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preLekára.sk / Odborné časopisy / PLOS One / 2020 - 1

Using machine learning methods to determine a typology of patients with HIV-HCV infection to be treated with antivirals

English version

Autoři: Antonio Rivero-Juárez aff001;  David Guijo-Rubio aff002;  Francisco Tellez aff003;  Rosario Palacios aff004;  Dolores Merino aff005;  Juan Macías aff006;  Juan Carlos Fernández aff002;  Pedro Antonio Gutiérrez aff002;  Antonio Rivero aff001;  César Hervás-Martínez aff002
Působiště autorů: Unidad de Enfermedades Infecciosas, Hospital Universitario Reina Sofía de Córdoba, Instituto Maimónides de Investigación Biomédica de Córdoba, Universidad de Córdoba, Córdoba, España aff001;  Departamento de Informática y Análisis Numérico, Universidad de Córdoba, Córdoba, España aff002;  Unidad de Enfermedades Infecciosas, Hospital Universitario de Puerto Real, Cádiz, España aff003;  Unidad de Enfermedades Infecciosas, Hospital Juan Ramón Jiménez e Infanta Elena de Huelva, Huelva, España aff004;  Unidad de Enfermedades Infecciosas, Hospital Universitario Virgen de la Victoria, Complejo Hospitalario Provincial de Málaga, Málaga, España aff005;  Unidad de Enfermedades Infecciosas, Hospital Universitario de Valme, Instituto de Biomedicina de Sevilla, Sevilla, España aff006
Vyšlo v časopise: PLoS ONE 15(1)
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.pone.0227188

Souhrn

Several European countries have established criteria for prioritising initiation of treatment in patients infected with the hepatitis C virus (HCV) by grouping patients according to clinical characteristics. Based on neural network techniques, our objective was to identify those factors for HIV/HCV co-infected patients (to which clinicians have given careful consideration before treatment uptake) that have not being included among the prioritisation criteria. This study was based on the Spanish HERACLES cohort (NCT02511496) (April-September 2015, 2940 patients) and involved application of different neural network models with different basis functions (product-unit, sigmoid unit and radial basis function neural networks) for automatic classification of patients for treatment. An evolutionary algorithm was used to determine the architecture and estimate the coefficients of the model. This machine learning methodology found that radial basis neural networks provided a very simple model in terms of the number of patient characteristics to be considered by the classifier (in this case, six), returning a good overall classification accuracy of 0.767 and a minimum sensitivity (for the classification of the minority class, untreated patients) of 0.550. Finally, the area under the ROC curve was 0.802, which proved to be exceptional. The parsimony of the model makes it especially attractive, using just eight connections. The independent variable “recent PWID” is compulsory due to its importance. The simplicity of the model means that it is possible to analyse the relationship between patient characteristics and the probability of belonging to the treated group.

Klíčová slova:

HIV – Hepatitis C virus – Neural networks – Drug abuse – Liver fibrosis – Evolutionary algorithms – Artificial neural networks – Mental health therapies

Zdroje

1. WHO. Global hepatitis report. World Health Organization; 2017.

2. Wiessing L, Ferri M, Grady B, Kantzanou M, Sperle I, Cullen KJ, et al. Hepatitis C virus infection epidemiology among people who inject drugs in Europe: a systematic review of data for scaling up treatment and prevention. PloS one. 2014;9(7):e103345. doi: 10.1371/journal.pone.0103345 25068274

3. Macias J, Berenguer J, Japón MA, Girón JA, Rivero A, López-Cortés LF, et al. Fast fibrosis progression between repeated liver biopsies in patients coinfected with human immunodeficiency virus/hepatitis C virus. Hepatology. 2009;50(4):1056–1063. doi: 10.1002/hep.23136 19670415

4. Pineda JA, García-García JA, Aguilar-Guisado M, Ríos-Villegas MJ, Ruiz-Morales J, Rivero A, et al. Clinical progression of hepatitis C virus–related chronic liver disease in human immunodeficiency virus–infected patients undergoing highly active antiretroviral therapy. Hepatology. 2007;46(3):622–630. doi: 10.1002/hep.21757 17659577

5. AASLD. HCV Guidance: Recommendations for Testing, Managing, and Treating Hepatitis C. American Association for the Study of Liver Disease (AASLD); 2018.

6. Omland LH, Christensen PB, Krarup H, Jepsen P, Weis N, Sørensen HT, et al. Mortality among patients with cleared hepatitis C virus infection compared to the general population: a Danish nationwide cohort study. PLoS One. 2011;6(7):e22476. doi: 10.1371/journal.pone.0022476 21789259

7. Truong TN, Laureillard D, Lacombe K, Thi HD, Hanh PPT, Xuan LTT, et al. High proportion of HIV-HCV Coinfected patients with advanced liver fibrosis requiring hepatitis C treatment in Haiphong, northern Vietnam (ANRS 12262). PloS one. 2016;11(5):e0153744. doi: 10.1371/journal.pone.0153744

8. Bishop CM, et al. Neural networks for pattern recognition. Oxford university press; 1995.

9. Wang D, Larder B, Revell A, Montaner J, Harrigan R, De Wolf F, et al. A comparison of three computational modelling methods for the prediction of virological response to combination HIV therapy. Artificial Intelligence in Medicine. 2009;47(1):63–74. doi: 10.1016/j.artmed.2009.05.002 19524413

10. Resino S, Seoane JA, Bellón JM, Dorado J, Martin-Sanchez F, Álvarez E, et al. An artificial neural network improves the non-invasive diagnosis of significant fibrosis in HIV/HCV coinfected patients. Journal of Infection. 2011;62(1):77–86. doi: 10.1016/j.jinf.2010.11.003 21073895

11. Lamers SL, Salemi M, McGrath MS, Fogel GB. Prediction of R5, X4, and R5X4 HIV-1 coreceptor usage with evolved neural networks. IEEE/ACM Transactions on Computational Biology and Bioinformatics (TCBB). 2008;5(2):291–300. doi: 10.1109/TCBB.2007.1074

12. Pradhan M, Sahu RK. Multilayer perceptron network in HIV/AIDS application. International Journal of Computer Applications in Engineering Sciences. 2011;1(1):41–48.

13. Bisaso KR, Anguzu GT, Karungi SA, Kiragga A, Castelnuovo B. A survey of machine learning applications in HIV clinical research and care. Computers in biology and medicine. 2017;91:366–371. doi: 10.1016/j.compbiomed.2017.11.001 29127902

14. Johansson EM, Dowla FU, Goodman DM. Backpropagation learning for multilayer feed-forward neural networks using the conjugate gradient method. International Journal of Neural Systems. 1991;2(04):291–301. doi: 10.1142/S0129065791000261

15. Durbin R, Rumelhart DE. Product units: A computationally powerful and biologically plausible extension to backpropagation networks. Neural computation. 1989;1(1):133–142. doi: 10.1162/neco.1989.1.1.133

16. Billings SA, Wei HL, Balikhin MA. Generalized multiscale radial basis function networks. Neural Networks. 2007;20(10):1081–1094. doi: 10.1016/j.neunet.2007.09.017 17993257

17. Fei Y, Hu J, Gao K, Tu J, Wang W, Li Wq. Risk Prediction for Portal Vein Thrombosis in Acute Pancreatitis Using Radial Basis Function. Annals of vascular surgery. 2018;47:78–84. doi: 10.1016/j.avsg.2017.09.004 28943487

18. Kim Y, Na YH, Xing L, Lee R, Park S. Automatic deformable surface registration for medical applications by radial basis function-based robust point-matching. Computers in biology and medicine. 2016;77:173–181. doi: 10.1016/j.compbiomed.2016.07.013 27567399

19. Griffiths GW, Schiesser W, et al. Analysis of cornea curvature using radial basis functions–Part I: Methodology. Computers in biology and medicine. 2016;77:274–284. doi: 10.1016/j.compbiomed.2016.08.011 27614697

20. Shaikhina T, Khovanova NA. Handling limited datasets with neural networks in medical applications: A small-data approach. Artificial Intelligence in Medicine. 2017;75:51–63. doi: 10.1016/j.artmed.2016.12.003 28363456

21. Dey P, Lamba A, Kumari S, Marwaha N. Application of an artificial neural network in the prognosis of chronic myeloid leukemia. Analytical and quantitative cytology and histology. 2011;33(6):335–339. 22590811

22. Amato F, López A, Peña-Méndez EM, Vaňhara P, Hampl A, Havel J. Artificial neural networks in medical diagnosis. Journal of Applied Biomedicine. 2013;11(2):47–58. doi: 10.2478/v10136-012-0031-x

23. Duch W, Jankowski N. Transfer functions: hidden possibilities for better neural networks. In: ESANN. Citeseer; 2001. p. 81–94.

24. Ismail A, Jeng DS, Zhang L. An optimised product-unit neural network with a novel PSO–BP hybrid training algorithm: Applications to load–deformation analysis of axially loaded piles. Engineering applications of artificial intelligence. 2013;26(10):2305–2314. doi: 10.1016/j.engappai.2013.04.007

25. Vukicevic AM, Stojadinovic M, Radovic M, Djordjevic M, Cirkovic BA, Pejovic T, et al. Automated development of artificial neural networks for clinical purposes: Application for predicting the outcome of choledocholithiasis surgery. Computers in biology and medicine. 2016;75:80–89. doi: 10.1016/j.compbiomed.2016.05.016 27261565

26. Cruz-Ramirez M, Hervas-Martinez C, Fernandez JC, Briceno J, De La Mata M. Predicting patient survival after liver transplantation using evolutionary multi-objective artificial neural networks. Artificial Intelligence in Medicine. 2013;58(1):37–49. doi: 10.1016/j.artmed.2013.02.004 23489761

27. Dorado-Moreno M, Pérez-Ortiz M, Gutiérrez PA, Ciria R, Briceño J, Hervás-Martínez C. Dynamically weighted evolutionary ordinal neural network for solving an imbalanced liver transplantation problem. Artificial Intelligence in Medicine. 2017;77:1–11. doi: 10.1016/j.artmed.2017.02.004 28545607

28. Martínez-Estudillo FJ, Hervás-Martínez C, Gutiérrez PA, Martínez-Estudillo AC. Evolutionary product-unit neural networks classifiers. Neurocomputing. 2008;72(1-3):548–561. doi: 10.1016/j.neucom.2007.11.019

29. Lippmann RP. Pattern classification using neural networks. IEEE communications magazine. 1989;27(11):47–50. doi: 10.1109/35.41401

30. Schmitt M. On the complexity of computing and learning with multiplicative neural networks. Neural Computation. 2002;14(2):241–301. doi: 10.1162/08997660252741121 11802913

31. Hornik K, Stinchcombe M, White H. Multilayer feedforward networks are universal approximators. Neural networks. 1989;2(5):359–366. doi: 10.1016/0893-6080(89)90020-8

32. Angeline PJ, Saunders GM, Pollack JB. An evolutionary algorithm that constructs recurrent neural networks. IEEE transactions on Neural Networks. 1994;5(1):54–65. doi: 10.1109/72.265960 18267779

33. Martínez-Estudillo A, Martínez-Estudillo F, Hervás-Martínez C, García-Pedrajas N. Evolutionary product unit based neural networks for regression. Neural Networks. 2006;19(4):477–486. doi: 10.1016/j.neunet.2005.11.001 16481148

34. Yao X. Evolving artificial neural networks. Proceedings of the IEEE. 1999;87(9):1423–1447. doi: 10.1109/5.784219

35. Ding S, Li H, Su C, Yu J, Jin F. Evolutionary artificial neural networks: a review. Artificial Intelligence Review. 2013;39(3):251–260. doi: 10.1007/s10462-011-9270-6

36. Yao X, Liu Y. A new evolutionary system for evolving artificial neural networks. IEEE transactions on neural networks. 1997;8(3):694–713. doi: 10.1109/72.572107 18255671

37. Odri SV, Petrovacki DP, Krstonosic GA. Evolutional development of a multilevel neural network. Neural Networks. 1993;6(4):583–595. doi: 10.1016/S0893-6080(05)80061-9

38. Bebis G, Georgiopoulos M, Kasparis T. Coupling weight elimination with genetic algorithms to reduce network size and preserve generalization. Neurocomputing. 1997;17(3-4):167–194. doi: 10.1016/S0925-2312(97)00050-7

39. Cantú-Paz E, Kamath C. An empirical comparison of combinations of evolutionary algorithms and neural networks for classification problems. IEEE Transactions on Systems, Man, and Cybernetics, Part B (Cybernetics). 2005;35(5):915–927. doi: 10.1109/TSMCB.2005.847740

40. Fernández JC, Martínez FJ, Hervás C, Gutiérrez PA. Sensitivity versus accuracy in multiclass problems using memetic pareto evolutionary neural networks. IEEE Transactions on Neural Networks. 2010;21(5):750–770. doi: 10.1109/TNN.2010.2041468

41. Fawcett T. An introduction to ROC analysis. Pattern recognition letters. 2006;27(8):861–874. doi: 10.1016/j.patrec.2005.10.010

42. Hervás C, Gutierrez PA, Silva M, Serrano JM. Combining classification and regression approaches for the quantification of highly overlapping capillary electrophoresis peaks by using evolutionary sigmoidal and product unit neural networks. Journal of Chemometrics: A Journal of the Chemometrics Society. 2007;21(12):567–577. doi: 10.1002/cem.1082

43. Cortes C, Vapnik V. Support-vector networks. Machine learning. 1995;20(3):273–297. doi: 10.1023/A:1022627411411

44. Jolliffe IT, Cadima J. Principal component analysis: a review and recent developments. Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences. 2016;374(2065):20150202. doi: 10.1098/rsta.2015.0202

45. Levene H. Robust tests for equality of variances. Contributions to probability and statistics Essays in honor of Harold Hotelling. 1961; p. 279–292.

46. Tukey JW. Comparing individual means in the analysis of variance. Biometrics. 1949; p. 99–114. doi: 10.2307/3001913 18151955

47. Peters PJ, Pontones P, Hoover KW, Patel MR, Galang RR, Shields J, et al. HIV infection linked to injection use of oxymorphone in Indiana, 2014–2015. New England Journal of Medicine. 2016;375(3):229–239. doi: 10.1056/NEJMoa1515195 27468059

48. Campo DS, Khudyakov Y. Intelligent Network DisRuption Analysis (INDRA): A targeted strategy for efficient interruption of hepatitis C transmissions. Infection, Genetics and Evolution. 2018;. doi: 10.1016/j.meegid.2018.05.028 29860098

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Článek What drugs modify the risk of iatrogenic impulse-control disorders in Parkinson’s disease? A preliminary pharmacoepidemiologic study
Článek Evaluating emotional distress and health-related quality of life in patients with heart failure and their family caregivers: Testing dyadic dynamics using the Actor-Partner Interdependence Model
Článek Association of ECG parameters with late gadolinium enhancement and outcome in patients with clinical suspicion of acute or subacute myocarditis referred for CMR imaging
Článek Catchment-scale export of antibiotic resistance genes and bacteria from an agricultural watershed in central Iowa
Článek Impact of multi-drug resistant bacteria on economic and clinical outcomes of healthcare-associated infections in adults: Systematic review and meta-analysis
Článek Characterization of a universal screening approach for congenital CMV infection based on a highly-sensitive, quantitative, multiplex real-time PCR assay
Článek Proof-of-concept for a non-invasive, portable, and wireless device for cardiovascular monitoring in pediatric patients
Článek On PTV definition for glioblastoma based on fiber tracking of diffusion tensor imaging data
Článek Genes associated with body weight gain and feed intake identified by meta-analysis of the mesenteric fat from crossbred beef steers
Článek Intraoperative computed tomography imaging for dose calculation in intraoperative electron radiation therapy: Initial clinical observations
Článek Human lung epithelial BEAS-2B cells exhibit characteristics of mesenchymal stem cells
Článek Simple non-mydriatic retinal photography is feasible and demonstrates retinal microvascular dilation in Chronic Obstructive Pulmonary Disease (COPD)
Článek Evaluation of a bioengineered ACL matrix’s osteointegration with BMP-2 supplementation
Článek Psychosocial profiles of physical activity fluctuation in office employees: A latent profile analysis
Článek Prevalence and characteristics of Livestock-Associated Methicillin-Resistant Staphylococcus aureus (LA-MRSA) isolated from chicken meat in the province of Quebec, Canada
Článek Soluble AXL as a marker of disease progression and survival in melanoma
Článek Gender differences influence over insomnia in Korean population: A cross-sectional study
Článek Impact of scion/rootstock reciprocal effects on metabolomics of fruit juice and phloem sap in grafted Citrus reticulata
Článek Adapting cognitive diagnosis computerized adaptive testing item selection rules to traditional item response theory
Článek Autumn shifts in cold tolerance metabolites in overwintering adult mountain pine beetles
Článek Umbilical cord separation time, predictors and healing complications in newborns with dry care
Článek Analysis of attitudinal components towards statistics among students from different academic degrees
Článek Effects of fatigue induced by repeated-sprint on kicking accuracy and velocity in female soccer players
Článek A pre-clinical validation plan to evaluate analytical sensitivities of molecular diagnostics such as BD MAX MDR-TB, Xpert MTB/Rif Ultra and FluoroType MTB
Článek Leadership for success in transforming medical abortion policy in Canada
Článek Clinical correlates associated with the long-term response of bipolar disorder patients to lithium, valproate or lamotrigine: A retrospective study
Článek Forecasting stock prices with long-short term memory neural network based on attention mechanism
Článek On the genus Crossaster (Echinodermata: Asteroidea) and its distribution
Článek Intracellular and in vivo evaluation of imidazo[2,1-b]thiazole-5-carboxamide anti-tuberculosis compounds
Článek An integrated vitamin E-coated polymer hybrid nanoplatform: A lucrative option for an enhanced in vitro macrophage retention for an anti-hepatitis B therapeutic prospect
Článek The effect of strontium and silicon substituted hydroxyapatite electrochemical coatings on bone ingrowth and osseointegration of selective laser sintered porous metal implants
Článek Molecular prevalence of Bartonella, Babesia, and hemotropic Mycoplasma species in dogs with hemangiosarcoma from across the United States
Článek Color discrimination and gas chromatography-mass spectrometry fingerprint based on chemometrics analysis for the quality evaluation of Schizonepetae Spica
Článek Comparisons of recurrence-free survival and overall survival between microwave versus radiofrequency ablation treatment for hepatocellular carcinoma: A multiple centers retrospective cohort study with propensity score matching
Článek Oral misoprostol, low dose vaginal misoprostol, and vaginal dinoprostone for labor induction: Randomized controlled trial
Článek The association between dietary patterns before and in early pregnancy and the risk of gestational diabetes mellitus (GDM): Data from the Malaysian SECOST cohort
Článek Dynamic Extreme Aneuploidy (DEA) in the vegetable pathogen Phytophthora capsici and the potential for rapid asexual evolution
Článek Assertive, trainable and older dogs are perceived as more dominant in multi-dog households
Článek Prediction of Uropathogens by Flow Cytometry and Dip-stick Test Results of Urine Through Multivariable Logistic Regression Analysis
Článek Interleukin 6 is increased in preclinical HNSCC models of acquired cetuximab resistance, but is not required for maintenance of resistance
Článek Impact of viral disease hypophagia on pig jejunal function and integrity
Článek Molecular evidence for horizontal transmission of chelonid alphaherpesvirus 5 at green turtle (Chelonia mydas) foraging grounds in Queensland, Australia
Článek Evaluation and validation of 2D biomechanical models of the knee for radiograph-based preoperative planning in total knee arthroplasty
Článek Soil-Transmitted Helminth infections reduction in Bhutan: A report of 29 years of deworming
Článek Fast quantitative time lapse displacement imaging of endothelial cell invasion
Článek Two novel mutations in MSX1 causing oligodontia
Článek Dome-shaped macula in children and adolescents
Článek Targeted transcriptomic study of the implication of central metabolic pathways in mannosylerythritol lipids biosynthesis in Pseudozyma antarctica T-34
Článek Preliminary evidences of the presence of extracellular DNA single stranded forms in soil
Článek A comparison of quality of life between patients treated with different dialysis modalities in Taiwan
Článek Morphological association between the muscles and bones in the craniofacial region
Článek Transcriptome analysis of Actinidia chinensis in response to Botryosphaeria dothidea infection
Článek Comparative study on skin protection activity of polyphenol-rich extract and polysaccharide-rich extract from Sargassum vachellianum
Článek Real-world data about emotional stress, disability and need for social care in a German IBD patient cohort
Článek The regenerative compatibility: A synergy between healthy ecosystems, environmental attitudes, and restorative experiences
Článek Perceptions of risk and influences of choice in pregnant women with obesity. An evidence synthesis of qualitative research
Článek The role of refugee and migrant migration status on medication adherence: Mediation through illness perceptions
Článek Sexual risk classes among youth experiencing homelessness: Relation to childhood adversities, current mental symptoms, substance use, and HIV testing
Článek Effects of CK2β subunit down-regulation on Akt signalling in HK-2 renal cells
Článek Novel broad-spectrum activity-based probes to profile malarial cysteine proteases
Článek Association between opioid analgesic therapy and initiation of buprenorphine management: An analysis of prescription drug monitoring program data
Článek Improvement project in higher education institutions: A BPEP-based model
Článek An updated evaluation of serum sHER2, CA15.3, and CEA levels as biomarkers for the response of patients with metastatic breast cancer to trastuzumab-based therapies
Článek Genome-wide association study of metabolic syndrome in Korean populations
Článek Drug therapy problems and treatment satisfaction among ambulatory patients with epilepsy in a specialized hospital in Ethiopia
Článek Plasma kynurenines and prognosis in patients with heart failure
Článek Occurrence and distribution of anthropogenic persistent organic pollutants in coastal sediments and mud shrimps from the wetland of central Taiwan
Článek Intensified visual clutter induces increased sympathetic signalling, poorer postural control, and faster torsional eye movements during visual rotation
Článek Gut microbiota composition alterations are associated with the onset of diabetes in kidney transplant recipients
Článek Shock index and TIMI risk index as valuable prognostic tools in patients with acute coronary syndrome complicated by cardiogenic shock
Článek Merit overrules theory of mind when young children share resources with others
Článek Metabolic analysis of amino acids and vitamin B6 pathways in lymphoma survivors with cancer related chronic fatigue
Článek Immunopathogenesis of canine chronic ulcerative stomatitis
Článek Generalizing findings from a randomized controlled trial to a real-world study of the iLookOut, an online education program to improve early childhood care and education providers’ knowledge and attitudes about reporting child maltreatment
Článek When and what to test for: A cost-effectiveness analysis of febrile illness test-and-treat strategies in the era of responsible antibiotic use
Článek Comparison of effects and safety in providing controlled hypotension during surgery between dexmedetomidine and magnesium sulphate: A meta-analysis of randomized controlled trials
Článek The gene encoding the ketogenic enzyme HMGCS2 displays a unique expression during gonad development in mice
Článek Efficacy of a mitochondrion-targeting agent for reducing the level of urinary protein in rats with puromycin aminonucleoside-induced minimal-change nephrotic syndrome
Článek Association of endothelial nitric oxide synthase (NOS3) gene polymorphisms with primary open-angle glaucoma in a Saudi cohort
Článek Antitrust analysis with upward pricing pressure and cost efficiencies
Článek Natural selection contributes to food web stability
Článek Pyramiding QTLs controlling tolerance against drought, salinity, and submergence in rice through marker assisted breeding
Článek Diversity and plant growth-promoting functions of diazotrophic/N-scavenging bacteria isolated from the soils and rhizospheres of two species of Solanum
Článek Sofosbuvir-based regimen for genotype 2 HCV infected patients in Taiwan: A real world experience
Článek The virulence domain of Shigella IcsA contains a subregion with specific host cell adhesion function
Článek Sequencing artifacts derived from a library preparation method using enzymatic fragmentation
Článek Quantitative analysis of adsorption and desorption of volatile organic compounds on reusable zeolite filters using gas chromatography
Článek Quo vadis Pantanal? Expected precipitation extremes and drought dynamics from changing sea surface temperature
Článek Cloud-computing and machine learning in support of country-level land cover and ecosystem extent mapping in Liberia and Gabon
Článek The Brief Measure of Emotional Preoperative Stress (B-MEPS) as a new predictive tool for postoperative pain: A prospective observational cohort study
Článek The impact of diabetes mellitus medication on the incidence of endogenous endophthalmitis
Článek Clinical and pathological features of thrombotic microangiopathy influencing long-term kidney transplant outcomes
Článek Occupational exposure to particulate matter from air pollution in the outdoor workplaces in Almaty during the cold season
Článek Morphological adjustment in free-living Steinernema feltiae infective juveniles to increasing concentration of Nemafric-BL phytonematicide
Článek Key necroptotic proteins are required for Smac mimetic-mediated sensitization of cholangiocarcinoma cells to TNF-α and chemotherapeutic gemcitabine-induced necroptosis
Článek Concurrent lipidomics and proteomics on malignant plasma cells from multiple myeloma patients: Probing the lipid metabolome
Článek Retraction: SDR9C7 Promotes Lymph Node Metastases in Patients with Esophageal Squamous Cell Carcinoma
Článek Association between tuberculosis and depression on negative outcomes of tuberculosis treatment: A systematic review and meta-analysis
Článek Bioluminescent imaging of Arabidopsis thaliana using an enhanced Nano-lantern luminescence reporter system
Článek Biosynthetic pathway of indole-3-acetic acid in ectomycorrhizal fungi collected from northern Thailand
Článek Sex-specific and opposite modulatory aspects revealed by PPI network and pathway analysis of ischemic stroke in humans
Článek Control of the microsporidian parasite Nosema ceranae in honey bees (Apis mellifera) using nutraceutical and immuno-stimulatory compounds
Článek Role of donor genotype in RT-QuIC seeding activity of chronic wasting disease prions using human and bank vole substrates
Článek Oral magnesium supplementation for leg cramps in pregnancy—An observational controlled trial
Článek Health care professionals’ knowledge of commonly used sedative, analgesic and neuromuscular drugs: A single center (Rambam Health Care Campus), prospective, observational survey
Článek Campylobacter portucalensis sp. nov., a new species of Campylobacter isolated from the preputial mucosa of bulls
Článek Transgenic interleukin 11 expression causes cross-tissue fibro-inflammation and an inflammatory bowel phenotype in mice
Článek Sleep quality and sex modify the relationships between trait energy and fatigue on state energy and fatigue
Článek The role of peer, parental, and school norms in predicting adolescents’ attitudes and behaviours of majority and different minority ethnic groups in Croatia
Článek Availability, prices and affordability of selected antibiotics and medicines against non-communicable diseases in western Cameroon and northeast DR Congo
Článek The effect of mutations derived from mouse-adapted H3N2 seasonal influenza A virus to pathogenicity and host adaptation
Článek Detection of posttraumatic pneumothorax using electrical impedance tomography—An observer-blinded study in pigs with blunt chest trauma
Článek Educators’ perceptions of organisational readiness for implementation of a pre-adolescent transdisciplinary school health intervention for inter-generational outcomes
Článek Beyond the heterodimer model for mineralocorticoid and glucocorticoid receptor interactions in nuclei and at DNA
Článek The effects of sport expertise and shot results on basketball players’ action anticipation
Článek Framework and algorithms for identifying honest blocks in blockchain
Článek Exploring the impact of terminology differences in blood and organ donor decision making
Článek Platelet indices significantly correlate with liver fibrosis in HCV-infected patients
Článek The nitrate content of fresh and cooked vegetables and their health-related risks
Článek Bioreactor for mobilization of mesenchymal stem/stromal cells into scaffolds under mechanical stimulation: Preliminary results
Článek Non-gradient and genotype-dependent patterns of RSV gene expression
Článek Multiplex real-time PCR for the detection of Clavibacter michiganensis subsp. michiganensis, Pseudomonas syringae pv. tomato and pathogenic Xanthomonas species on tomato plants
Článek The 24-hour urinary cortisol in post-traumatic stress disorder: A meta-analysis
Článek Health-related quality of life among patients with type 2 diabetes mellitus in Eastern Province, Saudi Arabia: A cross-sectional study
Článek “I like the way I am, but I feel like I could get a little bit bigger”: Perceptions of body image among adolescents and youth living with HIV in Durban, South Africa
Článek Nanoparticle-based ‘turn-on’ scattering and post-sample fluorescence for ultrasensitive detection of water pollution in wider window
Článek Insights into the strategy of micro-environmental adaptation: Transcriptomic analysis of two alvinocaridid shrimps at a hydrothermal vent
Článek Thirty-day readmission after medical-surgical hospitalization for people who experience imprisonment in Ontario, Canada: A retrospective cohort study
Článek Hyper-spectral response and estimation model of soil degradation in Kenli County, the Yellow River Delta
Článek The association of telomere length and telomerase activity with adverse outcomes in older patients with non-ST-elevation acute coronary syndrome
Článek Construction of a high-density genetic map and fine mapping of a candidate gene locus for a novel branched-spike mutant in barley
Článek Natural hybridization between Phyllagathis and Sporoxeia species produces a hybrid without reproductive organs
Článek The impact of peer attachment on prosocial behavior, emotional difficulties and conduct problems in adolescence: The mediating role of empathy
Článek Diagnostic performance of serum interferon gamma, matrix metalloproteinases, and periostin measurements for pulmonary tuberculosis in Japanese patients with pneumonia
Článek Characterization of black patina from the Tiber River embankments using Next-Generation Sequencing
Článek Problem gambling, associations with comorbid health conditions, substance use, and behavioural addictions: Opportunities for pathways to treatment
Článek Nanosheet wrapping-assisted coverslip-free imaging for looking deeper into a tissue at high resolution
Článek Validity of cerebrovascular ICD-9-CM codes in healthcare administrative databases. The Umbria Data-Value Project
Článek Torque teno virus viral load is related to age, CMV infection and HLA type but not to Alzheimer's disease
Článek Associations of cigarette smoking and burden of thoracic aortic calcification in asymptomatic individuals: A dose-response relationship
Článek Transforming assessment of speech in children with cleft palate via online crowdsourcing
Článek Assessment of peritoneal microbial features and tumor marker levels as potential diagnostic tools for ovarian cancer
Článek Deficiency syndromes in top predators associated with large-scale changes in the Baltic Sea ecosystem
Článek Perceived relative social status and cognitive load influence acceptance of unfair offers in the Ultimatum Game
Článek Hepatitis B and C virus infection among HIV patients within the public and private healthcare systems in Chile: A cross-sectional serosurvey
Článek Retraction: Oncogenic Fibulin-5 Promotes Nasopharyngeal Carcinoma Cell Metastasis through the FLJ10540/AKT Pathway and Correlates with Poor Prognosis
Článek From seed to flour: Sowing sustainability in the use of cantaloupe melon residue (Cucumis melo L. var. reticulatus)
Článek Core Scientific Dataset Model: A lightweight and portable model and file format for multi-dimensional scientific data
Článek Accounting for measurement error to assess the effect of air pollution on omic signals
Článek Leucine zipper transcription factor-like 1 binds adaptor protein complex-1 and 2 and participates in trafficking of transferrin receptor 1
Článek Barriers for tuberculosis case finding in Southwest Ethiopia: A qualitative study
Článek Genetic predisposition to celiac disease in Kazakhstan: Potential impact on the clinical practice in Central Asia
Článek A lower psoas muscle volume was associated with a higher rate of recurrence in male clear cell renal cell carcinoma
Článek Two angles of overqualification-the deviant behavior and creative performance: The role of career and survival job
Článek Cost-utility analysis of de-escalating biological disease-modifying anti-rheumatic drugs in patients with rheumatoid arthritis
Článek Efficient estimation of stereo thresholds: What slope should be assumed for the psychometric function?
Článek Learning efficient haptic shape exploration with a rigid tactile sensor array
Článek Effects of dietary supplementation with a microalga (Schizochytrium sp.) on the hemato-immunological, and intestinal histological parameters and gut microbiota of Nile tilapia in net cages
Článek Regional versus local wind speed and direction at a narrow beach with a high and steep foredune
Článek Fragmented QRS complex in patients with systemic lupus erythematosus at the time of diagnosis and its relationship with disease activity
Článek Severe thiamine deficiency in eastern Baltic cod (Gadus morhua)
Článek Transfer entropy as a variable selection methodology of cryptocurrencies in the framework of a high dimensional predictive model
Článek Psychometric validation of Czech version of the Sport Motivation Scale
Článek Correction: Multiple innate antibacterial immune defense elements are correlated in diverse ungulate species
Článek Recognition of personality disorder and anxiety disorder comorbidity in patients treated for depression in secondary psychiatric care
Článek Correction: Strategies for achieving high sequencing accuracy for low diversity samples and avoiding sample bleeding using illumina platform
Článek Number of days required to estimate physical activity constructs objectively measured in different age groups: Findings from three Brazilian (Pelotas) population-based birth cohorts
Článek Physicians’ perspectives regarding non-medical switching of prescription medications: Results of an internet e-survey
Článek Modeling aggressive market order placements with Hawkes factor models
Článek Healthy lifestyle index and its association with hypertension among community adults in Sri Lanka: A cross-sectional study
Článek Effects of Allium hookeri on gut microbiome related to growth performance in young broiler chickens
Článek Community- and trophic-level responses of soil nematodes to removal of a non-native tree at different stages of invasion
Článek Maternal depressive symptoms and children’s cognitive development: Does early childcare and child’s sex matter?
Článek cagA gene EPIYA motif genetic characterization from Colombian Helicobacter pylori isolates: Standardization of a molecular test for rapid clinical laboratory detection
Článek Spectral characteristics of urine from patients with end-stage kidney disease analyzed using Raman Chemometric Urinalysis (Rametrix)
Článek Comparison of Monocyte Distribution Width (MDW) and Procalcitonin for early recognition of sepsis
Článek Antenatal depression and its association with adverse birth outcomes in low and middle-income countries: A systematic review and meta-analysis
Článek Effect of a community-based approach of iron and folic acid supplementation on compliance by pregnant women in Kiambu County, Kenya: A quasi-experimental study
Článek Correction: Chl1 DNA helicase and Scc2 function in chromosome condensation through cohesin deposition
Článek Drug-eluting versus bare-metal stents for first myocardial infarction in patients with atrial fibrillation: A nationwide population-based cohort study
Článek Alterations of aqueous humor Aβ levels in Aβ-infused and transgenic mouse models of Alzheimer disease
Článek Human-raptor conflict in rural settlements of Colombia
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Autori: MUDr. Tomáš Ürge, PhD.
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