Platelet indices significantly correlate with liver fibrosis in HCV-infected patients

English version

Autoři: Lin-Nan Shao ^aff001; Shu-Ting Zhang ^aff001; Ni Wang ^aff001; Wei-Jian Yu ^aff001; Mei Chen ^aff001; Nan Xiao ^aff001; Ying Duan ^aff001; Ling-Zi Pan ^aff001; Wen-Qian Song ^aff001; Yue-Xin Xia ^aff001; Li Zhang ^aff001; Ning Qi ^aff001; Ming Liu ^aff002; Shi-Hang Zhou ^aff001
Působiště autorů: Dalian Blood Center, Zhongshan District, Dalian, Liaoning, China ^aff001; Department of Cell Biology, Dalian Medical University, Dalian, Liaoning, China ^aff002
Vyšlo v časopise: PLoS ONE 15(1)
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.pone.0227544

Souhrn

Aim

A total of 241 patients with chronic HCV infection were recruited to investigate the association between liver fibrosis and PLT counts, as well as with MPV, PDW and P-LCR indices.

Methods

The determination of PLT indices was carried out using a Sysmex XT-1800i automated hematology analyzer. Serological tests for HA, LN, C-IV and PIIINP were performed in 210 patients. The liver stiffness was measured in 69 patients by transient elastography (FibroScan).

Results

The analysis showed that the four serum fibrosis markers were negatively correlated with PLT counts, but positively correlated with the MPV, PDW and P-LCR values. Moreover, a similar pattern was found after analyzing the FibroScan measurements, which were negatively correlated with PLT counts, but positively correlated with MPV, PDW and P-LCR values. We subdivided the HCV-infected patients into mild and advanced fibrosis groups. The PLT counts were significantly decreased and the MPV, PDW and P-LCR values were significantly increased in the advanced fibrosis group when compared with the mild fibrosis group.

Conclusions

Our results demonstrate that not only the PLT counts but also the MPV, PDW and P-LCR indices significantly correlate with liver fibrosis in HCV-infected patients. Therefore, these indices may be useful laboratory measures for evaluating liver fibrosis progression.

Klíčová slova:

Hepatitis C virus – Hematology – Chronic liver disease – Collagens – Fibrosis – Blood counts – Liver fibrosis – Platelets

Zdroje

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