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preLekára.sk / Odborné časopisy / PLOS One / 2020 - 1

Evaluation of a bioengineered ACL matrix’s osteointegration with BMP-2 supplementation

English version

Autoři: Paulos Y. Mengsteab aff001;  Patrick Conroy aff001;  Mary Badon aff001;  Takayoshi Otsuka aff001;  Ho-Man Kan aff001;  Anthony T. Vella aff005;  Lakshmi S. Nair aff001;  Cato T. Laurencin aff001
Působiště autorů: Connecticut Convergence Institute for Translation in Regenerative Engineering, University of Connecticut Health, Farmington, CT, United States of America aff001;  Raymond and Beverly Sackler Center for Biological, Physical and Engineering Sciences, University of Connecticut Health, Farmington, CT, United States of America aff002;  Department of Orthopedic Surgery, University of Connecticut Health, Farmington, CT, United States of America aff003;  Department of Biomedical Engineering, University of Connecticut, Storrs, CT, United States of America aff004;  Department of Immunology, University of Connecticut School of Medicine, Farmington, CT, United States of America aff005;  Department of Materials Science and Engineering, University of Connecticut, Storrs, CT, United States of America aff006;  Department of Chemical and Biomolecular Engineering, University of Connecticut, Storrs, CT, United States of America aff007;  Department of Reconstructive Sciences, University of Connecticut Health Center, Farmington, CT, United States of America aff008
Vyšlo v časopise: PLoS ONE 15(1)
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.pone.0227181

Souhrn

A poly (l-lactic) acid bioengineered anterior cruciate ligament (ACL) matrix has previously demonstrated the ability to support tissue regeneration in a rabbit ACL reconstruction model. The matrix was designed for optimal bone and ligament regeneration by developing a matrix with differential pore sizes in its bone and ligament compartments. Building upon past success, we designed a new bioengineered ACL matrix that is easier to install and can be used with endobutton fixation during ACL reconstruction. To achieve this, a new braiding procedure was developed to allow the matrix to be folded in half, making two-limbs, while maintaining its bone and ligament compartments. The osteointegration of the matrix with and without bone morphogenetic protein 2 (BMP-2) supplementation was evaluated in a rabbit ACL reconstruction model. Two doses of BMP-2 were evaluated, 1 and 10 μg, and delivered by saline injection into the bone tunnel at the end of surgery. A fibrous matrix-to-bone interface with occasional Sharpey’s fibers was the primary mode of osteointegration observed. The matrix was also found to support a fibrocartilage matrix-to-bone interface. In some cases, the presence of chondrocyte-like cells was observed at the aperture of the bone tunnel and the center of the matrix within the bone tunnel. Treatment with BMP-2 was associated with a trend towards smaller bone tunnel cross-sectional areas, and 1 μg of BMP-2 was found to significantly enhance osteoid seam width in comparison with no BMP-2 or 10 μg of BMP-2 treatment. Regenerated tissue was well organized within the bioengineered ACL matrix and aligned with the poly (l-lactic) acid fibers. Disorganized tissue was found between the two-limbs of the bioengineered ACL matrix and hypothesized to be due to a lack of structural scaffolding. This study suggests that the bioengineered ACL matrix can undergo similar modes of osteointegration as current autografts and allografts, and that BMP-2 treatment may enhance osteoblastic activity within the bone tunnels.

Klíčová slova:

Cytokines – Cell staining – Tendons – Rabbits – Knees – Anterior cruciate ligament reconstruction – Fibrocartilage – Tibia

Zdroje

1. Ardern CL, Webster KE, Taylor NF, Feller JA. Return to sport following anterior cruciate ligament reconstruction surgery: a systematic review and meta-analysis of the state of play. Br J Sports Med. 2011;45: 596–606. doi: 10.1136/bjsm.2010.076364 21398310

2. Paterno M V., Rauh MJ, Schmitt LC, Ford KR, Hewett TE. Incidence of Second ACL Injuries 2 Years After Primary ACL Reconstruction and Return to Sport. Am J Sports Med. 2014;42: 1567–1573. doi: 10.1177/0363546514530088 24753238

3. Sajovic M, Stropnik D, Skaza K. Long-term Comparison of Semitendinosus and Gracilis Tendon Versus Patellar Tendon Autografts for Anterior Cruciate Ligament Reconstruction: A 17-Year Follow-up of a Randomized Controlled Trial. Am J Sports Med. 2018;46: 1800–1808. doi: 10.1177/0363546518768768 29741911

4. Gulotta L V, Rodeo SA. Biology of autograft and allograft healing in anterior cruciate ligament reconstruction. Clin Sports Med. 2007;26: 509–24. doi: 10.1016/j.csm.2007.06.007 17920950

5. Mengsteab PY, Nair LS, Laurencin CT. The past, present and future of ligament regenerative engineering. Regen Med. 2016;11: 871–881. doi: 10.2217/rme-2016-0125 27879170

6. Cooper JA, Sahota JS, Gorum WJ, Carter J, Doty SB, Laurencin CT. Biomimetic tissue-engineered anterior cruciate ligament replacement. Proc Natl Acad Sci U S A. 2007;104: 3049–54. doi: 10.1073/pnas.0608837104 17360607

7. Ma CB, Kawamura S, Deng X-H, Ying L, Schneidkraut J, Hays P, et al. Bone Morphogenetic Proteins-Signaling Plays A Role In Tendon-To-Bone Healing: A Study of rhBMP-2 and Noggin. Am J Sports Med. 2007;35: 597–604. doi: 10.1177/0363546506296312 17218656

8. Song EK, Rowe SM, Chung JY, Moon ES, Lee KB. Failure of Osteointegration of Hamstring Tendon Autograft After Anterior Cruciate Ligament Reconstruction. Arthrosc—J Arthrosc Relat Surg. 2004;20: 424–428. doi: 10.1016/j.arthro.2004.01.005 15067284

9. Rodeo SA, Suzuki K, Deng X, Wozney J, Warren RF. Use of Recombinant Human Bone Morphogenetic Protein-2 to Enhance Tendon Healing in a Bone Tunnel. Am J Sports Med. 1999;27: 476–488. doi: 10.1177/03635465990270041201 10424218

10. Yang HS, La WG, Cho YM, Shin W, Yeo GD, Kim BS. Comparison between heparin-conjugated fibrin and collagen sponge as bone morphogenetic protein-2 carriers for bone regeneration. Exp Mol Med. 2012;44: 350–355. doi: 10.3858/emm.2012.44.5.039 22322342

11. Schützenberger S, Schultz A, Hausner T, Hopf R, Zanoni G, Morton T, et al. The optimal carrier for BMP-2: A comparison of collagen versus fibrin matrix. Arch Orthop Trauma Surg. 2012;132: 1363–1370. doi: 10.1007/s00402-012-1551-2 22660797

12. Li RH, Bouxsein ML, Blake CA, D’Augusta D, Kim H, Li XJ, et al. rhBMP-2 injected in a calcium phosphate paste (α-BSM) accelerates healing in the rabbit ulnar osteotomy model. J Orthop Res. 2003;21: 997–1004. doi: 10.1016/S0736-0266(03)00082-2 14554211

13. Li Y, Li R, Hu J, Song D, Jiang X, Zhu S. Recombinant human bone morphogenetic protein-2 suspended in fibrin glue enhances bone formation during distraction osteogenesis in rabbits. Arch Med Sci. 2016;12: 494–501. doi: 10.5114/aoms.2016.59922 27279839

14. Van Der Stok J, Koolen MKE, De Maat MPM, Amin Yavari S, Alblas J, Patka P, et al. Full regeneration of segmental bone defects using porous titanium implants loaded with BMP-2 containing fibrin gels. Eur Cells Mater. 2015;29: 141–154. doi: 10.22203/eCM.v029a11 25738583

15. Kaipel M, Schützenberger S, Schultz A, Ferguson J, Slezak P, Morton TJ, et al. BMP-2 but not VEGF or PDGF in fibrin matrix supports bone healing in a delayed-union rat model. J Orthop Res. 2012;30: 1563–1569. doi: 10.1002/jor.22132 22508566

16. Murakami N, Saito N, Horiuchi H, Okada T, Nozaki K, Takaoka K. Repair of segmental defects in rabbit humeri with titanium fiber mesh cylinders containing recombinant human bone morphogenetic protein-2 (rhBMP-2) and a synthetic polymer. J Biomed Mater Res. 2002;62: 169–174. doi: 10.1002/jbm.10236 12209936

17. Milano G, Mulas PD, Ziranu F, Piras S, Manunta A, Fabbriciani C. Comparison Between Different Femoral Fixation Devices for ACL Reconstruction With Doubled Hamstring Tendon Graft: A Biomechanical Analysis. Arthrosc J Arthrosc Relat Surg. 2006;22: 660–668. doi: 10.1016/J.ARTHRO.2006.04.082 16762706

18. Madhavarapu S, Rao R, Libring S, Fleisher E, Yankannah Y, Freeman JW. Design and characterization of three-dimensional twist-braid scaffolds for anterior cruciate ligament regeneration. TECHNOLOGY. 2017;5: 98–106. doi: 10.1142/s2339547817500066

19. Erben RG. Embedding of Bone Samples in Methylmethacrylate: An Improved Method Suitable for Bone Histomorphometry, Histochemistry, and Immunohistochemistry. J Histochem Cytochem. 1997;45: 307–313. doi: 10.1177/002215549704500215 9016319

20. Villanueva AR, Mehr LA. Modifications of the Goldner and Gomori one-step trichrome stains for plastic-embedded thin sections of bone. Am J Med Technol. 1977;43: 536–8. Available: http://www.ncbi.nlm.nih.gov/pubmed/69401 69401

21. Thomopoulos S, Genin GM, Galatz LM. The development and morphogenesis of the tendon-to-bone insertion—what development can teach us about healing -. J Musculoskelet Neuronal Interact. 2010;10: 35–45. Available: http://www.ncbi.nlm.nih.gov/pubmed/20190378 20190378

22. Weiler A, Hoffmann RFG, Bail HJ, Rehm O, Südkamp NP. Tendon healing in a bone tunnel. Part II: Histologic analysis after biodegradable interference fit fixation in a model of anterior cruciate ligament reconstruction in sheep. Arthroscopy. 2002;18: 124–135. doi: 10.1053/jars.2002.30657 11830805

23. Fealy S, Rodeo SA, MacGillivray JD, Nixon AJ, Adler RS, Warren RF. Biomechanical evaluation of the relation between number of suture anchors and strength of the bone–tendon interface in a goat rotator cuff model. J Arthrosc Relat Surg. 2004;22: 595–602. doi: 10.1016/j.arthro.2006.03.008 16762696

24. Weimin P, Dan L, Yiyong W, Yunyu H, Li Z. Tendon-to-bone healing using an injectable calcium phosphate cement combined with bone xenograft/BMP composite. Biomaterials. 2013;34: 9926–9936. doi: 10.1016/j.biomaterials.2013.09.018 24075477

25. Ma CB, Kawamura S, Deng X-H, Ling Ying L, Schneidkraut J, Hays P, et al. Bone Morphogenetic Proteins-Signaling Plays a Role in Tendon-to-Bone Healing. Am J Sports Med. 2007;35: 597–604. doi: 10.1177/0363546506296312 17218656

26. Soon MYH, Hassan A, Hui JHP, Goh JCH, Lee EH. An Analysis of Soft Tissue Allograft Anterior Cruciate Ligament Reconstruction in a Rabbit Model. Am J Sports Med. 2007;35: 962–971. doi: 10.1177/0363546507300057 17400750

27. Lim JK, Hui J, Li L, Thambyah A, Goh J, Lee EH. Enhancement of tendon graft osteointegration using mesenchymal stem cells in a rabbit model of anterior cruciate ligament reconstruction. Arthrosc—J Arthrosc Relat Surg. 2004;20: 899–910. doi: 10.1016/S0749-8063(04)00653-X

28. Soon MYH, Hassan A, Hui JHP, Goh JCH, Lee EH. An Analysis of Soft Tissue Allograft Anterior Cruciate Ligament Reconstruction in a Rabbit Model. Am J Sports Med. 2007;35: 962–971. doi: 10.1177/0363546507300057 17400750

29. Dong Y, Zhang Q, Li Y, Jiang J, Chen S, Dong Y, et al. Enhancement of Tendon–Bone Healing for Anterior Cruciate Ligament (ACL) Reconstruction Using Bone Marrow-Derived Mesenchymal Stem Cells Infected with BMP-2. Int J Mol Sci. 2012;13: 13605–13620. doi: 10.3390/ijms131013605 23202970

30. Cheng P, Han P, Zhao C, Zhang S, Wu H, Ni J, et al. High-purity magnesium interference screws promote fibrocartilaginous entheses regeneration in the anterior cruciate ligament reconstruction rabbit model via accumulation of BMP-2 and VEGF. Biomaterials. 2016;81: 14–26. doi: 10.1016/j.biomaterials.2015.12.005 26713681

31. Hashimoto Y, Yoshida G, Toyoda H, Takaoka K. Generation of tendon-to-bone interface “enthesis” with use of recombinant BMP-2 in a rabbit model. J Orthop Res. 2007;25: 1415–24. doi: 10.1002/jor.20447 17557323

32. Pan W, Wei Y, Zhou L, Li D. Comparative in vivo study of injectable biomaterials combined with BMP for enhancing tendon graft osteointegration for anterior cruciate ligament reconstruction. J Orthop Res. 2011;29: 1015–1021. doi: 10.1002/jor.21351 21308754

33. Kim H-J, Kang S-W, Lim H-C, Han S-B, Lee J-S, Prasad L, et al. The Role of Transforming Growth Factor-β and Bone Morphogenetic Protein with Fibrin Glue in Healing of Bone-Tendon Junction Injury. Connect Tissue Res. 2007;48: 309–315. doi: 10.1080/03008200701692610 18075817

34. Guidoin MF, Marois Y, Bejui J, Poddevin N, King MW, Guidoin R. Analysis of retrieved polymer fiber based replacements for the ACL. Biomaterials. 2000;21: 2461–2474. doi: 10.1016/s0142-9612(00)00114-9 11055294

35. Hearle JWS. Atlas of fibre fracture and damage to textiles. 2nd ed. 2006.

36. Walsh WR, Bertollo N, Arciero RA, Stanton RA, Poggie RA. Long-term In-vivo Evaluation Of A Resorbable PLLA Scaffold For Regeneration Of The ACL. Orthop J Sport Med. 2015;3. doi: 10.1177/2325967115S00033

37. Miura K, Woo SL-Y, Brinkley R, Fu Y-C, Noorani S. Effects of Knee Flexion Angles for Graft Fixation on Force Distribution in Double-Bundle Anterior Cruciate Ligament Grafts. Am J Sports Med. 2006;34: 577–585. doi: 10.1177/0363546505281814 16282574

38. Mansour JM, Wentorf FA, Degoede KM. In Vivo Kinematics of the Rabbit Knee in Unstable Models of Osteoarthrosis. Ann Biomed Eng. 1998;26: 353–360. doi: 10.1114/1.133 9570218

39. Fleming B, Beynnon BD, Johnson RJ, McLeod WD, Pope MH. Isometric versus tension measurements. A comparison for the reconstruction of the anterior cruciate ligament. Am J Sports Med. 1993;21: 82–88. doi: 10.1177/036354659302100115 8427374

40. Carson E, Anisko E, Restrepo C, Panariello R, O’Brien S, Warren R. Revision Anterior Cruciate Ligament Reconstruction–Etiology of Failures and Clinical Results. J Knee Surg. 2010;17: 127–132. doi: 10.1055/s-0030-1248210 15366266

41. Nicholas SJ, D’Amato MJ, Mullaney MJ, Tyler TF, Kolstad K, McHugh MP. A Prospectively Randomized Double-Blind Study on the Effect of Initial Graft Tension on Knee Stability after Anterior Cruciate Ligament Reconstruction. Am J Sports Med. 2004;32: 1881–1886. doi: 10.1177/0363546504265924 15572316

42. Numazaki H, Tohyama H, Nakano H, Kikuchi S, Yasuda K. The Effect of Initial Graft Tension in Anterior Cruciate Ligament Reconstruction on the Mechanical Behaviors of the Femur-Graft-Tibia Complex during Cyclic Loading. Am J Sports Med. 2002;30: 800–805. doi: 10.1177/03635465020300060801 12435644

43. Kim SG, Kurosawa H, Sakuraba K, Ikeda H, Takazawa S. The effect of initial graft tension on postoperative clinical outcome in anterior cruciate ligament reconstruction with semitendinosus tendon. Arch Orthop Trauma Surg. 2006;126: 260–264. doi: 10.1007/s00402-005-0045-x 16193302

44. Yoshiya S, Andrish JT, Manley MT, Bauer TW. Graft tension in anterior cruciate ligament reconstruction. An in vivo study in dogs. Am J Sports Med. 1987;15: 464–470. doi: 10.1177/036354658701500506 3674269

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Článek Aberrant cervical innate immunity predicts onset of dysbiosis and sexually transmitted infections in women of reproductive age
Článek Safe mobility, socioeconomic inequalities, and aging: A 12-year multilevel interrupted time-series analysis of road traffic death rates in a Latin American country
Článek Lesion of striatal patches disrupts habitual behaviors and increases behavioral variability
Článek A clinical method for estimating the modulus of elasticity of the human cornea in vivo
Článek Patient perceived value of teleophthalmology in an urban, low income US population with diabetes
Článek Evidence in support of chromosomal sex influencing plasma based metabolome vs APOE genotype influencing brain metabolome profile in humanized APOE male and female mice
Článek Accelerated sparsity based reconstruction of compressively sensed multichannel EEG signals
Článek Dense carbon-nanotube coating scaffolds stimulate osteogenic differentiation of mesenchymal stem cells
Článek Gamma Knife radiosurgery for vestibular schwannomas: Evaluation of planning using the sphericity degree of the target volume
Článek Purification and molecular characterization of phospholipase, antigen 5 and hyaluronidases from the venom of the Asian hornet (Vespa velutina)
Článek A study to better understand under-utilization of laboratory tests for antenatal care in Senegal
Článek Physicians’ perspectives regarding non-medical switching of prescription medications: Results of an internet e-survey
Článek Effectiveness of information technology–enabled ‘SMART Eating’ health promotion intervention: A cluster randomized controlled trial
Článek Cauda Equina Syndrome Core Outcome Set (CESCOS): An international patient and healthcare professional consensus for research studies
Článek A new species of Macrocypraea (Gastropoda, Cypraeidae) from Trindade Island, Brazil, including phenotypic differentiation from remaining congeneric species
Článek Long term conjugated linoleic acid supplementation modestly improved growth performance but induced testicular tissue apoptosis and reduced sperm quality in male rabbit
Článek A new approach to the temporal significance of house orientations in European Early Neolithic settlements
Článek Persistence of chikungunya ECSA genotype and local outbreak in an upper medium class neighborhood in Northeast Brazil
Článek Effect of classroom intervention on student food selection and plate waste: Evidence from a randomized control trial
Článek Preventing HIV and HSV-2 through knowledge and attitudes: A replication study of a multi-component community-based intervention in Zimbabwe
Článek A randomized trial of a behavioral intervention to decrease hospital length of stay by decreasing bedrest
Článek Color image segmentation using adaptive hierarchical-histogram thresholding
Článek Potential socioeconomic impacts from ocean acidification and climate change effects on Atlantic Canadian fisheries
Článek Female finches prefer courtship signals indicating male vigor and neuromuscular ability
Článek The effect of spatial position and age within an egg-clutch on embryonic development and key metabolic enzymes in two clownfish species, Amphiprion ocellaris and Amphiprion frenatus
Článek The impact of translated reminder letters and phone calls on mammography screening booking rates: Two randomised controlled trials
Článek Application of a genetic algorithm to the keyboard layout problem
Článek Design and evaluation of a laboratory-based wheelchair castor testing protocol using community data
Článek Relationship between diabetic macular edema and choroidal layer thickness
Článek Evaluation of the predictive ability of ultrasound-based assessment of breast cancer using BI-RADS natural language reporting against commercial transcriptome-based tests
Článek A Comprehensive Data Gathering Network Architecture in Large-Scale Visual Sensor Networks
Článek Recovery of health-related quality of life after burn injuries: An individual participant data meta-analysis
Článek Modeling aggressive market order placements with Hawkes factor models
Článek High expression of olfactomedin-4 is correlated with chemoresistance and poor prognosis in pancreatic cancer
Článek Complex patterns of cell growth in the placenta in normal pregnancy and as adaptations to maternal diet restriction
Článek Tofu intake is inversely associated with risk of breast cancer: A meta-analysis of observational studies
Článek Temporal ordering of input modulates connectivity formation in a developmental neuronal network model of the cortex
Článek Healthy lifestyle index and its association with hypertension among community adults in Sri Lanka: A cross-sectional study
Článek From organ to cell: Multi-level telomere length assessment in patients with idiopathic pulmonary fibrosis
Článek An investigation of transportation practices in an Ontario swine system using descriptive network analysis
Článek Comparison of gridded precipitation datasets for rainfall-runoff and inundation modeling in the Mekong River Basin
Článek The effects of dual-task cognitive interference on gait and turning in Huntington’s disease
Článek Effects of Allium hookeri on gut microbiome related to growth performance in young broiler chickens
Článek Novel imaging biomarkers for mapping the impact of mild mitochondrial uncoupling in the outer retina in vivo
Článek Hyperkalemia treatment modalities: A descriptive observational study focused on medication and healthcare resource utilization
Článek Comparison of post-transplantation diabetes mellitus incidence and risk factors between kidney and liver transplantation patients
Článek A definition-by-example approach and visual language for activity patterns in engineering disciplines
Článek A network analysis revealed the essential and common downstream proteins related to inguinal hernia
Článek Use of conventional cardiac troponin assay for diagnosis of non-ST-elevation myocardial infarction: ‘The Ottawa Troponin Pathway’
Článek Identification and characterization of miRNAs involved in cold acclimation of zebrafish ZF4 cells
Článek Research on motion planning for an indoor spray arm based on an improved potential field method
Článek Detailed analysis of the transverse arch of hallux valgus feet with and without pain using weightbearing ultrasound imaging and precise force sensors
Článek Surrogate R-spondins for tissue-specific potentiation of Wnt Signaling
Článek Treating patients with driving phobia by virtual reality exposure therapy – a pilot study
Článek Efficient processing of raster and vector data
Článek Therapeutic hypothermia after out of hospital cardiac arrest improve 1-year survival rate for selective patients
Článek Diagnostic differences in respiratory breathing patterns and work of breathing indices in children with Duchenne muscular dystrophy
Článek Proportions of CD4 test results indicating advanced HIV disease remain consistently high at primary health care facilities across four high HIV burden countries
Článek Single-modal and multi-modal false arrhythmia alarm reduction using attention-based convolutional and recurrent neural networks
Článek Eye-gaze information input based on pupillary response to visual stimulus with luminance modulation
Článek Post mortem evaluation of inflammation, oxidative stress, and PPARγ activation in a nonhuman primate model of cardiac sympathetic neurodegeneration
Článek Were ancient foxes far more carnivorous than recent ones?—Carnassial morphological evidence
Článek Disruption in daily eating-fasting and activity-rest cycles in Indian adolescents attending school
Článek Are changes in depressive symptoms, general health and residential area socio-economic status associated with trajectories of waist circumference and body mass index?
Článek Extracellular vesicles of U937 macrophage cell line infected with DENV-2 induce activation in endothelial cells EA.hy926
Článek The Shapley value for a fair division of group discounts for coordinating cooling loads
Článek Incidence of hospital-acquired pressure ulcers in patients with "minimal risk" according to the "Norton-MI" scale
Článek Lipoprotein(a) plasma levels are not associated with survival after acute coronary syndromes: An observational cohort study
Článek Use of Nanotrap particles for the capture and enrichment of Zika, chikungunya and dengue viruses in urine
Článek Pancreatic secretory trypsin inhibitor reduces multi-organ injury caused by gut ischemia/reperfusion in mice
Článek Biochemical characterization of Ty1 retrotransposon protease
Článek The validation of the Beijing version of the Montreal Cognitive Assessment in Chinese patients undergoing hemodialysis
Článek Inflammasome expression is higher in ovarian tumors than in normal ovary
Článek Adherence to iron-folic acid supplement and associated factors among antenatal care attending pregnant mothers in governmental health institutions of Adwa town, Tigray, Ethiopia: Cross-sectional study
Článek Flower, seed, and fruit development in three Tunisian species of Polygonum: Implications for their taxonomy and evolution of distyly in Polygonaceae
Článek Preclinical evaluation of AT-527, a novel guanosine nucleotide prodrug with potent, pan-genotypic activity against hepatitis C virus
Článek Clinical, cytogenetic and molecular genetic characterization of a tandem fusion translocation in a male Holstein cattle with congenital hypospadias and a ventricular septal defect
Článek Detection of Torque Teno Virus (TTV) and TTV-Like Minivirus in patients with presumed infectious endophthalmitis in India
Článek Estimating the basic reproduction number of a pathogen in a single host when only a single founder successfully infects
Článek What drugs modify the risk of iatrogenic impulse-control disorders in Parkinson’s disease? A preliminary pharmacoepidemiologic study
Článek Community- and trophic-level responses of soil nematodes to removal of a non-native tree at different stages of invasion
Článek Association of ECG parameters with late gadolinium enhancement and outcome in patients with clinical suspicion of acute or subacute myocarditis referred for CMR imaging
Článek Catchment-scale export of antibiotic resistance genes and bacteria from an agricultural watershed in central Iowa
Článek Impact of multi-drug resistant bacteria on economic and clinical outcomes of healthcare-associated infections in adults: Systematic review and meta-analysis
Článek Characterization of a universal screening approach for congenital CMV infection based on a highly-sensitive, quantitative, multiplex real-time PCR assay
Článek Genes associated with body weight gain and feed intake identified by meta-analysis of the mesenteric fat from crossbred beef steers
Článek Intraoperative computed tomography imaging for dose calculation in intraoperative electron radiation therapy: Initial clinical observations
Článek Simple non-mydriatic retinal photography is feasible and demonstrates retinal microvascular dilation in Chronic Obstructive Pulmonary Disease (COPD)
Článek Maternal depressive symptoms and children’s cognitive development: Does early childcare and child’s sex matter?
Článek Prevalence and characteristics of Livestock-Associated Methicillin-Resistant Staphylococcus aureus (LA-MRSA) isolated from chicken meat in the province of Quebec, Canada
Článek Soluble AXL as a marker of disease progression and survival in melanoma
Článek Using machine learning methods to determine a typology of patients with HIV-HCV infection to be treated with antivirals
Článek Gender differences influence over insomnia in Korean population: A cross-sectional study
Článek Impact of scion/rootstock reciprocal effects on metabolomics of fruit juice and phloem sap in grafted Citrus reticulata
Článek Adapting cognitive diagnosis computerized adaptive testing item selection rules to traditional item response theory
Článek Umbilical cord separation time, predictors and healing complications in newborns with dry care
Článek Analysis of attitudinal components towards statistics among students from different academic degrees
Článek Effects of fatigue induced by repeated-sprint on kicking accuracy and velocity in female soccer players
Článek A pre-clinical validation plan to evaluate analytical sensitivities of molecular diagnostics such as BD MAX MDR-TB, Xpert MTB/Rif Ultra and FluoroType MTB
Článek Clinical correlates associated with the long-term response of bipolar disorder patients to lithium, valproate or lamotrigine: A retrospective study
Článek On the genus Crossaster (Echinodermata: Asteroidea) and its distribution
Článek An integrated vitamin E-coated polymer hybrid nanoplatform: A lucrative option for an enhanced in vitro macrophage retention for an anti-hepatitis B therapeutic prospect
Článek The effect of strontium and silicon substituted hydroxyapatite electrochemical coatings on bone ingrowth and osseointegration of selective laser sintered porous metal implants
Článek Molecular prevalence of Bartonella, Babesia, and hemotropic Mycoplasma species in dogs with hemangiosarcoma from across the United States
Článek Color discrimination and gas chromatography-mass spectrometry fingerprint based on chemometrics analysis for the quality evaluation of Schizonepetae Spica
Článek Comparisons of recurrence-free survival and overall survival between microwave versus radiofrequency ablation treatment for hepatocellular carcinoma: A multiple centers retrospective cohort study with propensity score matching
Článek Oral misoprostol, low dose vaginal misoprostol, and vaginal dinoprostone for labor induction: Randomized controlled trial
Článek The association between dietary patterns before and in early pregnancy and the risk of gestational diabetes mellitus (GDM): Data from the Malaysian SECOST cohort
Článek Dynamic Extreme Aneuploidy (DEA) in the vegetable pathogen Phytophthora capsici and the potential for rapid asexual evolution
Článek Prediction of Uropathogens by Flow Cytometry and Dip-stick Test Results of Urine Through Multivariable Logistic Regression Analysis
Článek Interleukin 6 is increased in preclinical HNSCC models of acquired cetuximab resistance, but is not required for maintenance of resistance
Článek Impact of viral disease hypophagia on pig jejunal function and integrity
Článek Molecular evidence for horizontal transmission of chelonid alphaherpesvirus 5 at green turtle (Chelonia mydas) foraging grounds in Queensland, Australia
Článek cagA gene EPIYA motif genetic characterization from Colombian Helicobacter pylori isolates: Standardization of a molecular test for rapid clinical laboratory detection
Článek Spectral characteristics of urine from patients with end-stage kidney disease analyzed using Raman Chemometric Urinalysis (Rametrix)
Článek Fast quantitative time lapse displacement imaging of endothelial cell invasion
Článek Two novel mutations in MSX1 causing oligodontia
Článek Dome-shaped macula in children and adolescents
Článek Targeted transcriptomic study of the implication of central metabolic pathways in mannosylerythritol lipids biosynthesis in Pseudozyma antarctica T-34
Článek Preliminary evidences of the presence of extracellular DNA single stranded forms in soil
Článek Comparison of Monocyte Distribution Width (MDW) and Procalcitonin for early recognition of sepsis
Článek Morphological association between the muscles and bones in the craniofacial region
Článek Transcriptome analysis of Actinidia chinensis in response to Botryosphaeria dothidea infection
Článek Comparative study on skin protection activity of polyphenol-rich extract and polysaccharide-rich extract from Sargassum vachellianum
Článek Antenatal depression and its association with adverse birth outcomes in low and middle-income countries: A systematic review and meta-analysis
Článek The role of refugee and migrant migration status on medication adherence: Mediation through illness perceptions
Článek Effects of CK2β subunit down-regulation on Akt signalling in HK-2 renal cells
Článek Novel broad-spectrum activity-based probes to profile malarial cysteine proteases
Článek Association between opioid analgesic therapy and initiation of buprenorphine management: An analysis of prescription drug monitoring program data
Článek Effect of a community-based approach of iron and folic acid supplementation on compliance by pregnant women in Kiambu County, Kenya: A quasi-experimental study
Článek Plasma kynurenines and prognosis in patients with heart failure
Článek Occurrence and distribution of anthropogenic persistent organic pollutants in coastal sediments and mud shrimps from the wetland of central Taiwan
Článek Gut microbiota composition alterations are associated with the onset of diabetes in kidney transplant recipients
Článek Metabolic analysis of amino acids and vitamin B6 pathways in lymphoma survivors with cancer related chronic fatigue
Článek Immunopathogenesis of canine chronic ulcerative stomatitis
Článek Generalizing findings from a randomized controlled trial to a real-world study of the iLookOut, an online education program to improve early childhood care and education providers’ knowledge and attitudes about reporting child maltreatment
Článek When and what to test for: A cost-effectiveness analysis of febrile illness test-and-treat strategies in the era of responsible antibiotic use
Článek Comparison of effects and safety in providing controlled hypotension during surgery between dexmedetomidine and magnesium sulphate: A meta-analysis of randomized controlled trials
Článek The gene encoding the ketogenic enzyme HMGCS2 displays a unique expression during gonad development in mice
Článek Association of endothelial nitric oxide synthase (NOS3) gene polymorphisms with primary open-angle glaucoma in a Saudi cohort
Článek Antitrust analysis with upward pricing pressure and cost efficiencies
Článek Natural selection contributes to food web stability
Článek Diversity and plant growth-promoting functions of diazotrophic/N-scavenging bacteria isolated from the soils and rhizospheres of two species of Solanum
Článek Sofosbuvir-based regimen for genotype 2 HCV infected patients in Taiwan: A real world experience
Článek The virulence domain of Shigella IcsA contains a subregion with specific host cell adhesion function
Článek Quantitative analysis of adsorption and desorption of volatile organic compounds on reusable zeolite filters using gas chromatography
Článek Cloud-computing and machine learning in support of country-level land cover and ecosystem extent mapping in Liberia and Gabon
Článek The Brief Measure of Emotional Preoperative Stress (B-MEPS) as a new predictive tool for postoperative pain: A prospective observational cohort study
Článek The impact of diabetes mellitus medication on the incidence of endogenous endophthalmitis
Článek Correction: Chl1 DNA helicase and Scc2 function in chromosome condensation through cohesin deposition
Článek Clinical and pathological features of thrombotic microangiopathy influencing long-term kidney transplant outcomes
Článek Occupational exposure to particulate matter from air pollution in the outdoor workplaces in Almaty during the cold season
Článek Concurrent lipidomics and proteomics on malignant plasma cells from multiple myeloma patients: Probing the lipid metabolome
Článek Association between tuberculosis and depression on negative outcomes of tuberculosis treatment: A systematic review and meta-analysis
Článek Control of the microsporidian parasite Nosema ceranae in honey bees (Apis mellifera) using nutraceutical and immuno-stimulatory compounds
Článek Oral magnesium supplementation for leg cramps in pregnancy—An observational controlled trial
Článek Health care professionals’ knowledge of commonly used sedative, analgesic and neuromuscular drugs: A single center (Rambam Health Care Campus), prospective, observational survey
Článek Campylobacter portucalensis sp. nov., a new species of Campylobacter isolated from the preputial mucosa of bulls
Článek Transgenic interleukin 11 expression causes cross-tissue fibro-inflammation and an inflammatory bowel phenotype in mice
Článek Sleep quality and sex modify the relationships between trait energy and fatigue on state energy and fatigue
Článek The role of peer, parental, and school norms in predicting adolescents’ attitudes and behaviours of majority and different minority ethnic groups in Croatia
Článek The effect of mutations derived from mouse-adapted H3N2 seasonal influenza A virus to pathogenicity and host adaptation
Článek Detection of posttraumatic pneumothorax using electrical impedance tomography—An observer-blinded study in pigs with blunt chest trauma
Článek Educators’ perceptions of organisational readiness for implementation of a pre-adolescent transdisciplinary school health intervention for inter-generational outcomes
Článek Beyond the heterodimer model for mineralocorticoid and glucocorticoid receptor interactions in nuclei and at DNA
Článek Framework and algorithms for identifying honest blocks in blockchain
Článek Exploring the impact of terminology differences in blood and organ donor decision making
Článek Platelet indices significantly correlate with liver fibrosis in HCV-infected patients
Článek The nitrate content of fresh and cooked vegetables and their health-related risks
Článek Bioreactor for mobilization of mesenchymal stem/stromal cells into scaffolds under mechanical stimulation: Preliminary results
Článek Non-gradient and genotype-dependent patterns of RSV gene expression
Článek Multiplex real-time PCR for the detection of Clavibacter michiganensis subsp. michiganensis, Pseudomonas syringae pv. tomato and pathogenic Xanthomonas species on tomato plants
Článek The 24-hour urinary cortisol in post-traumatic stress disorder: A meta-analysis
Článek Drug-eluting versus bare-metal stents for first myocardial infarction in patients with atrial fibrillation: A nationwide population-based cohort study
Článek Health-related quality of life among patients with type 2 diabetes mellitus in Eastern Province, Saudi Arabia: A cross-sectional study
Článek “I like the way I am, but I feel like I could get a little bit bigger”: Perceptions of body image among adolescents and youth living with HIV in Durban, South Africa
Článek Nanoparticle-based ‘turn-on’ scattering and post-sample fluorescence for ultrasensitive detection of water pollution in wider window
Článek Insights into the strategy of micro-environmental adaptation: Transcriptomic analysis of two alvinocaridid shrimps at a hydrothermal vent
Článek Thirty-day readmission after medical-surgical hospitalization for people who experience imprisonment in Ontario, Canada: A retrospective cohort study
Článek Hyper-spectral response and estimation model of soil degradation in Kenli County, the Yellow River Delta
Článek The association of telomere length and telomerase activity with adverse outcomes in older patients with non-ST-elevation acute coronary syndrome
Článek Construction of a high-density genetic map and fine mapping of a candidate gene locus for a novel branched-spike mutant in barley
Článek Alterations of aqueous humor Aβ levels in Aβ-infused and transgenic mouse models of Alzheimer disease
Článek Natural hybridization between Phyllagathis and Sporoxeia species produces a hybrid without reproductive organs
Článek The impact of peer attachment on prosocial behavior, emotional difficulties and conduct problems in adolescence: The mediating role of empathy
Článek Diagnostic performance of serum interferon gamma, matrix metalloproteinases, and periostin measurements for pulmonary tuberculosis in Japanese patients with pneumonia
Článek Characterization of black patina from the Tiber River embankments using Next-Generation Sequencing
Článek Problem gambling, associations with comorbid health conditions, substance use, and behavioural addictions: Opportunities for pathways to treatment
Článek Nanosheet wrapping-assisted coverslip-free imaging for looking deeper into a tissue at high resolution
Článek Validity of cerebrovascular ICD-9-CM codes in healthcare administrative databases. The Umbria Data-Value Project
Článek Torque teno virus viral load is related to age, CMV infection and HLA type but not to Alzheimer's disease
Článek Associations of cigarette smoking and burden of thoracic aortic calcification in asymptomatic individuals: A dose-response relationship
Článek Transforming assessment of speech in children with cleft palate via online crowdsourcing
Článek Human-raptor conflict in rural settlements of Colombia
Článek Assessment of peritoneal microbial features and tumor marker levels as potential diagnostic tools for ovarian cancer
Článek Deficiency syndromes in top predators associated with large-scale changes in the Baltic Sea ecosystem
Článek Perceived relative social status and cognitive load influence acceptance of unfair offers in the Ultimatum Game
Článek Hepatitis B and C virus infection among HIV patients within the public and private healthcare systems in Chile: A cross-sectional serosurvey
Článek Retraction: Oncogenic Fibulin-5 Promotes Nasopharyngeal Carcinoma Cell Metastasis through the FLJ10540/AKT Pathway and Correlates with Poor Prognosis
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2020 Číslo 1
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Aktuální možnosti diagnostiky a léčby litiáz
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Autori: MUDr. Tomáš Ürge, PhD.
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