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Impact of multi-drug resistant bacteria on economic and clinical outcomes of healthcare-associated infections in adults: Systematic review and meta-analysis


Autoři: Miquel Serra-Burriel aff001;  Matthew Keys aff001;  Carlos Campillo-Artero aff001;  Antonella Agodi aff003;  Martina Barchitta aff003;  Achilleas Gikas aff004;  Carlos Palos aff006;  Guillem López-Casasnovas aff001
Působiště autorů: Center for Research in Health and Economics, Pompeu Fabra University, Barcelona, Spain aff001;  Balearic Islands Health Service, Palma de Mallorca, Balearic Islands, Spain aff002;  Department of Medical and Surgical Sciences and Advanced Technologies “GF Ingrassia”, University of Catania, Catania, Italy aff003;  Internal Medicine Department, Infectious Diseases Unit, University Hospital of Heraklion, Crete, Greece aff004;  School of Medicine, University of Crete, Heraklion, Greece aff005;  Hospital Beatriz Ângelo, Loures, Lisbon, Portugal aff006
Vyšlo v časopise: PLoS ONE 15(1)
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.pone.0227139

Souhrn

Background

Infections with multidrug resistant (MDR) bacteria in hospital settings have substantial implications in terms of clinical and economic outcomes. However, due to clinical and methodological heterogeneity, estimates about the attributable economic and clinical effects of healthcare-associated infections (HAI) due to MDR microorganisms (MDR HAI) remain unclear. The objective was to review and synthesize the evidence on the impact of MDR HAI in adults on hospital costs, length of stay, and mortality at discharge.

Methods and findings

Literature searches were conducted in PubMed/MEDLINE, and Google Scholar databases to select studies that evaluated the impact of MDR HAI on economic and clinical outcomes. Eligible studies were conducted in adults, in order to ensure homogeneity of populations, used propensity score matched cohorts or included explicit confounding control, and had confirmed antibiotic susceptibility testing. Risk of bias was evaluated, and effects were measured with ratios of means (ROM) for cost and length of stay, and risk ratios (RR) for mortality. A systematic search was performed on 14th March 2019, re-run on the 10th of June 2019 and extended the 3rd of September 2019. Small effect sizes were assessed by examination of funnel plots. Sixteen articles (6,122 patients with MDR HAI and 8,326 patients with non-MDR HAI) were included in the systematic review of which 12 articles assessed cost, 19 articles length of stay, and 14 mortality. Compared to susceptible infections, MDR HAI were associated with increased cost (ROM 1.33, 95%CI [1.15; 1.54]), prolonged length of stay (ROM 1.27, 95%CI [1.18; 1.37]), and excess in-hospital mortality (RR 1.61, 95%CI [1.36; 1.90]) in the random effects models. Risk of publication bias was only found to be significant for mortality, and overall study quality good.

Conclusions

MDR HAI appears to be strongly associated with increases in direct cost, prolonged length of stay and increased mortality. However, further comprehensive studies in this setting are warranted.

Trial registration

PROSPERO (CRD42019126288).

Klíčová slova:

Hospitals – Health economics – Urinary tract infections – Systematic reviews – Database searching – Antimicrobial resistance – Nosocomial infections – Economic impact analysis


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