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preLekára.sk / Odborné časopisy / PLOS One / 2020 - 1

Evaluation and validation of 2D biomechanical models of the knee for radiograph-based preoperative planning in total knee arthroplasty

English version

Autoři: Malte Asseln aff001;  Jörg Eschweiler aff002;  Adam Trepczynski aff003;  Philipp Damm aff003;  Klaus Radermacher aff001
Působiště autorů: Chair of Medical Engineering, Helmholtz-Institute for Biomedical Engineering, RWTH Aachen University, Aachen, Germany aff001;  Department of Orthopaedics, Aachen University Clinic, RWTH Aachen University, Aachen, Germany aff002;  Julius Wolff Institute, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany aff003
Vyšlo v časopise: PLoS ONE 15(1)
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.pone.0227272

Souhrn

Thorough preoperative planning in total knee arthroplasty is essential to reduce implant failure by proper implant sizing and alignment. The “gold standard” in conventional preoperative planning is based on anterior-posterior long-leg radiographs. However, the coronal component alignment is still an open discussion in literature, since studies have reported contradictory outcomes on survivorship, indicating that optimal individual alignment goals still need to be defined. Two-dimensional biomechanical models of the knee have the potential to predict joint forces and, therefore, objectify therapy planning. Previously published two-dimensional biomechanical models were evaluated and validated for the first time in this study by comparison of model predictions to corresponding in vivo measurements obtained from telemetric implants for a one- and two-leg stance. Model input parameters were acquired from weight-bearing anterior-posterior long-leg radiographs and statistical assumptions for patient-specific model adaptation. The overall time from initialization to load prediction was in the range of 7–8 minutes per patient for all models. However, no model could accurately predict the correct trend of knee joint forces over patients. Two dimensional biomechanical models of the knee have the potential to improve preoperative planning in total knee arthroplasty by providing additional individual biomechanical information to the surgeon. Although integration into the clinical workflow might be performed with acceptable costs, the models’ accuracy is insufficient for the moment. Future work is needed for model optimization and more sophisticated modelling approaches.

Klíčová slova:

Body weight – Medical implants – Hip – Skeletal joints – Knee joints – Knees – Ligaments – Total knee arthroplasty

Zdroje

1. Ettinger M, Claassen L, Paes P, Calliess T. 2D versus 3D templating in total knee arthroplasty. Knee. 2016; 23: 149–151. doi: 10.1016/j.knee.2015.08.014 26765862

2. Wirtz DC. AE-Manual der Endoprothetik. Knie. Berlin, Heidelberg: Arbeitsgemeinschaft Endoprothetik; 2011.

3. Abdel MP, Oussedik S, Parratte S, Lustig S, Haddad FS. Coronal alignment in total knee replacement: historical review, contemporary analysis, and future direction. Bone Joint J. 2014; 96-B: 857–862. doi: 10.1302/0301-620X.96B7.33946 24986936

4. Kuster MS. Factors affecting polyethylene wear in total knee arthroplasty. Orthopedics. 2002; 25: S235. 11866159

5. Naudie D, Ammeen DJ, Engh GA, Rorabeck CH. Wear and osteolysis around total knee arthroplasty. Journal of the American Academy of Orthopaedic Surgeons. 2007; 15: 53–64. doi: 10.5435/00124635-200701000-00006 17213382

6. Schroer WC, Berend KR, Lombardi AV, Barnes CL, Bolognesi MP, Berend ME, et al. Why are total knees failing today? Etiology of total knee revision in 2010 and 2011. J Arthroplasty. 2013; 28: 116–119. doi: 10.1016/j.arth.2013.04.056 23954423

7. Halder A, Kutzner I, Graichen F, Heinlein B, Beier A, Bergmann G. Influence of limb alignment on mediolateral loading in total knee replacement: in vivo measurements in five patients. J Bone Joint Surg Am. 2012; 94: 1023–1029. doi: 10.2106/JBJS.K.00927 22637208

8. Kutzner I, Bender A, Dymke J, Duda G, von Roth P, Bergmann G. Mediolateral force distribution at the knee joint shifts across activities and is driven by tibiofemoral alignment. Bone Joint J. 2017; 99-B: 779–787. doi: 10.1302/0301-620X.99B6.BJJ-2016-0713.R1 28566397

9. Verstraete MA, Meere PA, Salvadore G, Victor J, Walker PS. Contact forces in the tibiofemoral joint from soft tissue tensions: Implications to soft tissue balancing in total knee arthroplasty. J Biomech. 2017; 58: 195–202. doi: 10.1016/j.jbiomech.2017.05.008 28579262

10. Fang DM, Ritter MA, Davis KE. Coronal alignment in total knee arthroplasty: just how important is it. J Arthroplasty. 2009; 24: 39–43. doi: 10.1016/j.arth.2009.04.034 19553073

11. Kim Y-H, Park J-W, Kim J-S, Park S-D. The relationship between the survival of total knee arthroplasty and postoperative coronal, sagittal and rotational alignment of knee prosthesis. Int Orthop. 2014; 38: 379–385. doi: 10.1007/s00264-013-2097-9 24173677

12. Berend ME, Ritter MA, Meding JB, Faris PM, Keating EM, Redelman R, et al. Tibial Component Failure Mechanisms in Total Knee Arthroplasty. Clinical Orthopaedics and Related Research. 2004; 428: 26–34. doi: 10.1097/01.blo.0000148578.22729.0e 15534515

13. Jeffery R, Morris R, Denham R. Coronal alignment after total knee replacement. Bone & Joint Journal. 1991; 73-B: 709–714.

14. Bellemans J, Colyn W, Vandenneucker H, Victor J. The Chitranjan Ranawat award: is neutral mechanical alignment normal for all patients? The concept of constitutional varus. Clinical Orthopaedics and Related Research. 2012; 470: 45–53. doi: 10.1007/s11999-011-1936-5 21656315

15. Bonner TJ, Eardley WGP, Patterson P, Gregg PJ. The effect of post-operative mechanical axis alignment on the survival of primary total knee replacements after a follow-up of 15 years. J Bone Joint Surg Br. 2011; 93: 1217–1222. doi: 10.1302/0301-620X.93B9.26573 21911533

16. Morgan SS, Bonshahi A, Pradhan N, Gregory A, Gambhir A, Porter ML. The influence of postoperative coronal alignment on revision surgery in total knee arthroplasty. Int Orthop. 2008; 32: 639–642. doi: 10.1007/s00264-007-0391-0 17611758

17. Heller MO, Schröder JH, Matziolis G, Sharenkov A, Taylor WR, Perka C, et al. Muskuloskeletale Belastungsanalysen. Biomechanische Erklärung klinischer Resultate—und mehr. Orthopade. 2007; 36: 188, 190–4.

18. Baldwin MA, Clary CW, Fitzpatrick CK, Deacy JS, Maletsky LP, Rullkoetter PJ. Dynamic finite element knee simulation for evaluation of knee replacement mechanics. J Biomech. 2012; 45: 474–483. doi: 10.1016/j.jbiomech.2011.11.052 22209313

19. Perillo-Marcone A, Taylor M. Effect of varus/valgus malalignment on bone strains in the proximal tibia after TKR: an explicit finite element study. J Biomech Eng. 2007; 129: 1–11. doi: 10.1115/1.2401177 17227092

20. Freeman MAR, Pinskerova V. The movement of the normal tibio-femoral joint. J Biomech. 2005; 38: 197–208. doi: 10.1016/j.jbiomech.2004.02.006 15598446

21. Marra MA, Vanheule V, Fluit R, Koopman, Bart H F J M, Rasmussen J, Verdonschot N, et al. A subject-specific musculoskeletal modeling framework to predict in vivo mechanics of total knee arthroplasty. J Biomech Eng. 2015; 137: 20904. doi: 10.1115/1.4029258 25429519

22. Hefzy MS, Grood ES. Review of Knee Models. Appl. Mech. Rev. 1988; 41: 1. doi: 10.1115/1.3151876

23. Maquet PG, Pelzer GA. Evolution of the maximum stress in osteo-arthritis of the knee. J Biomech. 1977; 10: 107–117. doi: 10.1016/0021-9290(77)90074-4 858709

24. Kettelkamp DB, Chao EY. A method for quantitative analysis of medial and lateral compression forces at the knee during standing. Clinical Orthopaedics and Related Research. 1972; 83: 202–213. doi: 10.1097/00003086-197203000-00037 5014814

25. Minns RJ. Forces at the knee joint: anatomical considerations. J Biomech. 1981; 14: 633–643. doi: 10.1016/0021-9290(81)90089-0 7334046

26. Richard HA, Kullmer G, Nöcker D. Biomechanik. Grundlagen und Anwendungen auf den menschlichen Bewegungsapparat; [mit 15 Tabellen]. Wiesbaden: Springer Vieweg; 2013.

27. van Eijden TM, de Boer W, Weijs WA. The orientation of the distal part of the quadriceps femoris muscle as a function of the knee flexion-extension angle. J Biomech. 1985; 18: 803–809. doi: 10.1016/0021-9290(85)90055-7 4066722

28. Winter DA. Biomechanics and motor control of human movement. 4th ed. Hoboken, N.J: Wiley; 2009.

29. Bergmann G, Bender A, Graichen F, Dymke J, Rohlmann A, Trepczynski A, et al. Standardized loads acting in knee implants. PLoS One. 2014; 9: e86035. doi: 10.1371/journal.pone.0086035 24465856

30. Stylianou AP, Guess TM, Kia M. Multibody muscle driven model of an instrumented prosthetic knee during squat and toe rise motions. J Biomech Eng. 2013; 135: 41008. doi: 10.1115/1.4023982 24231902

31. Guess TM, Stylianou AP, Kia M. Concurrent Prediction of Muscle and Tibiofemoral Contact Forces During Treadmill Gait. J Biomech Eng. 2014; 136: 210321–210329. doi: 10.1115/1.4026359 24389997

32. Chen Z, Zhang X, Ardestani MM, Wang L, Liu Y, Lian Q, et al. Prediction of in vivo joint mechanics of an artificial knee implant using rigid multi-body dynamics with elastic contacts. Proc Inst Mech Eng H. 2014; 228: 564–575. doi: 10.1177/0954411914537476 24878735

33. Lin Y-C, Walter JP, Pandy MG. Predictive Simulations of Neuromuscular Coordination and Joint-Contact Loading in Human Gait. Ann Biomed Eng. 2018; 46: 1216–1227. doi: 10.1007/s10439-018-2026-6 29671152

34. Eskinazi I, Fregly BJ. A computational framework for simultaneous estimation of muscle and joint contact forces and body motion using optimization and surrogate modeling. Med Eng Phys. 2018; 54: 56–64. doi: 10.1016/j.medengphy.2018.02.002 29487037

35. Eschweiler J, Asseln M, Damm P, Quack V, Rath B, Bergmann G, et al. Evaluation of biomechanical models for therapy planning of total hip arthroplasty—direct comparison of computational results with in vivo measurements. Z Orthop Unfall. 2014; 152: 603–615. doi: 10.1055/s-0034-1383221 25531522

36. Kutzner I, Heinlein B, Graichen F, Bender A, Rohlmann A, Halder A, et al. Loading of the knee joint during activities of daily living measured in vivo in five subjects. J Biomech. 2010; 43: 2164–2173. doi: 10.1016/j.jbiomech.2010.03.046 20537336

37. Bargren JH, BLAHA JD, Freeman MA. Alignment in total knee arthroplasty. Correlated biomechanical and clinical observations. Clinical Orthopaedics and Related Research. 1983: 178–183.

38. Hsu RW, Himeno S, Coventry MB, Chao EY. Normal axial alignment of the lower extremity and load-bearing distribution at the knee. Clinical Orthopaedics and Related Research. 1990: 215–227.

39. Herzog W, Longino D, Clark A. The role of muscles in joint adaptation and degeneration. Langenbecks Arch Surg. 2003; 388: 305–315. doi: 10.1007/s00423-003-0402-6 14504930

40. Meere PA, Schneider SM, Walker PS. Accuracy of Balancing at Total Knee Surgery Using an Instrumented Tibial Trial. J Arthroplasty. 2016; 31: 1938–1942. doi: 10.1016/j.arth.2016.02.050 27369302

41. Robinson M, Eckhoff DG, Reinig KD, Bagur MM, Bach JM. Variability of Landmark Identification in Total Knee Arthroplasty. Clinical Orthopaedics and Related Research. 2006; 442: 57–62. doi: 10.1097/01.blo.0000197081.72341.4b 16394739

42. Bender A, Bergmann G. Determination of typical patterns from strongly varying signals. Comput Methods Biomech Biomed Engin. 2012; 15: 761–769. doi: 10.1080/10255842.2011.560841 21722048

43. Jonsson E, Seiger Å, Hirschfeld H. One-leg stance in healthy young and elderly adults: a measure of postural steadiness. Clinical biomechanics. 2004; 19: 688–694. doi: 10.1016/j.clinbiomech.2004.04.002 15288454

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Článek Apolipoprotein-AI mimetic peptides D-4F and L-5F decrease hepatic inflammation and increase insulin sensitivity in C57BL/6 mice
Článek Treating patients with driving phobia by virtual reality exposure therapy – a pilot study
Článek Efficient processing of raster and vector data
Článek Therapeutic hypothermia after out of hospital cardiac arrest improve 1-year survival rate for selective patients
Článek Association between coffee drinking and telomere length in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial
Článek Hyperbaric oxygen preconditioning and the role of NADPH oxidase inhibition in postischemic acute kidney injury induced in spontaneously hypertensive rats
Článek Diagnostic differences in respiratory breathing patterns and work of breathing indices in children with Duchenne muscular dystrophy
Článek Proportions of CD4 test results indicating advanced HIV disease remain consistently high at primary health care facilities across four high HIV burden countries
Článek Single-modal and multi-modal false arrhythmia alarm reduction using attention-based convolutional and recurrent neural networks
Článek Eye-gaze information input based on pupillary response to visual stimulus with luminance modulation
Článek Post mortem evaluation of inflammation, oxidative stress, and PPARγ activation in a nonhuman primate model of cardiac sympathetic neurodegeneration
Článek Were ancient foxes far more carnivorous than recent ones?—Carnassial morphological evidence
Článek Disruption in daily eating-fasting and activity-rest cycles in Indian adolescents attending school
Článek Percent amplitude of fluctuation: A simple measure for resting-state fMRI signal at single voxel level
Článek Are changes in depressive symptoms, general health and residential area socio-economic status associated with trajectories of waist circumference and body mass index?
Článek Extracellular vesicles of U937 macrophage cell line infected with DENV-2 induce activation in endothelial cells EA.hy926
Článek Tobacco smoking and health-related quality of life among university students: Mediating effect of depression
Článek The Shapley value for a fair division of group discounts for coordinating cooling loads
Článek Incidence of hospital-acquired pressure ulcers in patients with "minimal risk" according to the "Norton-MI" scale
Článek Lipoprotein(a) plasma levels are not associated with survival after acute coronary syndromes: An observational cohort study
Článek Use of Nanotrap particles for the capture and enrichment of Zika, chikungunya and dengue viruses in urine
Článek Pancreatic secretory trypsin inhibitor reduces multi-organ injury caused by gut ischemia/reperfusion in mice
Článek Biochemical characterization of Ty1 retrotransposon protease
Článek The validation of the Beijing version of the Montreal Cognitive Assessment in Chinese patients undergoing hemodialysis
Článek Inflammasome expression is higher in ovarian tumors than in normal ovary
Článek Adherence to iron-folic acid supplement and associated factors among antenatal care attending pregnant mothers in governmental health institutions of Adwa town, Tigray, Ethiopia: Cross-sectional study
Článek Flower, seed, and fruit development in three Tunisian species of Polygonum: Implications for their taxonomy and evolution of distyly in Polygonaceae
Článek Preclinical evaluation of AT-527, a novel guanosine nucleotide prodrug with potent, pan-genotypic activity against hepatitis C virus
Článek Aqueous extract from Mangifera indica Linn. (Anacardiaceae) leaves exerts long-term hypoglycemic effect, increases insulin sensitivity and plasma insulin levels on diabetic Wistar rats
Článek Clinical, cytogenetic and molecular genetic characterization of a tandem fusion translocation in a male Holstein cattle with congenital hypospadias and a ventricular septal defect
Článek Detection of Torque Teno Virus (TTV) and TTV-Like Minivirus in patients with presumed infectious endophthalmitis in India
Článek Estimating the basic reproduction number of a pathogen in a single host when only a single founder successfully infects
Článek What drugs modify the risk of iatrogenic impulse-control disorders in Parkinson’s disease? A preliminary pharmacoepidemiologic study
Článek Evaluating emotional distress and health-related quality of life in patients with heart failure and their family caregivers: Testing dyadic dynamics using the Actor-Partner Interdependence Model
Článek Community- and trophic-level responses of soil nematodes to removal of a non-native tree at different stages of invasion
Článek Association of ECG parameters with late gadolinium enhancement and outcome in patients with clinical suspicion of acute or subacute myocarditis referred for CMR imaging
Článek Catchment-scale export of antibiotic resistance genes and bacteria from an agricultural watershed in central Iowa
Článek Impact of multi-drug resistant bacteria on economic and clinical outcomes of healthcare-associated infections in adults: Systematic review and meta-analysis
Článek Characterization of a universal screening approach for congenital CMV infection based on a highly-sensitive, quantitative, multiplex real-time PCR assay
Článek Genes associated with body weight gain and feed intake identified by meta-analysis of the mesenteric fat from crossbred beef steers
Článek Intraoperative computed tomography imaging for dose calculation in intraoperative electron radiation therapy: Initial clinical observations
Článek Simple non-mydriatic retinal photography is feasible and demonstrates retinal microvascular dilation in Chronic Obstructive Pulmonary Disease (COPD)
Článek Maternal depressive symptoms and children’s cognitive development: Does early childcare and child’s sex matter?
Článek Evaluation of a bioengineered ACL matrix’s osteointegration with BMP-2 supplementation
Článek Psychosocial profiles of physical activity fluctuation in office employees: A latent profile analysis
Článek Prevalence and characteristics of Livestock-Associated Methicillin-Resistant Staphylococcus aureus (LA-MRSA) isolated from chicken meat in the province of Quebec, Canada
Článek Soluble AXL as a marker of disease progression and survival in melanoma
Článek Using machine learning methods to determine a typology of patients with HIV-HCV infection to be treated with antivirals
Článek Gender differences influence over insomnia in Korean population: A cross-sectional study
Článek Impact of scion/rootstock reciprocal effects on metabolomics of fruit juice and phloem sap in grafted Citrus reticulata
Článek Adapting cognitive diagnosis computerized adaptive testing item selection rules to traditional item response theory
Článek Autumn shifts in cold tolerance metabolites in overwintering adult mountain pine beetles
Článek Umbilical cord separation time, predictors and healing complications in newborns with dry care
Článek Analysis of attitudinal components towards statistics among students from different academic degrees
Článek Effects of fatigue induced by repeated-sprint on kicking accuracy and velocity in female soccer players
Článek A pre-clinical validation plan to evaluate analytical sensitivities of molecular diagnostics such as BD MAX MDR-TB, Xpert MTB/Rif Ultra and FluoroType MTB
Článek Leadership for success in transforming medical abortion policy in Canada
Článek Clinical correlates associated with the long-term response of bipolar disorder patients to lithium, valproate or lamotrigine: A retrospective study
Článek On the genus Crossaster (Echinodermata: Asteroidea) and its distribution
Článek An integrated vitamin E-coated polymer hybrid nanoplatform: A lucrative option for an enhanced in vitro macrophage retention for an anti-hepatitis B therapeutic prospect
Článek The effect of strontium and silicon substituted hydroxyapatite electrochemical coatings on bone ingrowth and osseointegration of selective laser sintered porous metal implants
Článek Molecular prevalence of Bartonella, Babesia, and hemotropic Mycoplasma species in dogs with hemangiosarcoma from across the United States
Článek Color discrimination and gas chromatography-mass spectrometry fingerprint based on chemometrics analysis for the quality evaluation of Schizonepetae Spica
Článek Comparisons of recurrence-free survival and overall survival between microwave versus radiofrequency ablation treatment for hepatocellular carcinoma: A multiple centers retrospective cohort study with propensity score matching
Článek Oral misoprostol, low dose vaginal misoprostol, and vaginal dinoprostone for labor induction: Randomized controlled trial
Článek The association between dietary patterns before and in early pregnancy and the risk of gestational diabetes mellitus (GDM): Data from the Malaysian SECOST cohort
Článek Dynamic Extreme Aneuploidy (DEA) in the vegetable pathogen Phytophthora capsici and the potential for rapid asexual evolution
Článek Prediction of Uropathogens by Flow Cytometry and Dip-stick Test Results of Urine Through Multivariable Logistic Regression Analysis
Článek Interleukin 6 is increased in preclinical HNSCC models of acquired cetuximab resistance, but is not required for maintenance of resistance
Článek Impact of viral disease hypophagia on pig jejunal function and integrity
Článek Molecular evidence for horizontal transmission of chelonid alphaherpesvirus 5 at green turtle (Chelonia mydas) foraging grounds in Queensland, Australia
Článek cagA gene EPIYA motif genetic characterization from Colombian Helicobacter pylori isolates: Standardization of a molecular test for rapid clinical laboratory detection
Článek Spectral characteristics of urine from patients with end-stage kidney disease analyzed using Raman Chemometric Urinalysis (Rametrix)
Článek Fast quantitative time lapse displacement imaging of endothelial cell invasion
Článek Two novel mutations in MSX1 causing oligodontia
Článek Dome-shaped macula in children and adolescents
Článek Targeted transcriptomic study of the implication of central metabolic pathways in mannosylerythritol lipids biosynthesis in Pseudozyma antarctica T-34
Článek Preliminary evidences of the presence of extracellular DNA single stranded forms in soil
Článek Comparison of Monocyte Distribution Width (MDW) and Procalcitonin for early recognition of sepsis
Článek Morphological association between the muscles and bones in the craniofacial region
Článek Transcriptome analysis of Actinidia chinensis in response to Botryosphaeria dothidea infection
Článek Comparative study on skin protection activity of polyphenol-rich extract and polysaccharide-rich extract from Sargassum vachellianum
Článek Antenatal depression and its association with adverse birth outcomes in low and middle-income countries: A systematic review and meta-analysis
Článek The role of refugee and migrant migration status on medication adherence: Mediation through illness perceptions
Článek Effects of CK2β subunit down-regulation on Akt signalling in HK-2 renal cells
Článek Novel broad-spectrum activity-based probes to profile malarial cysteine proteases
Článek Association between opioid analgesic therapy and initiation of buprenorphine management: An analysis of prescription drug monitoring program data
Článek Effect of a community-based approach of iron and folic acid supplementation on compliance by pregnant women in Kiambu County, Kenya: A quasi-experimental study
Článek An updated evaluation of serum sHER2, CA15.3, and CEA levels as biomarkers for the response of patients with metastatic breast cancer to trastuzumab-based therapies
Článek Plasma kynurenines and prognosis in patients with heart failure
Článek Occurrence and distribution of anthropogenic persistent organic pollutants in coastal sediments and mud shrimps from the wetland of central Taiwan
Článek Gut microbiota composition alterations are associated with the onset of diabetes in kidney transplant recipients
Článek Metabolic analysis of amino acids and vitamin B6 pathways in lymphoma survivors with cancer related chronic fatigue
Článek Immunopathogenesis of canine chronic ulcerative stomatitis
Článek Generalizing findings from a randomized controlled trial to a real-world study of the iLookOut, an online education program to improve early childhood care and education providers’ knowledge and attitudes about reporting child maltreatment
Článek When and what to test for: A cost-effectiveness analysis of febrile illness test-and-treat strategies in the era of responsible antibiotic use
Článek Comparison of effects and safety in providing controlled hypotension during surgery between dexmedetomidine and magnesium sulphate: A meta-analysis of randomized controlled trials
Článek The gene encoding the ketogenic enzyme HMGCS2 displays a unique expression during gonad development in mice
Článek Association of endothelial nitric oxide synthase (NOS3) gene polymorphisms with primary open-angle glaucoma in a Saudi cohort
Článek Antitrust analysis with upward pricing pressure and cost efficiencies
Článek Natural selection contributes to food web stability
Článek Pyramiding QTLs controlling tolerance against drought, salinity, and submergence in rice through marker assisted breeding
Článek Diversity and plant growth-promoting functions of diazotrophic/N-scavenging bacteria isolated from the soils and rhizospheres of two species of Solanum
Článek Sofosbuvir-based regimen for genotype 2 HCV infected patients in Taiwan: A real world experience
Článek The virulence domain of Shigella IcsA contains a subregion with specific host cell adhesion function
Článek Quantitative analysis of adsorption and desorption of volatile organic compounds on reusable zeolite filters using gas chromatography
Článek Quo vadis Pantanal? Expected precipitation extremes and drought dynamics from changing sea surface temperature
Článek Cloud-computing and machine learning in support of country-level land cover and ecosystem extent mapping in Liberia and Gabon
Článek The Brief Measure of Emotional Preoperative Stress (B-MEPS) as a new predictive tool for postoperative pain: A prospective observational cohort study
Článek The impact of diabetes mellitus medication on the incidence of endogenous endophthalmitis
Článek Correction: Chl1 DNA helicase and Scc2 function in chromosome condensation through cohesin deposition
Článek Clinical and pathological features of thrombotic microangiopathy influencing long-term kidney transplant outcomes
Článek Occupational exposure to particulate matter from air pollution in the outdoor workplaces in Almaty during the cold season
Článek Key necroptotic proteins are required for Smac mimetic-mediated sensitization of cholangiocarcinoma cells to TNF-α and chemotherapeutic gemcitabine-induced necroptosis
Článek Concurrent lipidomics and proteomics on malignant plasma cells from multiple myeloma patients: Probing the lipid metabolome
Článek Association between tuberculosis and depression on negative outcomes of tuberculosis treatment: A systematic review and meta-analysis
Článek Control of the microsporidian parasite Nosema ceranae in honey bees (Apis mellifera) using nutraceutical and immuno-stimulatory compounds
Článek Role of donor genotype in RT-QuIC seeding activity of chronic wasting disease prions using human and bank vole substrates
Článek Oral magnesium supplementation for leg cramps in pregnancy—An observational controlled trial
Článek Health care professionals’ knowledge of commonly used sedative, analgesic and neuromuscular drugs: A single center (Rambam Health Care Campus), prospective, observational survey
Článek Campylobacter portucalensis sp. nov., a new species of Campylobacter isolated from the preputial mucosa of bulls
Článek Transgenic interleukin 11 expression causes cross-tissue fibro-inflammation and an inflammatory bowel phenotype in mice
Článek Sleep quality and sex modify the relationships between trait energy and fatigue on state energy and fatigue
Článek The role of peer, parental, and school norms in predicting adolescents’ attitudes and behaviours of majority and different minority ethnic groups in Croatia
Článek Availability, prices and affordability of selected antibiotics and medicines against non-communicable diseases in western Cameroon and northeast DR Congo
Článek The effect of mutations derived from mouse-adapted H3N2 seasonal influenza A virus to pathogenicity and host adaptation
Článek Detection of posttraumatic pneumothorax using electrical impedance tomography—An observer-blinded study in pigs with blunt chest trauma
Článek Educators’ perceptions of organisational readiness for implementation of a pre-adolescent transdisciplinary school health intervention for inter-generational outcomes
Článek Beyond the heterodimer model for mineralocorticoid and glucocorticoid receptor interactions in nuclei and at DNA
Článek Framework and algorithms for identifying honest blocks in blockchain
Článek Exploring the impact of terminology differences in blood and organ donor decision making
Článek Platelet indices significantly correlate with liver fibrosis in HCV-infected patients
Článek The nitrate content of fresh and cooked vegetables and their health-related risks
Článek Bioreactor for mobilization of mesenchymal stem/stromal cells into scaffolds under mechanical stimulation: Preliminary results
Článek Non-gradient and genotype-dependent patterns of RSV gene expression
Článek Multiplex real-time PCR for the detection of Clavibacter michiganensis subsp. michiganensis, Pseudomonas syringae pv. tomato and pathogenic Xanthomonas species on tomato plants
Článek The 24-hour urinary cortisol in post-traumatic stress disorder: A meta-analysis
Článek Drug-eluting versus bare-metal stents for first myocardial infarction in patients with atrial fibrillation: A nationwide population-based cohort study
Článek Health-related quality of life among patients with type 2 diabetes mellitus in Eastern Province, Saudi Arabia: A cross-sectional study
Článek “I like the way I am, but I feel like I could get a little bit bigger”: Perceptions of body image among adolescents and youth living with HIV in Durban, South Africa
Článek Nanoparticle-based ‘turn-on’ scattering and post-sample fluorescence for ultrasensitive detection of water pollution in wider window
Článek Insights into the strategy of micro-environmental adaptation: Transcriptomic analysis of two alvinocaridid shrimps at a hydrothermal vent
Článek Thirty-day readmission after medical-surgical hospitalization for people who experience imprisonment in Ontario, Canada: A retrospective cohort study
Článek Hyper-spectral response and estimation model of soil degradation in Kenli County, the Yellow River Delta
Článek The association of telomere length and telomerase activity with adverse outcomes in older patients with non-ST-elevation acute coronary syndrome
Článek Construction of a high-density genetic map and fine mapping of a candidate gene locus for a novel branched-spike mutant in barley
Článek Alterations of aqueous humor Aβ levels in Aβ-infused and transgenic mouse models of Alzheimer disease
Článek Natural hybridization between Phyllagathis and Sporoxeia species produces a hybrid without reproductive organs
Článek The impact of peer attachment on prosocial behavior, emotional difficulties and conduct problems in adolescence: The mediating role of empathy
Článek Diagnostic performance of serum interferon gamma, matrix metalloproteinases, and periostin measurements for pulmonary tuberculosis in Japanese patients with pneumonia
Článek Characterization of black patina from the Tiber River embankments using Next-Generation Sequencing
Článek Problem gambling, associations with comorbid health conditions, substance use, and behavioural addictions: Opportunities for pathways to treatment
Článek Nanosheet wrapping-assisted coverslip-free imaging for looking deeper into a tissue at high resolution
Článek Validity of cerebrovascular ICD-9-CM codes in healthcare administrative databases. The Umbria Data-Value Project
Článek Torque teno virus viral load is related to age, CMV infection and HLA type but not to Alzheimer's disease
Článek Associations of cigarette smoking and burden of thoracic aortic calcification in asymptomatic individuals: A dose-response relationship
Článek Transforming assessment of speech in children with cleft palate via online crowdsourcing
Článek Human-raptor conflict in rural settlements of Colombia
Článek Assessment of peritoneal microbial features and tumor marker levels as potential diagnostic tools for ovarian cancer
Článek Deficiency syndromes in top predators associated with large-scale changes in the Baltic Sea ecosystem
Článek Perceived relative social status and cognitive load influence acceptance of unfair offers in the Ultimatum Game
Článek Hepatitis B and C virus infection among HIV patients within the public and private healthcare systems in Chile: A cross-sectional serosurvey
Článek Retraction: Oncogenic Fibulin-5 Promotes Nasopharyngeal Carcinoma Cell Metastasis through the FLJ10540/AKT Pathway and Correlates with Poor Prognosis
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2020 Číslo 1
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Aktuální možnosti diagnostiky a léčby litiáz
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Autori: MUDr. Tomáš Ürge, PhD.
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