A network analysis revealed the essential and common downstream proteins related to inguinal hernia
Autoři:
Yimin Mao aff001; Le Chen aff001; Jianghua Li aff001; Anna Junjie Shangguan aff003; Stacy Kujawa aff004; Hong Zhao aff004
Působiště autorů:
School of Information and Technology, Jiangxi University of Science and Technology, Jiangxi, China
aff001; Applied Science Institute, Jiangxi University of Science and Technology, Jiangxi, China
aff002; Department of Radiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America
aff003; Division of Reproductive Science in Medicine, Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America
aff004
Vyšlo v časopise:
PLoS ONE 15(1)
Kategorie:
Research Article
prolekare.web.journal.doi_sk:
https://doi.org/10.1371/journal.pone.0226885
Souhrn
Although more than 1 in 4 men develop symptomatic inguinal hernia during their lifetime, the molecular mechanism behind inguinal hernia remains unknown. Here, we explored the protein-protein interaction network built on known inguinal hernia-causative genes to identify essential and common downstream proteins for inguinal hernia formation. We discovered that PIK3R1, PTPN11, TGFBR1, CDC42, SOS1, and KRAS were the most essential inguinal hernia-causative proteins and UBC, GRB2, CTNNB1, HSP90AA1, CBL, PLCG1, and CRK were listed as the most commonly-involved downstream proteins. In addition, the transmembrane receptor protein tyrosine kinase signaling pathway was the most frequently found inguinal hernia-related pathway. Our in silico approach was able to uncover a novel molecular mechanism underlying inguinal hernia formation by identifying inguinal hernia-related essential proteins and potential common downstream proteins of inguinal hernia-causative proteins.
Klíčová slova:
Centrality – TGF-beta signaling cascade – MAPK signaling cascades – Membrane receptor signaling – Hernia – Protein kinase signaling cascade – Protein interaction networks – VEGF signaling
Zdroje
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