Is Antigenic Sin Always “Original?” Re-examining the Evidence Regarding Circulation of a Human H1 Influenza Virus Immediately Prior to the 1918 Spanish Flu

1. Luk J, Gross P, Thompson WW (2001) Observations on mortality during the 1918 influenza pandemic. Clin Infect Dis 33(8):1375–8. 11565078

2. Morens DM, Taubenberger JK (2012) 1918 influenza, a puzzle with missing pieces. Emerg Infect Dis 18(2):332–335. doi: 10.3201/eid1802.111409 22304897

3. Worobey M, Han G-Z, Rambaut A (2014) Genesis and pathogenesis of the 1918 pandemic H1N1 influenza A virus. Proc Natl Acad Sci:201324197.

4. Shanks GD, Brundage JF (2012) Pathogenic responses among young adults during the 1918 influenza pandemic. Emerg Infect Dis 18(2):201–207. doi: 10.3201/eid1802.102042 22306191

5. Gagnon A, Miller M, Hallman S, Bourbeau R, Herring A, et al. (2013) Age-Specific Mortality During the 1918 Influenza Pandemic: Unravelling the Mystery of High Young Adult Mortality. PLoS ONE 8(8):e69586. doi: 10.1371/journal.pone.0069586 23940526

6. Hallman S, Gagnon A (2014) Does Exposure to Influenza Very Early in Life Affect Mortality Risk during a Subsequent Outbreak? The 1890 and 1918 Pandemics in Canada. Modern Environments and Human Health, ed Zuckerman MK (John Wiley & Sons, Inc), pp 123–135. http://onlinelibrary.wiley.com/doi/10.1002/9781118504338.ch7/summary [Accessed August 14, 2014].

7. Oeppen J, Wilson C (2006) Epidemiological evidence for viral exposure in childhood as a risk-factor in subsequent influenza pandemics. Population Association of America, Los Angeles, March 30-April 1 2006.

8. Masurel N (1969) Serological characteristics of a “new” serotype of influenza A virus: the Hong Kong strain. Bull World Health Organ 41(3):461–468. 5309456

9. Masurel N (1976) Swine influenza virus and the recycling of influenza-A viruses in man. Lancet 2(7979):244–247. 59252

10. Dowdle WR (1999) Influenza A virus recycling revisited. Bull World Health Organ 77(10):820–828. 10593030

11. Itoh Y, Shinya K, Kiso M, Watanabe T, Sakoda Y, et al. (2009) In vitro and in vivo characterization of new swine-origin H1N1 influenza viruses. Nature 460(7258):1021–1025. doi: 10.1038/nature08260 19672242

12. Fukumi H (1969) Interpretation of influenza antibody patterns in man. Bull World Health Organ 41(3–4–5):469–473.

13. Davenport FM, Hennessy AV, Drescher J, Mulder J, Francis T (1964) Futher observations on the relevance of serologic recapitulations of human infection with influenza viruses. J Exp Med 120:1087–1097. 14238927

14. Simonsen L, Reichert TA, Miller MA (2004) The virtues of antigenic sin: consequences of pandemic recycling on influenza-associated mortality. Int Congr Ser 1263:791–794.

15. Francis T Jr (1960) On the Doctrine of Original Antigenic Sin. Proc Am Philos Soc 104(6):572–578.

16. O’Donnell CD, Wright A, Vogel L, Boonnak K, Treanor JJ, et al. (2014) Humans and ferrets with prior H1N1 influenza virus infections do not exhibit evidence of original antigenic sin after infection or vaccination with the 2009 pandemic H1N1 influenza virus. Clin Vaccine Immunol CVI 21(5):737–746. doi: 10.1128/CVI.00790-13 24648486

17. Lessler J, Riley S, Read JM, Wang S, Zhu H, et al. (2012) Evidence for Antigenic Seniority in Influenza A (H3N2) Antibody Responses in Southern China. PLoS Pathog 8(7):e1002802. doi: 10.1371/journal.ppat.1002802 22829765

18. Miller MS, Gardner TJ, Krammer F, Aguado LC, Tortorella D, et al. (2013) Neutralizing antibodies against previously encountered influenza virus strains increase over time: a longitudinal analysis. Sci Transl Med 5(198):198ra107.

19. Ma J, Dushoff J, Earn DJD (2011) Age-specific mortality risk from pandemic influenza. J Theor Biol 288:29–34. doi: 10.1016/j.jtbi.2011.08.003 21856313

20. Yang W, Petkova E, Shaman J (2014) The 1918 influenza pandemic in New York City: age-specific timing, mortality, and transmission dynamics. Influenza Other Respir Viruses 8(2):177–188. doi: 10.1111/irv.12217 24299150

21. Wilson N, Oliver J, Rice G, Summers JA, Baker MG, et al. (2014) Age-Specific Mortality During the 1918–19 Influenza Pandemic and Possible Relationship to the 1889–92 Influenza Pandemic. J Infect Dis:jiu191.

22. Viboud C, Eisenstein J, Reid A, Janczewski T, Morens D, et al. (2012) Age and gender mortality profile associated with the 1918–19 influenza pandemic in Kentucky, USA. J Infect Dis. http://jid.oxfordjournals.org/content/early/2012/12/10/infdis.jis745.long.

23. Reiss CS, Schulman JL (1980) Influenza type A virus M protein expression on infected cells is responsible for cross-reactive recognition by cytotoxic thymus-derived lymphocytes. Infect Immun 29(2):719–723. 7011983

24. Schulman JL, Petigrow C, Woodruff J (1977) Effects of cell mediated immunity in influenza virus infection in mice. Dev Biol Stand 39:385–390. 304820

25. Masurel N (1969) Relation between Hong Kong virus and former human A2 isolates and the A/Equi2 virus in human sera collected before 1957. The Lancet 293(7601):907–910. 4180894

26. Human Life-Table Database. http://www.lifetable.de [Accessed November 20, 2014].

27. Flu.gov Pandemic Flu History. http://www.flu.gov/pandemic/history/ [Accessed July 21, 2014].

28. NBER DID Mortality Data. http://www.nber.org/data/vital-statistics-mortality-data-multiple-cause-of-death.html [Accessed January 14, 2014].

29. Human Mortality Database The United States of America, Exposure to risk (period 1x1). http://www.mortality.org/hmd/USA/STATS/Exposures_1x1.txt [Accessed July 21, 2014].