Unsaturation of Very-Long-Chain Ceramides Protects Plant from Hypoxia-Induced Damages by Modulating Ethylene Signaling in

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Hypoxia is one of the most important abiotic stresses of worldwide concern that determines the crop productivity and the natural distribution of plant species. Flooding events such as root waterlogging and submergence strongly affect diffusion of gasses into plant cells, which eventually leads to hypoxia and carbohydrate shortages in terrestrial plants. The gaseous hormone ethylene is considered as the primary determinant of hypoxia response in plants. In particular, the Group VII ethylene-responsive factors (ERFs) have been demonstrated to be master regulators for oxygen sensing through an N-end rule protein degradation mechanism. Recent investigations have suggested that lipid molecules such VLC ceramides may play crucial roles in hypoxia signaling in both animal and plant cells. Here, we identified the unsaturated VLC ceramide species including C22:1-, C24:1- and C26:1-Cers which were essential for hypoxia response by interacting with CTR1 protein, inhibiting its kinase activity, and modulating subsequent ethylene signaling in Arabidopsis. The dynamic unsaturation of VLC ceramides is likely to serve as a novel protective strategy for enhancing plant tolerance to the frequent environmental stresses, including flooding.

Vyšlo v časopise: Unsaturation of Very-Long-Chain Ceramides Protects Plant from Hypoxia-Induced Damages by Modulating Ethylene Signaling in. PLoS Genet 11(3): e32767. doi:10.1371/journal.pgen.1005143
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.pgen.1005143

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