Improving accuracy for finite element modeling of endovascular coiling of intracranial aneurysm

English version

Autoři: Robert J. Damiano ^aff001; Vincent M. Tutino ^aff002; Saeb R. Lamooki ^aff001; Nikhil Paliwal ^aff001; Gary F. Dargush ^aff001; Jason M. Davies ^aff003; Adnan H. Siddiqui ^aff002; Hui Meng ^aff001
Působiště autorů: Department of Mechanical and Aerospace Engineering, University at Buffalo, State University of New York, Buffalo, New York, United States of America ^aff001; Canon Stroke & Vascular Research Center, University at Buffalo, State University of New York, Buffalo, New York, United States of America ^aff002; Department of Neurosurgery, University at Buffalo, State University of New York, Buffalo, New York, United States of America ^aff003; Department of Pathology and Anatomical Sciences, University at Buffalo, State University of New York, Buffalo, New York, United States of America ^aff004; Department of Biomedical Engineering, University at Buffalo, State University of New York, Buffalo, New York, United States of America ^aff005
Vyšlo v časopise: PLoS ONE 14(12)
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.pone.0226421

Souhrn

Background

Computer modeling of endovascular coiling intervention for intracranial aneurysm could enable a priori patient-specific treatment evaluation. To that end, we previously developed a finite element method (FEM) coiling technique, which incorporated simplified assumptions. To improve accuracy in capturing real-life coiling, we aimed to enhance the modeling strategies and experimentally test whether improvements lead to more accurate coiling simulations.

Methods

We previously modeled coils using a pre-shape based on mathematical curves and mechanical properties based on those of platinum wires. In the improved version, to better represent the physical properties of coils, we model coil pre-shapes based on how they are manufactured, and their mechanical properties based on their spring-like geometric structures. To enhance the deployment mechanics, we include coil advancement to the aneurysm in FEM simulations. To test if these new strategies produce more accurate coil deployments, we fabricated silicone phantoms of 2 patient-specific aneurysms in duplicate, deployed coils in each, and quantified coil distributions from intra-aneurysmal cross-sections using coil density (CD) and lacunarity (L). These deployments were simulated 9 times each using the original and improved techniques, and CD and L were calculated for cross-sections matching those in the experiments. To compare the 2 simulation techniques, Euclidean distances (d_Min, d_Max, and d_Avg) between experimental and simulation points in standardized CD-L space were evaluated. Univariate tests were performed to determine if these distances were significantly different between the 2 simulations.

Results

Coil deployments using the improved technique agreed better with experiments than the original technique. All d_Min, d_Max, and d_Avg values were smaller for the improved technique, and the average values across all simulations for the improved technique were significantly smaller than those from the original technique (d_Min: p = 0.014, d_Max: p = 0.013, d_Avg: p = 0.045).

Conclusion

Incorporating coil-specific physical properties and mechanics improves accuracy of FEM simulations of endovascular intracranial aneurysm coiling.

Klíčová slova:

Simulation and modeling – Arteries – Catheters – Aneurysms – Mechanical properties – Platinum – Finite element analysis – Physical properties

Zdroje

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