#PAGE_PARAMS# #ADS_HEAD_SCRIPTS# #MICRODATA#
preLekára.sk / Odborné časopisy / PLOS Genetics / 2014 - 10

Role of and in Development of Abdominal Epithelia Breaks Posterior Prevalence Rule

English version České info

The spatially non-overlapping function of Hox genes is known to determine Antero-posterior body axis in all the bilaterians. The expression of Hox genes is found to be overlapping in several cases. According to the posterior prevalence rule, posterior Hox genes suppress the function of anterior Hox genes in the overlapping expression domains. Our findings show an exception to the rule of posterior prevalence. We show that in the overlapping expression domains of abd-A and Abd-B in early pupal abdominal epithelia, both the genes have essential roles. While abd-A is required for cell proliferation, Abd-B determines the segmental identity.

Vyšlo v časopise: Role of and in Development of Abdominal Epithelia Breaks Posterior Prevalence Rule. PLoS Genet 10(10): e32767. doi:10.1371/journal.pgen.1004717
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.pgen.1004717

Souhrn

The spatially non-overlapping function of Hox genes is known to determine Antero-posterior body axis in all the bilaterians. The expression of Hox genes is found to be overlapping in several cases. According to the posterior prevalence rule, posterior Hox genes suppress the function of anterior Hox genes in the overlapping expression domains. Our findings show an exception to the rule of posterior prevalence. We show that in the overlapping expression domains of abd-A and Abd-B in early pupal abdominal epithelia, both the genes have essential roles. While abd-A is required for cell proliferation, Abd-B determines the segmental identity.

Zdroje

1. PearsonJC, LemonsD, McGinnisW (2005) Modulating Hox gene functions during animal body patterning. Nat Rev Genet 6: 893–904.

2. McGinnisW, GarberRL, WirzJ, KuroiwaA, GehringWJ (1984) A homologous protein-coding sequence in Drosophila homeotic genes and its conservation in other metazoans. Cell 37: 403–408.

3. Sanchez-HerreroE, VernosI, MarcoR, MorataG (1985) Genetic organization of Drosophila bithorax complex. Nature 313: 108–113.

4. ScottMP, WeinerAJ, HazelriggTI, PoliskyBA, PirrottaV, et al. (1983) The molecular organization of the Antennapedia locus of Drosophila. Cell 35: 763–776.

5. DuncanI (1987) The bithorax complex. Annu Rev Genet 21: 285–319.

6. WhiteRA, WilcoxM (1984) Protein products of the bithorax complex in Drosophila. Cell 39: 163–171.

7. KarchF, BenderW, WeiffenbachB (1990) abdA expression in Drosophila embryos. Genes Dev 4: 1573–1587.

8. CelnikerSE, KeelanDJ, LewisEB (1989) The molecular genetics of the bithorax complex of Drosophila: characterization of the products of the Abdominal-B domain. Genes & development 3: 1424–1436.

9. MaedaRK, KarchF (2006) The ABC of the BX-C: the bithorax complex explained. Development 133: 1413–1422.

10. DubouleD, MorataG (1994) Colinearity and functional hierarchy among genes of the homeotic complexes. Trends Genet 10: 358–364.

11. KmitaM, van Der HoevenF, ZakanyJ, KrumlaufR, DubouleD (2000) Mechanisms of Hox gene colinearity: transposition of the anterior Hoxb1 gene into the posterior HoxD complex. Genes & development 14: 198–211.

12. Gonzalez-ReyesA, UrquiaN, GehringWJ, StruhlG, MorataG (1990) Are cross-regulatory interactions between homoeotic genes functionally significant? Nature 344: 78–80.

13. LamkaML, BouletAM, SakonjuS (1992) Ectopic expression of UBX and ABD-B proteins during Drosophila embryogenesis: competition, not a functional hierarchy, explains phenotypic suppression. Development 116: 841–854.

14. MaciasA, MorataG (1996) Functional hierarchy and phenotypic suppression among Drosophila homeotic genes: the labial and empty spiracles genes. Embo J 15: 334–343.

15. NoroB, LelliK, SunL, MannRS (2011) Competition for cofactor-dependent DNA binding underlies Hox phenotypic suppression. Genes Dev 25: 2327–2332.

16. ForondaD, EstradaB, de NavasL, Sanchez-HerreroE (2006) Requirement of Abdominal-A and Abdominal-B in the developing genitalia of Drosophila breaks the posterior downregulation rule. Development 133: 117–127.

17. MillerDF, RogersBT, KalkbrennerA, HamiltonB, HoltzmanSL, et al. (2001) Cross-regulation of Hox genes in the Drosophila melanogaster embryo. Mech Dev 102: 3–16.

18. MadhavanMM, MadhavanK (1980) Morphogenesis of the epidermis of adult abdomen of Drosophila. Journal of embryology and experimental morphology 60: 1–31.

19. NinovN, ChiarelliDA, Martin-BlancoE (2007) Extrinsic and intrinsic mechanisms directing epithelial cell sheet replacement during Drosophila metamorphosis. Development 134: 367–379.

20. McGinnisW, KrumlaufR (1992) Homeobox genes and axial patterning. Cell 68: 283–302.

21. CelnikerSE, SharmaS, KeelanDJ, LewisEB (1990) The molecular genetics of the bithorax complex of Drosophila: cis-regulation in the Abdominal-B domain. EMBO J 9: 4277–4286.

22. IrishVF, Martinez-AriasA, AkamM (1989) Spatial regulation of the Antennapedia and Ultrabithorax homeotic genes during Drosophila early development. EMBO J 8: 1527–1537.

23. BeachyPA, HelfandSL, HognessDS (1985) Segmental distribution of bithorax complex proteins during Drosophila development. Nature 313: 545–551.

24. WangW, YoderJH (2012) Hox-mediated regulation of doublesex sculpts sex-specific abdomen morphology in Drosophila. Developmental dynamics: an official publication of the American Association of Anatomists 241: 1076–1090.

25. WangW, TindellN, YanS, YoderJH (2013) Homeotic functions of the Teashirt transcription factor during adult Drosophila development. Biology open 2: 18–29.

26. HayashiS, HiroseS, MetcalfeT, ShirrasAD (1993) Control of imaginal cell development by the escargot gene of Drosophila. Development 118: 105–115.

27. BrandAH, PerrimonN (1993) Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. Development 118: 401–415.

28. KarchF, WeiffenbachB, PeiferM, BenderW, DuncanI, et al. (1985) The abdominal region of the bithorax complex. Cell 43: 81–96.

29. SinghNP, MishraRK (2008) A double-edged sword to force posterior dominance of Hox genes. Bioessays 30: 1058–1061.

30. TylerDM, OkamuraK, ChungWJ, HagenJW, BerezikovE, et al. (2008) Functionally distinct regulatory RNAs generated by bidirectional transcription and processing of microRNA loci. Genes Dev 22: 26–36.

31. KarchF, GalloniM, SiposL, GauszJ, GyurkovicsH, et al. (1994) Mcp and Fab-7: molecular analysis of putative boundaries of cis-regulatory domains in the bithorax complex of Drosophila melanogaster. Nucleic Acids Res 22: 3138–3146.

32. BantigniesF, RoureV, CometI, LeblancB, SchuettengruberB, et al. (2011) Polycomb-dependent regulatory contacts between distant Hox loci in Drosophila. Cell 144: 214–226.

33. ForondaD, MartinP, Sanchez-HerreroE (2012) Drosophila Hox and sex-determination genes control segment elimination through EGFR and extramacrochetae activity. PLoS Genet 8: e1002874.

34. WangW, KiddBJ, CarrollSB, YoderJH (2011) Sexually dimorphic regulation of the Wingless morphogen controls sex-specific segment number in Drosophila. Proc Natl Acad Sci U S A 108: 11139–11144.

35. ChenEH, ChristiansenAE, BakerBS (2005) Allocation and specification of the genital disc precursor cells in Drosophila. Developmental biology 281: 270–285.

36. GyurkovicsH, GauszJ, KummerJ, KarchF (1990) A new homeotic mutation in the Drosophila bithorax complex removes a boundary separating two domains of regulation. EMBO J 9: 2579–2585.

37. ShirrasAD, CousoJP (1996) Cell fates in the adult abdomen of Drosophila are determined by wingless during pupal development. Dev Biol 175: 24–36.

38. KoppA, DuncanI, GodtD, CarrollSB (2000) Genetic control and evolution of sexually dimorphic characters in Drosophila. Nature 408: 553–559.

39. KoppA, DuncanI (2002) Anteroposterior patterning in adult abdominal segments of Drosophila. Developmental biology 242: 15–30.

40. GummallaM, GalettiS, MaedaRK, KarchF (2014) Hox gene regulation in the central nervous system of Drosophila. Front Cell Neurosci 8: 96.

41. WangW, YoderJH (2011) Drosophila pupal abdomen immunohistochemistry. J Vis Exp 2: 3139.

42. CurtissJ, HeiligJS (1995) Establishment of Drosophila imaginal precursor cells is controlled by the Arrowhead gene. Development 121: 3819–3828.

Štítky
Genetika Reprodukčná medicína
Článek An Deletion Is Highly Associated with a Juvenile-Onset Inherited Polyneuropathy in Leonberger and Saint Bernard Dogs
Článek Licensing of Yeast Centrosome Duplication Requires Phosphoregulation of Sfi1
Článek Oligoasthenoteratozoospermia and Infertility in Mice Deficient for miR-34b/c and miR-449 Loci
Článek Basement Membrane and Cell Integrity of Self-Tissues in Maintaining Immunological Tolerance
Článek The Kinesin AtPSS1 Promotes Synapsis and is Required for Proper Crossover Distribution in Meiosis
Článek Germline Mutations in Are Associated with Familial Gastric Cancer
Článek POT1a and Components of CST Engage Telomerase and Regulate Its Activity in
Článek Controlling Meiotic Recombinational Repair – Specifying the Roles of ZMMs, Sgs1 and Mus81/Mms4 in Crossover Formation
Článek Payoffs, Not Tradeoffs, in the Adaptation of a Virus to Ostensibly Conflicting Selective Pressures
Článek FHIT Suppresses Epithelial-Mesenchymal Transition (EMT) and Metastasis in Lung Cancer through Modulation of MicroRNAs
Článek Genome-Wide Mapping of Yeast RNA Polymerase II Termination
Článek Examination of Prokaryotic Multipartite Genome Evolution through Experimental Genome Reduction
Článek White Cells Facilitate Opposite- and Same-Sex Mating of Opaque Cells in
Článek BMP-FGF Signaling Axis Mediates Wnt-Induced Epidermal Stratification in Developing Mammalian Skin
Článek Genome-Wide Association Study of CSF Levels of 59 Alzheimer's Disease Candidate Proteins: Significant Associations with Proteins Involved in Amyloid Processing and Inflammation
Článek COE Loss-of-Function Analysis Reveals a Genetic Program Underlying Maintenance and Regeneration of the Nervous System in Planarians
Článek Fat-Dachsous Signaling Coordinates Cartilage Differentiation and Polarity during Craniofacial Development
Článek Identification of Genes Important for Cutaneous Function Revealed by a Large Scale Reverse Genetic Screen in the Mouse
Článek Sensors at Centrosomes Reveal Determinants of Local Separase Activity
Článek Genes Integrate and Hedgehog Pathways in the Second Heart Field for Cardiac Septation
Článek Systematic Dissection of Coding Exons at Single Nucleotide Resolution Supports an Additional Role in Cell-Specific Transcriptional Regulation
Článek Recovery from an Acute Infection in Requires the GATA Transcription Factor ELT-2
Článek HIPPO Pathway Members Restrict SOX2 to the Inner Cell Mass Where It Promotes ICM Fates in the Mouse Blastocyst
Článek The Formation of Endoderm-Derived Taste Sensory Organs Requires a -Dependent Expansion of Embryonic Taste Bud Progenitor Cells
Článek Role of STN1 and DNA Polymerase α in Telomere Stability and Genome-Wide Replication in Arabidopsis
Článek Keratin 76 Is Required for Tight Junction Function and Maintenance of the Skin Barrier
Článek Encodes the Catalytic Subunit of N Alpha-Acetyltransferase that Regulates Development, Metabolism and Adult Lifespan
Článek Disruption of SUMO-Specific Protease 2 Induces Mitochondria Mediated Neurodegeneration
Článek Caudal Regulates the Spatiotemporal Dynamics of Pair-Rule Waves in
Článek It's All in Your Mind: Determining Germ Cell Fate by Neuronal IRE-1 in
Článek A Conserved Role for Homologs in Protecting Dopaminergic Neurons from Oxidative Stress
Článek The Master Activator of IncA/C Conjugative Plasmids Stimulates Genomic Islands and Multidrug Resistance Dissemination
Článek An AGEF-1/Arf GTPase/AP-1 Ensemble Antagonizes LET-23 EGFR Basolateral Localization and Signaling during Vulva Induction
Článek The Proteomic Landscape of the Suprachiasmatic Nucleus Clock Reveals Large-Scale Coordination of Key Biological Processes
Článek RNA-Processing Protein TDP-43 Regulates FOXO-Dependent Protein Quality Control in Stress Response
Článek A Complex Genetic Switch Involving Overlapping Divergent Promoters and DNA Looping Regulates Expression of Conjugation Genes of a Gram-positive Plasmid
Článek ZTF-8 Interacts with the 9-1-1 Complex and Is Required for DNA Damage Response and Double-Strand Break Repair in the Germline
Článek Integrating Functional Data to Prioritize Causal Variants in Statistical Fine-Mapping Studies
Článek Tpz1-Ccq1 and Tpz1-Poz1 Interactions within Fission Yeast Shelterin Modulate Ccq1 Thr93 Phosphorylation and Telomerase Recruitment
Článek Salt-Induced Stabilization of EIN3/EIL1 Confers Salinity Tolerance by Deterring ROS Accumulation in
Článek Telomeric (s) in spp. Encode Mediator Subunits That Regulate Distinct Virulence Traits
Článek Ethylene-Induced Inhibition of Root Growth Requires Abscisic Acid Function in Rice ( L.) Seedlings
Článek Ancient Expansion of the Hox Cluster in Lepidoptera Generated Four Homeobox Genes Implicated in Extra-Embryonic Tissue Formation
Článek Mechanism of Suppression of Chromosomal Instability by DNA Polymerase POLQ
Článek A Mutation in the Mouse Gene Leads to Impaired Hedgehog Signaling
Článek Keeping mtDNA in Shape between Generations
Článek Targeted Exon Capture and Sequencing in Sporadic Amyotrophic Lateral Sclerosis
Článek TIF-IA-Dependent Regulation of Ribosome Synthesis in Muscle Is Required to Maintain Systemic Insulin Signaling and Larval Growth
Článek At Short Telomeres Tel1 Directs Early Replication and Phosphorylates Rif1
Článek Evidence of a Bacterial Receptor for Lysozyme: Binding of Lysozyme to the Anti-σ Factor RsiV Controls Activation of the ECF σ Factor σ
Článek Hsp40s Specify Functions of Hsp104 and Hsp90 Protein Chaperone Machines
Článek Feeding State, Insulin and NPR-1 Modulate Chemoreceptor Gene Expression via Integration of Sensory and Circuit Inputs
Článek Functional Interaction between Ribosomal Protein L6 and RbgA during Ribosome Assembly
Článek Multiple Regulatory Systems Coordinate DNA Replication with Cell Growth in
Článek Fast Evolution from Precast Bricks: Genomics of Young Freshwater Populations of Threespine Stickleback
Článek Mmp1 Processing of the PDF Neuropeptide Regulates Circadian Structural Plasticity of Pacemaker Neurons
Článek The Nuclear Immune Receptor Is Required for -Dependent Constitutive Defense Activation in
Článek Genetic Modifiers of Neurofibromatosis Type 1-Associated Café-au-Lait Macule Count Identified Using Multi-platform Analysis
Článek Juvenile Hormone-Receptor Complex Acts on and to Promote Polyploidy and Vitellogenesis in the Migratory Locust
Článek Uncovering Enhancer Functions Using the α-Globin Locus
Článek The Analysis of Mutant Alleles of Different Strength Reveals Multiple Functions of Topoisomerase 2 in Regulation of Chromosome Structure
Článek Metabolic Respiration Induces AMPK- and Ire1p-Dependent Activation of the p38-Type HOG MAPK Pathway
Článek The Specification and Global Reprogramming of Histone Epigenetic Marks during Gamete Formation and Early Embryo Development in
Článek The DAF-16 FOXO Transcription Factor Regulates to Modulate Stress Resistance in , Linking Insulin/IGF-1 Signaling to Protein N-Terminal Acetylation
Článek Genetic Influences on Translation in Yeast
Článek Analysis of Mutants Defective in the Cdk8 Module of Mediator Reveal Links between Metabolism and Biofilm Formation
Článek Ribosomal Readthrough at a Short UGA Stop Codon Context Triggers Dual Localization of Metabolic Enzymes in Fungi and Animals
Článek Gene Duplication Restores the Viability of Δ and Δ Mutants
Článek Selection on a Variant Associated with Improved Viral Clearance Drives Local, Adaptive Pseudogenization of Interferon Lambda 4 ()
Článek Break-Induced Replication Requires DNA Damage-Induced Phosphorylation of Pif1 and Leads to Telomere Lengthening
Článek Dynamic Partnership between TFIIH, PGC-1α and SIRT1 Is Impaired in Trichothiodystrophy
Článek Signature Gene Expression Reveals Novel Clues to the Molecular Mechanisms of Dimorphic Transition in
Článek Mutations in Moderate or Severe Intellectual Disability
Článek Multifaceted Genome Control by Set1 Dependent and Independent of H3K4 Methylation and the Set1C/COMPASS Complex
Článek A Role for Taiman in Insect Metamorphosis
Článek The Small RNA Rli27 Regulates a Cell Wall Protein inside Eukaryotic Cells by Targeting a Long 5′-UTR Variant
Článek MMS Exposure Promotes Increased MtDNA Mutagenesis in the Presence of Replication-Defective Disease-Associated DNA Polymerase γ Variants
Článek Coexistence and Within-Host Evolution of Diversified Lineages of Hypermutable in Long-term Cystic Fibrosis Infections
Článek Comprehensive Mapping of the Flagellar Regulatory Network
Článek Topoisomerase II Is Required for the Proper Separation of Heterochromatic Regions during Female Meiosis
Článek A Splice Mutation in the Gene Causes High Glycogen Content and Low Meat Quality in Pig Skeletal Muscle
Článek KDM5 Interacts with Foxo to Modulate Cellular Levels of Oxidative Stress
Článek H2B Mono-ubiquitylation Facilitates Fork Stalling and Recovery during Replication Stress by Coordinating Rad53 Activation and Chromatin Assembly
Článek Copy Number Variation in the Horse Genome
Článek Unifying Genetic Canalization, Genetic Constraint, and Genotype-by-Environment Interaction: QTL by Genomic Background by Environment Interaction of Flowering Time in
Článek Spinster Homolog 2 () Deficiency Causes Early Onset Progressive Hearing Loss
Článek Genome-Wide Discovery of Drug-Dependent Human Liver Regulatory Elements
Článek Developmentally-Regulated Excision of the SPβ Prophage Reconstitutes a Gene Required for Spore Envelope Maturation in
Článek Protein Phosphatase 4 Promotes Chromosome Pairing and Synapsis, and Contributes to Maintaining Crossover Competence with Increasing Age
Článek The bHLH-PAS Transcription Factor Dysfusion Regulates Tarsal Joint Formation in Response to Notch Activity during Leg Development
Článek A Mouse Model Uncovers LKB1 as an UVB-Induced DNA Damage Sensor Mediating CDKN1A (p21) Degradation
Článek Notch3 Interactome Analysis Identified WWP2 as a Negative Regulator of Notch3 Signaling in Ovarian Cancer
Článek An Integrated Cell Purification and Genomics Strategy Reveals Multiple Regulators of Pancreas Development
Článek Dominant Sequences of Human Major Histocompatibility Complex Conserved Extended Haplotypes from to
Článek The Vesicle Protein SAM-4 Regulates the Processivity of Synaptic Vesicle Transport
Článek A Gain-of-Function Mutation in Impeded Bone Development through Increasing Expression in DA2B Mice
Článek Nephronophthisis-Associated Regulates Cell Cycle Progression, Apoptosis and Epithelial-to-Mesenchymal Transition
Článek Beclin 1 Is Required for Neuron Viability and Regulates Endosome Pathways via the UVRAG-VPS34 Complex
Článek The Not5 Subunit of the Ccr4-Not Complex Connects Transcription and Translation
Článek Abnormal Dosage of Ultraconserved Elements Is Highly Disfavored in Healthy Cells but Not Cancer Cells
Článek Genome-Wide Distribution of RNA-DNA Hybrids Identifies RNase H Targets in tRNA Genes, Retrotransposons and Mitochondria
Článek The Chromosomal Association of the Smc5/6 Complex Depends on Cohesion and Predicts the Level of Sister Chromatid Entanglement
Článek Cell-Autonomous Progeroid Changes in Conditional Mouse Models for Repair Endonuclease XPG Deficiency
Článok vyšiel v časopise

PLOS Genetics

2014 Číslo 10
Najčítanejšie tento týždeň
Najčítanejšie v tomto čísle
Kurzy

Zvýšte si kvalifikáciu online z pohodlia domova

Aktuální možnosti diagnostiky a léčby litiáz
nový kurz
Autori: MUDr. Tomáš Ürge, PhD.
Všetky kurzy
Prihlásenie
Zabudnuté heslo

Zadajte e-mailovú adresu, s ktorou ste vytvárali účet. Budú Vám na ňu zasielané informácie k nastaveniu nového hesla.

Prihlásenie

Nemáte účet?  Registrujte sa

#ADS_BOTTOM_SCRIPTS#