ZTF-8 Interacts with the 9-1-1 Complex and Is Required for DNA Damage Response and Double-Strand Break Repair in the Germline

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Proper response to DNA damage and repair of DNA double-strand breaks (DSBs) is important to maintain genomic integrity and promote both accurate chromosome segregation and tumor suppression. Here we define the roles of a previously uncharacterized and conserved protein, ZTF-8, which is required for proper DNA damage checkpoint activation as well as DSB repair. Specifically, we provide a direct demonstration that ZTF-8 participates in both mitotic and meiotic DSB repair and in the meiotic DNA damage checkpoint via interacting with the 9-1-1 complex in the C. elegans germline. We propose that ZTF-8 is involved in promoting repair at blocked replication fork sites and meiotic DSBs in part by transducing DNA damage checkpoint signaling via the 9-1-1 DNA damage response complex.

Vyšlo v časopise: ZTF-8 Interacts with the 9-1-1 Complex and Is Required for DNA Damage Response and Double-Strand Break Repair in the Germline. PLoS Genet 10(10): e32767. doi:10.1371/journal.pgen.1004723
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.pgen.1004723

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