Bacterial Immune Evasion through Manipulation of Host Inhibitory Immune Signaling

1. Cohen J (2002) The immunopathogenesis of sepsis. Nature 420: 885–891. 12490963

2. Zhu Y, Yao S, Chen L (2011) Cell surface signaling molecules in the control of immune responses: a tide model. Immunity 34: 466–478. doi: 10.1016/j.immuni.2011.04.008 21511182

3. Lu R, Pan H, Shively JE (2012) CEACAM1 negatively regulates IL-1β production in LPS activated neutrophils by recruiting SHP-1 to a SYK-TLR4-CEACAM1 complex. PLoS Pathog 8: e1002597. doi: 10.1371/journal.ppat.1002597 22496641

4. Chang Y-C, Olson J, Beasley FC, Tung C, Zhang J, et al. (2014) Group B Streptococcus engages an inhibitory Siglec through sialic acid mimicry to blunt innate immune and inflammatory responses in vivo. PLoS Pathog 10: e1003846. doi: 10.1371/journal.ppat.1003846 24391502

5. Nakayama M, Kurokawa K, Nakamura K, Lee BL, Sekimizu K, et al. (2012) Inhibitory receptor paired Ig-like receptor B is exploited by Staphylococcus aureus for virulence. J Immunol Baltim Md 1950 189: 5903–5911. doi: 10.4049/jimmunol.1201940 23152562

6. Choi HW, Brooking-Dixon R, Neupane S, Lee C- J, Miao EA, et al. (2013) Salmonella typhimurium impedes innate immunity with a mast-cell-suppressing protein tyrosine phosphatase, SptP. Immunity 39: 1108–1120. doi: 10.1016/j.immuni.2013.11.009 24332031

7. Rolán HG, Durand EA, Mecsas J (2013) Identifying Yersinia YopH-targeted signal transduction pathways that impair neutrophil responses during in vivo murine infection. Cell Host Microbe 14: 306–317. doi: 10.1016/j.chom.2013.08.013 24034616

8. Wang Y-C, Chen C-L, Sheu B-S, Yang Y-J, Tseng P-C, et al. (2014) Helicobacter pylori Infection Activates Src Homology-2 Domain-Containing Phosphatase 2 To Suppress IFN-γ Signaling. J Immunol Baltim Md 1950 193: 4149–4158. doi: 10.4049/jimmunol.1400594 25225672

9. Vivier E, Daëron M (1997) Immunoreceptor tyrosine-based inhibition motifs. Immunol Today 18: 286–291. 9190115

10. Slevogt H, Zabel S, Opitz B, Hocke A, Eitel J, et al. (2008) CEACAM1 inhibits Toll-like receptor 2-triggered antibacterial responses of human pulmonary epithelial cells. Nat Immunol 9: 1270–1278. doi: 10.1038/ni.1661 18836450

11. Nakayama M, Underhill DM, Petersen TW, Li B, Kitamura T, et al. (2007) Paired Ig-like receptors bind to bacteria and shape TLR-mediated cytokine production. J Immunol Baltim Md 1950 178: 4250–4259. 17371981

12. Carlin AF, Uchiyama S, Chang Y-C, Lewis AL, Nizet V, et al. (2009) Molecular mimicry of host sialylated glycans allows a bacterial pathogen to engage neutrophil Siglec-9 and dampen the innate immune response. Blood 113: 3333–3336. doi: 10.1182/blood-2008-11-187302 19196661

13. Carlin AF, Chang Y-C, Areschoug T, Lindahl G, Hurtado-Ziola N, et al. (2009) Group B Streptococcus suppression of phagocyte functions by protein-mediated engagement of human Siglec-5. J Exp Med 206: 1691–1699. doi: 10.1084/jem.20090691 19596804

14. Ali SR, Fong JJ, Carlin AF, Busch TD, Linden R, et al. (2014) Siglec-5 and Siglec-14 are polymorphic paired receptors that modulate neutrophil and amnion signaling responses to group B Streptococcus. J Exp Med 211: 1231–1242. doi: 10.1084/jem.20131853 24799499

15. Wang L, Gordon RA, Huynh L, Su X, Park Min K H, et al. (2010) Indirect inhibition of Toll-like receptor and type I interferon responses by ITAM-coupled receptors and integrins. Immunity 32: 518–530. doi: 10.1016/j.immuni.2010.03.014 20362473

16. Pinheiro da Silva F, Aloulou M, Benhamou M, Monteiro RC (2008) Inhibitory ITAMs: a matter of life and death. Trends Immunol 29: 366–373. doi: 10.1016/j.it.2008.05.001 18602341

17. Pinheiro da Silva F, Aloulou M, Skurnik D, Benhamou M, Andremont A, et al. (2007) CD16 promotes Escherichia coli sepsis through an FcR gamma inhibitory pathway that prevents phagocytosis and facilitates inflammation. Nat Med 13: 1368–1374. 17934470

18. Yan D, Wang X, Luo L, Cao X, Ge B (2012) Inhibition of TLR signaling by a bacterial protein containing immunoreceptor tyrosine-based inhibitory motifs. Nat Immunol 13: 1063–1071. doi: 10.1038/ni.2417 23001144

19. Yan D, Quan H, Wang L, Liu F, Liu H, et al. (2013) Enteropathogenic Escherichia coli Tir recruits cellular SHP-2 through ITIM motifs to suppress host immune response. Cell Signal 25: 1887–1894. doi: 10.1016/j.cellsig.2013.05.020 23707390

20. Bauer B, Pang E, Holland C, Kessler M, Bartfeld S, et al. (2012) The Helicobacter pylori virulence effector CagA abrogates human β-defensin 3 expression via inactivation of EGFR signaling. Cell Host Microbe 11: 576–586. doi: 10.1016/j.chom.2012.04.013 22704618

21. Higashi H, Tsutsumi R, Muto S, Sugiyama T, Azuma T, et al. (2002) SHP-2 tyrosine phosphatase as an intracellular target of Helicobacter pylori CagA protein. Science 295: 683–686. 11743164

22. Barrow AD, Trowsdale J (2006) You say ITAM and I say ITIM, let’s call the whole thing off: the ambiguity of immunoreceptor signalling. Eur J Immunol 36: 1646–1653. 16783855

23. Kaniga K, Uralil J, Bliska JB, Galán JE (1996) A secreted protein tyrosine phosphatase with modular effector domains in the bacterial pathogen Salmonella typhimurium. Mol Microbiol 21: 633–641. 8866485

24. LaRock CN, Cookson BT (2012) The Yersinia Virulence Effector YopM Binds Caspase-1 to Arrest Inflammasome Assembly and Processing. Cell Host Microbe 12: 799–805. doi: 10.1016/j.chom.2012.10.020 23245324

25. Ye Z, Gorman AA, Uittenbogaard AM, Myers-Morales T, Kaplan AM, et al. (2014) Caspase-3 Mediates the Pathogenic Effect of Yersinia pestis YopM in Liver of C57BL/6 Mice and Contributes to YopM’s Function in Spleen. PLoS ONE 9: e110956. doi: 10.1371/journal.pone.0110956 25372388

26. Daëron M, Latour S, Malbec O, Espinosa E, Pina P, et al. (1995) The same tyrosine-based inhibition motif, in the intracytoplasmic domain of Fc gamma RIIB, regulates negatively BCR-, TCR-, and FcR-dependent cell activation. Immunity 3: 635–646. 7584153

27. Doody GM, Justement LB, Delibrias CC, Matthews RJ, Lin J, et al. (1995) A role in B cell activation for CD22 and the protein tyrosine phosphatase SHP. Science 269: 242–244. 7618087

28. Staub E, Rosenthal A, Hinzmann B (2004) Systematic identification of immunoreceptor tyrosine-based inhibitory motifs in the human proteome. Cell Signal 16: 435–456. 14709333

29. Daëron M, Jaeger S, Du Pasquier L, Vivier E (2008) Immunoreceptor tyrosine-based inhibition motifs: a quest in the past and future. Immunol Rev 224: 11–43. doi: 10.1111/j.1600-065X.2008.00666.x 18759918