A Role for Taiman in Insect Metamorphosis

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Insect metamorphosis is one of the most fascinating processes of animal development. However, the mechanisms governing metamorphosis only started to be unveiled in the last century, when physiological research revealed that the main factor involved is juvenile hormone (JH), which represses metamorphosis in juvenile stages. Further steps to elucidate the molecular mechanisms underlying the action of JH remained elusive until recently, when the transcription factor Methoprene-tolerant (Met) was reported to be the JH receptor in the context of metamorphosis. Further experiments in vitro suggested that Met did not act alone as the JH receptor, but had to heterodimerise with another protein, Taiman (Tai). Unfortunately, Tai depletion experiments to demonstrate this protein's involvement in metamorphosis proved unsuccessful because they resulted in 100% mortality. We have discovered that Tai is expressed in a number of isoforms, and selective depletion has shown that at least some of these are involved in transducing the JH signal that represses metamorphosis. Moreover, our results show that the whole range of isoforms should be considered when studying Tai functions.

Vyšlo v časopise: A Role for Taiman in Insect Metamorphosis. PLoS Genet 10(10): e32767. doi:10.1371/journal.pgen.1004769
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.pgen.1004769

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