Basement Membrane and Cell Integrity of Self-Tissues in Maintaining Immunological Tolerance

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Autoimmune diseases may be caused by failures in the immune system or by altered selfness in target tissues; however, which of these is more critical is controversial. To better understand such diseases, it is necessary to first define the molecular mechanisms that provide self-tolerance to healthy tissues. As a model system, we used Drosophila melanotic mass formation, in which blood cells encapsulate degenerating self-tissues. By manipulating basement-membrane components specifically in target tissues, not in blood cells, we could elicit autoimmune responses against the altered self-tissues. Moreover, we found that at least two different checkpoints for self-tolerance operate discretely in Drosophila tissues. This parallels mammalian immunity and provides etiological insight into certain autoimmune diseases in which structural abnormalities precede immune system pathology, such as Sjögren's syndrome and type I diabetes mellitus.

Vyšlo v časopise: Basement Membrane and Cell Integrity of Self-Tissues in Maintaining Immunological Tolerance. PLoS Genet 10(10): e32767. doi:10.1371/journal.pgen.1004683
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.pgen.1004683

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