Brief communication: Long-term absence of Langerhans cells alters the gene expression profile of keratinocytes and dendritic epidermal T cells

English version

Autoři: Qingtai Su ^aff001; Aurélie Bouteau ^aff001; Jacob Cardenas ^aff003; Balaji Uthra ^aff003; Yuanyaun Wang ^aff003; Cynthia Smitherman ^aff003; Jinghua Gu ^aff003; Botond Z. Igyártó ^aff001
Působiště autorů: Baylor Scott & White Research Institute, Baylor Institute for Immunology Research, Dallas, Texas, United States of America ^aff001; Baylor University, Institute of Biomedical Studies, Waco, Texas, United States of America ^aff002; Baylor Scott & White Research Institute, Dallas, Texas, United States of America ^aff003; Thomas Jefferson University, Department of Microbiology and Immunology, Philadelphia, Pennsylvania, United States of America ^aff004
Vyšlo v časopise: PLoS ONE 15(1)
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.pone.0223397

Souhrn

Tissue-resident and infiltrating immune cells are continuously exposed to molecules derived from the local cells that often come in form of secreted factors, such as cytokines. These factors are known to impact the immune cells’ biology. However, very little is known about whether the tissue resident immune cells in return also affect the local environment. In this study, with the help of RNA-sequencing, we show for the first time that long-term absence of epidermal resident Langerhans cells led to significant gene expression changes in the local keratinocytes and resident dendritic epidermal T cells. Thus, immune cells might play an active role in maintaining tissue homeostasis, which should be taken in consideration at data interpretation.

Klíčová slova:

Gene expression – Sequence alignment – Cytokines – Homeostasis – Immune cells – Gene ontologies – RNA sequencing – Principal component analysis

Zdroje

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Brief communication: Long-term absence of Langerhans cells alters the gene expression profile of keratinocytes and dendritic epidermal T cells

Souhrn

Klíčová slova:

Zdroje

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