A ABC Transporter Regulates Lifespan

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The drug transporters are often known for their ability to transport different physiological-related compounds across cell membranes. Although the abnormal up-regulation of some these transporters is believed to be the common cause of the clinic problem called drug resistance, the biological functions of these transporters remain largely unknown. Here we show that a Drosophila homolog of the mammalian drug transporter plays a role in lifespan regulation. Mutations of this gene increase the sensitivity to oxidative stress and reduce lifespan, while overexpression of this gene increases resistance to oxidative stress and extends lifespan. By molecular and genetic analyses, we have linked functions of this gene to a key signaling transduction pathway that has been known to be important in lifespan regulation.

Vyšlo v časopise: A ABC Transporter Regulates Lifespan. PLoS Genet 10(12): e32767. doi:10.1371/journal.pgen.1004844
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.pgen.1004844

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