Exploring the mechanism of olfactory recognition in the initial stage by modeling the emission spectrum of electron transfer
Autoři:
Shu Liu aff001; Rao Fu aff002; Guangwu Li aff001
Působiště autorů:
Department of Anatomy, Anhui Medical University, Hefei, Anhui, China
aff001; Department of Anatomy, School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong, China
aff002
Vyšlo v časopise:
PLoS ONE 15(1)
Kategorie:
Research Article
prolekare.web.journal.doi_sk:
https://doi.org/10.1371/journal.pone.0217665
Souhrn
Olfactory sense remains elusive regarding the primary reception mechanism. Some studies suggest that olfaction is a spectral sense, the olfactory event is triggered by electron transfer (ET) across the odorants at the active sites of odorant receptors (ORs). Herein we present a Donor-Bridge-Acceptor model, proposing that the ET process can be viewed as an electron hopping from the donor molecule to the odorant molecule (Bridge), then hopping off to the acceptor molecule, making the electronic state of the odorant molecule change along with vibrations (vibronic transition). The odorant specific parameter, Huang–Rhys factor can be derived from ab initio calculations, which make the simulation of ET spectra achievable. In this study, we revealed that the emission spectra (after Gaussian convolution) can be acted as odor characteristic spectra. Using the emission spectrum of ET, we were able to reasonably interpret the similar bitter-almond odors among hydrogen cyanide, benzaldehyde and nitrobenzene. In terms of isotope effects, we succeeded in explaining why subjects can easily distinguish cyclopentadecanone from its fully deuterated analogue cyclopentadecanone-d28 but not distinguishing acetophenone from acetophenone-d8.
Klíčová slova:
Vibration – Smell – Odorants – Vibration engineering – Emission spectra – Benzaldehydes – Nitrobenzenes – Electron transfer
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