The Role of Misshapen NCK-related kinase (MINK), a Novel Ste20 Family Kinase, in the IRES-Mediated Protein Translation of Human Enterovirus 71

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Since its first isolation, human Enterovirus 71 (EV71) has been known to cause hand, foot and mouth disease in children, with some cases developing severe neurologic complications, leading to death. In the recent years, outbreaks within the Asia-Pacific region have caused significant deaths, making EV71 a major public health risk. Despite the growing threat from the spread of EV71 and increased research in this area, there are no clinically approved vaccines or antiviral drugs available against EV71. Cellular signalling and host kinases have been reported to play significant roles in the replication and propagation of many different pathogens. In this paper, we show that a serine/threonine kinase, Misshapen NIK-related kinase (MINK), plays a role in the replication of EV71 by stimulating the p38 mitogen activated protein kinase (p38-MAPK) pathway which in turns promotes the translation efficiency of EV71 viral protein synthesis. As the synthesis of viral proteins is crucial for the replication of the virus during infection, discovery of a crucial host kinase in this process may provide insights on the replication of EV71. With deeper understanding of the functions and regulation of MINK, this kinase may serve as a promising target for the development of antiviral therapy.

Vyšlo v časopise: The Role of Misshapen NCK-related kinase (MINK), a Novel Ste20 Family Kinase, in the IRES-Mediated Protein Translation of Human Enterovirus 71. PLoS Pathog 11(3): e32767. doi:10.1371/journal.ppat.1004686
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.ppat.1004686

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