-
Články
- Časopisy
- Kurzy
- Témy
- Kongresy
- Videa
- Podcasty
Framework and algorithms for identifying honest blocks in blockchain
Authors: Xu Wang aff001; Guohua Gan aff003; Ling-Yun Wu aff001
Authors place of work: Key Laboratory of Management, Decision and Information Systems, Institute of Applied Mathematics, Academy of Mathematics and Systems Science, Chinese Academy of Sciences, Beijing, China aff001; School of Mathematical Sciences, University of Chinese Academy of Sciences, Beijing, China aff002; Laboratory of Big Data and Blockchain, National Center for Mathematics and Interdisciplinary Sciences, Chinese Academy of Sciences, Beijing, China aff003; Beijing Taiyiyun Technology Co., Ltd., Beijing, China aff004; University of Science & Technology Beijing, Beijing, China aff005
Published in the journal: PLoS ONE 15(1)
Category: Research Article
doi: https://doi.org/10.1371/journal.pone.0227531Summary
Blockchain technology gains more and more attention in the past decades and has been applied in many areas. The main bottleneck for the development and application of blockchain is its limited scalability. Blockchain with directed acyclic graph structure (BlockDAG) is proposed in order to alleviate the scalability problem. One of the key technical problems in BlockDAG is the identification of honest blocks which are very important for establishing a stable and invulnerable total order of all the blocks. The stability and security of BlockDAG largely depends on the precision of honest block identification. This paper presents a novel universal framework based on graph theory, called MaxCord, for identifying the honest blocks in BlockDAG. By introducing the concept of discord, the honest block identification is modelled as a generalized maximum independent set problem. Several algorithms are developed, including exact, greedy and iterative filtering algorithms. The extensive comparisons between proposed algorithms and the existing method were conducted on the simulated BlockDAG data to show that the proposed iterative filtering algorithm identifies the honest blocks both efficiently and effectively. The proposed MaxCord framework and algorithms can set the solid foundation for the BlockDAG technology.
Keywords:
Data management – Markov models – Algorithms – Finance – Internet – Valleys – Graph theory – Directed acyclic graphs
1. Introduction
Blockchain is a decentralized transaction and data management technology which was firstly developed by Nakamoto [1] for Bitcoin. A sequence of blocks which contain block head and block body form blockchain chronologically. Marc Andreessen, the doyen of Silicon Valley’s capitalists, listed blockchain as the most significant invention which has the potential to transform the world of finance and beyond since the Internet itself [2,3]. Nowadays blockchain has gained more and more attention, and has been applied in lots of areas, such as IoT [4–7], healthcare [8], finance [9–12] and supply chain [13]. But there still exist some developmental bottlenecks for blockchain. Swan [14] points out seven challenges that the blockchain technology faces, including throughput, security and so on. The throughput of current blockchain system under the Proof of Work (PoW) consensus mechanism is very low, nearly 6–7 transactions per second, while bank card such as Visa can process thousands of transactions per second. Many other consensus mechanisms such as Proof of Stake (PoS), Delegated Proof of Stake (DPoS), Proof of Importance (PoI), Proof of Luck (PoL), hybrid PoW/PoS, were proposed to accelerate the block validation process, but the performance of blockchain is still not substantially improved due to the occurrence of blockchain forks. Moreover, the consensus mechanisms with higher throughput often sacrifice the decentralization to some extent. The poor scalability limits the development and application of blockchain greatly, especially in the areas with high-frequency transactions.
Most of research on blockchain focused on improving blockchain from the perspective of privacy and security [15–19], and some worked on the consensus algorithms [20], while only a few of researchers conducted some research on its scalable limitation. Lin et al. [21] showed the SPV (Simplified Payment Verification) technology to handle with the scalable limitation of blockchain by only using the block head message without maintaining the full block information, which is equivalent to expand the block size in disguised form. Decker et al. [22] studied the information propagation in the Bitcoin network and pointed out that the propagation delay in the network is the main reason for blockchain forks, and the abandoned blocks due to blockchain forks are the source of low throughput and poor scalability. Biais et al. [23] modeled the blockchain protocol as a stochastic game to analyze the equilibrium strategies of miners. They found the longest chain without forks is a Markov perfect equilibrium and there also exist equilibria with forks, which leads to the orphaned blocks. The model can show how folks can be generated through information delays and software updates. Zohar et al. [24] proposed an alternative to the longest-chain rule used in Bitcoin, named as GHOST, which determines the main chain using all blocks in the subtree at the fork. By utilizing the abandoned blocks, GHOST can improve the security of blockchain, but the throughput remains the same. In another paper, Zohar et al. [25] presented the blockchain with directed acyclic graph structure (BlockDAG), which allows the blocks to reference multiple predecessors to incorporate the information from all blocks into log. The DAG structure works well and leads to an increased throughput. More and more researchers agreed that BlockDAG is the next generation direction for the blockchain technology. An increasing number of BlockDAG-based blockchain platforms appeared in industry, such as IOTA (Tangle), byteball, and XDAG [26–28].
The block ordering problem is the main concern under directed acyclic graph (DAG) structure. In order to avoid the double-spending attack (attackers try to spend the same cryptocurrencies more than once), the ordering of transactions is very necessary: People can determine the valid transactions through accepting the first transaction and rejecting the later one according to the order of two conflict transactions. And the ordering of transactions is dependent on the ordering of blocks. Unlike the traditional blockchain, the ordering of blocks in the DAG is not straightforward since the DAG is essentially a partial order graph. Therefore, many approaches were developed to derive a stable and invulnerable total order of blocks from the DAG. A typical approach for block ordering problem, as PHANTOM proposed by Zohar et al. [29], is mainly composed of two steps. First, distinguish the honest blocks (blocks generated and propagated timely by the miners who conform with the rules of blockchain) from the suspect dishonest blocks (blocks generated by the miners who deliberately keep the blocks secrete for a long time or take other actions which are not in accordance with the rules of blockchain). Second, derive a full topological ordering based on the temporal information embedded in the topological structure of honest blocks. In the two-step approach, the quality of final block ordering is largely dependent on the precision of the honest block identification since the dishonest blocks might disturb the true temporal information. The more precise the honest block identification is, the better the block ordering.
In this paper, we presented a novel graph theory-based framework MaxCord for identifying the honest blocks in BlockDAG. Using this framework, several algorithms were developed and evaluated on the simulated BlockDAG data. Compared with the existing approach PHANTOM, the proposed algorithms are both effective and efficient which can lay the solid foundation for the following development of BlockDAG technology. The following of the paper is organized as follows. In Section 2, we described the honest block identification problem and proposed a novel general framework and illustrated its relationship with PHANTOM. Several algorithms for solving the problem were presented, including an iterative filtering algorithm MAXCORD-IFA. The algorithms were evaluated, analyzed and compared in Section 3 based on the simulated BlockDAG datasets. The conclusions were drawn, and further research directions were given in the last section.
2. Honest block identification problem
Briefly speaking, BlockDAG is a DAG of blocks, in which each block is constructed by one of the participated miners and linked to other blocks. The new block is connected to the existing DAG by referencing all tip blocks (those blocks are not referenced by any other blocks) of the DAG found by the miner. If there is no network delay, the DAG will become a directed chain where the first block (genesis block) is the root. Generally, the blocks constitute a growing DAG. If all participated miner honestly obey the rules of block generation and connection, the relative temporal order of blocks can be straightforwardly inferred, with acceptable small error which depends on the extent of network delay. However, the blocks generated by potential attackers might significantly disturb the temporal order information embedded in the BlockDAG. By analyzing the possible attack modes, we found that there are two key policies can be taken by the attackers:
keep their blocks secret and publish them later, e.g. after a certain transaction is confirmed;
only reference the specific blocks, e.g. the blocks created by themselves.
When generating a block and connecting it to the BlockDAG, the attackers might take any one or both two of the above policies depending on their attacking strategy. Whatever the policy the attackers use, the connection patterns between the blocks created by the attackers and the normal blocks are very different from the patterns within each group. Based on the intuition, we first defined a novel discord measurement which can estimate the possibility of two blocks belonging to different groups. Using the discord measurement, the honest block identification problem can be formulated as a maximum k-independent set problem.
2.1 Discord between blocks
Given a block DAG G = (V,E) where each vertex in V represents the block and each directed edge in E represents the reference link. For a block A, the future set is the blocks that can reach A, denoted as future(A,G). Similarly, the past set of block A is the blocks that can be reached from A, denoted as past(A,G). Fig 1 shows an example of the future and past sets. Naturally, there are still some blocks left except the block’s future, past and itself. These blocks are the complementary set of the past(A,G), A and future(A,G), denoted as anticone(A,G):
The example of anticone is also illustrated in Fig 1. Normally, the anticone set denotes the blocks that are created during the block A’s propagation time. When blocks are created very frequently, there are more blocks in the anticone set of each block.
Fig. 1. The illustration of past, future, anticone of block A. The discord between blocks A and B is 6 (the length of blue loop), and the discord between blocks A and D is 4 (the length of red loop). We further define a novel measurement called discord to distinguish the blocks in the anticone set. For a block A, the discord between A and any block in past(A,G) and future(A,G), is defined as zero. The discord between A and a block B in anticone(A,G) is defined as the length of loop formed by A, B, their nearest common ancestor and nearest common descendant. For the situation where there is no common descendant between two blocks, a virtual block is added which references all tip blocks so that the blocks A, B, their nearest common ancestor and the virtual block can form a loop. An example of discord is illustrated in Fig 1.
Suppose dij denotes the shortest distance from block i to block j in the original DAG, and dABA=mink(dAk+dBk), dABD=mink(dkA+dkB), dAT=mini∈Tips(diA), dBT=mini∈Tips(diB). The discord between blocks A and B can be mathematically defined by the following formula.
2.2 MaxCord framework
The discord is designed to estimate the temporal inconsistency (ambiguity) between two blocks. If two blocks are in the anticone of each other, their temporal order cannot be determined. But the time discrepancy of two blocks are bounded by their nearest common ancestor and nearest common descendant, since the real creation time of a block is bounded by its ancestors and descendants. The dishonest blocks always intend to hide or counterfeit its real creation time in order to carry out some attack such as double spending. Therefore, the discords between the dishonest block and most honest blocks should be very large, otherwise the real creation time of the dishonest block would be bounded by some honest blocks into a small interval. On the other hand, the discord of two honest blocks is normally much smaller. If the links between blocks are not artificially manipulated, the discord of two blocks should only depend on the network propagation speed and the block creation rate. When the network propagation speed or the block creation rate increases, the time discrepancy between the nearest common ancestor and the nearest common descendant will decline, however, the length of shortest path between two blocks will increase and cancel out the decline of time discrepancy to some extent. Therefore, the discords are not very sensitive to the network propagation speed and the block creation rate. The analysis on simulated BlockDAG datasets shows that the discords between two honest blocks are mostly smaller than 10 while the discords between the honest block and the dishonest block might be higher in two or more order of magnitude. Fig 2 shows the relationship between the block creation rate and the maximum discord between honest blocks. In every case of block creation rate, 100 simulations are conducted. The statistical analysis is shown in Table 1. Even when the block creation rate reaches 600 blocks per second, the discord between honest blocks still does not increase too much. Therefore, the discords can be utilized to filter the suspect dishonest blocks. In this section, we give a novel framework named MaxCord for identifying the honest blocks based on the discord.
Fig. 2. The relationship between block generation rate and maximum honest block discord. Tab. 1. The statistical analysis of maximum honest block discords. Given a block DAG, we first calculate the discords for every pairs of blocks and get the discord matrix. Then the discord matrix is converted into a binary matrix where each element is 1 if the corresponding element in the discord matrix is larger than a preset threshold d and 0 otherwise. By using the obtained binary matrix as the adjacency matrix, we can construct an undirected graph, in which each vertex represents a block. This graph is called d-discord graph of the given block DAG. Intuitively, if a block DAG only contains honest blocks, the degrees in the d-discord graph would be very small since the discords between most honest blocks are zero and the remaining non-zero discords are also very small. Considering the honest blocks are the majority, the honest block identification problem can be addressed by identifying the maximum subset of vertexes with small degrees.
Considering a graph G = (V,E), the k-independent set of G refers to the vertex subset V’ in which the maximum degree in the induced subgraph does not exceed k. The maximum k-independent set problem is to find the k-independent set with maximum size, which is a generalization of classical maximum independent set problem. The maximum k-independent set can be formulated as the following integer programming, in which xs represents whether a certain vertex s is selected and aij denotes the element of adjacency matrix of the graph G.
Given the non-negative integer parameters k and d, the honest block identification problem can be formulated as a maximum k-independent set problem in the d-discord graph of the given block DAG, denoted as MaxCord-(k,d).
It is straightforward to verify that MaxCord-(0,0) is equivalent to the longest-chain rule adopted in the traditional blockchain system such as Bitcoin. PHANTOM also falls into the MaxCord framework as it indeed solves the model MaxCord-(k,0). PHANTOM’s intuition is that the number of honest blocks in the anticone set of each honest block should be very small, e.g. less than k, since there are not many blocks generated during the propagation of the honest block. However, the parameter k is closely related to the block creation rate and it is difficult to determine a proper value of k in practice. Notice that the discord information is not fully utilized in the model MaxCord-(k,0). In this paper, we focus on the other special case, i.e. MaxCord-(0,d), which assumes the discords between each pair of honest blocks should be very small, e.g. less than d.
The parameter d in the model MaxCord-(0,d) plays a very important role as it determines the potential boundary between the honest blocks and the suspect dishonest blocks. Smaller threshold d implies more stringent criterion of honest blocks. If the discords between a suspect dishonest block and all honest blocks are smaller than the threshold, the suspect dishonest block might be misidentified as an honest block. Therefore, larger threshold might decline the precision of honest block identification. On the other hand, if the discord between two honest blocks is larger than the threshold, one of these two blocks would be misidentified as suspect dishonest block. Thus, smaller threshold might decrease the recall. In a word, small d emphasizes the precision of honest block identification, while large d emphasizes the recall. This property will be exploited to develop a heuristic algorithm in the next section.
2.3 Algorithms for MaxCord-(0,d)
There are many algorithms of maximum independent set which can be directly applied to solve the model MaxCord-(0,d), including approximation algorithms [30, 31] and exact algorithms for particular graphs [32, 33]. It is well-known that the maximum independent set problem is NP-hard, thus, there does not exist a polynomial-time exact algorithm. Generally, the exact algorithm is fast if the graph is very sparse, and very slow for dense graph. Besides the exact algorithm, a simple greedy algorithm was also implemented to solve the problem more efficiently, in which the vertex with the maximum degree is repeatedly removed as long as the remaining vertex set is not an independent set. The exact and greedy algorithms are named MAXCORD-EXACT and MAXCORD-GREEDY, respectively. In order to solve the honest block identification problem more efficiently, we further developed a new heuristic algorithm called MAXCORD-IFA.
Notice that when the threshold d is large, the model MaxCord-(0,d) has high recall. Large d also leads to a sparse d-discord graph. By exploiting these two special characteristics of MaxCord framework, MAXCORD-IFA solves the model MaxCord-(0,d) by iteratively filtering out the suspect dishonest blocks identified by a series of models MaxCord-(0,s) with s > d. Starting with a very large s, MAXCORD-IFA applies the exact algorithm of the maximum independent set problem to solve the model MaxCord-(0,s), and removes the vertexes identified as suspect dishonest blocks. Then it decreases the value of s and solves a new model MaxCord-(0,s) defined on the remain blocks. The procedure is repeated until s converges to the predetermined d. The detail of the MAXCORD-IFA algorithm is described in Fig 3.
Fig. 3. The pseudocode of MAXCORD-IFA algorithm. There are two parameters in Algorithm 1. The parameter d is the final value of the threshold for constructing the d-discord graph. In each iteration, the algorithm takes the top (1-alpha) percentage discords into account. That is, we gradually decrease the value of the threshold until it reaches the desired value d. In this way, the suspect dishonest blocks with high probability are filtered out step by step. The parameter alpha determines the sparsity of the d-discord graph in each iteration. If it is set close to 1, the d-discord graph becomes very sparse thus the computation of each iteration is fast, but more iterations are required to finish the algorithm. On the other hand, if it is set too low, the computation of each iteration would be unacceptably slow, and the result would be similar to that of the single iteration exact algorithm. Because MAXCORD-IFA is by means of multiple iterations while MAXCORD-EXACT is through one iteration to convert the discord matrix into binary matrix, as long as the parameters d takes the same value, MAXCORD-EXACT is a special case of MAXCORD-IFA.
3. Results
In order to evaluate the proposed MaxCord framework, we applied several algorithms, including MAXCORD-EXACT, MAXCORD-GREEDY and MAXCORD-IFA to the simulated BlockDAG datasets and compared them with the existing method PHANTOM. Although there already exist some real BlockDAG systems, it is hard to get the real data. We simulated the BlockDAG datasets by using the probabilistic model of block creation and propagation on the P2P network. The computation power is assumed equally distributed, i.e. the blocks are created by the participated miners with equal probability. Two types of interval between two consecutively generated blocks is considered, including fixed interval and random interval (e.g. exponential distribution). The block transfer time on the P2P network is simulated using a gamma distribution. The parameters are tuned so that the throughput of blockchain with the longest-chain rule approximates the real world. The simulation algorithm is implemented in the R package BlockSim which is available at http://github.com/wulingyun/BlockSim. The following simulation experiments were all run in R 3.5.1.
3.1 Parameter determination
The parameter d of the MaxCord-(0,d) model is set identical for three algorithms MAXCORD-EAXCT, MAXCORD-GREEDY and MAXCORD-IFA. According to the analysis in the previous section, we take 8 as the default value of the parameter d to identify the honest blocks in this study.
There is an additional parameter alpha in the algorithm MAXCORD-IFA. The parameter alpha is chosen not only to make sure the d-discord graph constructed in each iteration is sparse enough thus easy to solve by the exact algorithm of maximum independent set problem, but also to strike a balance between the number of iterations and the time taken by each iteration.
The influence of the parameter alpha on running time, precision and recall of different attack powers is shown in Fig 4. The results of MAXCORD-EXACT are also shown for comparison. Two attack modes are simulated, moderate attack (the attackers have 33% of all computation power) and heavy attack (the attackers have 49% of all computation power). In each attack mode, the algorithms are applied to 100 BlockDAG datasets. Each dataset contains 1000 blocks and the block creation rate is 10 blocks per second. The left part A of Fig 4 is the results under the moderate attack case while the right part B is the results under the heavy attack case. The horizontal axis represents that the parameter alpha ranges from 0.7 to 0.95. Notice that when the parameter alpha takes the value of 0.7, the results of MAXCORD-EXACT and MAXCORD-IFA are the same. Because when the value of alpha is small enough, MAXCORD-IFA takes only one iteration, and degenerates to MAXCORD-EXACT. From the aspect of running time, as the number of iterations increases, namely the gradual increment of the alpha, the total running time decreases although the decrements become less and less. Considering the indicators of precision and recall, 0.9 is the best choice for alpha no matter what level the attack power. In the following analysis of this study, we set the default value of alpha as 0.9.
Fig. 4. The influence of the parameter alpha on MAXCORD-IFA. Part A represents the case with moderate attack power, while part B represents the case with heavy attack power. 3.2 Comparison between algorithms for MaxCord-(0,d)
We first evaluated several algorithms proposed for the MaxCord-(0,d) model, including MAXCORD-EXACT, MAXCORD-GREEDY and MAXCORD-IFA, and the comparisons among them are made. The BlockDAG is simulated with 1000 blocks and the block creation rate is 10 blocks per second. For each circumstance, we simulate 100 BlockDAG networks and the algorithms are applied to the same block DAG each time. The results are shown in Fig 5.
Fig. 5. The comparisons among the algorithms for MaxCord-(0,d). The left part A represents the case with moderate attack power, while right part B represents the case with heavy attack power. The horizontal axis represents the parameter d. With the increment of the parameter d, the indicator precision of the three algorithms decreases step by step, while their indicator of recall makes no big difference and approximates 1 when the attack power is moderate. The results of MAXCORD-GREEDY and MAXCORD-EXACT are almost identical under this case. MAXCORD-EXACT is a little bit better than MAXCORD-IFA in the aspect of the indicator of recall and they are nearly the same in the aspect of the indicator of precision. Stated in another way, MAXCORD-IFA improves the running time a lot by omitting a little bit honest blocks and maintaining the precision of the honest blocks when the attack power is moderate, but this little omission does not have large influence on the subsequent blocks ordering problem.
When the attack power is heavy, the parameter d has larger influence on the results for MAXCORD-EXACT than the MAXCORD-IFA, that is MAXCORD-IFA is more robust. MAXCORD-IFA outperforms MAXCORD-EXACT no matter the indicators of precision or recall. MAXCORD-GREEDY is the worst under this case. In a word, MAXCORD-IFA is both effective and efficient in distinguishing the honest blocks from the suspect dishonest blocks.
3.3 Comparison between MAXCORD-IFA and PHANTOM
Because PHANTOM is a recursive algorithm which is very time-consuming, it is impracticable to apply PHANTOM in large-scales cases. Therefore, we only simulated small-scale cases to compare MAXCORD-IFA with PHANTOM. In detail, we simulated the BlockDAG with 200 blocks and the block creation rate is 1/10 blocks per second. The attackers’ computation power percentage ranges from 0.1 to 0.45. For each attack circumstance, we conducted 10 simulations and both MAXCORD-IFA and PHANTOM are applied to the same 10 BlockDAG datasets. The parameter k in PHANTOM takes the default value 3.
Fig 6 shows the precision and recall indicators of the two algorithms. It can be seen that MAXCORD-IFA can well recognize the honest blocks no matter how much computation power the attackers own. Even if the recall indicator of MAXCORD-IFA is not always 1 (very close to 1), which means it may omit a little bit honest blocks. This small sacrifice is worthwhile since it can save plenty of time. When the attack power is very strong, MAXCORD-IFA obviously outperforms PHANTOM. In a word, MAXCORD-IFA is an effective and efficient algorithm in the honest block identification problem.
Fig. 6. The comparison between MAXCORD-IFA and PHANTOM. 4. Conclusions and discussions
In the paper, we introduce the honest block identification problem in the BlockDAG technology and present a novel universal framework of honest block identification problem through converting it into the maximum k-independent set problem on the basis of the definition of discord measurement between blocks. We point out the existing method PHANTOM is one of its special cases, and give several algorithms for the other special case MaxCord-(0,d), named MAXCORD-EXACT, MAXCORD-GREEDY, and MAXCORD-IFA.
Comparisons are made among these algorithms on the simulated BlockDAG datasets. MAXCORD-IFA outperforms PHANTOM to large extents, especially when the attack power is heavy. PHANTOM takes very long time therefore can only be applied to small-scale cases. The results of PHANTOM are sensitive to the value of parameter k which is difficult to be determined for a given dataset. In large-scale cases, MAXCORD-IFA outperforms MAXCORD-EXACT and MAXCORD-GREEDY except that the recall of MAXCORD-IFA is a little bit lower than that of another two algorithms when the attack power is moderate. But this small sacrifice, only omitting a little bit honest blocks while maintaining the precision of identification, can save lots of time and does not have significant influence on the subsequent block ordering problem.
This study is the first work on the MaxCord framework. In this direction, there are many problems deserved for future research. For example, MaxCord-(0,d) and MaxCord(k,0) are only two special cases of the MaxCord framework to identify the honest blocks. As our study suggests that MaxCord-(0,d) is better than MaxCord-(k,0), it is interesting to investigate the performance of general model MaxCord-(k,d) for the cases where d and k are both non-zero. Development of better algorithms for MaxCord models is also a very important and challenging task. The influence of different algorithms on the following block ordering problem is still not very clear. The block ordering derived from the honest block sets identified by several algorithms might be very different, even if their honest block identification results are very similar. There are also other mathematical problems in the BlockDAG technology that is closely related to the honest block identification, such as the transaction fee allocation.
In this paper, we consider the BlockDAG in which the new block could be connected to all the tip blocks observed by the node when issuing the new block. All blocks are kept in the system and can be referenced directly or indirectly by the new blocks in the future. BlockDAG attempts to identify the dishonest blocks by an algorithm independent of the construction of DAG. There also exist different approaches for the DAG-based blockchain technology. For example, IOTA Tangle attempts to distinguish the dishonest transactions from normal transactions by the tip selection algorithm based on MCMC (Markov Chain Monte Carlo) random walk and cumulative weights, and the dishonest transaction may fall into oblivion. It is interesting and important to study the pros and cons of two different approaches as well as the possible meld of them.
Supporting information
S1 Supporting Data [zip]
Simulated datasets and full results.
Zdroje
1. Nakamoto S. Bitcoin: A peer-to-peer electronic cash system. 2008. Available from: http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.221.9986&rep=rep1&type=pdf
2. Iansiti M, Lakhani K R. The truth about blockchain. Harv Bus Rev. 2017; 95 : 118–127.
3. Crosby M, Nachiappan, Pattanayak P, Verma S, Kalyanaraman V. Blockchain technology: Beyond bitcoin. Applied Innovation. 2016; 2(6–10):71.
4. Bahga A, Madisetti V K. Blockchain platform for industrial internet of things. Journal of Software Engineering and Applications. 2016; 9(10):533.
5. Huh S, Cho S, Kim S. Managing IoT devices using blockchain platform. 19th international conference on advanced communication technology (ICACT), IEEE. 2017 : 464–467.
6. Zhang Y, Wen J. The IoT electric business model: Using blockchain technology for the internet of things. Peer Peer Netw Appl. 2017; 10(4):983–994.
7. Reyna A, Martín C, Chen J, Soler M, Diaz M. On blockchain and its integration with IoT Challenges and opportunities. Future Gener Comput Syst. 2018; 88 : 173–190.
8. Mettler M. Blockchain technology in healthcare: The revolution starts here. 18th International Conference on e-Health Networking, Applications and Services (Healthcom), IEEE. 2016 : 1–3.
9. Treleaven P, Brown R G, Yang D. Blockchain technology in finance. Computer. 2017; 50(9): 14–17.
10. Tapscott A, Tapscott D. How blockchain is changing finance. Harv Bus Rev. 2017; 1(9):2–5.
11. Kristoufek L. What are the main drivers of the Bitcoin price? Evidence from wavelet coherence analysis. PLoS ONE. 2015; 10(4):e0123923. doi: 10.1371/journal.pone.0123923 25874694
12. Kim Y B, Lee J, Park N, Choo J, Kim J, Kim CH. When Bitcoin encounters information in an online forum: Using text mining to analyse user opinions and predict value fluctuation. PLoS ONE. 2017; 12(5):e0177630. doi: 10.1371/journal.pone.0177630 28498843
13. Apte S, Petrovsky N. Will blockchain technology revolutionize excipient supply chain management? Journal of Excipients and Food Chemicals. 2016; 7(3):910.
14. Swan M. Blockchain: Blueprint for a new economy. O'Reilly Media, Inc; 2015.
15. Yli-Huumo J, Ko D, Choi S, Park S, Smolander K. Where is current research on blockchain technology?—a systematic review. PLoS ONE. 2016; 11(10):e0163477. doi: 10.1371/journal.pone.0163477 27695049
16. Zheng Z, Xie S, Dai H N, Chen X, Wang H. Blockchain challenges and opportunities: A survey. International Journal of Web and Grid Services. 2018; 14(4):352–375.
17. Li X, Jiang P, Chen T, Luo X, Wen Q. A survey on the security of blockchain systems. Future Gener Comput Syst. 2017.
18. Feng Q, He D, Zeadally S, Khan MK, Kumar N. A survey on privacy protection in blockchain system. Journal of Network and Computer Applications. 2019; 126 : 45–58.
19. Juhász P L, Stéger J, Kondor D, Vattay G. A Bayesian approach to identify Bitcoin users. PLoS ONE. 2018; 13(12):e0207000. doi: 10.1371/journal.pone.0207000 30543629
20. Nguyen G T, Kim K. A Survey about Consensus Algorithms Used in Blockchain. Journal of Information processing systems. 2018; 14(1).
21. Lin I C, Liao T C. A Survey of Blockchain Security Issues and Challenges. IJ Network Security. 2017, 19(5):653–659.
22. Decker C, Wattenhofer R. Information propagation in the bitcoin network. IEEE Thirteenth International Conference on P2P Computing. 2013 : 1–10.
23. Biais B, Bisiere C, Bouvard M, Casamatta C. The blockchain folk theorem. The Review of Financial Studies. 2019, 32(5):1662–1715.
24. Sompolinsky Y, Zohar A. Secure high-rate transaction processing in bitcoin. International Conference on Financial Cryptography and Data Security, Springer, Berlin, Heidelberg. 2015 : 507–527.
25. Lewenberg Y, Sompolinsky Y, Zohar A. Inclusive block chain protocols. International Conference on Financial Cryptography and Data Security, Springer, Berlin, Heidelberg. 2015 : 528–547.
26. Popov Serguei. The tangle. 2016. Available from: https://www.iota-wiki.com/download/iota_whitepaper.pdf
27. Pervez H, Muneeb M, Irfan MU, Haq IU. A comparative analysis of DAG-based blockchain architectures. 12th International Conference on Open Source Systems and Technologies, IEEE. 2018 : 27–34.
28. Bai Chong. State-of-the-art and future trends on blockchain based on DAG structure. International workshop on structured object-oriented formal language and method, Springer, Cham. 2018 : 183–196.
29. Sompolinsky Y, Zohar A. PHANTOM: A scalable block DAG protocol. IACR Cryptology ePrint Archive, Report. 2018, 104.
30. Tarjan R E, Trojanowski A E. Finding a maximum independent set. SIAM J Sci Comput. 1977; 6(3):537–546.
31. Feo T A, Resende M G C, Smith S H. A greedy randomized adaptive search procedure for maximum independent set. Operations Research. 1994; 42(5):860–878.
32. Xiao M, Nagamochi H. An exact algorithm for maximum independent set in degree-5 graphs. Discrete Applied Mathematics. 2016; 199 : 137–155.
33. Tsukiyama S, Ide M, Ariyoshi H, Shirakawa I. A new algorithm for generating all the maximal independent sets. SIAM J Sci Comput. 1977; 6(3):505–517.
Článek Disparate effects of antibiotic-induced microbiome change and enhanced fitness in Daphnia magnaČlánek Effects of Transcranial Direct Current Stimulation on GABA and Glx in Children: A pilot studyČlánek Role of ecology in shaping external nasal morphology in bats and implications for olfactory trackingČlánek Influence of light on the infection of Aureococcus anophagefferens CCMP 1984 by a “giant virus”Článek A network analysis revealed the essential and common downstream proteins related to inguinal herniaČlánek Forecasting stock prices with long-short term memory neural network based on attention mechanismČlánek Transcriptome analysis of Actinidia chinensis in response to Botryosphaeria dothidea infectionČlánek The virulence domain of Shigella IcsA contains a subregion with specific host cell adhesion functionČlánek Regional versus local wind speed and direction at a narrow beach with a high and steep foreduneČlánek Patient perceived value of teleophthalmology in an urban, low income US population with diabetesČlánek A study to better understand under-utilization of laboratory tests for antenatal care in SenegalČlánek Design and evaluation of a laboratory-based wheelchair castor testing protocol using community dataČlánek Effects of Allium hookeri on gut microbiome related to growth performance in young broiler chickensČlánek Identification and characterization of miRNAs involved in cold acclimation of zebrafish ZF4 cellsČlánek Research on motion planning for an indoor spray arm based on an improved potential field methodČlánek Eye-gaze information input based on pupillary response to visual stimulus with luminance modulationČlánek Disruption in daily eating-fasting and activity-rest cycles in Indian adolescents attending schoolČlánek Umbilical cord separation time, predictors and healing complications in newborns with dry careČlánek Analysis of attitudinal components towards statistics among students from different academic degreesČlánek Comparison of Monocyte Distribution Width (MDW) and Procalcitonin for early recognition of sepsisČlánek Sofosbuvir-based regimen for genotype 2 HCV infected patients in Taiwan: A real world experience
Článok vyšiel v časopisePLOS One
Najčítanejšie tento týždeň
2020 Číslo 1- Metamizol jako analgetikum první volby: kdy, pro koho, jak a proč?
- Nejasný stín na plicích – kazuistika
- Masturbační chování žen v ČR − dotazníková studie
- Kombinace metamizol/paracetamol v léčbě pooperační bolesti u zákroků v rámci jednodenní chirurgie
- Představa veřejnosti o rezistenci na antibiotika je často mimo realitu − výsledky průzkumu WHO
-
Všetky články tohto čísla
- ETAPOD: A forecast model for prediction of black pod disease outbreak in Nigeria
- Disparate effects of antibiotic-induced microbiome change and enhanced fitness in Daphnia magna
- Deliver on Your Own: Disrespectful Maternity Care in rural Kenya
- Number of days required to estimate physical activity constructs objectively measured in different age groups: Findings from three Brazilian (Pelotas) population-based birth cohorts
- Exploring the mechanism of olfactory recognition in the initial stage by modeling the emission spectrum of electron transfer
- Risk of complications among diabetics self-reporting oral health status in Canada: A population-based cohort study
- Practical considerations in the use of a porcine model (Sus scrofa domesticus) to assess prevention of postoperative peritubal adhesions
- Transcriptional Differences in Peanut (Arachis hypogaea L.) Seeds at the Freshly Harvested, After-ripening and Newly Germinated Seed Stages: Insights into the Regulatory Networks of Seed Dormancy Release and Germination
- Identifying maintenance hosts for infection with Dichelobacter nodosus in free-ranging wild ruminants in Switzerland: A prevalence study
- Model order reduction for left ventricular mechanics via congruency training
- Production, purification and evaluation of biodegradation potential of PHB depolymerase of Stenotrophomonas sp. RZS7
- The impact of a wireless audio system on communication in robotic-assisted laparoscopic surgery: A prospective controlled trial
- Seroprevalence of viral and vector-borne bacterial pathogens in domestic dogs (Canis familiaris) in northern Botswana
- Musical expertise generalizes to superior temporal scaling in a Morse code tapping task
- Cross-cultural adaptation and psychometric evaluation of the Yoruba version of Oswestry disability index
- Post-transcriptional regulation of Rad51c by miR-222 contributes cellular transformation
- Can scientists fill the science journalism void? Online public engagement with science stories authored by scientists
- Retention and predictors of attrition among patients who started antiretroviral therapy in Zimbabwe’s national antiretroviral therapy programme between 2012 and 2015
- Prognostics for pain in osteoarthritis: Do clinical measures predict pain after total joint replacement?
- Effects of Transcranial Direct Current Stimulation on GABA and Glx in Children: A pilot study
- Evaluation of rice wild relatives as a source of traits for adaptation to iron toxicity and enhanced grain quality
- Brief communication: Long-term absence of Langerhans cells alters the gene expression profile of keratinocytes and dendritic epidermal T cells
- APOBEC3B reporter myeloma cell lines identify DNA damage response pathways leading to APOBEC3B expression
- Morphological diversity within a core collection of subterranean clover (Trifolium subterraneum L.): Lessons in pasture adaptation from the wild
- Feasibility of real-time in vivo 89Zr-DFO-labeled CAR T-cell trafficking using PET imaging
- Repository-based plasmid design
- A new method of recording from the giant fiber of Drosophila melanogaster shows that the strength of its auditory inputs remains constant with age
- Aberrant cervical innate immunity predicts onset of dysbiosis and sexually transmitted infections in women of reproductive age
- Safe mobility, socioeconomic inequalities, and aging: A 12-year multilevel interrupted time-series analysis of road traffic death rates in a Latin American country
- THAP11F80L cobalamin disorder-associated mutation reveals normal and pathogenic THAP11 functions in gene expression and cell proliferation
- Lesion of striatal patches disrupts habitual behaviors and increases behavioral variability
- A clinical method for estimating the modulus of elasticity of the human cornea in vivo
- Patient perceived value of teleophthalmology in an urban, low income US population with diabetes
- Evidence in support of chromosomal sex influencing plasma based metabolome vs APOE genotype influencing brain metabolome profile in humanized APOE male and female mice
- Accelerated sparsity based reconstruction of compressively sensed multichannel EEG signals
- Microvesicles from Lactobacillus reuteri (DSM-17938) completely reproduce modulation of gut motility by bacteria in mice
- Dense carbon-nanotube coating scaffolds stimulate osteogenic differentiation of mesenchymal stem cells
- Gamma Knife radiosurgery for vestibular schwannomas: Evaluation of planning using the sphericity degree of the target volume
- Purification and molecular characterization of phospholipase, antigen 5 and hyaluronidases from the venom of the Asian hornet (Vespa velutina)
- Why are animal source foods rarely consumed by 6-23 months old children in rural communities of Northern Ethiopia? A qualitative study
- A study to better understand under-utilization of laboratory tests for antenatal care in Senegal
- Physicians’ perspectives regarding non-medical switching of prescription medications: Results of an internet e-survey
- Effectiveness of information technology–enabled ‘SMART Eating’ health promotion intervention: A cluster randomized controlled trial
- Cauda Equina Syndrome Core Outcome Set (CESCOS): An international patient and healthcare professional consensus for research studies
- A new species of Macrocypraea (Gastropoda, Cypraeidae) from Trindade Island, Brazil, including phenotypic differentiation from remaining congeneric species
- Long term conjugated linoleic acid supplementation modestly improved growth performance but induced testicular tissue apoptosis and reduced sperm quality in male rabbit
- A new approach to the temporal significance of house orientations in European Early Neolithic settlements
- Persistence of chikungunya ECSA genotype and local outbreak in an upper medium class neighborhood in Northeast Brazil
- In vivo elongation of thin filaments results in heart failure
- Disparity in depressive symptoms between heterosexual and sexual minority men in China: The role of social support
- Effect of classroom intervention on student food selection and plate waste: Evidence from a randomized control trial
- Mating strategy is determinant of adenovirus prevalence in European bats
- Preventing HIV and HSV-2 through knowledge and attitudes: A replication study of a multi-component community-based intervention in Zimbabwe
- Randomized clinical trial analyzing maintenance of peripheral venous catheters in an internal medicine unit: Heparin vs. saline
- Patient-related factors may influence nursing perception of sleep in the Intensive Care Unit
- A randomized trial of a behavioral intervention to decrease hospital length of stay by decreasing bedrest
- Color image segmentation using adaptive hierarchical-histogram thresholding
- The role of demographic history and selection in shaping genetic diversity of the Galápagos penguin (Spheniscus mendiculus)
- Attitudes towards animal study registries and their characteristics: An online survey of three cohorts of animal researchers
- Risk perception and behavioral change during epidemics: Comparing models of individual and collective learning
- Risk factors for third-generation cephalosporin resistant Enterobacteriaceae in gestational urine cultures: A retrospective cohort study based on centralized electronic health records
- Residential neighbourhood greenspace is associated with reduced risk of cardiovascular disease: A prospective cohort study
- Potential socioeconomic impacts from ocean acidification and climate change effects on Atlantic Canadian fisheries
- Prevention and control of cholera with household and community water, sanitation and hygiene (WASH) interventions: A scoping review of current international guidelines
- Female finches prefer courtship signals indicating male vigor and neuromuscular ability
- The effect of spatial position and age within an egg-clutch on embryonic development and key metabolic enzymes in two clownfish species, Amphiprion ocellaris and Amphiprion frenatus
- The impact of translated reminder letters and phone calls on mammography screening booking rates: Two randomised controlled trials
- Application of a genetic algorithm to the keyboard layout problem
- Design and evaluation of a laboratory-based wheelchair castor testing protocol using community data
- Relationship between diabetic macular edema and choroidal layer thickness
- Evaluation of the predictive ability of ultrasound-based assessment of breast cancer using BI-RADS natural language reporting against commercial transcriptome-based tests
- A Comprehensive Data Gathering Network Architecture in Large-Scale Visual Sensor Networks
- Recovery of health-related quality of life after burn injuries: An individual participant data meta-analysis
- Modeling aggressive market order placements with Hawkes factor models
- Role of ecology in shaping external nasal morphology in bats and implications for olfactory tracking
- High expression of olfactomedin-4 is correlated with chemoresistance and poor prognosis in pancreatic cancer
- Development and validation of a prognostic model predicting symptomatic hemorrhagic transformation in acute ischemic stroke at scale in the OHDSI network
- Complex patterns of cell growth in the placenta in normal pregnancy and as adaptations to maternal diet restriction
- Tofu intake is inversely associated with risk of breast cancer: A meta-analysis of observational studies
- Influence of light on the infection of Aureococcus anophagefferens CCMP 1984 by a “giant virus”
- Temporal ordering of input modulates connectivity formation in a developmental neuronal network model of the cortex
- Healthy lifestyle index and its association with hypertension among community adults in Sri Lanka: A cross-sectional study
- From organ to cell: Multi-level telomere length assessment in patients with idiopathic pulmonary fibrosis
- How do critical care staff respond to organisational challenge? A qualitative exploration into personality types and cognitive processing in critical care
- Effects of supplemental creatine and guanidinoacetic acid on spatial memory and the brain of weaned Yucatan miniature pigs
- Community-Based Health Planning and Services Plus programme in Ghana: A qualitative study with stakeholders in two Systems Learning Districts on improving the implementation of primary health care
- An investigation of transportation practices in an Ontario swine system using descriptive network analysis
- Comparison of gridded precipitation datasets for rainfall-runoff and inundation modeling in the Mekong River Basin
- Functional interactions in patients with hemianopia: A graph theory-based connectivity study of resting fMRI signal
- The effects of dual-task cognitive interference on gait and turning in Huntington’s disease
- Effects of Allium hookeri on gut microbiome related to growth performance in young broiler chickens
- Novel imaging biomarkers for mapping the impact of mild mitochondrial uncoupling in the outer retina in vivo
- Hyperkalemia treatment modalities: A descriptive observational study focused on medication and healthcare resource utilization
- Long term impact of PositiveLinks: Clinic-deployed mobile technology to improve engagement with HIV care
- Comparison of post-transplantation diabetes mellitus incidence and risk factors between kidney and liver transplantation patients
- A definition-by-example approach and visual language for activity patterns in engineering disciplines
- A network analysis revealed the essential and common downstream proteins related to inguinal hernia
- Use of conventional cardiac troponin assay for diagnosis of non-ST-elevation myocardial infarction: ‘The Ottawa Troponin Pathway’
- Identification and characterization of miRNAs involved in cold acclimation of zebrafish ZF4 cells
- Research on motion planning for an indoor spray arm based on an improved potential field method
- Detailed analysis of the transverse arch of hallux valgus feet with and without pain using weightbearing ultrasound imaging and precise force sensors
- Surrogate R-spondins for tissue-specific potentiation of Wnt Signaling
- Apolipoprotein-AI mimetic peptides D-4F and L-5F decrease hepatic inflammation and increase insulin sensitivity in C57BL/6 mice
- Treating patients with driving phobia by virtual reality exposure therapy – a pilot study
- Efficient processing of raster and vector data
- Therapeutic hypothermia after out of hospital cardiac arrest improve 1-year survival rate for selective patients
- Carotid plaques and neurological impairment in patients with acute cerebral infarction
- Deep learning based image reconstruction algorithm for limited-angle translational computed tomography
- Association between coffee drinking and telomere length in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial
- Hyperbaric oxygen preconditioning and the role of NADPH oxidase inhibition in postischemic acute kidney injury induced in spontaneously hypertensive rats
- Rad51 paralogs and the risk of unselected breast cancer: A case-control study
- Diagnostic differences in respiratory breathing patterns and work of breathing indices in children with Duchenne muscular dystrophy
- The role of narrative in collaborative reasoning and intelligence analysis: A case study
- Proportions of CD4 test results indicating advanced HIV disease remain consistently high at primary health care facilities across four high HIV burden countries
- Modelling of amino acid turnover in the horse during training and racing: A basis for developing a novel supplementation strategy
- Single-modal and multi-modal false arrhythmia alarm reduction using attention-based convolutional and recurrent neural networks
- Eye-gaze information input based on pupillary response to visual stimulus with luminance modulation
- Trends of litter decomposition and soil organic matter stocks across forested swamp environments of the southeastern US
- Post mortem evaluation of inflammation, oxidative stress, and PPARγ activation in a nonhuman primate model of cardiac sympathetic neurodegeneration
- Were ancient foxes far more carnivorous than recent ones?—Carnassial morphological evidence
- Disruption in daily eating-fasting and activity-rest cycles in Indian adolescents attending school
- Plasma proteome profiling of freshwater and seawater life stages of rainbow trout (Oncorhynchus mykiss)
- Percent amplitude of fluctuation: A simple measure for resting-state fMRI signal at single voxel level
- Antimicrobial activity of Asteraceae species against bacterial pathogens isolated from postmenopausal women
- Are changes in depressive symptoms, general health and residential area socio-economic status associated with trajectories of waist circumference and body mass index?
- Extracellular vesicles of U937 macrophage cell line infected with DENV-2 induce activation in endothelial cells EA.hy926
- Link-centric analysis of variation by demographics in mobile phone communication patterns
- Tobacco smoking and health-related quality of life among university students: Mediating effect of depression
- The Shapley value for a fair division of group discounts for coordinating cooling loads
- Incidence of hospital-acquired pressure ulcers in patients with "minimal risk" according to the "Norton-MI" scale
- Lipoprotein(a) plasma levels are not associated with survival after acute coronary syndromes: An observational cohort study
- Use of Nanotrap particles for the capture and enrichment of Zika, chikungunya and dengue viruses in urine
- Pancreatic secretory trypsin inhibitor reduces multi-organ injury caused by gut ischemia/reperfusion in mice
- Biochemical characterization of Ty1 retrotransposon protease
- Lateral pressure equalisation as a principle for designing support surfaces to prevent deep tissue pressure ulcers
- The validation of the Beijing version of the Montreal Cognitive Assessment in Chinese patients undergoing hemodialysis
- Inflammasome expression is higher in ovarian tumors than in normal ovary
- HCV genotype profile in Brazil of mono-infected and HIV co-infected individuals: A survey representative of an entire country
- Engaging with change: Information and communication technology professionals’ perspectives on change at the mid-point in the UK/EU Brexit process
- Adherence to iron-folic acid supplement and associated factors among antenatal care attending pregnant mothers in governmental health institutions of Adwa town, Tigray, Ethiopia: Cross-sectional study
- Flower, seed, and fruit development in three Tunisian species of Polygonum: Implications for their taxonomy and evolution of distyly in Polygonaceae
- Development of a risk score for prediction of poor treatment outcomes among patients with multidrug-resistant tuberculosis
- Preclinical evaluation of AT-527, a novel guanosine nucleotide prodrug with potent, pan-genotypic activity against hepatitis C virus
- Aqueous extract from Mangifera indica Linn. (Anacardiaceae) leaves exerts long-term hypoglycemic effect, increases insulin sensitivity and plasma insulin levels on diabetic Wistar rats
- Discovery of Jogalong virus, a novel hepacivirus identified in a Culex annulirostris (Skuse) mosquito from the Kimberley region of Western Australia
- Clinical, cytogenetic and molecular genetic characterization of a tandem fusion translocation in a male Holstein cattle with congenital hypospadias and a ventricular septal defect
- Detection of Torque Teno Virus (TTV) and TTV-Like Minivirus in patients with presumed infectious endophthalmitis in India
- CD4 rate of increase is preferred to CD4 threshold for predicting outcomes among virologically suppressed HIV-infected adults on antiretroviral therapy
- Estimating the basic reproduction number of a pathogen in a single host when only a single founder successfully infects
- What drugs modify the risk of iatrogenic impulse-control disorders in Parkinson’s disease? A preliminary pharmacoepidemiologic study
- Evaluating emotional distress and health-related quality of life in patients with heart failure and their family caregivers: Testing dyadic dynamics using the Actor-Partner Interdependence Model
- Community- and trophic-level responses of soil nematodes to removal of a non-native tree at different stages of invasion
- Association of ECG parameters with late gadolinium enhancement and outcome in patients with clinical suspicion of acute or subacute myocarditis referred for CMR imaging
- Catchment-scale export of antibiotic resistance genes and bacteria from an agricultural watershed in central Iowa
- Impact of multi-drug resistant bacteria on economic and clinical outcomes of healthcare-associated infections in adults: Systematic review and meta-analysis
- Characterization of a universal screening approach for congenital CMV infection based on a highly-sensitive, quantitative, multiplex real-time PCR assay
- Proof-of-concept for a non-invasive, portable, and wireless device for cardiovascular monitoring in pediatric patients
- On PTV definition for glioblastoma based on fiber tracking of diffusion tensor imaging data
- Genes associated with body weight gain and feed intake identified by meta-analysis of the mesenteric fat from crossbred beef steers
- Intraoperative computed tomography imaging for dose calculation in intraoperative electron radiation therapy: Initial clinical observations
- Human lung epithelial BEAS-2B cells exhibit characteristics of mesenchymal stem cells
- Simple non-mydriatic retinal photography is feasible and demonstrates retinal microvascular dilation in Chronic Obstructive Pulmonary Disease (COPD)
- Maternal depressive symptoms and children’s cognitive development: Does early childcare and child’s sex matter?
- Evaluation of a bioengineered ACL matrix’s osteointegration with BMP-2 supplementation
- Psychosocial profiles of physical activity fluctuation in office employees: A latent profile analysis
- Prevalence and characteristics of Livestock-Associated Methicillin-Resistant Staphylococcus aureus (LA-MRSA) isolated from chicken meat in the province of Quebec, Canada
- Soluble AXL as a marker of disease progression and survival in melanoma
- Using machine learning methods to determine a typology of patients with HIV-HCV infection to be treated with antivirals
- Gender differences influence over insomnia in Korean population: A cross-sectional study
- Impact of scion/rootstock reciprocal effects on metabolomics of fruit juice and phloem sap in grafted Citrus reticulata
- Adapting cognitive diagnosis computerized adaptive testing item selection rules to traditional item response theory
- Autumn shifts in cold tolerance metabolites in overwintering adult mountain pine beetles
- Umbilical cord separation time, predictors and healing complications in newborns with dry care
- Analysis of attitudinal components towards statistics among students from different academic degrees
- Effects of fatigue induced by repeated-sprint on kicking accuracy and velocity in female soccer players
- A pre-clinical validation plan to evaluate analytical sensitivities of molecular diagnostics such as BD MAX MDR-TB, Xpert MTB/Rif Ultra and FluoroType MTB
- Leadership for success in transforming medical abortion policy in Canada
- Clinical correlates associated with the long-term response of bipolar disorder patients to lithium, valproate or lamotrigine: A retrospective study
- Forecasting stock prices with long-short term memory neural network based on attention mechanism
- On the genus Crossaster (Echinodermata: Asteroidea) and its distribution
- Intracellular and in vivo evaluation of imidazo[2,1-b]thiazole-5-carboxamide anti-tuberculosis compounds
- An integrated vitamin E-coated polymer hybrid nanoplatform: A lucrative option for an enhanced in vitro macrophage retention for an anti-hepatitis B therapeutic prospect
- The effect of strontium and silicon substituted hydroxyapatite electrochemical coatings on bone ingrowth and osseointegration of selective laser sintered porous metal implants
- Molecular prevalence of Bartonella, Babesia, and hemotropic Mycoplasma species in dogs with hemangiosarcoma from across the United States
- Color discrimination and gas chromatography-mass spectrometry fingerprint based on chemometrics analysis for the quality evaluation of Schizonepetae Spica
- Comparisons of recurrence-free survival and overall survival between microwave versus radiofrequency ablation treatment for hepatocellular carcinoma: A multiple centers retrospective cohort study with propensity score matching
- Oral misoprostol, low dose vaginal misoprostol, and vaginal dinoprostone for labor induction: Randomized controlled trial
- The association between dietary patterns before and in early pregnancy and the risk of gestational diabetes mellitus (GDM): Data from the Malaysian SECOST cohort
- Dynamic Extreme Aneuploidy (DEA) in the vegetable pathogen Phytophthora capsici and the potential for rapid asexual evolution
- Assertive, trainable and older dogs are perceived as more dominant in multi-dog households
- Prediction of Uropathogens by Flow Cytometry and Dip-stick Test Results of Urine Through Multivariable Logistic Regression Analysis
- Interleukin 6 is increased in preclinical HNSCC models of acquired cetuximab resistance, but is not required for maintenance of resistance
- Impact of viral disease hypophagia on pig jejunal function and integrity
- Molecular evidence for horizontal transmission of chelonid alphaherpesvirus 5 at green turtle (Chelonia mydas) foraging grounds in Queensland, Australia
- Evaluation and validation of 2D biomechanical models of the knee for radiograph-based preoperative planning in total knee arthroplasty
- Soil-Transmitted Helminth infections reduction in Bhutan: A report of 29 years of deworming
- cagA gene EPIYA motif genetic characterization from Colombian Helicobacter pylori isolates: Standardization of a molecular test for rapid clinical laboratory detection
- Spectral characteristics of urine from patients with end-stage kidney disease analyzed using Raman Chemometric Urinalysis (Rametrix)
- Fast quantitative time lapse displacement imaging of endothelial cell invasion
- Two novel mutations in MSX1 causing oligodontia
- Dome-shaped macula in children and adolescents
- Targeted transcriptomic study of the implication of central metabolic pathways in mannosylerythritol lipids biosynthesis in Pseudozyma antarctica T-34
- Preliminary evidences of the presence of extracellular DNA single stranded forms in soil
- A comparison of quality of life between patients treated with different dialysis modalities in Taiwan
- Comparison of Monocyte Distribution Width (MDW) and Procalcitonin for early recognition of sepsis
- Morphological association between the muscles and bones in the craniofacial region
- Transcriptome analysis of Actinidia chinensis in response to Botryosphaeria dothidea infection
- Comparative study on skin protection activity of polyphenol-rich extract and polysaccharide-rich extract from Sargassum vachellianum
- Real-world data about emotional stress, disability and need for social care in a German IBD patient cohort
- The regenerative compatibility: A synergy between healthy ecosystems, environmental attitudes, and restorative experiences
- Antenatal depression and its association with adverse birth outcomes in low and middle-income countries: A systematic review and meta-analysis
- Perceptions of risk and influences of choice in pregnant women with obesity. An evidence synthesis of qualitative research
- The role of refugee and migrant migration status on medication adherence: Mediation through illness perceptions
- Sexual risk classes among youth experiencing homelessness: Relation to childhood adversities, current mental symptoms, substance use, and HIV testing
- Effects of CK2β subunit down-regulation on Akt signalling in HK-2 renal cells
- Novel broad-spectrum activity-based probes to profile malarial cysteine proteases
- Association between opioid analgesic therapy and initiation of buprenorphine management: An analysis of prescription drug monitoring program data
- Effect of a community-based approach of iron and folic acid supplementation on compliance by pregnant women in Kiambu County, Kenya: A quasi-experimental study
- Improvement project in higher education institutions: A BPEP-based model
- An updated evaluation of serum sHER2, CA15.3, and CEA levels as biomarkers for the response of patients with metastatic breast cancer to trastuzumab-based therapies
- Genome-wide association study of metabolic syndrome in Korean populations
- Drug therapy problems and treatment satisfaction among ambulatory patients with epilepsy in a specialized hospital in Ethiopia
- Plasma kynurenines and prognosis in patients with heart failure
- Occurrence and distribution of anthropogenic persistent organic pollutants in coastal sediments and mud shrimps from the wetland of central Taiwan
- Intensified visual clutter induces increased sympathetic signalling, poorer postural control, and faster torsional eye movements during visual rotation
- Gut microbiota composition alterations are associated with the onset of diabetes in kidney transplant recipients
- Shock index and TIMI risk index as valuable prognostic tools in patients with acute coronary syndrome complicated by cardiogenic shock
- Merit overrules theory of mind when young children share resources with others
- Metabolic analysis of amino acids and vitamin B6 pathways in lymphoma survivors with cancer related chronic fatigue
- Immunopathogenesis of canine chronic ulcerative stomatitis
- Generalizing findings from a randomized controlled trial to a real-world study of the iLookOut, an online education program to improve early childhood care and education providers’ knowledge and attitudes about reporting child maltreatment
- When and what to test for: A cost-effectiveness analysis of febrile illness test-and-treat strategies in the era of responsible antibiotic use
- Comparison of effects and safety in providing controlled hypotension during surgery between dexmedetomidine and magnesium sulphate: A meta-analysis of randomized controlled trials
- The gene encoding the ketogenic enzyme HMGCS2 displays a unique expression during gonad development in mice
- Efficacy of a mitochondrion-targeting agent for reducing the level of urinary protein in rats with puromycin aminonucleoside-induced minimal-change nephrotic syndrome
- Association of endothelial nitric oxide synthase (NOS3) gene polymorphisms with primary open-angle glaucoma in a Saudi cohort
- Antitrust analysis with upward pricing pressure and cost efficiencies
- Natural selection contributes to food web stability
- Pyramiding QTLs controlling tolerance against drought, salinity, and submergence in rice through marker assisted breeding
- Diversity and plant growth-promoting functions of diazotrophic/N-scavenging bacteria isolated from the soils and rhizospheres of two species of Solanum
- Sofosbuvir-based regimen for genotype 2 HCV infected patients in Taiwan: A real world experience
- The virulence domain of Shigella IcsA contains a subregion with specific host cell adhesion function
- Sequencing artifacts derived from a library preparation method using enzymatic fragmentation
- Quantitative analysis of adsorption and desorption of volatile organic compounds on reusable zeolite filters using gas chromatography
- Quo vadis Pantanal? Expected precipitation extremes and drought dynamics from changing sea surface temperature
- Cloud-computing and machine learning in support of country-level land cover and ecosystem extent mapping in Liberia and Gabon
- The Brief Measure of Emotional Preoperative Stress (B-MEPS) as a new predictive tool for postoperative pain: A prospective observational cohort study
- The impact of diabetes mellitus medication on the incidence of endogenous endophthalmitis
- Correction: Chl1 DNA helicase and Scc2 function in chromosome condensation through cohesin deposition
- Clinical and pathological features of thrombotic microangiopathy influencing long-term kidney transplant outcomes
- Occupational exposure to particulate matter from air pollution in the outdoor workplaces in Almaty during the cold season
- Morphological adjustment in free-living Steinernema feltiae infective juveniles to increasing concentration of Nemafric-BL phytonematicide
- Key necroptotic proteins are required for Smac mimetic-mediated sensitization of cholangiocarcinoma cells to TNF-α and chemotherapeutic gemcitabine-induced necroptosis
- Concurrent lipidomics and proteomics on malignant plasma cells from multiple myeloma patients: Probing the lipid metabolome
- Retraction: SDR9C7 Promotes Lymph Node Metastases in Patients with Esophageal Squamous Cell Carcinoma
- Association between tuberculosis and depression on negative outcomes of tuberculosis treatment: A systematic review and meta-analysis
- Bioluminescent imaging of Arabidopsis thaliana using an enhanced Nano-lantern luminescence reporter system
- Biosynthetic pathway of indole-3-acetic acid in ectomycorrhizal fungi collected from northern Thailand
- Sex-specific and opposite modulatory aspects revealed by PPI network and pathway analysis of ischemic stroke in humans
- Control of the microsporidian parasite Nosema ceranae in honey bees (Apis mellifera) using nutraceutical and immuno-stimulatory compounds
- Role of donor genotype in RT-QuIC seeding activity of chronic wasting disease prions using human and bank vole substrates
- Oral magnesium supplementation for leg cramps in pregnancy—An observational controlled trial
- Health care professionals’ knowledge of commonly used sedative, analgesic and neuromuscular drugs: A single center (Rambam Health Care Campus), prospective, observational survey
- Campylobacter portucalensis sp. nov., a new species of Campylobacter isolated from the preputial mucosa of bulls
- Transgenic interleukin 11 expression causes cross-tissue fibro-inflammation and an inflammatory bowel phenotype in mice
- Sleep quality and sex modify the relationships between trait energy and fatigue on state energy and fatigue
- The role of peer, parental, and school norms in predicting adolescents’ attitudes and behaviours of majority and different minority ethnic groups in Croatia
- Availability, prices and affordability of selected antibiotics and medicines against non-communicable diseases in western Cameroon and northeast DR Congo
- The effect of mutations derived from mouse-adapted H3N2 seasonal influenza A virus to pathogenicity and host adaptation
- Detection of posttraumatic pneumothorax using electrical impedance tomography—An observer-blinded study in pigs with blunt chest trauma
- Educators’ perceptions of organisational readiness for implementation of a pre-adolescent transdisciplinary school health intervention for inter-generational outcomes
- Beyond the heterodimer model for mineralocorticoid and glucocorticoid receptor interactions in nuclei and at DNA
- The effects of sport expertise and shot results on basketball players’ action anticipation
- Framework and algorithms for identifying honest blocks in blockchain
- Exploring the impact of terminology differences in blood and organ donor decision making
- Platelet indices significantly correlate with liver fibrosis in HCV-infected patients
- The nitrate content of fresh and cooked vegetables and their health-related risks
- Bioreactor for mobilization of mesenchymal stem/stromal cells into scaffolds under mechanical stimulation: Preliminary results
- Non-gradient and genotype-dependent patterns of RSV gene expression
- Multiplex real-time PCR for the detection of Clavibacter michiganensis subsp. michiganensis, Pseudomonas syringae pv. tomato and pathogenic Xanthomonas species on tomato plants
- The 24-hour urinary cortisol in post-traumatic stress disorder: A meta-analysis
- Drug-eluting versus bare-metal stents for first myocardial infarction in patients with atrial fibrillation: A nationwide population-based cohort study
- Health-related quality of life among patients with type 2 diabetes mellitus in Eastern Province, Saudi Arabia: A cross-sectional study
- “I like the way I am, but I feel like I could get a little bit bigger”: Perceptions of body image among adolescents and youth living with HIV in Durban, South Africa
- Nanoparticle-based ‘turn-on’ scattering and post-sample fluorescence for ultrasensitive detection of water pollution in wider window
- Insights into the strategy of micro-environmental adaptation: Transcriptomic analysis of two alvinocaridid shrimps at a hydrothermal vent
- Thirty-day readmission after medical-surgical hospitalization for people who experience imprisonment in Ontario, Canada: A retrospective cohort study
- Hyper-spectral response and estimation model of soil degradation in Kenli County, the Yellow River Delta
- The association of telomere length and telomerase activity with adverse outcomes in older patients with non-ST-elevation acute coronary syndrome
- Construction of a high-density genetic map and fine mapping of a candidate gene locus for a novel branched-spike mutant in barley
- Alterations of aqueous humor Aβ levels in Aβ-infused and transgenic mouse models of Alzheimer disease
- Natural hybridization between Phyllagathis and Sporoxeia species produces a hybrid without reproductive organs
- The impact of peer attachment on prosocial behavior, emotional difficulties and conduct problems in adolescence: The mediating role of empathy
- Diagnostic performance of serum interferon gamma, matrix metalloproteinases, and periostin measurements for pulmonary tuberculosis in Japanese patients with pneumonia
- Characterization of black patina from the Tiber River embankments using Next-Generation Sequencing
- Problem gambling, associations with comorbid health conditions, substance use, and behavioural addictions: Opportunities for pathways to treatment
- Nanosheet wrapping-assisted coverslip-free imaging for looking deeper into a tissue at high resolution
- Validity of cerebrovascular ICD-9-CM codes in healthcare administrative databases. The Umbria Data-Value Project
- Torque teno virus viral load is related to age, CMV infection and HLA type but not to Alzheimer's disease
- Associations of cigarette smoking and burden of thoracic aortic calcification in asymptomatic individuals: A dose-response relationship
- Transforming assessment of speech in children with cleft palate via online crowdsourcing
- Human-raptor conflict in rural settlements of Colombia
- Assessment of peritoneal microbial features and tumor marker levels as potential diagnostic tools for ovarian cancer
- Deficiency syndromes in top predators associated with large-scale changes in the Baltic Sea ecosystem
- Perceived relative social status and cognitive load influence acceptance of unfair offers in the Ultimatum Game
- Hepatitis B and C virus infection among HIV patients within the public and private healthcare systems in Chile: A cross-sectional serosurvey
- Retraction: Oncogenic Fibulin-5 Promotes Nasopharyngeal Carcinoma Cell Metastasis through the FLJ10540/AKT Pathway and Correlates with Poor Prognosis
- From seed to flour: Sowing sustainability in the use of cantaloupe melon residue (Cucumis melo L. var. reticulatus)
- Core Scientific Dataset Model: A lightweight and portable model and file format for multi-dimensional scientific data
- Accounting for measurement error to assess the effect of air pollution on omic signals
- Leucine zipper transcription factor-like 1 binds adaptor protein complex-1 and 2 and participates in trafficking of transferrin receptor 1
- Barriers for tuberculosis case finding in Southwest Ethiopia: A qualitative study
- Genetic predisposition to celiac disease in Kazakhstan: Potential impact on the clinical practice in Central Asia
- A lower psoas muscle volume was associated with a higher rate of recurrence in male clear cell renal cell carcinoma
- Two angles of overqualification-the deviant behavior and creative performance: The role of career and survival job
- Cost-utility analysis of de-escalating biological disease-modifying anti-rheumatic drugs in patients with rheumatoid arthritis
- Efficient estimation of stereo thresholds: What slope should be assumed for the psychometric function?
- Learning efficient haptic shape exploration with a rigid tactile sensor array
- Effects of dietary supplementation with a microalga (Schizochytrium sp.) on the hemato-immunological, and intestinal histological parameters and gut microbiota of Nile tilapia in net cages
- Regional versus local wind speed and direction at a narrow beach with a high and steep foredune
- Fragmented QRS complex in patients with systemic lupus erythematosus at the time of diagnosis and its relationship with disease activity
- Severe thiamine deficiency in eastern Baltic cod (Gadus morhua)
- Transfer entropy as a variable selection methodology of cryptocurrencies in the framework of a high dimensional predictive model
- Psychometric validation of Czech version of the Sport Motivation Scale
- Correction: Multiple innate antibacterial immune defense elements are correlated in diverse ungulate species
- Recognition of personality disorder and anxiety disorder comorbidity in patients treated for depression in secondary psychiatric care
- Correction: Strategies for achieving high sequencing accuracy for low diversity samples and avoiding sample bleeding using illumina platform
- PLOS One
- Archív čísel
- Aktuálne číslo
- Informácie o časopise
Najčítanejšie v tomto čísle- Psychometric validation of Czech version of the Sport Motivation Scale
- Comparison of Monocyte Distribution Width (MDW) and Procalcitonin for early recognition of sepsis
- Effects of supplemental creatine and guanidinoacetic acid on spatial memory and the brain of weaned Yucatan miniature pigs
- Alterations of aqueous humor Aβ levels in Aβ-infused and transgenic mouse models of Alzheimer disease
Prihlásenie#ADS_BOTTOM_SCRIPTS#Zabudnuté hesloZadajte e-mailovú adresu, s ktorou ste vytvárali účet. Budú Vám na ňu zasielané informácie k nastaveniu nového hesla.
- Časopisy