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preLekára.sk / Odborné časopisy / PLOS One / 2020 - 1

Clinical, cytogenetic and molecular genetic characterization of a tandem fusion translocation in a male Holstein cattle with congenital hypospadias and a ventricular septal defect

English version

Autoři: Alessandra Iannuzzi aff001;  Marina Braun aff002;  Viviana Genualdo aff001;  Angela Perucatti aff001;  Sina Reinartz aff002;  Ioannis Proios aff003;  Maike Heppelmann aff003;  Jürgen Rehage aff003;  Kirsten Hülskötter aff004;  Andreas Beineke aff004;  Julia Metzger aff002;  Ottmar Distl aff002
Působiště autorů: Institute for the Animal Production System in Mediterranean Environment (ISPAAM), National Research Council (CNR), Naples, Italy aff001;  Institute for Animal Breeding and Genetics, University of Veterinary Medicine Hannover, Hannover, Germany aff002;  Clinic for Cattle, University of Veterinary Medicine Hannover, Hannover, Germany aff003;  Department of Pathology, University of Veterinary Medicine Hannover, Hannover, Germany aff004
Vyšlo v časopise: PLoS ONE 15(1)
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.pone.0227117

Souhrn

Hypospadias, disorder of sex development (DSD), is a sporadic congenital abnormality of the genital region in male ruminants, which is characterized by a non-fused urethra during fetal development. Detailed clinical examination classified the hypospadias phenotype of a male Holstein calf studied here as the perineal type. In combined use of cytogenetic analysis and whole genome sequencing, a non-mosaic, pseudo-monosomy 59, XY + tan(18;27) was detected. This chromosomal aberration had its origin in a tandem fusion translocation of the bovine autosomes (BTA) 18 and 27 with an accompanying loss of genomic sequences mainly in the distal end of BTA 18 and the proximal end of BTA 27. The resulting phenotype included hypospadias, growth retardation and ventricular septal defect.

Klíčová slova:

Telomeres – Y chromosomes – Cattle – Metaphase – Genome sequencing – Penis – Hypospadias – Chromosomal translocations

Zdroje

1. Nassar N, Bower C, Barker A. Increasing prevalence of hypospadias in Western Australia, 1980–2000. Archives of disease in childhood. 2007;92(7):580–4. doi: 10.1136/adc.2006.112862 17405856

2. Goldblatt J, Wallis C, Viljoen D. A New hypospadias-mental retardation syndrome in three brothers. American Journal of Diseases of Children. 1987;141(11):1168–9. 3673966

3. Fredell L, Iselius L, Collins A, Hansson E, Holmner S, Lundquist L, et al. Complex segregation analysis of hypospadias. Human Genetics. 2002;111(3):231–4. doi: 10.1007/s00439-002-0799-y 12215834

4. Fukami M, Wada Y, Miyabayashi K, Nishino I, Hasegawa T, Nordenskjold A, et al. CXorf6 is a causative gene for hypospadias. Nature Genetics. 2006;38(12):1369–71. doi: 10.1038/ng1900 17086185

5. Van der Zanden L, Van Rooij I, Feitz W, Franke B, Knoers N, Roeleveld N. Aetiology of hypospadias: a systematic review of genes and environment. Human reproduction update. 2012;18(3):260–83. doi: 10.1093/humupd/dms002 22371315

6. King G, Johnson E. Hypospadias in a Himalayan cat. Journal of Small Animal Practice. 2000;41(11):508–10. doi: 10.1111/j.1748-5827.2000.tb03973.x 11105790

7. Rahal SC, da Mota LS, Mamprim MJ, Ciani RB. Perineal hypospadias in a dog. In: priory.com [internet]. [cited 15 July 2019] http://www.priory.com/vet/hypospadias.htm.

8. Brink P, Schumacher J. Hypospadias in a Friesian gelding. Veterinary Surgery. 2011;40(1):120–3. doi: 10.1111/j.1532-950X.2010.00762.x 21198681

9. Bleul U, Theiss F, Rütten M, Kähn W. Clinical, cytogenetic and hormonal findings in a stallion with hypospadias–a case report. The Veterinary Journal. 2007;173(3):679–82. doi: 10.1016/j.tvjl.2006.03.005 16820309

10. De Lorenzi L, Genualdo V, Iannuzzi A, Di Meo GP, Perucatti A, Mancuso R, et al. Cytogenetic and genetic studies in a hypospadic horse (Equus caballus, 2n = 64). Sexual development: genetics, molecular biology, evolution, endocrinology, embryology, and pathology of sex determination and differentiation. 2010;4(6):352–7.

11. Röder P. Hypospadie beim Pferd. Berliner und Münchener Tierärztliche Wochenschrift. 1929;47:797–8.

12. Smith K, Brown P, Parkinson T. Hypospadias in rams. Veterinary Record: Journal of the British Veterinary Association. 2006;158(23).

13. Sakhaee E, Azari O. Hypospadias in goats. Iranian Journal of Veterinary Research. 2009;10(3):298–301.

14. Misk NA, Misk TN, Semieka MA. Diagnosis and treatment of affections of the urethra in male ruminants: A review of 403 cases. International Journal of Veterinary Medicine: Research and Reports. 2013;Article ID 715907.

15. Kumi-Diaka J, Osori D. Perineal hypospadias in two related bull calves, a case report. Theriogenology. 1979;11(2):163–4. doi: 10.1016/0093-691x(79)90068-2 16725401

16. Cassata R, Iannuzzi A, Parma P, De Lorenzi L, Peretti V, Perucatti A, et al. Clinical, cytogenetic and molecular evaluation in a dog with bilateral cryptorchidism and hypospadias. Cytogenetic and Genome Research. 2008;120(1–2):140–3. doi: 10.1159/000118753 18467838

17. Switonski M, Payan-Carreira R, Bartz M, Nowacka-Woszuk J, Szczerbal I, Colaco B, et al. Hypospadias in a male (78,XY; SRY-positive) dog and sex reversal female (78,XX; SRY-negative) dogs: clinical, histological and genetic studies. Sexual development: genetics, molecular biology, evolution, endocrinology, embryology, and pathology of sex determination and differentiation. 2012;6(1–3):128–34.

18. Switonski M, Dzimira S, Aleksiewicz R, Szczerbal I, Nowacka-Woszuk J, Krzeminska P, et al. Hypospadias Is Not Rare in Dogs: Five new cases, a retrospective study, and a review of the literature. Sexual development: genetics, molecular biology, evolution, endocrinology, embryology, and pathology of sex determination and differentiation. 2018;12(5):244–50.

19. Hynes P, Fraher J. The development of the male genitourinary system. I. The origin of the urorectal septum and the formation of the perineum. British Journal of Plastic Surgery. 2004;57(1):27–36. doi: 10.1016/j.bjps.2003.08.019 14672675

20. Kluth D, Lambrecht W, Reich P. Pathogenesis of hypospadias—more questions than answers. Journal of Pediatric Surgery. 1988;23(12):1095–101. doi: 10.1016/s0022-3468(88)80322-1 3236174

21. Yamada G, Satoh Y, Baskin LS, Cunha GR. Cellular and molecular mechanisms of development of the external genitalia. Differentiation. 2003;71(8):445–60. doi: 10.1046/j.1432-0436.2003.7108001.x 14641326

22. Switonski M, Payan-Carreira R, Bartz M, Nowacka-Woszuk J, Szczerbal I, Colaço B, et al. Hypospadias in a male (78, XY; SRY-positive) dog and sex reversal female (78, XX; SRY-negative) dogs: clinical, histological and genetic studies. Sexual development: genetics, molecular biology, evolution, endocrinology, embryology, and pathology of sex determination and differentiation. 2011;6(1–3):128–34.

23. Alam M, Shin S, Lee H, Choi I, Kim N. Hypospadias in three calves: a case report. Veterinarni Medicina -Praha-. 2005;50(11):506.

24. Usta Z, Distl O. Atresia ani, hypospadia and rudimentary external genitalia in two German Holstein calves. Atatürk Üniversitesi Veteriner Bilimleri Dergisi. 2017;12(2):195–202.

25. Jurka P, Galanty M, Zielinska P, Max A, Sysa P. Hypospadias in six dogs. The Veterinary Record. 2009;164(11):331–3. doi: 10.1136/vr.164.11.331 19287029

26. McFarland L. Perineal hypospadias in male lambs. Journal of the American Veterinary Medical Association. 1958;133(1):81–2. 13549337

27. Phiri AM, Sakala M, Soko J. Management of atresia ani with concurrent hypospadias and penile aplasia in a 3-day-old calf. International Journal of Livestock Research. 2016;6(1):98–103.

28. Abd-El-Hady A, El-Din MMM. Hypospadia and urethral diverticulum in a female pseudohermaphrodite calf. Scholars Journal of Agriculture and Veterinary Sciences. 2014;1(4B):288–292.

29. Maiti S, Raghuvanshi P, Divya M, Sangeetha P, Deepesh G, Naveen K. Surgical correction of urethral diverticulum in a female pseudo-hermaphrodite crossbred calf. Iranian Journal of Veterinary Research. 2018;19(1):57. 29805465

30. Misk N, Rilat J. Surgical management of congenital anomalies of ruminants. Agri-Practice. 1984;5:38–47.

31. Murakami T. Anatomical examination of hypospadias in cattle. Journal of the Japan Veterinary Medical Association (Japan). 2008;61:931–935.

32. Jeong W-S, Seong Y-S, Kim I-S, Jang H-S, Oh T-H, Lee K-W, et al. Radiographic diagnosis of hypospadias in three Korean native calves. Journal of Veterinary Clinics. 2008;25(6):557–9.

33. Pamuk K, Korkmaz M, Saritaş ZK, Orhan İÖ. Simental Irkı Bir Buzağıda Hypospadiasis ve Urogenital Anomali. Kocatepe Veterinary Journal. 2010;3(2).

34. Vidal G, Traslavina RP, Cabrera C, Gaffney PM, Lane VM. Theriogenology question of the month. Journal of the American Veterinary Medical Association. 2011;239(10):1295–7. doi: 10.2460/javma.239.10.1295 22044324

35. Park Y-S, Yang H-S, Ko M-H, Ko J-S, Cho S-R, Kim N-Y, et al. A case of urinary tract infection in a calf with hypospadias. Journal of Veterinary Clinics 2012;29(4):352–5.

36. Mihsler L, Hussein H, Wehrend A. Perineal hypospadia in a red Holstein-calf. Tierärztliche Praxis Großtiere. 2015;43(2):105–8.

37. Potliya S, Chaudhary R, Pal M, Kumar S, Kumar S. Hypospadias with atresia ani in a cow calf. Haryana Veterinarian 2016;55(1):118–9.

38. Torres AAA, Lhamas CL, da Graça Macoris D, de Oliveira Vasconcelos R. Macroscopic and microscopic findings in a set of congenital anomalies in two calves produced through in vitro production. Brazilian Journal of Veterinary Pathology. 2017;6(2):65–8.

39. Volpato R, Araujo MS, Vexenate SC, Oba E. Hypospadias in buffalo (Bubalus Bubalis) mediterranean breed. Journal of Buffalo Science. 2013;2:85–7.

40. Smith K, Brown P, Barr F. A survey of congenital reproductive abnormalities in rams in abattoirs in south west England. Reproduction in Domestic Animals. 2012;47(5):740–5. doi: 10.1111/j.1439-0531.2011.01952.x 22136299

41. Veena P, Sankar P, S RV, Kokila KS. Congenital absence of tail with atresia ani and hypospadias in a kid-A case report. Journal of Advanced Veterinary Research. 2011;1(2):76–9.

42. Omidi A, Monjezi S, Nabipour A. Hypospadias, diverticulum, and agenesis in the penile shaft of a goat kid (Capra hircus). Comparative Clinical Pathology. 2011;20(4):417–9.

43. Bokhari S. Hypospadias and urethral diverticulum in two goat kids: a case report. Journal of Animal and Plant Science. 2013;23:675–7.

44. Almubarak AM, Abdelghafar RM, Gameel AA, Osman NM. Penile urethral hypospadias with two fistulae and diverticulum in a Saanen kid. Hindawi Publishing Corporation. 2016;Article ID 6534062.

45. Ducos A, Revay T, Kovacs A, Hidas A, Pinton A, Bonnet-Garnier A, et al. Cytogenetic screening of livestock populations in Europe: an overview. Cytogenetic and Genome Research. 2008;120(1–2):26–41. doi: 10.1159/000118738 18467823

46. Pinheiro LEL, Carvalho TB, Oliveira DAA, Popescu CP, Basrur PK. A 4/21 tandem fusion in cattle. Hereditas. 1995;122:99:102. doi: 10.1111/j.1601-5223.1995.00099.x 7558885

47. Popescu CP. Les anomalies chromosomiques des bovins (Bos taurus L.). Etat actuel des connaissances. Annales de Génétique et de Sélection Animale. 1977;9(4):463:70. doi: 10.1186/1297-9686-9-4-463 22896549

48. Bruere A, McDonald M, Marshall R. Cytogenetical analysis of an ovine male pseudohermaphrodite and the possible role of the Y chromosome in cryptorchidism of sheep. Cytogenetic and Genome Research. 1969;8(2):148–57.

49. Thauvin‐Robinet C, Faivre L, Cusin V, Khau Van Kien P, Callier P, Parker KL, et al. Cloacal exstrophy in an infant with 9q34. 1‐qter deletion resulting from a de novo unbalanced translocation between chromosome 9q and Yq. American Journal of Medical Genetics Part A. 2004;126(3):303–7.

50. Horiike S, Taniwaki M, Misawa S, Nishigaki H, Okuda T, Yokota S, et al. The unbalanced 1; 7 translocation in de novo myelodysplastic syndrome and its clinical implication. Cancer. 1990;65(6):1350–4. doi: 10.1002/1097-0142(19900315)65:6<1350::aid-cncr2820650617>3.0.co;2-j 2306683

51. Riegel M, Hargreaves P, Baumer A, Guc-Scekic M, Ignjatovic M, Schinzel A. Unbalanced 18q/21q translocation in a patient previously reported as monosomy 21. European Journal of Medical Genetics. 2005;48(2):167–74. doi: 10.1016/j.ejmg.2005.01.026 16053908

52. Zneimer SM, Cotter PD, Stewart SD. Telomere‐telomere (end to end) fusion of chromosomes 7 and 22 with an interstitial deletion of chromosome 7p11. 2→ p15. 1: phenotypic consequences and possible mechanisms. Clinical Genetics. 2000;58(2):129–33. doi: 10.1034/j.1399-0004.2000.580207.x 11005146

53. Van der Zanden LF, Van Rooij IA, Feitz WF, Knight J, Donders ART, Renkema KY, et al. Common variants in DGKK are strongly associated with risk of hypospadias. Nature Genetics. 2011;43(1):48. doi: 10.1038/ng.721 21113153

54. Richard MA, Sok P, Canon S, Brown AL, Peckham‐Gregory EC, Nembhard WN, et al. The role of genetic variation in DGKK on moderate and severe hypospadias. Birth Defects Research. 2019; 111:932–937. doi: 10.1002/bdr2.1522 31102501

55. Kalfa N, Philibert P, Sultan C. Is hypospadias a genetic, endocrine or environmental disease, or still an unexplained malformation? International Journal of Andrology. 2009;32(3):187–97. doi: 10.1111/j.1365-2605.2008.00899.x 18637150

56. Stratmann N, Wehrend A. Perineale Hypospadie bei einem Chihuahua-Mischling. Ein Fallbericht. Tierärztliche Praxis Kleintiere. 2004;32(5):294–7.

57. Saunders P, Ladds P. Congenital and developmental anomalies of the genitalia of slaughtered bulls. Australian Veterinary Journal. 1978;54(1):10–3. doi: 10.1111/j.1751-0813.1978.tb00261.x 26328

58. Herzog A. Pareys Lexikon der Syndrome: Erb-und Zuchtkrankheiten der Haus-und Nutztiere. Parey; 2001.

59. Hynes P, Fraher J. The development of the male genitourinary system: II. The origin and formation of the urethral plate. British Journal of Plastic Surgery. 2004;57(2):112–21. doi: 10.1016/j.bjps.2003.08.018 15037165

60. Buczinski S, Fecteau G, DiFruscia R. Ventricular septal defects in cattle: A retrospective study of 25 cases. The Canadian Veterinary Journal. 2006;47(3):246. 16604981

61. Iannuzzi L, Di Meo GP, Leifsson PS, Eggen A, Christensen K. A case of trisomy 28 in cattle revealed by both banding and FISH-mapping techniques. Hereditas. 2001;134(2):147–51. doi: 10.1111/j.1601-5223.2001.00147.x 11732851

62. Berry D, Wolfe A, O’Donovan J, Byrne N, Sayers R, Dodds K, et al. Characterization of an X-chromosomal non-mosaic monosomy (59, X0) dairy heifer detected using routinely available single nucleotide polymorphism genotype data. Journal of Animal Science. 2017;95(3):1042–9. doi: 10.2527/jas.2016.1279 28380529

63. Fiorentino F, Bono S, Biricik A, Nuccitelli A, Cotroneo E, Cottone G, et al. Application of next-generation sequencing technology for comprehensive aneuploidy screening of blastocysts in clinical preimplantation genetic screening cycles. Human Reproduction. 2014;29(12):2802–13. doi: 10.1093/humrep/deu277 25336713

64. Metzger J, Rau J, Naccache F, Conn LB, Lindgren G, Distl O. Genome data uncover four synergistic key regulators for extremely small body size in horses. BMC Genomics. 2018;19(1):492. doi: 10.1186/s12864-018-4877-5 29940849

65. Aslan H, Karaca N, Basaran S, Ermis H, Ceylan Y. Prenatal diagnosis of Wolf-Hirschhorn syndrome (4p-) in association with congenital hypospadias and foot deformity. BMC Pregnancy and Childbirth. 2003;3(1):1. doi: 10.1186/1471-2393-3-1 12546710

66. Garcia NM, Allgood J, Santos LJ, Lonergan D, Batanian JR, Henkemeyer M, et al. Deletion mapping of critical region for hypospadias, penoscrotal transposition and imperforate anus on human chromosome 13. Journal of Pediatric Urology. 2006;2(4):233–42. doi: 10.1016/j.jpurol.2006.03.006 17476316

67. Ravnan JB, Tepperberg JH, Papenhausen P, Lamb AN, Hedrick J, Eash D, et al. Subtelomere FISH analysis of 11 688 cases: an evaluation of the frequency and pattern of subtelomere rearrangements in individuals with developmental disabilities. Journal of Medical Genetics. 2006;43(6):478–89. doi: 10.1136/jmg.2005.036350 16199540

68. Almind GJ, Brondum-Nielsen K, Bangsgaard R, Baekgaard P, Gronskov K. 11p Microdeletion including WT1 but not PAX6, presenting with cataract, mental retardation, genital abnormalities and seizures: a case report. Molecular Cytogenetics. 2009;2:6. doi: 10.1186/1755-8166-2-6 19222835

69. Belligni EF, Biamino E, Molinatto C, Messa J, Pierluigi M, Faravelli F, et al. Subtelomeric FISH analysis in 76 patients with syndromic developmental delay/intellectual disability. Italian Journal of Pediatrics. 2009;35(1):9. doi: 10.1186/1824-7288-35-9 19490664

70. Iannuzzi A, Perucatti A, Genualdo V, Pauciullo A, Incarnato D, Musilova P, et al. The utility of chromosome microdissection in clinical cytogenetics: a new reciprocal translocation in sheep. Cytogenetic and Genome Research. 2014;142(3):174–8. doi: 10.1159/000361000 24733039

71. Genualdo V, Perucatti A, Marletta D, Castiglioni B, Bordonaro S, Iannaccone M, et al. Cytogenetic investigation in two endangered pig breeds raised in Southern-Italy: Clinical and environmental aspects. Livestock Science. 2018;216:36–43.

72. Eggen A, Gautier M, Billaut A, Petit E, Hayes H, Laurent P, et al. Construction and characterization of a bovine BAC library with four genome-equivalent coverage. Genetics, Selection, Evolution. 2001;33(5):543–8. doi: 10.1186/1297-9686-33-5-543 11712974

73. Hayes H, Di Meo GP, Gautier M, Laurent P, Eggen A, Iannuzzi L. Localization by FISH of the 31 Texas nomenclature type I markers to both Q- and R-banded bovine chromosomes. Cytogenetics and Cell Genetics. 2000;90(3–4):315–20. doi: 10.1159/000056795 11124540

74. Iannuzzi A, Perucatti A, Genualdo V, De Lorenzi L, Di Berardino D, Parma P, et al. Cytogenetic Elaboration of a Novel Reciprocal Translocation in Sheep. Cytogenetic and Genome Research. 2013;139(2):97–101. doi: 10.1159/000346193 23328281

75. Iannuzzi A, Pereira J, Iannuzzi C, Fu BY, Ferguson-Smith M. Pooling strategy and chromosome painting characterize a living zebroid for the first time. Plos One. 2017;12(7).

76. Cribiu EP, Di Berardino D, Di Meo GP, Eggen A, Gallagher DS, Gustavsson I, et al. International System for Chromosome Nomenclature of Domestic Bovids (ISCNDB 2000). Cytogenetics and Cell Genetics. 2001;92(3–4):283–99. doi: 10.1159/000056917 11435702

77. Iannuzzi A, Genualdo V, Perucatti A, Pauciullo A, Varricchio G, Incarnato D, et al. Fatal Outcome in a Newborn Calf Associated with Partial Trisomy 25q and Partial Monosomy 11q, 60,XX,der(11)t(11;25)(q11;q14 similar to 21). Cytogenetic and Genome Research. 2015;146(3):222–9. doi: 10.1159/000438973 26337016

78. Meinecke B, Kuiper H, Drögemüller C, Leeb T, Meinecke-Tillmann S. A mola hydatidosa coexistent with a foetus in a bovine freemartin pregnancy. Placenta. 2003;24(1):107–12. doi: 10.1053/plac.2002.0872 12495666

79. Schwarzenbacher H, Wurmser C, Flisikowski K, Misurova L, Jung S, Langenmayer MC, et al. A frameshift mutation in GON4L is associated with dwarfism in Fleckvieh cattle. bioRxiv. 2016:036889.

80. Braun M, Reinartz S, Heppelmann M, Rehage J, Sürie C, Distl O, et al. Curly coat caused by a keratin 27 variant was transmitted from Fleckvieh into German Angus. Animal Genetics. 2018; 49(4):349–350. doi: 10.1111/age.12669 29932459

81. Li H, Durbin R. Fast and accurate short read alignment with Burrows-Wheeler transform. Bioinformatics. 2009;25(14):1754–60. doi: 10.1093/bioinformatics/btp324 19451168

82. Li H, Handsaker B, Wysoker A, Fennell T, Ruan J, Homer N, et al. The sequence alignment/map format and SAMtools. Bioinformatics. 2009;25(16):2078–9. doi: 10.1093/bioinformatics/btp352 19505943

83. McKenna A, Hanna M, Banks E, Sivachenko A, Cibulskis K, Kernytsky A, et al. The genome analysis toolkit: a MapReduce framework for analyzing next-generation DNA sequencing data. Genome Research. 2010;20(9):1297–303. doi: 10.1101/gr.107524.110 20644199

84. Layer RM, Chiang C, Quinlan AR, Hall IM. LUMPY: a probabilistic framework for structural variant discovery. Genome Biology. 2014;15(6):R84. doi: 10.1186/gb-2014-15-6-r84 24970577

85. Cingolani P, Platts A, Wang LL, Coon M, Nguyen T, Wang L, et al. A program for annotating and predicting the effects of single nucleotide polymorphisms, SnpEff: SNPs in the genome of Drosophila melanogaster strain w1118; iso-2; iso-3. Fly. 2012;6(2):80–92. doi: 10.4161/fly.19695 22728672

86. McLaren W, Pritchard B, Rios D, Chen Y, Flicek P, Cunningham F. Deriving the consequences of genomic variants with the Ensembl API and SNP effect predictor. Bioinformatics. 2010;26(16):2069–70. doi: 10.1093/bioinformatics/btq330 20562413

87. Kumar P, Henikoff S, Ng PC. Predicting the effects of coding non-synonymous variants on protein function using the SIFT algorithm. Nature Protocols. 2009;4(7):1073. doi: 10.1038/nprot.2009.86 19561590

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Článek Long term conjugated linoleic acid supplementation modestly improved growth performance but induced testicular tissue apoptosis and reduced sperm quality in male rabbit
Článek A new approach to the temporal significance of house orientations in European Early Neolithic settlements
Článek Persistence of chikungunya ECSA genotype and local outbreak in an upper medium class neighborhood in Northeast Brazil
Článek In vivo elongation of thin filaments results in heart failure
Článek Disparity in depressive symptoms between heterosexual and sexual minority men in China: The role of social support
Článek Effect of classroom intervention on student food selection and plate waste: Evidence from a randomized control trial
Článek Mating strategy is determinant of adenovirus prevalence in European bats
Článek Preventing HIV and HSV-2 through knowledge and attitudes: A replication study of a multi-component community-based intervention in Zimbabwe
Článek Randomized clinical trial analyzing maintenance of peripheral venous catheters in an internal medicine unit: Heparin vs. saline
Článek Patient-related factors may influence nursing perception of sleep in the Intensive Care Unit
Článek A randomized trial of a behavioral intervention to decrease hospital length of stay by decreasing bedrest
Článek Color image segmentation using adaptive hierarchical-histogram thresholding
Článek The role of demographic history and selection in shaping genetic diversity of the Galápagos penguin (Spheniscus mendiculus)
Článek Attitudes towards animal study registries and their characteristics: An online survey of three cohorts of animal researchers
Článek Risk perception and behavioral change during epidemics: Comparing models of individual and collective learning
Článek Risk factors for third-generation cephalosporin resistant Enterobacteriaceae in gestational urine cultures: A retrospective cohort study based on centralized electronic health records
Článek Residential neighbourhood greenspace is associated with reduced risk of cardiovascular disease: A prospective cohort study
Článek Prevention and control of cholera with household and community water, sanitation and hygiene (WASH) interventions: A scoping review of current international guidelines
Článek Female finches prefer courtship signals indicating male vigor and neuromuscular ability
Článek The effect of spatial position and age within an egg-clutch on embryonic development and key metabolic enzymes in two clownfish species, Amphiprion ocellaris and Amphiprion frenatus
Článek The impact of translated reminder letters and phone calls on mammography screening booking rates: Two randomised controlled trials
Článek Application of a genetic algorithm to the keyboard layout problem
Článek Relationship between diabetic macular edema and choroidal layer thickness
Článek Evaluation of the predictive ability of ultrasound-based assessment of breast cancer using BI-RADS natural language reporting against commercial transcriptome-based tests
Článek A Comprehensive Data Gathering Network Architecture in Large-Scale Visual Sensor Networks
Článek Recovery of health-related quality of life after burn injuries: An individual participant data meta-analysis
Článek Role of ecology in shaping external nasal morphology in bats and implications for olfactory tracking
Článek High expression of olfactomedin-4 is correlated with chemoresistance and poor prognosis in pancreatic cancer
Článek Development and validation of a prognostic model predicting symptomatic hemorrhagic transformation in acute ischemic stroke at scale in the OHDSI network
Článek Complex patterns of cell growth in the placenta in normal pregnancy and as adaptations to maternal diet restriction
Článek Tofu intake is inversely associated with risk of breast cancer: A meta-analysis of observational studies
Článek Influence of light on the infection of Aureococcus anophagefferens CCMP 1984 by a “giant virus”
Článek Temporal ordering of input modulates connectivity formation in a developmental neuronal network model of the cortex
Článek From organ to cell: Multi-level telomere length assessment in patients with idiopathic pulmonary fibrosis
Článek How do critical care staff respond to organisational challenge? A qualitative exploration into personality types and cognitive processing in critical care
Článek Effects of supplemental creatine and guanidinoacetic acid on spatial memory and the brain of weaned Yucatan miniature pigs
Článek Community-Based Health Planning and Services Plus programme in Ghana: A qualitative study with stakeholders in two Systems Learning Districts on improving the implementation of primary health care
Článek An investigation of transportation practices in an Ontario swine system using descriptive network analysis
Článek Comparison of gridded precipitation datasets for rainfall-runoff and inundation modeling in the Mekong River Basin
Článek Functional interactions in patients with hemianopia: A graph theory-based connectivity study of resting fMRI signal
Článek The effects of dual-task cognitive interference on gait and turning in Huntington’s disease
Článek Novel imaging biomarkers for mapping the impact of mild mitochondrial uncoupling in the outer retina in vivo
Článek Hyperkalemia treatment modalities: A descriptive observational study focused on medication and healthcare resource utilization
Článek Long term impact of PositiveLinks: Clinic-deployed mobile technology to improve engagement with HIV care
Článek Comparison of post-transplantation diabetes mellitus incidence and risk factors between kidney and liver transplantation patients
Článek A definition-by-example approach and visual language for activity patterns in engineering disciplines
Článek A network analysis revealed the essential and common downstream proteins related to inguinal hernia
Článek Use of conventional cardiac troponin assay for diagnosis of non-ST-elevation myocardial infarction: ‘The Ottawa Troponin Pathway’
Článek Identification and characterization of miRNAs involved in cold acclimation of zebrafish ZF4 cells
Článek Research on motion planning for an indoor spray arm based on an improved potential field method
Článek Detailed analysis of the transverse arch of hallux valgus feet with and without pain using weightbearing ultrasound imaging and precise force sensors
Článek Surrogate R-spondins for tissue-specific potentiation of Wnt Signaling
Článek Apolipoprotein-AI mimetic peptides D-4F and L-5F decrease hepatic inflammation and increase insulin sensitivity in C57BL/6 mice
Článek Treating patients with driving phobia by virtual reality exposure therapy – a pilot study
Článek Efficient processing of raster and vector data
Článek Therapeutic hypothermia after out of hospital cardiac arrest improve 1-year survival rate for selective patients
Článek Carotid plaques and neurological impairment in patients with acute cerebral infarction
Článek Deep learning based image reconstruction algorithm for limited-angle translational computed tomography
Článek Association between coffee drinking and telomere length in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial
Článek Hyperbaric oxygen preconditioning and the role of NADPH oxidase inhibition in postischemic acute kidney injury induced in spontaneously hypertensive rats
Článek Rad51 paralogs and the risk of unselected breast cancer: A case-control study
Článek Diagnostic differences in respiratory breathing patterns and work of breathing indices in children with Duchenne muscular dystrophy
Článek The role of narrative in collaborative reasoning and intelligence analysis: A case study
Článek Proportions of CD4 test results indicating advanced HIV disease remain consistently high at primary health care facilities across four high HIV burden countries
Článek Modelling of amino acid turnover in the horse during training and racing: A basis for developing a novel supplementation strategy
Článek Single-modal and multi-modal false arrhythmia alarm reduction using attention-based convolutional and recurrent neural networks
Článek Eye-gaze information input based on pupillary response to visual stimulus with luminance modulation
Článek Trends of litter decomposition and soil organic matter stocks across forested swamp environments of the southeastern US
Článek Post mortem evaluation of inflammation, oxidative stress, and PPARγ activation in a nonhuman primate model of cardiac sympathetic neurodegeneration
Článek Were ancient foxes far more carnivorous than recent ones?—Carnassial morphological evidence
Článek Disruption in daily eating-fasting and activity-rest cycles in Indian adolescents attending school
Článek Plasma proteome profiling of freshwater and seawater life stages of rainbow trout (Oncorhynchus mykiss)
Článek Percent amplitude of fluctuation: A simple measure for resting-state fMRI signal at single voxel level
Článek Antimicrobial activity of Asteraceae species against bacterial pathogens isolated from postmenopausal women
Článek Are changes in depressive symptoms, general health and residential area socio-economic status associated with trajectories of waist circumference and body mass index?
Článek Extracellular vesicles of U937 macrophage cell line infected with DENV-2 induce activation in endothelial cells EA.hy926
Článek Link-centric analysis of variation by demographics in mobile phone communication patterns
Článek Tobacco smoking and health-related quality of life among university students: Mediating effect of depression
Článek Incidence of hospital-acquired pressure ulcers in patients with "minimal risk" according to the "Norton-MI" scale
Článek Lipoprotein(a) plasma levels are not associated with survival after acute coronary syndromes: An observational cohort study
Článek Use of Nanotrap particles for the capture and enrichment of Zika, chikungunya and dengue viruses in urine
Článek Biochemical characterization of Ty1 retrotransposon protease
Článek Lateral pressure equalisation as a principle for designing support surfaces to prevent deep tissue pressure ulcers
Článek The validation of the Beijing version of the Montreal Cognitive Assessment in Chinese patients undergoing hemodialysis
Článek Inflammasome expression is higher in ovarian tumors than in normal ovary
Článek HCV genotype profile in Brazil of mono-infected and HIV co-infected individuals: A survey representative of an entire country
Článek Engaging with change: Information and communication technology professionals’ perspectives on change at the mid-point in the UK/EU Brexit process
Článek Adherence to iron-folic acid supplement and associated factors among antenatal care attending pregnant mothers in governmental health institutions of Adwa town, Tigray, Ethiopia: Cross-sectional study
Článek Flower, seed, and fruit development in three Tunisian species of Polygonum: Implications for their taxonomy and evolution of distyly in Polygonaceae
Článek Development of a risk score for prediction of poor treatment outcomes among patients with multidrug-resistant tuberculosis
Článek Preclinical evaluation of AT-527, a novel guanosine nucleotide prodrug with potent, pan-genotypic activity against hepatitis C virus
Článek Aqueous extract from Mangifera indica Linn. (Anacardiaceae) leaves exerts long-term hypoglycemic effect, increases insulin sensitivity and plasma insulin levels on diabetic Wistar rats
Článek Discovery of Jogalong virus, a novel hepacivirus identified in a Culex annulirostris (Skuse) mosquito from the Kimberley region of Western Australia
Článek Detection of Torque Teno Virus (TTV) and TTV-Like Minivirus in patients with presumed infectious endophthalmitis in India
Článek CD4 rate of increase is preferred to CD4 threshold for predicting outcomes among virologically suppressed HIV-infected adults on antiretroviral therapy
Článek Estimating the basic reproduction number of a pathogen in a single host when only a single founder successfully infects
Článek What drugs modify the risk of iatrogenic impulse-control disorders in Parkinson’s disease? A preliminary pharmacoepidemiologic study
Článek Evaluating emotional distress and health-related quality of life in patients with heart failure and their family caregivers: Testing dyadic dynamics using the Actor-Partner Interdependence Model
Článek Catchment-scale export of antibiotic resistance genes and bacteria from an agricultural watershed in central Iowa
Článek Characterization of a universal screening approach for congenital CMV infection based on a highly-sensitive, quantitative, multiplex real-time PCR assay
Článek Proof-of-concept for a non-invasive, portable, and wireless device for cardiovascular monitoring in pediatric patients
Článek On PTV definition for glioblastoma based on fiber tracking of diffusion tensor imaging data
Článek Genes associated with body weight gain and feed intake identified by meta-analysis of the mesenteric fat from crossbred beef steers
Článek Human lung epithelial BEAS-2B cells exhibit characteristics of mesenchymal stem cells
Článek Evaluation of a bioengineered ACL matrix’s osteointegration with BMP-2 supplementation
Článek Psychosocial profiles of physical activity fluctuation in office employees: A latent profile analysis
Článek Soluble AXL as a marker of disease progression and survival in melanoma
Článek Gender differences influence over insomnia in Korean population: A cross-sectional study
Článek Impact of scion/rootstock reciprocal effects on metabolomics of fruit juice and phloem sap in grafted Citrus reticulata
Článek Adapting cognitive diagnosis computerized adaptive testing item selection rules to traditional item response theory
Článek Autumn shifts in cold tolerance metabolites in overwintering adult mountain pine beetles
Článek Umbilical cord separation time, predictors and healing complications in newborns with dry care
Článek Analysis of attitudinal components towards statistics among students from different academic degrees
Článek Effects of fatigue induced by repeated-sprint on kicking accuracy and velocity in female soccer players
Článek A pre-clinical validation plan to evaluate analytical sensitivities of molecular diagnostics such as BD MAX MDR-TB, Xpert MTB/Rif Ultra and FluoroType MTB
Článek Leadership for success in transforming medical abortion policy in Canada
Článek Clinical correlates associated with the long-term response of bipolar disorder patients to lithium, valproate or lamotrigine: A retrospective study
Článek Forecasting stock prices with long-short term memory neural network based on attention mechanism
Článek On the genus Crossaster (Echinodermata: Asteroidea) and its distribution
Článek Intracellular and in vivo evaluation of imidazo[2,1-b]thiazole-5-carboxamide anti-tuberculosis compounds
Článek An integrated vitamin E-coated polymer hybrid nanoplatform: A lucrative option for an enhanced in vitro macrophage retention for an anti-hepatitis B therapeutic prospect
Článek The effect of strontium and silicon substituted hydroxyapatite electrochemical coatings on bone ingrowth and osseointegration of selective laser sintered porous metal implants
Článek Molecular prevalence of Bartonella, Babesia, and hemotropic Mycoplasma species in dogs with hemangiosarcoma from across the United States
Článek Color discrimination and gas chromatography-mass spectrometry fingerprint based on chemometrics analysis for the quality evaluation of Schizonepetae Spica
Článek Comparisons of recurrence-free survival and overall survival between microwave versus radiofrequency ablation treatment for hepatocellular carcinoma: A multiple centers retrospective cohort study with propensity score matching
Článek Dynamic Extreme Aneuploidy (DEA) in the vegetable pathogen Phytophthora capsici and the potential for rapid asexual evolution
Článek Assertive, trainable and older dogs are perceived as more dominant in multi-dog households
Článek Prediction of Uropathogens by Flow Cytometry and Dip-stick Test Results of Urine Through Multivariable Logistic Regression Analysis
Článek Interleukin 6 is increased in preclinical HNSCC models of acquired cetuximab resistance, but is not required for maintenance of resistance
Článek Impact of viral disease hypophagia on pig jejunal function and integrity
Článek Molecular evidence for horizontal transmission of chelonid alphaherpesvirus 5 at green turtle (Chelonia mydas) foraging grounds in Queensland, Australia
Článek Evaluation and validation of 2D biomechanical models of the knee for radiograph-based preoperative planning in total knee arthroplasty
Článek Soil-Transmitted Helminth infections reduction in Bhutan: A report of 29 years of deworming
Článek Fast quantitative time lapse displacement imaging of endothelial cell invasion
Článek Two novel mutations in MSX1 causing oligodontia
Článek Dome-shaped macula in children and adolescents
Článek Targeted transcriptomic study of the implication of central metabolic pathways in mannosylerythritol lipids biosynthesis in Pseudozyma antarctica T-34
Článek Preliminary evidences of the presence of extracellular DNA single stranded forms in soil
Článek A comparison of quality of life between patients treated with different dialysis modalities in Taiwan
Článek Transcriptome analysis of Actinidia chinensis in response to Botryosphaeria dothidea infection
Článek Comparative study on skin protection activity of polyphenol-rich extract and polysaccharide-rich extract from Sargassum vachellianum
Článek Real-world data about emotional stress, disability and need for social care in a German IBD patient cohort
Článek The regenerative compatibility: A synergy between healthy ecosystems, environmental attitudes, and restorative experiences
Článek Perceptions of risk and influences of choice in pregnant women with obesity. An evidence synthesis of qualitative research
Článek Sexual risk classes among youth experiencing homelessness: Relation to childhood adversities, current mental symptoms, substance use, and HIV testing
Článek Effects of CK2β subunit down-regulation on Akt signalling in HK-2 renal cells
Článek Novel broad-spectrum activity-based probes to profile malarial cysteine proteases
Článek Association between opioid analgesic therapy and initiation of buprenorphine management: An analysis of prescription drug monitoring program data
Článek Improvement project in higher education institutions: A BPEP-based model
Článek An updated evaluation of serum sHER2, CA15.3, and CEA levels as biomarkers for the response of patients with metastatic breast cancer to trastuzumab-based therapies
Článek Genome-wide association study of metabolic syndrome in Korean populations
Článek Drug therapy problems and treatment satisfaction among ambulatory patients with epilepsy in a specialized hospital in Ethiopia
Článek Occurrence and distribution of anthropogenic persistent organic pollutants in coastal sediments and mud shrimps from the wetland of central Taiwan
Článek Intensified visual clutter induces increased sympathetic signalling, poorer postural control, and faster torsional eye movements during visual rotation
Článek Gut microbiota composition alterations are associated with the onset of diabetes in kidney transplant recipients
Článek Shock index and TIMI risk index as valuable prognostic tools in patients with acute coronary syndrome complicated by cardiogenic shock
Článek Merit overrules theory of mind when young children share resources with others
Článek Metabolic analysis of amino acids and vitamin B6 pathways in lymphoma survivors with cancer related chronic fatigue
Článek Immunopathogenesis of canine chronic ulcerative stomatitis
Článek Generalizing findings from a randomized controlled trial to a real-world study of the iLookOut, an online education program to improve early childhood care and education providers’ knowledge and attitudes about reporting child maltreatment
Článek When and what to test for: A cost-effectiveness analysis of febrile illness test-and-treat strategies in the era of responsible antibiotic use
Článek Comparison of effects and safety in providing controlled hypotension during surgery between dexmedetomidine and magnesium sulphate: A meta-analysis of randomized controlled trials
Článek The gene encoding the ketogenic enzyme HMGCS2 displays a unique expression during gonad development in mice
Článek Efficacy of a mitochondrion-targeting agent for reducing the level of urinary protein in rats with puromycin aminonucleoside-induced minimal-change nephrotic syndrome
Článek Association of endothelial nitric oxide synthase (NOS3) gene polymorphisms with primary open-angle glaucoma in a Saudi cohort
Článek Antitrust analysis with upward pricing pressure and cost efficiencies
Článek Natural selection contributes to food web stability
Článek Pyramiding QTLs controlling tolerance against drought, salinity, and submergence in rice through marker assisted breeding
Článek Diversity and plant growth-promoting functions of diazotrophic/N-scavenging bacteria isolated from the soils and rhizospheres of two species of Solanum
Článek Sofosbuvir-based regimen for genotype 2 HCV infected patients in Taiwan: A real world experience
Článek The virulence domain of Shigella IcsA contains a subregion with specific host cell adhesion function
Článek Sequencing artifacts derived from a library preparation method using enzymatic fragmentation
Článek Quantitative analysis of adsorption and desorption of volatile organic compounds on reusable zeolite filters using gas chromatography
Článek Quo vadis Pantanal? Expected precipitation extremes and drought dynamics from changing sea surface temperature
Článek The Brief Measure of Emotional Preoperative Stress (B-MEPS) as a new predictive tool for postoperative pain: A prospective observational cohort study
Článek The impact of diabetes mellitus medication on the incidence of endogenous endophthalmitis
Článek Clinical and pathological features of thrombotic microangiopathy influencing long-term kidney transplant outcomes
Článek Morphological adjustment in free-living Steinernema feltiae infective juveniles to increasing concentration of Nemafric-BL phytonematicide
Článek Key necroptotic proteins are required for Smac mimetic-mediated sensitization of cholangiocarcinoma cells to TNF-α and chemotherapeutic gemcitabine-induced necroptosis
Článek Concurrent lipidomics and proteomics on malignant plasma cells from multiple myeloma patients: Probing the lipid metabolome
Článek Retraction: SDR9C7 Promotes Lymph Node Metastases in Patients with Esophageal Squamous Cell Carcinoma
Článek Association between tuberculosis and depression on negative outcomes of tuberculosis treatment: A systematic review and meta-analysis
Článek Bioluminescent imaging of Arabidopsis thaliana using an enhanced Nano-lantern luminescence reporter system
Článek Biosynthetic pathway of indole-3-acetic acid in ectomycorrhizal fungi collected from northern Thailand
Článek Sex-specific and opposite modulatory aspects revealed by PPI network and pathway analysis of ischemic stroke in humans
Článek Control of the microsporidian parasite Nosema ceranae in honey bees (Apis mellifera) using nutraceutical and immuno-stimulatory compounds
Článek Role of donor genotype in RT-QuIC seeding activity of chronic wasting disease prions using human and bank vole substrates
Článek Oral magnesium supplementation for leg cramps in pregnancy—An observational controlled trial
Článek Health care professionals’ knowledge of commonly used sedative, analgesic and neuromuscular drugs: A single center (Rambam Health Care Campus), prospective, observational survey
Článek Campylobacter portucalensis sp. nov., a new species of Campylobacter isolated from the preputial mucosa of bulls
Článek Transgenic interleukin 11 expression causes cross-tissue fibro-inflammation and an inflammatory bowel phenotype in mice
Článek Sleep quality and sex modify the relationships between trait energy and fatigue on state energy and fatigue
Článek The role of peer, parental, and school norms in predicting adolescents’ attitudes and behaviours of majority and different minority ethnic groups in Croatia
Článek Availability, prices and affordability of selected antibiotics and medicines against non-communicable diseases in western Cameroon and northeast DR Congo
Článek The effect of mutations derived from mouse-adapted H3N2 seasonal influenza A virus to pathogenicity and host adaptation
Článek Detection of posttraumatic pneumothorax using electrical impedance tomography—An observer-blinded study in pigs with blunt chest trauma
Článek Educators’ perceptions of organisational readiness for implementation of a pre-adolescent transdisciplinary school health intervention for inter-generational outcomes
Článek The effects of sport expertise and shot results on basketball players’ action anticipation
Článek Framework and algorithms for identifying honest blocks in blockchain
Článek Exploring the impact of terminology differences in blood and organ donor decision making
Článek Platelet indices significantly correlate with liver fibrosis in HCV-infected patients
Článek The nitrate content of fresh and cooked vegetables and their health-related risks
Článek Multiplex real-time PCR for the detection of Clavibacter michiganensis subsp. michiganensis, Pseudomonas syringae pv. tomato and pathogenic Xanthomonas species on tomato plants
Článek The 24-hour urinary cortisol in post-traumatic stress disorder: A meta-analysis
Článek “I like the way I am, but I feel like I could get a little bit bigger”: Perceptions of body image among adolescents and youth living with HIV in Durban, South Africa
Článek Nanoparticle-based ‘turn-on’ scattering and post-sample fluorescence for ultrasensitive detection of water pollution in wider window
Článek Insights into the strategy of micro-environmental adaptation: Transcriptomic analysis of two alvinocaridid shrimps at a hydrothermal vent
Článek Hyper-spectral response and estimation model of soil degradation in Kenli County, the Yellow River Delta
Článek Construction of a high-density genetic map and fine mapping of a candidate gene locus for a novel branched-spike mutant in barley
Článek Natural hybridization between Phyllagathis and Sporoxeia species produces a hybrid without reproductive organs
Článek Diagnostic performance of serum interferon gamma, matrix metalloproteinases, and periostin measurements for pulmonary tuberculosis in Japanese patients with pneumonia
Článek Characterization of black patina from the Tiber River embankments using Next-Generation Sequencing
Článek Validity of cerebrovascular ICD-9-CM codes in healthcare administrative databases. The Umbria Data-Value Project
Článek Torque teno virus viral load is related to age, CMV infection and HLA type but not to Alzheimer's disease
Článek Associations of cigarette smoking and burden of thoracic aortic calcification in asymptomatic individuals: A dose-response relationship
Článek Transforming assessment of speech in children with cleft palate via online crowdsourcing
Článek Assessment of peritoneal microbial features and tumor marker levels as potential diagnostic tools for ovarian cancer
Článek Deficiency syndromes in top predators associated with large-scale changes in the Baltic Sea ecosystem
Článek Perceived relative social status and cognitive load influence acceptance of unfair offers in the Ultimatum Game
Článek Hepatitis B and C virus infection among HIV patients within the public and private healthcare systems in Chile: A cross-sectional serosurvey
Článek Retraction: Oncogenic Fibulin-5 Promotes Nasopharyngeal Carcinoma Cell Metastasis through the FLJ10540/AKT Pathway and Correlates with Poor Prognosis
Článek From seed to flour: Sowing sustainability in the use of cantaloupe melon residue (Cucumis melo L. var. reticulatus)
Článek Core Scientific Dataset Model: A lightweight and portable model and file format for multi-dimensional scientific data
Článek Accounting for measurement error to assess the effect of air pollution on omic signals
Článek Leucine zipper transcription factor-like 1 binds adaptor protein complex-1 and 2 and participates in trafficking of transferrin receptor 1
Článek Barriers for tuberculosis case finding in Southwest Ethiopia: A qualitative study
Článek Genetic predisposition to celiac disease in Kazakhstan: Potential impact on the clinical practice in Central Asia
Článek A lower psoas muscle volume was associated with a higher rate of recurrence in male clear cell renal cell carcinoma
Článek Two angles of overqualification-the deviant behavior and creative performance: The role of career and survival job
Článek Cost-utility analysis of de-escalating biological disease-modifying anti-rheumatic drugs in patients with rheumatoid arthritis
Článek Efficient estimation of stereo thresholds: What slope should be assumed for the psychometric function?
Článek Learning efficient haptic shape exploration with a rigid tactile sensor array
Článek Effects of dietary supplementation with a microalga (Schizochytrium sp.) on the hemato-immunological, and intestinal histological parameters and gut microbiota of Nile tilapia in net cages
Článek Regional versus local wind speed and direction at a narrow beach with a high and steep foredune
Článek Fragmented QRS complex in patients with systemic lupus erythematosus at the time of diagnosis and its relationship with disease activity
Článek Severe thiamine deficiency in eastern Baltic cod (Gadus morhua)
Článek Transfer entropy as a variable selection methodology of cryptocurrencies in the framework of a high dimensional predictive model
Článek Psychometric validation of Czech version of the Sport Motivation Scale
Článek Correction: Multiple innate antibacterial immune defense elements are correlated in diverse ungulate species
Článek Recognition of personality disorder and anxiety disorder comorbidity in patients treated for depression in secondary psychiatric care
Článek Correction: Strategies for achieving high sequencing accuracy for low diversity samples and avoiding sample bleeding using illumina platform
Článek ETAPOD: A forecast model for prediction of black pod disease outbreak in Nigeria
Článek Number of days required to estimate physical activity constructs objectively measured in different age groups: Findings from three Brazilian (Pelotas) population-based birth cohorts
Článek Exploring the mechanism of olfactory recognition in the initial stage by modeling the emission spectrum of electron transfer
Článek The impact of a wireless audio system on communication in robotic-assisted laparoscopic surgery: A prospective controlled trial
Článek Dense carbon-nanotube coating scaffolds stimulate osteogenic differentiation of mesenchymal stem cells
Článek Physicians’ perspectives regarding non-medical switching of prescription medications: Results of an internet e-survey
Článek Potential socioeconomic impacts from ocean acidification and climate change effects on Atlantic Canadian fisheries
Článek Design and evaluation of a laboratory-based wheelchair castor testing protocol using community data
Článek Modeling aggressive market order placements with Hawkes factor models
Článek Healthy lifestyle index and its association with hypertension among community adults in Sri Lanka: A cross-sectional study
Článek Effects of Allium hookeri on gut microbiome related to growth performance in young broiler chickens
Článek The Shapley value for a fair division of group discounts for coordinating cooling loads
Článek Pancreatic secretory trypsin inhibitor reduces multi-organ injury caused by gut ischemia/reperfusion in mice
Článek Community- and trophic-level responses of soil nematodes to removal of a non-native tree at different stages of invasion
Článek Association of ECG parameters with late gadolinium enhancement and outcome in patients with clinical suspicion of acute or subacute myocarditis referred for CMR imaging
Článek Impact of multi-drug resistant bacteria on economic and clinical outcomes of healthcare-associated infections in adults: Systematic review and meta-analysis
Článek Intraoperative computed tomography imaging for dose calculation in intraoperative electron radiation therapy: Initial clinical observations
Článek Simple non-mydriatic retinal photography is feasible and demonstrates retinal microvascular dilation in Chronic Obstructive Pulmonary Disease (COPD)
Článek Maternal depressive symptoms and children’s cognitive development: Does early childcare and child’s sex matter?
Článek Prevalence and characteristics of Livestock-Associated Methicillin-Resistant Staphylococcus aureus (LA-MRSA) isolated from chicken meat in the province of Quebec, Canada
Článek Using machine learning methods to determine a typology of patients with HIV-HCV infection to be treated with antivirals
Článek Oral misoprostol, low dose vaginal misoprostol, and vaginal dinoprostone for labor induction: Randomized controlled trial
Článek The association between dietary patterns before and in early pregnancy and the risk of gestational diabetes mellitus (GDM): Data from the Malaysian SECOST cohort
Článek cagA gene EPIYA motif genetic characterization from Colombian Helicobacter pylori isolates: Standardization of a molecular test for rapid clinical laboratory detection
Článek Spectral characteristics of urine from patients with end-stage kidney disease analyzed using Raman Chemometric Urinalysis (Rametrix)
Článek Comparison of Monocyte Distribution Width (MDW) and Procalcitonin for early recognition of sepsis
Článek Morphological association between the muscles and bones in the craniofacial region
Článek Antenatal depression and its association with adverse birth outcomes in low and middle-income countries: A systematic review and meta-analysis
Článek The role of refugee and migrant migration status on medication adherence: Mediation through illness perceptions
Článek Effect of a community-based approach of iron and folic acid supplementation on compliance by pregnant women in Kiambu County, Kenya: A quasi-experimental study
Článek Plasma kynurenines and prognosis in patients with heart failure
Článek Cloud-computing and machine learning in support of country-level land cover and ecosystem extent mapping in Liberia and Gabon
Článek Correction: Chl1 DNA helicase and Scc2 function in chromosome condensation through cohesin deposition
Článek Occupational exposure to particulate matter from air pollution in the outdoor workplaces in Almaty during the cold season
Článek Beyond the heterodimer model for mineralocorticoid and glucocorticoid receptor interactions in nuclei and at DNA
Článek Bioreactor for mobilization of mesenchymal stem/stromal cells into scaffolds under mechanical stimulation: Preliminary results
Článek Non-gradient and genotype-dependent patterns of RSV gene expression
Článek Drug-eluting versus bare-metal stents for first myocardial infarction in patients with atrial fibrillation: A nationwide population-based cohort study
Článek Health-related quality of life among patients with type 2 diabetes mellitus in Eastern Province, Saudi Arabia: A cross-sectional study
Článek Thirty-day readmission after medical-surgical hospitalization for people who experience imprisonment in Ontario, Canada: A retrospective cohort study
Článek The association of telomere length and telomerase activity with adverse outcomes in older patients with non-ST-elevation acute coronary syndrome
Článek Alterations of aqueous humor Aβ levels in Aβ-infused and transgenic mouse models of Alzheimer disease
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2020 Číslo 1
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Aktuální možnosti diagnostiky a léčby litiáz
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Autori: MUDr. Tomáš Ürge, PhD.
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