Disruption of SUMO-Specific Protease 2 Induces Mitochondria Mediated Neurodegeneration

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Protein modification by SUMO is a reversible and evolutionarily conserved process. Members of the SUMO-specific protease (SENP) family are known to reverse SUMO-conjugation in many defined systems, but their importance in mammalian development and pathogenesis remains largely elusive. Although SUMO-conjugated proteins have been shown to aberrantly accumulate in patients with neurodegeneration, there is no evidence supporting a direct involvement of SUMO modification enzymes in human diseases. This study reveals that disruption of SENP2 causes neurodegeneration through modulation of mitochondrial morphogenesis. Our findings provide a causal link of SUMO modification enzymes to cell survival, suggesting a new pathogenic mechanism for neurodegeneration. Exploring the protective effect of SENP2 on neuronal cell death may uncover important preventive and therapeutic strategies for neurodegenerative diseases.

Vyšlo v časopise: Disruption of SUMO-Specific Protease 2 Induces Mitochondria Mediated Neurodegeneration. PLoS Genet 10(10): e32767. doi:10.1371/journal.pgen.1004579
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.pgen.1004579

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