus during 40S Ribosomal Subunit Biogenesis

Článek The Mutations in the ATP-Binding Groove of the Rad3/XPD Helicase Lead to -Cockayne Syndrome-Like Phenotypes

Článek Topoisomerase I Plays a Critical Role in Suppressing Genome Instability at a Highly Transcribed G-Quadruplex-Forming Sequence

Článek A Cbx8-Containing Polycomb Complex Facilitates the Transition to Gene Activation during ES Cell Differentiation

Článek Transcriptional Frameshifting Rescues Type VI Secretion by the Production of Two Length Variants from the Prematurely Interrupted Gene

Článek Association Mapping across Numerous Traits Reveals Patterns of Functional Variation in Maize

Článek Genome-Wide Analysis of -Regulated and Phased Small RNAs Underscores the Importance of the ta-siRNA Pathway to Maize Development

Článek Dissemination of Cephalosporin Resistance Genes between Strains from Farm Animals and Humans by Specific Plasmid Lineages

Článek The Tau Tubulin Kinases TTBK1/2 Promote Accumulation of Pathological TDP-43

Článek Germline Signals Deploy NHR-49 to Modulate Fatty-Acid β-Oxidation and Desaturation in Somatic Tissues of

Článek Microevolution of in Macrophages Restores Filamentation in a Nonfilamentous Mutant

Článek Vangl2-Regulated Polarisation of Second Heart Field-Derived Cells Is Required for Outflow Tract Lengthening during Cardiac Development

Článek Chondrocytes Transdifferentiate into Osteoblasts in Endochondral Bone during Development, Postnatal Growth and Fracture Healing in Mice

Článek A ABC Transporter Regulates Lifespan

Článek RA and FGF Signalling Are Required in the Zebrafish Otic Vesicle to Pattern and Maintain Ventral Otic Identities

Článek , and Reprogram Thymocytes into Self-Renewing Cells

Článek The miR9863 Family Regulates Distinct Alleles in Barley to Attenuate NLR Receptor-Triggered Disease Resistance and Cell-Death Signaling

Článek Detection of Pleiotropy through a Phenome-Wide Association Study (PheWAS) of Epidemiologic Data as Part of the Environmental Architecture for Genes Linked to Environment (EAGLE) Study

Článek Extensive Copy-Number Variation of Young Genes across Stickleback Populations

Článek The and Genetic Modules Interact to Regulate Ciliogenesis and Ciliary Microtubule Patterning in

Článek Analysis of the Genome, Transcriptome and Secretome Provides Insight into Its Pioneer Colonization Strategies of Wood

Článok vyšiel v časopise

PLOS Genetics

2014 Číslo 12

Najčítanejšie tento týždeň

Najčítanejšie v tomto čísle

Kurzy

Zvýšte si kvalifikáciu online z pohodlia domova

Aktuální možnosti diagnostiky a léčby litiáz

nový kurz

Autori: MUDr. Tomáš Ürge, PhD.

#ADS_BOTTOM_SCRIPTS#