The Impact of Host Diet on Titer in

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Many invertebrate organisms carry bacterial endosymbionts within their cells. In many cases, this ensures host access to resources provided by the endosymbionts, and reciprocally, a rich source of host-supplied nutrients supports bacterial growth and reproduction. However if bacterial reproduction is uncontrolled, an over-abundance of bacteria will ultimately destroy the host cell. Here we explore the factors that regulate endosymbiont abundance in host cells. We focused on Wolbachia endosymbionts that are carried naturally in the germ cells of fruit flies. Specifically, we determined whether dietary nutrients affect the amount of Wolbachia bacteria carried by female flies. We found that yeast-enriched diets strongly depleted Wolbachia in fly ovarian cells. By contrast, sucrose-enriched diets doubled the amount of Wolbachia in ovarian cells. In addition, we found that this response to diet is mediated through highly conserved TORC1 and insulin signaling pathways in the fly. Recent studies have revealed that host diet dramatically influences the types and abundance of gut microbes. Our study informs how host diet affects endosymbiotic bacteria housed within specific types of host cells.

Vyšlo v časopise: The Impact of Host Diet on Titer in. PLoS Pathog 11(3): e32767. doi:10.1371/journal.ppat.1004777
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.ppat.1004777

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