#PAGE_PARAMS# #ADS_HEAD_SCRIPTS# #MICRODATA#

Epidemiology of cardiovascular diseases related admissions in a referral hospital in the South West region of Cameroon: A cross-sectional study in sub-Saharan Africa


Autoři: Clovis Nkoke aff001;  Ahmadou Musa Jingi aff002;  Christelle Makoge aff003;  Denis Teuwafeu aff001;  Cyrille Nkouonlack aff001;  Anastase Dzudie aff002
Působiště autorů: Buea Regional Hospital, Buea, Cameroon aff001;  Clinical Research Education, Networking and Consultancy, Douala, Cameroon aff002;  Faculty of Medicine and Biomedical Sciences, University of Yaounde, Yaounde, Cameroon aff003;  Faculty of Health Sciences, University of Buea, Buea, Cameroon aff004;  Douala General Hospital, Douala, Cameroon aff005
Vyšlo v časopise: PLoS ONE 14(12)
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.pone.0226644

Souhrn

Background

Sub-Saharan Africa (SSA) is experiencing an epidemic of cardiovascular diseases (CVD) as a result of a rapid epidemiological transition. Little is known about the admission for CVD and outcome in rural and semi-urban settings in Cameroon in this era of epidemiological transition. The aim of this study was to determine the frequency and the pattern of CVD admissions in the South West region of Cameroon.

Methods

This retrospective descriptive study included all adult patients admitted for CVD in the medical unit of the Buea Regional Hospital between Jan 2016 and December 2017.

Results

Out of the 3140 patients admitted, 499(15.9%) had CVD. There were 304(60.9%) females. The mean age was 58.7±16.2 years. There was no age difference between men and women (59.7 years vs 58.1years, p = 0.29). The most commonly affected age group was those aged 50–59 years (22%). Heart failure (38.5%), stroke (33.3%) and uncontrolled hypertension (22.4%) were the most prevalent CVDs. The length of hospital stay ranged from 1 to 37 days with a median length of hospital stay of 7 days. In-hospital case fatality was 78(15.8%). Mortality was higher in women compared to men (9% vs 7%, p = 0.43). The case fatality for stroke was higher compared to case fatality for heart failure (21.7% vs 16.7%, p = 0.23).

Conclusion

CVDs are a common cause of hospital admission in this semi-urban setting, dominated by heart failure. Women were disproportionately affected and it was associated with high mortality. Prevention, early detection and management of risk factors for cardiovascular disease are imperative given the growing burden of CVD in SSA to reduce CVD morbidity and mortality.

Klíčová slova:

Hospitals – Africa – Hypertension – Epidemiology – Cardiovascular diseases – Heart failure – Cameroon – Cardiovascular disease epidemiology


Zdroje

1. World Health Organization Noncommunicable Diseases. [(accessed on 1 June 2018)]; Available online: http://www.who.int/news-room/fact-sheets/detail/noncommunicable-diseases

2. Fezeu L., Minkoulou E., Balkau B., Kengne A.-P., Awah P., Unwin N., et al. Association between socioeconomic status and adiposity in urban Cameroon. Int. J. Epidemiol. 2005;35:105–111. doi: 10.1093/ije/dyi214 16258058

3. Mayosi B.M., Flisher A.J., Lalloo U.G., Sitas F., Tollman S.M., Bradshaw D. The burden of non-communicable diseases in South Africa. Lancet. 2009;374:934–947. doi: 10.1016/S0140-6736(09)61087-4 19709736

4. Hamid Suzan, Groot Wim & Pavlova Milena (2019) Trends in cardiovascular diseases and associated risks in sub-Saharan Africa: a review of the evidence for Ghana, Nigeria, South Africa, Sudan and Tanzania, The Aging Male, doi: 10.1080/13685538.2019.1582621 30879380

5. WHO. Global Health Estimates 2015: Death by Cause, Age, Sex, by Country and by Region, 2000–2015. Geneva, World Health Organization. 2016

6. Kariuki JK, Stuart-Shor EM, Leveille SG, et al. Methodological challenges in estimating trends and burden of cardiovascular disease in sub-Saharan Africa. Cardiol Res Pract. 2015;2015:921021. doi: 10.1155/2015/921021 26697260

7. Yach D, Hawkes C, Gould CL, Hofman KJ. The global burden of chronic diseases: overcoming impediments to prevention and control. JAMA. 2004 Jun 2; 291(21):2616–22 doi: 10.1001/jama.291.21.2616 15173153

8. Mathers CD, Loncar D. Projections of global mortality and burden of disease from 2002 to 2030.PLoS Med. 2006 Nov; 3(11):e442 doi: 10.1371/journal.pmed.0030442 17132052

9. Appiah LT, Sarfo FS, Agyemang C, et al. Current trends in admissions and outcomes of cardiac diseases in Ghana. Clin Cardiol. 2017;40:783–788. doi: 10.1002/clc.22753 28692760

10. Osuji CU, Onwubuya EI, Ahaneku GI, Omejua EG. Pattern of cardiovascular admissions at Nnamdi Azikiwe University Teaching Hospital Nnewi, South East Nigeria. Pan Afr Med J. 2014;17:116. doi: 10.11604/pamj.2014.17.116.1837 25120860

11. Pancha Mbouemboue Olivier Ngoufack Jacques Olivier, Koona Koona Adonis Maha Falmata, Kingue Samuel. Epidemiological aspects of cardiovascular diseases in Ngaoundéré Regional Hospital. Health Sci. Dis: Vol 16 (1) January–February—March 2015

12. Mocumbi AO. Lack of focus on cardiovascular disease in sub-Saharan Africa. Cardiovasc Diagn Ther. 2012;2:74–77. doi: 10.3978/j.issn.2223-3652.2012.01.03 24282699

13. Ukpabi OJ, Uwanurochi K. Comparing indications for cardiovascular admissions into a Nigerian and an Israeli Hospital. Ann Afr Med. 2017;16(2):70–73. doi: 10.4103/aam.aam_30_16 28469120

14. Lekoubou A, Nkoke C, Dzudie A, Kengne AP. Stroke admission and case-fatality in an urban medical unit in sub-Saharan Africa: a fourteen year trend study from 1999 to 2012. J Neurol Sci. 2015 Mar 15;350(1–2):24–32. doi: 10.1016/j.jns.2015.02.002 Epub 2015 Feb 7 25684340

15. Charles Ukachukwu Osuji Emmanuel Ikechukwu Onwubuya, Gladys Ifesinachi Ahaneku Emeka Godwin Omejua. Pattern of cardiovascular admissions at Nnamdi Azikiwe University Teaching Hospital Nnewi, South East Nigeria.The Pan African Medical Journal. 2014;17:116. doi: 10.11604/pamj.2014.17.116.183

16. Ansa VO, Ekott JU, Bassey EO. Profile and outcome of cardiovascular admissions at the University of Uyo Teaching Hospital, Uyo: a five year review. Niger J Clin Pract. 2008; 11(1):22–24. 18689134

17. Amendezo E, Twagirumukiza M, Sebantunzi O, Kagame A. Inhospital Cardiovascular morbidity and mortality in the department of internal Medicine at CHU Kigali (Rwanda). Ann Trop Med Public Health. 2008; 1(1): 9–14.

18. Fleg JL, Aronow WS, Frishman WH. Cardiovascular drug therapy in the elderly: benefits and challenges. Nat Rev Cardiol. 2011 Jan;8(1):13–28. doi: 10.1038/nrcardio.2010.162 20978470

19. Damasceno A, Mayosi BM, Sani M, Ogah OS, Mondo C, Ojji D. et al. The causes, treatment, and outcome of acute heart failure in 1006 africans from 9 countries. Arch Intern Med. 2012;172:1386–1394. doi: 10.1001/archinternmed.2012.3310 22945249

20. Mosca L, Benjamin EJ, Berra K, et al. Effectiveness-based guidelines for the prevention of cardiovascular disease in women– 2011 update: a guideline from the American Heart Association. Circulation 2011;123:1243–62. doi: 10.1161/CIR.0b013e31820faaf8 21325087

21. Kip KE, Marroquin OC, Kelley DE, et al. Clinical importance of obesity versus the metabolic syndrome in cardiovascular risk in women: a report from the Women’s Ischemia Syndrome Evaluation (WISE) study. Circulation 2004;109:706–13 doi: 10.1161/01.CIR.0000115514.44135.A8 14970104

22. Huxley R, Barzi F, Woodward M. Excess risk of fatal coronary heart disease associated with diabetes in men and women: meta-analysis of 37 prospective cohort studies. BMJ 2006;332:73–8. doi: 10.1136/bmj.38678.389583.7C 16371403

23. Okunola OO, Akintunde AA, Akinwusi PO. Some emerging issues in medical admission pattern in the tropics. J Dent Med Med Sci. 2011; 1(11): 005–008.

24. Damasceno A, Cotter G, Dzudie A, Sliwa K, Mayosi BM. Heart failure in sub‐saharan Africa: time for action. J Am Coll Cardiol 2007: 50: 1688–1693. doi: 10.1016/j.jacc.2007.07.030 17950152

25. Dzudie A, Djomou A, Ba H, Njume E, Ndom MS, Mfekeu LK, et al.; Cameroon Cardiac Society and MMM Cameroon Investigator Group. MMM17-Cameroon, analysis and opportunities-Sub-Saharan Africa. Eur Heart J Suppl. 2019 Apr;21(Suppl D):D31–D33. doi: 10.1093/eurheartj/suz081 Epub 2019 Apr 24 31043871

26. Nkoke C, Jingi AM, Aminde LN, Teuwafeu D, Nkouonlack C, Noubiap JJ, et al. Heart failure in a semi-urban setting in Cameroon: clinical characteristics, etiologies, treatment and outcome. J Xiangya Med 2019;4:11

27. Menanga A, Edie S, Nkoke C, et al. Factors associated with blood pressure control amongst adults with hypertension in Yaounde, Cameroon: a cross-sectional study. Cardiovasc Diagn Ther. 2016;6(5):439–445. doi: 10.21037/cdt.2016.04.03 27747167

28. Aminde LN, Takah N, Ngwasiri C, et al. Population awareness of cardiovascular disease and its risk factors in Buea, Cameroon. BMC Public Health. 2017;17(1)


Článok vyšiel v časopise

PLOS One


2019 Číslo 12
Najčítanejšie tento týždeň
Najčítanejšie v tomto čísle
Kurzy

Zvýšte si kvalifikáciu online z pohodlia domova

Aktuální možnosti diagnostiky a léčby litiáz
nový kurz
Autori: MUDr. Tomáš Ürge, PhD.

Všetky kurzy
Prihlásenie
Zabudnuté heslo

Zadajte e-mailovú adresu, s ktorou ste vytvárali účet. Budú Vám na ňu zasielané informácie k nastaveniu nového hesla.

Prihlásenie

Nemáte účet?  Registrujte sa

#ADS_BOTTOM_SCRIPTS#