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preLekára.sk / Odborné časopisy / PLOS Genetics / 2014 - 10

Keratin 76 Is Required for Tight Junction Function and Maintenance of the Skin Barrier

English version České info

The generation of knockout mice is a central approach to studying gene function. We have examined the consequences of the germ line inactivation of Keratin 76 in mice and in doing so we reveal a previously undescribed mechanism by which keratin intermediate filaments regulate cellular interactions and tissue homeostasis. Our study supports an emerging body of evidence which challenges the classical view of the keratin intermediate filaments as simple structural proteins, highlighting Krt76 as a gene whose function is indispensable for barrier function and skin wound repair as a result of its novel interaction with tight junction complexes. This study identifies a previously unknown and critical link between intermediate filaments and tight junctions where intermediate filament dysfunction influences skin disease.

Vyšlo v časopise: Keratin 76 Is Required for Tight Junction Function and Maintenance of the Skin Barrier. PLoS Genet 10(10): e32767. doi:10.1371/journal.pgen.1004706
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.pgen.1004706

Souhrn

The generation of knockout mice is a central approach to studying gene function. We have examined the consequences of the germ line inactivation of Keratin 76 in mice and in doing so we reveal a previously undescribed mechanism by which keratin intermediate filaments regulate cellular interactions and tissue homeostasis. Our study supports an emerging body of evidence which challenges the classical view of the keratin intermediate filaments as simple structural proteins, highlighting Krt76 as a gene whose function is indispensable for barrier function and skin wound repair as a result of its novel interaction with tight junction complexes. This study identifies a previously unknown and critical link between intermediate filaments and tight junctions where intermediate filament dysfunction influences skin disease.

Zdroje

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