Hyperdiverse Gene Cluster in Snail Host Conveys Resistance to Human Schistosome Parasites

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Schistosomes are water-borne blood-flukes that are transmitted by snail vectors. They infect over 200 million people in more than 70 countries and cause severe and chronic disability. Snails naturally vary in resistance to this parasite even within species, so bolstering snail resistance in the wild would block transmission. We artificially selected snails for resistance and observed a rapid evolutionary response, with the greatest change occurring in the same genomic region in two independent trials. We subsequently confirmed that the selected haplotype conveys resistance to infection by schistosomes. The extraordinarily high sequence divergence among haplotypes in this region appears to be elevated due to ongoing natural selection, likely via host-parasite co-evolution. We observed the highest variation in genes encoding putative parasite recognition proteins, suggesting that these control the resistance phenotype in a manner reminiscent of immune gene complexes in other taxa. Thus, this gene cluster presents a potential new target to interfere with parasite transmission at the vector stage.

Vyšlo v časopise: Hyperdiverse Gene Cluster in Snail Host Conveys Resistance to Human Schistosome Parasites. PLoS Genet 11(3): e32767. doi:10.1371/journal.pgen.1005067
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.pgen.1005067

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