#PAGE_PARAMS# #ADS_HEAD_SCRIPTS# #MICRODATA#
preLekára.sk / Odborné časopisy / PLOS One / 2019 - 12

Fragment-based design of small molecule PCSK9 inhibitors using simulated annealing of chemical potential simulations

English version

Autoři: Frank Guarnieri aff001;  John L. Kulp, Jr. aff003;  John L. Kulp, III aff003;  Ian S. Cloudsdale aff003
Působiště autorů: Center for Drug Discovery, Northeastern University, Boston, MA, United States of America aff001;  PAKA Pulmonary Pharmaceuticals, Acton, MA, United States of America aff002;  Conifer Point Pharmaceuticals, Doylestown, PA, United States of America aff003;  Department of Chemistry, Baruch S. Blumberg Institute, Doylestown, PA, United States of America aff004
Vyšlo v časopise: PLoS ONE 14(12)
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.pone.0225780

Souhrn

PCSK9 is a protein secreted by the liver that binds to the low-density lipoprotein receptor (LDLR), causing LDLR internalization, decreasing the clearance of circulating LDL particles. Mutations in PCSK9 that strengthen its interactions with LDLR result in familial hypercholesterolemia (FH) and early onset atherosclerosis, while nonsense mutations of PCSK9 result in cardio-protective hypocholesterolemia. These observations led to PCSK9 inhibition for cholesterol lowering becoming a high-interest therapeutic target, with antibody drugs reaching the market. An orally-available small molecule drug is highly desirable, but inhibiting the PCSK9/LDLR protein-protein interaction (PPI) has proven challenging. Alternate approaches to finding good lead candidates are needed. Motivated by the FH mutation data on PCSK9, we found that modeling the PCSK9/LDLR interface revealed extensive electron delocalization between and within the protein partners. Based on this, we hypothesized that compounds assembled from chemical fragments could achieve the affinity required to inhibit the PCSK9/LDLR PPI if they were selected to interact with PCSK9 in a way that, like LDLR, also involves significant fractional charge transfer to form partially covalent bonds. To identify such fragments, Simulated Annealing of Chemical Potential (SACP) fragment simulations were run on multiple PCSK9 structures, using optimized partial charges for the protein. We designed a small molecule, composed of several fragments, predicted to interact at two sites on the PCSK9. This compound inhibits the PPI with 1 μM affinity. Further, we designed two similar small molecules where one allows charge delocalization though a linker and the other doesn’t. The first inhibitor with charge delocalization enhances LDLR surface expression by 60% at 10 nM, two orders of magnitude more potent than the EGF domain of LDLR. The other enhances LDLR expression by only 50% at 1 μM. This supports our conjecture that fragments can have surprisingly outsized efficacy in breaking PPI’s by achieving fractional charge transfer leading to partially covalent bonding.

Klíčová slova:

Protein interactions – Drug discovery – Biochemical simulations – Hydrogen bonding – Salt bridges – Small molecules – Carbon – Familial hypercholesterolemia

Zdroje

1. Goldstein JL, Brown MS. Familial hypercholesterolemia: pathogenesis of a receptor disease. Johns Hopkins Med J. 1978;143(1):8–16. Epub 1978/07/01. 209238.

2. Innerarity TL, Weisgraber KH, Arnold KS, Mahley RW, Krauss RM, Vega GL, et al. Familial defective apolipoprotein B-100: low density lipoproteins with abnormal receptor binding. Proc Natl Acad Sci U S A. 1987;84(19):6919–23. Epub 1987/10/01. doi: 10.1073/pnas.84.19.6919 3477815; PubMed Central PMCID: PMC299196.

3. Abifadel M, Elbitar S, El Khoury P, Ghaleb Y, Chemaly M, Moussalli ML, et al. Living the PCSK9 adventure: from the identification of a new gene in familial hypercholesterolemia towards a potential new class of anticholesterol drugs. Curr Atheroscler Rep. 2014;16(9):439. Epub 2014/07/24. doi: 10.1007/s11883-014-0439-8 25052769

4. Ajufo E, Rader DJ. Recent advances in the pharmacological management of hypercholesterolaemia. Lancet Diabetes Endocrinol. 2016;4(5):436–46. Epub 2016/03/26. doi: 10.1016/S2213-8587(16)00074-7 [pii]. 27012540.

5. Bauer RC, Khetarpal SA, Hand NJ, Rader DJ. Therapeutic Targets of Triglyceride Metabolism as Informed by Human Genetics. Trends Mol Med. 2016;22(4):328–40. Epub 2016/03/19. doi: 10.1016/j.molmed.2016.02.005 [pii]. 26988439.

6. Besseling J, Sjouke B, Kastelein JJ. Screening and treatment of familial hypercholesterolemia—Lessons from the past and opportunities for the future (based on the Anitschkow Lecture 2014). Atherosclerosis. 2015;241(2):597–606. Epub 2015/06/27. doi: 10.1016/j.atherosclerosis.2015.06.011 [pii]. 26115072.

7. Brautbar A, Leary E, Rasmussen K, Wilson DP, Steiner RD, Virani S. Genetics of familial hypercholesterolemia. Curr Atheroscler Rep. 2015;17(4):491. Epub 2015/02/26. doi: 10.1007/s11883-015-0491-z 25712136.

8. Bruikman CS, Hovingh GK, Kastelein JJ. Molecular basis of familial hypercholesterolemia. Curr Opin Cardiol. 2017. Epub 2017/02/09. doi: 10.1097/HCO.0000000000000385 28169949.

9. Di Taranto MD, D'Agostino MN, Fortunato G. Functional characterization of mutant genes associated with autosomal dominant familial hypercholesterolemia: integration and evolution of genetic diagnosis. Nutr Metab Cardiovasc Dis. 2015;25(11):979–87. Epub 2015/07/15. doi: 10.1016/j.numecd.2015.06.007 [pii]. 26165249.

10. Dron JS, Hegele RA. Complexity of mechanisms among human proprotein convertase subtilisin-kexin type 9 variants. Curr Opin Lipidol. 2017. Epub 2017/02/06. doi: 10.1097/MOL.0000000000000386 28157721.

11. Gabcova-Balaziova D, Stanikova D, Vohnout B, Huckova M, Stanik J, Klimes I, et al. Molecular-genetic aspects of familial hypercholesterolemia. Endocr Regul. 2015;49(3):164–81. Epub 2015/08/05. doi: 10.4149/endo_2015_03_164 26238499.

12. Hartgers ML, Ray KK, Hovingh GK. New Approaches in Detection and Treatment of Familial Hypercholesterolemia. Curr Cardiol Rep. 2015;17(12):109. Epub 2015/10/21. doi: 10.1007/s11886-015-0665-x [pii]. 26482752; PubMed Central PMCID: PMC4611021.

13. Henderson R, O'Kane M, McGilligan V, Watterson S. The genetics and screening of familial hypercholesterolaemia. J Biomed Sci. 2016;23:39. Epub 2016/04/17. doi: 10.1186/s12929-016-0256-1 [pii]. 27084339; PubMed Central PMCID: PMC4833930.

14. Hewing B, Landmesser U. LDL, HDL, VLDL, and CVD Prevention: Lessons from Genetics? Curr Cardiol Rep. 2015;17(7):610. Epub 2015/06/03. doi: 10.1007/s11886-015-0610-z 26031673.

15. Orho-Melander M. Genetics of coronary heart disease: towards causal mechanisms, novel drug targets and more personalized prevention. J Intern Med. 2015;278(5):433–46. Epub 2015/10/20. doi: 10.1111/joim.12407 26477595.

16. Patni N, Ahmad Z, Wilson DP. Genetics and Dyslipidemia. 2000. Epub 2016/11/05. doi: NBK395584 [bookaccession]. 27809445.

17. Ramasamy I. Update on the molecular biology of dyslipidemias. Clin Chim Acta. 2016;454:143–85. Epub 2015/11/08. doi: 10.1016/j.cca.2015.10.033 [pii]. 26546829.

18. Santos RD, Gidding SS, Hegele RA, Cuchel MA, Barter PJ, Watts GF, et al. Defining severe familial hypercholesterolaemia and the implications for clinical management: a consensus statement from the International Atherosclerosis Society Severe Familial Hypercholesterolemia Panel. Lancet Diabetes Endocrinol. 2016;4(10):850–61. Epub 2016/06/02. doi: 10.1016/S2213-8587(16)30041-9 [pii]. 27246162.

19. Wang LR, Hegele RA. Genetics for the Identification of Lipid Targets Beyond PCSK9. Can J Cardiol. 2017;33(3):334–42. Epub 2017/01/23. doi: S0828-282X(16)31088-1 [pii] doi: 10.1016/j.cjca.2016.11.003 28109622.

20. Wiegman A, Gidding SS, Watts GF, Chapman MJ, Ginsberg HN, Cuchel M, et al. Familial hypercholesterolaemia in children and adolescents: gaining decades of life by optimizing detection and treatment. Eur Heart J. 2015;36(36):2425–37. Epub 2015/05/27. doi: 10.1093/eurheartj/ehv157 [pii]. 26009596; PubMed Central PMCID: PMC4576143.

21. Cohen J, Pertsemlidis A, Kotowski IK, Graham R, Garcia CK, Hobbs HH. Low LDL cholesterol in individuals of African descent resulting from frequent nonsense mutations in PCSK9. Nat Genet. 2005;37(2):161–5. Epub 2005/01/18. doi: ng1509 [pii] doi: 10.1038/ng1509 15654334.

22. Cohen JC, Boerwinkle E, Mosley TH Jr., Hobbs HH. Sequence variations in PCSK9, low LDL, and protection against coronary heart disease. N Engl J Med. 2006;354(12):1264–72. Epub 2006/03/24. doi: 354/12/1264 [pii] doi: 10.1056/NEJMoa054013 16554528.

23. Fasano T, Cefalu AB, Di Leo E, Noto D, Pollaccia D, Bocchi L, et al. A novel loss of function mutation of PCSK9 gene in white subjects with low-plasma low-density lipoprotein cholesterol. Arterioscler Thromb Vasc Biol. 2007;27(3):677–81. Epub 2006/12/16. doi: 01.ATV.0000255311.26383.2f [pii] doi: 10.1161/01.ATV.0000255311.26383.2f 17170371.

24. Hallman DM, Srinivasan SR, Chen W, Boerwinkle E, Berenson GS. Relation of PCSK9 mutations to serum low-density lipoprotein cholesterol in childhood and adulthood (from The Bogalusa Heart Study). Am J Cardiol. 2007;100(1):69–72. Epub 2007/06/30. doi: S0002-9149(07)00575-9 [pii] doi: 10.1016/j.amjcard.2007.02.057 17599443.

25. Hooper AJ, Marais AD, Tanyanyiwa DM, Burnett JR. The C679X mutation in PCSK9 is present and lowers blood cholesterol in a Southern African population. Atherosclerosis. 2007;193(2):445–8. Epub 2006/09/23. doi: S0021-9150(06)00522-3 [pii] doi: 10.1016/j.atherosclerosis.2006.08.039 16989838.

26. Kotowski IK, Pertsemlidis A, Luke A, Cooper RS, Vega GL, Cohen JC, et al. A spectrum of PCSK9 alleles contributes to plasma levels of low-density lipoprotein cholesterol. Am J Hum Genet. 2006;78(3):410–22. Epub 2006/02/09. doi: S0002-9297(07)62381-7 [pii] doi: 10.1086/500615 16465619; PubMed Central PMCID: PMC1380285.

27. Miyake Y, Kimura R, Kokubo Y, Okayama A, Tomoike H, Yamamura T, et al. Genetic variants in PCSK9 in the Japanese population: rare genetic variants in PCSK9 might collectively contribute to plasma LDL cholesterol levels in the general population. Atherosclerosis. 2008;196(1):29–36. Epub 2007/02/24. doi: S0021-9150(07)00051-2 [pii] doi: 10.1016/j.atherosclerosis.2006.12.035 17316651.

28. Blom DJ, Hala T, Bolognese M, Lillestol MJ, Toth PD, Burgess L, et al. A 52-week placebo-controlled trial of evolocumab in hyperlipidemia. N Engl J Med. 2014;370(19):1809–19. Epub 2014/04/01. doi: 10.1056/NEJMoa1316222 24678979.

29. Cock PJa, Antao T, Chang JT, Chapman Ba, Cox CJ, Dalke A, et al. Biopython: Freely available Python tools for computational molecular biology and bioinformatics. Bioinformatics. 2009;25(11):1422–3. doi: 10.1093/bioinformatics/btp163 19304878.

30. Dias CS, Shaywitz AJ, Wasserman SM, Smith BP, Gao B, Stolman DS, et al. Effects of AMG 145 on low-density lipoprotein cholesterol levels: results from 2 randomized, double-blind, placebo-controlled, ascending-dose phase 1 studies in healthy volunteers and hypercholesterolemic subjects on statins. J Am Coll Cardiol. 2012;60(19):1888–98. Epub 2012/10/23. doi: 10.1016/j.jacc.2012.08.986 [pii]. 23083772.

31. Raal FJ, Giugliano RP, Sabatine MS, Koren MJ, Langslet G, Bays H, et al. Reduction in lipoprotein(a) with PCSK9 monoclonal antibody evolocumab (AMG 145): a pooled analysis of more than 1,300 patients in 4 phase II trials. J Am Coll Cardiol. 2014;63(13):1278–88. Epub 2014/02/11. doi: 10.1016/j.jacc.2014.01.006 [pii]. 24509273.

32. Raal FJ, Stein EA, Dufour R, Turner T, Civeira F, Burgess L, et al. PCSK9 inhibition with evolocumab (AMG 145) in heterozygous familial hypercholesterolaemia (RUTHERFORD-2): a randomised, double-blind, placebo-controlled trial. Lancet. 2015;385(9965):331–40. Epub 2014/10/06. doi: 10.1016/S0140-6736(14)61399-4 [pii]. 25282519.

33. Stein EA, Honarpour N, Wasserman SM, Xu F, Scott R, Raal FJ. Effect of the proprotein convertase subtilisin/kexin 9 monoclonal antibody, AMG 145, in homozygous familial hypercholesterolemia. Circulation. 2013;128(19):2113–20. Epub 2013/09/10. doi: 10.1161/CIRCULATIONAHA.113.004678 [pii]. 24014831.

34. Stroes E, Colquhoun D, Sullivan D, Civeira F, Rosenson RS, Watts GF, et al. Anti-PCSK9 antibody effectively lowers cholesterol in patients with statin intolerance: the GAUSS-2 randomized, placebo-controlled phase 3 clinical trial of evolocumab. J Am Coll Cardiol. 2014;63(23):2541–8. Epub 2014/04/04. doi: 10.1016/j.jacc.2014.03.019 [pii]. 24694531.

35. Dufour R, Bergeron J, Gaudet D, Weiss R, Hovingh GK, Qing Z, et al. Open-label therapy with alirocumab in patients with heterozygous familial hypercholesterolemia: Results from three years of treatment. Int J Cardiol. 2017;228:754–60. Epub 2016/11/26. doi: S0167-5273(16)33493-3 [pii] doi: 10.1016/j.ijcard.2016.11.046 27886619.

36. Ginsberg HN, Rader DJ, Raal FJ, Guyton JR, Baccara-Dinet MT, Lorenzato C, et al. Efficacy and Safety of Alirocumab in Patients with Heterozygous Familial Hypercholesterolemia and LDL-C of 160 mg/dl or Higher. Cardiovasc Drugs Ther. 2016;30(5):473–83. Epub 2016/09/14. doi: 10.1007/s10557-016-6685-y [pii]. 27618825; PubMed Central PMCID: PMC5055560.

37. Kastelein JJ, Ginsberg HN, Langslet G, Hovingh GK, Ceska R, Dufour R, et al. ODYSSEY FH I and FH II: 78 week results with alirocumab treatment in 735 patients with heterozygous familial hypercholesterolaemia. Eur Heart J. 2015;36(43):2996–3003. Epub 2015/09/04. doi: 10.1093/eurheartj/ehv370 [pii]. 26330422; PubMed Central PMCID: PMC4644253.

38. Kereiakes DJ, Robinson JG, Cannon CP, Lorenzato C, Pordy R, Chaudhari U, et al. Efficacy and safety of the proprotein convertase subtilisin/kexin type 9 inhibitor alirocumab among high cardiovascular risk patients on maximally tolerated statin therapy: The ODYSSEY COMBO I study. Am Heart J. 2015;169(6):906–15 e13. Epub 2015/06/02. doi: 10.1016/j.ahj.2015.03.004 S0002-8703(15)00168-4 [pii]. 26027630.

39. Kuhnast S, van der Hoorn JW, Pieterman EJ, van den Hoek AM, Sasiela WJ, Gusarova V, et al. Alirocumab inhibits atherosclerosis, improves the plaque morphology, and enhances the effects of a statin. J Lipid Res. 2014;55(10):2103–12. Epub 2014/08/21. doi: 10.1194/jlr.M051326 [pii]. 25139399; PubMed Central PMCID: PMC4174003.

40. Robinson JG, Farnier M, Krempf M, Bergeron J, Luc G, Averna M, et al. Efficacy and safety of alirocumab in reducing lipids and cardiovascular events. N Engl J Med. 2015;372(16):1489–99. Epub 2015/03/17. doi: 10.1056/NEJMoa1501031 25773378.

41. Roth EM, Moriarty PM, Bergeron J, Langslet G, Manvelian G, Zhao J, et al. A phase III randomized trial evaluating alirocumab 300 mg every 4 weeks as monotherapy or add-on to statin: ODYSSEY CHOICE I. Atherosclerosis. 2016;254:254–62. Epub 2016/09/19. doi: S0021-9150(16)31311-9 [pii] doi: 10.1016/j.atherosclerosis.2016.08.043 27639753.

42. Roth EM, Taskinen MR, Ginsberg HN, Kastelein JJ, Colhoun HM, Robinson JG, et al. Monotherapy with the PCSK9 inhibitor alirocumab versus ezetimibe in patients with hypercholesterolemia: results of a 24 week, double-blind, randomized Phase 3 trial. Int J Cardiol. 2014;176(1):55–61. Epub 2014/07/20. doi: 10.1016/j.ijcard.2014.06.049 S0167-5273(14)01116-4 [pii]. 25037695.

43. Stroes E, Guyton JR, Lepor N, Civeira F, Gaudet D, Watts GF, et al. Efficacy and Safety of Alirocumab 150 mg Every 4 Weeks in Patients With Hypercholesterolemia Not on Statin Therapy: The ODYSSEY CHOICE II Study. J Am Heart Assoc. 2016;5(9). Epub 2016/09/15. doi: 10.1161/JAHA.116.003421e003421 [pii] JAHA.116.003421 [pii]. 27625344.

44. Taylor BA, Panza G, Pescatello LS, Chipkin S, Gipe D, Shao W, et al. Serum PCSK9 Levels Distinguish Individuals Who Do Not Respond to High-Dose Statin Therapy with the Expected Reduction in LDL-C. J Lipids. 2014;2014:140723. Epub 2014/08/20. doi: 10.1155/2014/140723 25136459; PubMed Central PMCID: PMC4127223.

45. Schmidt MW, Baldridge KK, Boatz JA, Elbert ST, Gordon MS, Jensen JH, et al. General atomic and molecular electronic structure system. Journal of Computational Chemistry. 1993;14(11):1347–63. doi: 10.1002/jcc.540141112

46. Leren TP. Sorting an LDL receptor with bound PCSK9 to intracellular degradation. Atherosclerosis. 2014;237(1):76–81. Epub 2014/09/16. doi: 10.1016/j.atherosclerosis.2014.08.038 [pii]. 25222343.

47. Tveten K, Holla OL, Cameron J, Strom TB, Berge KE, Laerdahl JK, et al. Interaction between the ligand-binding domain of the LDL receptor and the C-terminal domain of PCSK9 is required for PCSK9 to remain bound to the LDL receptor during endosomal acidification. Hum Mol Genet. 2012;21(6):1402–9. Epub 2011/12/14. doi: 10.1093/hmg/ddr578 [pii]. 22156580.

48. Guarnieri F, Mezei M. Simulated Annealing of Chemical Potential: A General Procedure for Locating Bound Waters. Application to the Study of the Differential Hydration Propensities of the Major and Minor Grooves of DNA. J Am Chem Soc. 1996;118(35):8493–94.

49. Guarnieri F. Computational Protein Probing to Identify Binding Sites. 2004;U.S. Patent 6735530.

50. Clark M, Guarnieri F, Shkurko I, Wiseman J. Grand canonical Monte Carlo simulation of ligand-protein binding. J Chem Inf Model. 2006;46(1):231–42. Epub 2006/01/24. doi: 10.1021/ci050268f 16426059.

51. Kulp JL 3rd, Cloudsdale IS, Kulp JL Jr., Guarnieri F. Hot-spot identification on a broad class of proteins and RNA suggest unifying principles of molecular recognition. PLoS One. 2017;12(8):e0183327. Epub 2017/08/25. doi: 10.1371/journal.pone.0183327 [pii]. 28837642; PubMed Central PMCID: PMC5570288.

52. Bradbury MW, Stump D, Guarnieri F, Berk PD. Molecular modeling and functional confirmation of a predicted fatty acid binding site of mitochondrial aspartate aminotransferase. J Mol Biol. 2011;412(3):412–22. Epub 2011/08/02. doi: S0022-2836(11)00799-6 [pii] doi: 10.1016/j.jmb.2011.07.034 21803047; PubMed Central PMCID: PMC3167029.

53. Kulp JL 3rd, Blumenthal SN, Wang Q, Bryan RL, Guarnieri F. A fragment-based approach to the SAMPL3 Challenge. J Comput Aided Mol Des. 2012;26(5):583–94. Epub 2012/02/01. doi: 10.1007/s10822-012-9546-1 22290624.

54. Kulp JL 3rd, Kulp JL Jr., Pompliano DL, Guarnieri F. Diverse fragment clustering and water exclusion identify protein hot spots. J Am Chem Soc. 2011;133(28):10740–3. Epub 2011/06/21. doi: 10.1021/ja203929x 21682273.

55. Vallee M, Vitiello S, Bellocchio L, Hebert-Chatelain E, Monlezun S, Martin-Garcia E, et al. Pregnenolone can protect the brain from cannabis intoxication. Science. 2014;343(6166):94–8. Epub 2014/01/05. doi: 10.1126/science.1243985 [pii]. 24385629; PubMed Central PMCID: PMC4057431.

56. Cloudsdale IS, Dickson JK Jr., Barta TE, Grella BS, Smith ED, Kulp JL 3rd, et al. Design, synthesis and biological evaluation of renin inhibitors guided by simulated annealing of chemical potential simulations. Bioorg Med Chem. 2017;25(15):3947–63. Epub 2017/06/12. doi: S0968-0896(17)30568-0 [pii] doi: 10.1016/j.bmc.2017.05.032 28601508; PubMed Central PMCID: PMC5553068.

57. Guarnieri F. Designing an Orally Available Nontoxic p38 Inhibitor with a Fragment-Based Strategy. Fragment-Based Methods in Drug Discovery; Klon Anthony, Editor. 2015;1289:211–26.

58. Guarnieri F. Designing a small molecule erythropoietin mimetic. Fragment-Based Methods in Drug Discovery; Klon Anthony, Editor. 2015;1289:185–210.

59. Guarnieri F. Analysis of the Asymmetry of Activated EPO Receptor Enables Designing Small Molecule Agonists. Vitam Horm. 2017;105:19–37. Epub 2017/06/21. doi: S0083-6729(17)30025-0 [pii] doi: 10.1016/bs.vh.2017.03.004 28629518.

60. Moffett K, Konteatis Z, Nguyen D, Shetty R, Ludington J, Fujimoto T, et al. Discovery of a novel class of non-ATP site DFG-out state p38 inhibitors utilizing computationally assisted virtual fragment-based drug design (vFBDD). Bioorg Med Chem Lett. 2011;21(23):7155–65. Epub 2011/10/22. doi: S0960-894X(11)01322-9 [pii] doi: 10.1016/j.bmcl.2011.09.078 22014550.

61. Kirkpatrick S, Gelatt CD Jr., Vecchi MP. Optimization by simulated annealing. Science. 1983;220(4598):671–80. Epub 1983/05/13. doi: 220/4598/671 [pii] doi: 10.1126/science.220.4598.671 17813860.

62. Chung F, Tisne C, Lecourt T, Seijo B, Dardel F, Micouin L. Design of tRNA(Lys)3 ligands: fragment evolution and linker selection guided by NMR spectroscopy. Chemistry. 2009;15(29):7109–16. Epub 2009/06/23. doi: 10.1002/chem.200802451 19544516.

63. Chung S, Parker JB, Bianchet M, Amzel LM, Stivers JT. Impact of linker strain and flexibility in the design of a fragment-based inhibitor. Nat Chem Biol. 2009;5(6):407–13. Epub 2009/04/28. doi: 10.1038/nchembio.163 [pii]. 19396178; PubMed Central PMCID: PMC3178264.

64. Jahnke W, Florsheimer A, Blommers MJ, Paris CG, Heim J, Nalin CM, et al. Second-site NMR screening and linker design. Curr Top Med Chem. 2003;3(1):69–80. Epub 2003/02/07. doi: 10.2174/1568026033392778 12570778.

65. Ranjan N, Kellish P, King A, Arya DP. Impact of Linker Length and Composition on Fragment Binding and Cell Permeation: Story of a Bisbenzimidazole Dye Fragment. Biochemistry. 2017;56(49):6434–47. Epub 2017/11/14. doi: 10.1021/acs.biochem.7b00929 29131946.

66. Zhou Y, Zhang N, Qi X, Tang S, Sun G, Zhao L, et al. Insights into the Impact of Linker Flexibility and Fragment Ionization on the Design of CK2 Allosteric Inhibitors: Comparative Molecular Dynamics Simulation Studies. Int J Mol Sci. 2018;19(1). Epub 2018/01/06. doi: E111 [pii] doi: 10.3390/ijms19010111 ijms19010111 [pii]. 29301250; PubMed Central PMCID: PMC5796060.

67. Boyer RD, Bryan RL. Fast estimation of solvation free energies for diverse chemical species. J Phys Chem B. 2012;116(12):3772–9. Epub 2012/02/22. doi: 10.1021/jp300440d 22339050

68. Bottomley MJ, Cirillo A, Orsatti L, Ruggeri L, Fisher TS, Santoro JC, et al. Structural and biochemical characterization of the wild type PCSK9-EGF(AB) complex and natural familial hypercholesterolemia mutants. J Biol Chem. 2009;284(2):1313–23. Epub 2008/11/13. doi: 10.1074/jbc.M808363200 [pii]. 19001363.

69. Golunski G, Borowik A, Derewonko N, Kawiak A, Rychlowski M, Woziwodzka A, et al. Pentoxifylline as a modulator of anticancer drug doxorubicin. Part II: Reduction of doxorubicin DNA binding and alleviation of its biological effects. Biochimie. 2016;123:95–102. Epub 2016/02/09. doi: 10.1016/j.biochi.2016.02.003 [pii]. 26855172.

70. Hartlieb KJ, Witus LS, Ferris DP, Basuray AN, Algaradah MM, Sarjeant AA, et al. Anticancer activity expressed by a library of 2,9-diazaperopyrenium dications. ACS Nano. 2015;9(2):1461–70. Epub 2015/01/03. doi: 10.1021/nn505895j 25555133; PubMed Central PMCID: PMC4344210.

71. Stornaiuolo M, De Kloe GE, Rucktooa P, Fish A, van Elk R, Edink ES, et al. Assembly of a pi-pi stack of ligands in the binding site of an acetylcholine-binding protein. Nat Commun. 2013;4:1875. Epub 2013/05/23. doi: 10.1038/ncomms2900 [pii]. 23695669; PubMed Central PMCID: PMC3674282.

72. Hahn L, Lubtow MM, Lorson T, Schmitt F, Appelt-Menzel A, Schobert R, et al. Investigating the Influence of Aromatic Moieties on the Formulation of Hydrophobic Natural Products and Drugs in Poly(2-oxazoline)-Based Amphiphiles. Biomacromolecules. 2018. Epub 2018/05/11. doi: 10.1021/acs.biomac.8b00708 29746117.

73. Li S, Zhou S, Li Y, Li X, Zhu J, Fan L, et al. Exceptionally High Payload of the IR780 Iodide on Folic Acid-Functionalized Graphene Quantum Dots for Targeted Photothermal Therapy. ACS Appl Mater Interfaces. 2017;9(27):22332–41. Epub 2017/06/24. doi: 10.1021/acsami.7b07267 28643511.

74. Yang X, Xue X, Luo Y, Lin TY, Zhang H, Lac D, et al. Sub-100nm, long tumor retention SN-38-loaded photonic micelles for tri-modal cancer therapy. J Control Release. 2017;261:297–306. Epub 2017/07/13. doi: S0168-3659(17)30722-8 [pii] doi: 10.1016/j.jconrel.2017.07.014 28700898; PubMed Central PMCID: PMC5589441.

75. Zhu S, Gao H, Babu S, Garad S. Co-Amorphous Formation of High-Dose Zwitterionic Compounds with Amino Acids To Improve Solubility and Enable Parenteral Delivery. Mol Pharm. 2018;15(1):97–107. Epub 2017/11/23. doi: 10.1021/acs.molpharmaceut.7b00738 29164901.

76. Taechalertpaisarn J, Zhao B, Liang X, Burgess K. Small Molecule Inhibitors of the PCSK9.LDLR Interaction. J Am Chem Soc. 2018;140(9):3242–9. Epub 2018/01/31. doi: 10.1021/jacs.7b09360 29378408; PubMed Central PMCID: PMC6404525.

77. Ni YG, Condra JH, Orsatti L, Shen X, Di Marco S, Pandit S, et al. A proprotein convertase subtilisin-like/kexin type 9 (PCSK9) C-terminal domain antibody antigen-binding fragment inhibits PCSK9 internalization and restores low density lipoprotein uptake. J Biol Chem. 2010;285(17):12882–91. Epub 2010/02/23. doi: 10.1074/jbc.M110.113035 [pii]. 20172854; PubMed Central PMCID: PMC2857140.

78. Zhang Y, Eigenbrot C, Zhou L, Shia S, Li W, Quan C, et al. Identification of a small peptide that inhibits PCSK9 protein binding to the low density lipoprotein receptor. J Biol Chem. 2014;289(2):942–55. Epub 2013/11/15. doi: 10.1074/jbc.M113.514067 [pii]. 24225950; PubMed Central PMCID: PMC3887217.

79. Fisher TS, Lo Surdo P, Pandit S, Mattu M, Santoro JC, Wisniewski D, et al. Effects of pH and low density lipoprotein (LDL) on PCSK9-dependent LDL receptor regulation. J Biol Chem. 2007;282(28):20502–12. Epub 2007/05/12. doi: M701634200 [pii] doi: 10.1074/jbc.M701634200 17493938.

Článek On simulating cold-stunned sea turtle strandings on Cape Cod, Massachusetts
Článek Assemblage of Focal Species Recognizers—AFSR: A technique for decreasing false indications of presence from acoustic automatic identification in a multiple species context
Článek Bio-control agents activate plant immune response and prime susceptible tomato against root-knot nematodes
Článek Impact of permagarden intervention on improving fruit and vegetable intake among vulnerable groups in an urban setting of Ethiopia: A quasi-experimental study
Článek Iron nanoparticle-labeled murine mesenchymal stromal cells in an osteoarthritic model persists and suggests anti-inflammatory mechanism of action
Článek Utilisation of health services fails to meet the needs of pregnancy-related illnesses in rural southern Ethiopia: A prospective cohort study
Článek Bottom trawl catch comparison in the Mediterranean Sea: Flexible Turtle Excluder Device (TED) vs traditional gear
Článek Removal of an established invader can change gross primary production of native macroalgae and alter carbon flow in intertidal rock pools
Článek Drone-based effective counting and ageing of hippopotamus (Hippopotamus amphibius) in the Okavango Delta in Botswana
Článek Assessing the performance of genome-wide association studies for predicting disease risk
Článek Drug-related and psychopathological symptoms in HIV-positive men who have sex with men who inject drugs during sex (slamsex): Data from the U-SEX GESIDA 9416 Study
Článek Canine distemper in Nepal's Annapurna Conservation Area – Implications of dog husbandry and human behaviour for wildlife disease
Článek Computational search for UV radiation resistance strategies in Deinococcus swuensis isolated from Paramo ecosystems
Článek Effects of breed, management and personality on cortisol reactivity in sport horses
Článek Intensity of physical activity as a percentage of peak oxygen uptake, heart rate and Borg RPE in motor-complete para- and tetraplegia
Článek Alteration of the anatomical covariance network after corpus callosotomy in pediatric intractable epilepsy
Článek Validation of a cross-NTD toolkit for assessment of NTD-related morbidity and disability. A cross-cultural qualitative validation of study instruments in Colombia
Článek The effect of bigger human bodies on the future global calorie requirements
Článek Incidence of statin use in older adults with and without cardiovascular disease and diabetes mellitus, January 2008- March 2018
Článek Behavioural risks in female dogs with minimal lifetime exposure to gonadal hormones
Článek Transcutaneous vagus nerve stimulation (t-VNS): A novel effective treatment for temper outbursts in adults with Prader-Willi Syndrome indicated by results from a non-blind study
Článek The novel aminoglycoside, ELX-02, permits CTNSW138X translational read-through and restores lysosomal cystine efflux in cystinosis
Článek An oral care programme for adults- Evaluation after 15 years
Článek Genetic variation across trophic levels: A test of the correlation between population size and genetic diversity in sympatric desert lizards
Článek Dendrochronological evidence for long-distance timber trading in the Roman Empire
Článek Influence of traffic accessibility on land use based on Landsat imagery and internet map: A case study of the Pearl River Delta urban agglomeration
Článek Growth of young HIV-infected and HIV-exposed children in western Kenya: A retrospective chart review
Článek Comparison of traditional methods versus SAFEcount for filling prescriptions: A pilot study of an innovative pill counting solution in eSwatini
Článek Estimating relative CWD susceptibility and disease progression in farmed white-tailed deer with rare PRNP alleles
Článek Twins! Microsatellite analysis of two embryos within one egg case in oviparous elasmobranchs
Článek Significant alteration of liver metabolites by AAV8.Urocortin 2 gene transfer in mice with insulin resistance
Článek Trust, and distrust, of Ebola Treatment Centers: A case-study from Sierra Leone
Článek Macmoondongtang modulates Th1-/Th2-related cytokines and alleviates asthma in a murine model
Článek Expressional artifact caused by a co-injection marker rol-6 in C. elegans
Článek Cost-effectiveness analysis of aspirin for primary prevention of cardiovascular events among patients with type 2 diabetes in China
Článek Factors that enable effective One Health collaborations - A scoping review of the literature
Článek Functional connectivity dynamics slow with descent from wakefulness to sleep
Článek User abnormal behavior recommendation via multilayer network
Článek SparkGA2: Production-quality memory-efficient Apache Spark based genome analysis framework
Článek People versus machines in the UK: Minimum wages, labor reallocation and automatable jobs
Článek Histo- and immunohistochemistry-based estimation of the TCGA and ACRG molecular subtypes for gastric carcinoma and their prognostic significance: A single-institution study
Článek Long-term outcomes of macrovascular diseases and metabolic indicators of bariatric surgery for severe obesity type 2 diabetes patients with a meta-analysis
Článek Effect of dietary cellulose supplementation on gut barrier function and apoptosis in a murine model of endotoxemia
Článek Cannabis users: Screen systematically, treat individually. A descriptive study of participants in a randomized trial in primary care
Článek Head to head comparison of two commercial fecal calprotectin kits as predictor of Mayo endoscopic sub-score and mucosal TNF expression in ulcerative colitis
Článek Exploring the hospital patient journey: What does the patient experience?
Článek CD200 is up-regulated in R6/1 transgenic mouse model of Huntington's disease
Článek Three-dimensional analysis of pancreatic fat by fat-water magnetic resonance imaging provides detailed characterization of pancreatic steatosis with improved reproducibility
Článek Lower IQ and poorer cognitive profiles in treated perinatally HIV-infected children is irrespective of having a background of international adoption
Článek Strengthening counseling on barriers to exclusive breastfeeding through use of job aids in Nampula, Mozambique
Článek A population-based study of tuberculosis incidence among rheumatic disease patients under anti-TNF treatment
Článek Health risk assessment on musculoskeletal disorders among potato-chip processing workers
Článek Processed and ultra-processed foods are associated with high prevalence of inadequate selenium intake and low prevalence of vitamin B1 and zinc inadequacy in adolescents from public schools in an urban area of northeastern Brazil
Článek Is half the world’s population really below ‘replacement-rate’?
Článek Seasonal variation of a plant-pollinator network in the Brazilian Cerrado: Implications for community structure and robustness
Článek Neonatal and neurodevelopmental outcomes in preterm infants according to maternal body mass index: A prospective cohort study
Článek Genetic variability of five ADRB2 polymorphisms among Mexican Amerindian ethnicities and the Mestizo population
Článek Late Glacial rapid climate change and human response in the Westernmost Mediterranean (Iberia and Morocco)
Článek The role of endothelial MERTK during the inflammatory response in lungs
Článek Does prior knowledge of food fraud affect consumer behavior? Evidence from an incentivized economic experiment
Článek Isolation and characterization of the EgWRI1 promoter from oil palm (Elaeis guineensis Jacq.) and its response to environmental stress and ethylene
Článek Plasma metabolites as possible biomarkers for diagnosis of breast cancer
Článek Altitude and human disturbance are associated with helminth diversity in an endangered primate, Procolobus gordonorum
Článek Effects of the killer immunoglobulin–like receptor (KIR) polymorphisms on HIV acquisition: A meta-analysis
Článek Reaction-diffusion memory unit: Modeling of sensitization, habituation and dishabituation in the brain
Článek Early rise in central venous pressure during a spontaneous breathing trial: A promising test to identify patients at high risk of weaning failure?
Článek Consumption of psychoactive substances in prison: Between initiation and improvement, what trajectories occur after incarceration? COSMOS study data
Článek Prevalence of damaged and missing teeth among women in the southern plains of Nepal: Findings of a simplified assessment tool
Článek A global model for predicting the arrival of imported dengue infections
Článek From social interactions to interpersonal relationships: Influences on ultra-runners’ race experience
Článek Anxiety reduction through art therapy in women. Exploring stress regulation and executive functioning as underlying neurocognitive mechanisms
Článek Acceptability of early childhood obesity prediction models to New Zealand families
Článek Analysing trajectories of a longitudinal exposure: A causal perspective on common methods in lifecourse research
Článek Ex vivo perfusion-based engraftment of genetically engineered cell sensors into transplantable organs
Článek Disturbance study of seismic vibrator reaction mass and piston
Článek Gene expression is associated with virulence in murine macrophages infected with Leptospira spp
Článek Polysubstance use patterns and novel synthetics: A cluster analysis from three U.S. cities
Článek Cost-effectiveness of prenatal screening and diagnostic strategies for Down syndrome: A microsimulation modeling analysis
Článek Social vulnerability assessment of dog intake location data as a planning tool for community health program development: A case study in Athens-Clarke County, GA, 2014-2016
Článek The subjective value of a smile alters social behaviour
Článek The logic of basic education provision and public goods preferences in Chinese fiscal federalism
Článek The Black identity, hair product use, and breast cancer scale
Článek Impact of perceived distances on international tourism
Článek Exposure to household pet cats and dogs in childhood and risk of subsequent diagnosis of schizophrenia or bipolar disorder
Článek The prognostic value of myeloid derived suppressor cell level in hepatocellular carcinoma: A systematic review and meta-analysis
Článek Myeloid cell deletion of Aryl hydrocarbon Receptor Nuclear Translocator (ARNT) induces non-alcoholic steatohepatitis
Článek Long-term ambient hydrocarbons exposure and incidence of ischemic stroke
Článek Assessing recall of personal sun exposure by integrating UV dosimeter and self-reported data with a network flow framework
Článek Public attitudes toward genetic modification in dairy cattle
Článek Quantification of speech and synchrony in the conversation of adults with autism spectrum disorder
Článek Genome-wide association study of drought tolerance and biomass allocation in wheat
Článek Robust blind spectral unmixing for fluorescence microscopy using unsupervised learning
Článek What do we really know about the appropriateness of radiation emitting imaging for low back pain in primary and emergency care? A systematic review and meta-analysis of medical record reviews
Článek Fluid balance correlates with clinical course of multiple organ dysfunction syndrome and mortality in patients with septic shock
Článek Withdrawn medicines included in the essential medicines lists of 136 countries
Článek Whose data can we trust: How meta-predictions can be used to uncover credible respondents in survey data
Článek The optimal delivery time and order quantity in an oligopoly market with time-sensitive customers
Článek Feature identification in time-indexed model output
Článek Influence of microwave-assisted dehydration on morphological integrity and viability of cat ovarian tissues: First steps toward long-term preservation of complex biomaterials at supra-zero temperatures
Článek Relationship between land surface temperature and fraction of anthropized area in the Atlantic forest region, Brazil
Článek The coevolution of contagion and behavior with increasing and decreasing awareness
Článek A simplistic approach of algal biofuels production from wastewater using a Hybrid Anaerobic Baffled Reactor and Photobioreactor (HABR-PBR) System
Článek HeLa-CCL2 cell heterogeneity studied by single-cell DNA and RNA sequencing
Článek Elucidation of a non-thermal mechanism for DNA/RNA fragmentation and protein degradation when using Lyse-It
Článek Viral load testing among women on ‘option B+’ in Mazowe, Zimbabwe: How well are we doing?
Článek The majority of skin lesions in pediatric primary care attention could be managed by Teledermatology
Článek Interactions of pharmaceutical companies with world countries, cancers and rare diseases from Wikipedia network analysis
Článek Effect of the casein phosphopeptide-amorphous calcium phosphate fluoride (CPP-ACPF) and photobiomodulation (PBM) on dental hypersensitivity: A randomized controlled clinical trial
Článek Cost-effectiveness analysis of parenting interventions for the prevention of behaviour problems in children
Článek Stochasticity and non-additivity expose hidden evolutionary pathways to cooperation
Článek Emergency traffic adaptive MAC protocol for wireless body area networks based on prioritization
Článek Face recognition and memory in congenital amusia
Článek Variations of training load, monotony, and strain and dose-response relationships with maximal aerobic speed, maximal oxygen uptake, and isokinetic strength in professional soccer players
Článek Hydrogel based protein biochip for parallel detection of biomarkers for diagnosis of a Systemic Inflammatory Response Syndrome (SIRS) in human serum
Článek Transcranial magnetic stimulation induced early silent period and rebound activity re-examined
Článek Heterogenous wealth effects of minimum unit price on purchase of alcohol: Evidence using scanner data
Článek Associations between adverse childhood family environments and blood pressure differ between men and women
Článek The influence of the fetal leg position on the outcome in vaginally intended deliveries out of breech presentation at term – A FRABAT prospective cohort study
Článek Colorectal cancer incidence among young adults in England: Trends by anatomical sub-site and deprivation
Článek Assessing service and treatment needs and barriers of youth who use illicit and non-medical prescription drugs in Northern Ontario, Canada
Článek Composition and structure of the marine benthic community in Terra Nova Bay, Antarctica: Responses of the benthic assemblage to disturbances
Článek Lie prevalence, lie characteristics and strategies of self-reported good liars
Článek Prevalent, persistent anal HPV infection and squamous intraepithelial lesions: Findings from a cohort of men living with HIV in South Africa
Článek Assessment of the real-world safety profile of vedolizumab using the United States Food and Drug Administration adverse event reporting system
Článek Machine learning approach to single nucleotide polymorphism-based asthma prediction
Článek Local risk perception enhances epidemic control
Článek Designing machine learning workflows with an application to topological data analysis
Článek Phylogenetic position of the ‘extinct’ Fijian coconut moth, Levuana iridescens (Lepidoptera: Zygaenidae)
Článek Location of sources in reaction-diffusion equations using support vector machines
Článek Methylsulfonylmethane increases osteogenesis and regulates the mineralization of the matrix by transglutaminase 2 in SHED cells
Článek Effect of anti-epileptic drugs on the survival of patients with glioblastoma multiforme: A retrospective, single-center study
Článek Hyperglycemia induces key genetic and phenotypic changes in human liver epithelial HepG2 cells which parallel the Leprdb/J mouse model of non-alcoholic fatty liver disease (NAFLD)
Článek Clinical outcomes and mortality in old and very old patients undergoing cardiac resynchronization therapy
Článek Glycemic-aware metrics and oversampling techniques for predicting blood glucose levels using machine learning
Článek Shifting perceptions of female genital cutting in a Swedish migration context
Článek Estimating the degree to which distance and temperature differences drive changes in fish community composition over time in the upper Mississippi River
Článek Nucleotide composition affects codon usage toward the 3'-end
Článek Results from one-year use of an electronic Clinical Decision Support System in a post-conflict context: An implementation research
Článek Development of refractive error in children treated for retinopathy of prematurity with anti-vascular endothelial growth factor (anti-VEGF) agents: A meta-analysis and systematic review
Článek High diversity of coralline algae in New Zealand revealed: Knowledge gaps and implications for future research
Článek Electromyographic characteristics of pelvic floor muscles in women with stress urinary incontinence following sEMG-assisted biofeedback training and Pilates exercises
Článek The effect of visceral fat on the hemodilution effect of serum carcinoembryonic antigen in Korean population
Článek A Bayesian gene network reveals insight into the JAK-STAT pathway in systemic lupus erythematosus
Článek Sap flow of Salix psammophila and its principal influencing factors at different slope positions in the Mu Us desert
Článek Long-term outcomes of prismatic correction in partially accommodative esotropia
Článek Does in vitro selection of biocontrol agents guarantee success in planta? A study case of wheat protection against Fusarium seedling blight by soil bacteria
Článek Highly multiplexed quantitative PCR-based platform for evaluation of chicken immune responses
Článek Research trends in farmers’ mental health: A scoping review of mental health outcomes and interventions among farming populations worldwide
Článek Limits in reliability of leg-spring and joint stiffness measures during single-leg hopping within a sled-based system
Článek Genomic and phylogenetic analysis of choriolysins, and biological activity of hatching liquid in the flatfish Senegalese sole
Článek Physical activity levels in adults and elderly from triaxial and uniaxial accelerometry. The Tromsø Study
Článek Pathologic changes and immune responses against Coxiella burnetii in mice following infection via non-invasive intratracheal inoculation
Článek Exploring resources and environmental carrying capacities at the county level: A case study of China’s Fengxian County
Článek The opportunities and risks of mobile phones for refugees’ experience: A scoping review
Článek Motor vehicle crash reconstruction: Does it relate to the heterogeneity of whiplash recovery?
Článek Frequency and determinants of health care utilization for symptomatic reproductive tract infections in rural Indian women: A cross-sectional study
Článek Gang confrontation: The case of Medellin (Colombia)
Článek Adaptive smartphone-based sensor fusion for estimating competitive rowing kinematic metrics
Článek Prevalence of Cryptococcal Antigenemia and associated factors among HIV/AIDS patients on second-line antiretroviral therapy at two hospitals in Western Oromia, Ethiopia
Článek Characterization of the cecal microbiome composition of Wenchang chickens before and after fattening
Článek A leader-follower model for discrete competitive facility location problem under the partially proportional rule with a threshold
Článek Process elements contributing to community mobilization for HIV risk reduction and gender equality in rural South Africa
Článek Quantitative dynamics of Salmonella and E. coli in feces of feedlot cattle treated with ceftiofur and chlortetracycline
Článek Incidences of community onset severe sepsis, Sepsis-3 sepsis, and bacteremia in Sweden – A prospective population-based study
Článek Antiphagocytic protein 1 increases the susceptibility of Cryptococcus neoformans to amphotericin B and fluconazole
Článek Towards text mining therapeutic change: A systematic review of text-based methods for Therapeutic Change Process Research
Článek Intrinsic group behaviour II: On the dependence of triad spatial dynamics on social and personal features; and on the effect of social interaction on small group dynamics
Článek Student engagement, assessed using heart rate, shows no reset following active learning sessions in lectures
Článek Examining transmission of gut bacteria to preserved carcass via anal secretions in Nicrophorus defodiens
Článek Anemia and associated factors among type-2 diabetes mellitus patients attending public hospitals in Harari Region, Eastern Ethiopia
Článek The KLDpT activation loop motif is critical for MARK kinase activity
Článek Pro-renin receptor suppresses mitochondrial biogenesis and function via AMPK/SIRT-1/ PGC-1α pathway in diabetic kidney
Článek Severe childhood anemia and emergency blood transfusion in Gadarif Hospital, eastern Sudan
Článek Gender differences in the effect of self-rated health (SRH) on all-cause mortality and specific causes of mortality among individuals aged 50 years and older
Článek PyLandStats: An open-source Pythonic library to compute landscape metrics
Článek Snow avalanche deaths in Switzerland from 1995 to 2014—Results of a nation-wide linkage study
Článek Association between attitudes of stigma toward mental illness and attitudes toward adoption of evidence-based practice within health care providers in Bahrain
Článek The efficacy of conditioned medium released by tonsil-derived mesenchymal stem cells in a chronic murine colitis model
Článek Generation of targeted homozygosity in the genome of human induced pluripotent stem cells
Článek Intraoperative ketorolac in high-risk breast cancer patients. A prospective, randomized, placebo-controlled clinical trial
Článek An add-on training program involving breathing exercises, cold exposure, and meditation attenuates inflammation and disease activity in axial spondyloarthritis – A proof of concept trial
Článek Comparative study of the composition of cultivated, naturally grown Cordyceps sinensis, and stiff worms across different sampling years
Článek Non-structural carbohydrates in maize with different nitrogen tolerance are affected by nitrogen addition
Článek Neuroimaging modality fusion in Alzheimer’s classification using convolutional neural networks
Článek Ginkgo biloba extract increases neurite outgrowth and activates the Akt/mTOR pathway
Článek Systematic review and meta-analysis comparing Adjustable Transobturator Male System (ATOMS) and Adjustable Continence Therapy (ProACT) for male stress incontinence
Článek Men and women differ in their perception of gender bias in research institutions
Článek Visual inspection of vaccine storage conditions in general practices: A study of 75 vaccine refrigerators
Článek New physiological bench test reproducing nocturnal breathing pattern of patients with sleep disordered breathing
Článek Respiratory syncytial virus exhibits differential tropism for distinct human placental cell types with Hofbauer cells acting as a permissive reservoir for infection
Článek Correlation analysis of physical fitness and retinal microvasculature by OCT angiography in healthy adults
Článek Non-spherical particles in optical tweezers: A numerical solution
Článek Development and validation of the Scale of Motives for Using Social Networking Sites (SMU-SNS) for adolescents and youths
Článek Formation of a structurally-stable conformation by the intrinsically disordered MYC:TRRAP complex
Článek Generation of swine movement network and analysis of efficient mitigation strategies for African swine fever virus
Článek The Determinants of Household Food Waste Generation and its Associated Caloric and Nutrient Losses: The Case of Lebanon
Článek ABO blood group and risk of newly diagnosed nonalcoholic fatty liver disease: A case-control study in Han Chinese population
Článek Circulation of influenza virus from 2009 to 2018 in Cameroon: 10 years of surveillance data
Článek Parametric CAD modeling for open source scientific hardware: Comparing OpenSCAD and FreeCAD Python scripts
Článek Fatty acid profiling of 75 Indian snack samples highlights overall low trans fatty acid content with high polyunsaturated fatty acid content in some samples
Článek Quinolone nonsusceptibility among enteric pathogens isolated from international travelers – Foodborne Diseases Active Surveillance Network (FoodNet) and National Antimicrobial Monitoring System (NARMS), 10 United States sites, 2004 – 2014
Článek Effects of nutrient level and planting density on population relationship in soybean and wheat intercropping populations
Článek Antihypertensive treatment and risk of cardiovascular mortality in patients with chronic kidney disease diagnosed based on the presence of proteinuria and renal function: A large longitudinal study in Japan
Článek Description and phylogeny of a new species of Liolaemus (Iguania: Liolaemidae) endemic to the south of the Plurinational State of Bolivia
Článek Wireless intravesical device for real-time bladder pressure measurement: Study of consecutive voiding in awake minipigs
Článek Use of three points to determine the accuracy of guided implantation
Článek Citric-acid dialysate improves the calcification propensity of hemodialysis patients: A multicenter prospective randomized cross-over trial
Článek Predicting the replicability of social science lab experiments
Článek Global longitudinal strain can predict heart failure exacerbation in stable outpatients with ischemic left ventricular systolic dysfunction
Článek Barriers to chronic Hepatitis B treatment and care in Ghana: A qualitative study with people with Hepatitis B and healthcare providers
Článek Exploring the workplace climate and culture in relation to food environment-related factors in Norwegian kindergartens: The BRA-study
Článek Composition and structure of the culturable gut bacterial communities in Anopheles albimanus from Colombia
Článek A siRNA mediated hepatic dpp4 knockdown affects lipid, but not glucose metabolism in diabetic mice
Článek Central sensitization in knee osteoarthritis and fibromyalgia: Beyond depression and anxiety
Článek Clinical and epidemiological characteristics of imported dengue fever among inbound passengers: Infrared thermometer–based active surveillance at an international airport
Článek An investigation of the equine epidermal growth factor system during hyperinsulinemic laminitis
Článek Ranking hospitals when performance and risk factors are correlated: A simulation-based comparison of risk adjustment approaches for binary outcomes
Článek The effect of carbohydrate sources: Sucrose, invert sugar and components of mānuka honey, on core bacteria in the digestive tract of adult honey bees (Apis mellifera)
Článek Runs of Homozygosity and NetView analyses provide new insight into the genome-wide diversity and admixture of three German cattle breeds
Článek Total sleep deprivation increases pain sensitivity, impairs conditioned pain modulation and facilitates temporal summation of pain in healthy participants
Článek The effects of urbanization on bee communities depends on floral resource availability and bee functional traits
Článek Robust effect of metabolic syndrome on major metabolic pathways in the myocardium
Článek Using baited remote underwater videos (BRUVs) to characterize chondrichthyan communities in a global biodiversity hotspot
Článek Grazing offsets the stimulating effects of nitrogen addition on soil CH4 emissions in a meadow steppe in Northeast China
Článek Agriculture development and CO2 emissions nexus in Saudi Arabia
Článek Influence of a neck compression collar on cerebrovascular and autonomic function in men and women
Článek Visceral leishmaniasis in Northeast Brazil: What is the impact of HIV on this protozoan infection?
Článek βC1, pathogenicity determinant encoded by Cotton leaf curl Multan betasatellite, interacts with calmodulin-like protein 11 (Gh-CML11) in Gossypium hirsutum
Článek The higher they go the harder they could fall: The impact of risk-glorifying commercials on risk behavior
Článek Optimization of TripleTOF spectral simulation and library searching for confident localization of phosphorylation sites
Článek Evidence for pre-climacteric activation of AOX transcription during cold-induced conditioning to ripen in European pear (Pyrus communis L.)
Článek Expression of myeloid Src-family kinases is associated with poor prognosis in AML and influences Flt3-ITD kinase inhibitor acquired resistance
Článek Examining psychosocial correlates of physical activity and sedentary behavior in youth with and without HIV
Článek Modeling record scores in the snatch and its variations in the long-term training of young weightlifters
Článek Life-cycle mediated effects of urbanization on parasite communities in the estuarine fish, Fundulus heteroclitus
Článek Rapid serial blinks: An index of temporally increased cognitive load
Článek Diversity of a cytokinin dehydrogenase gene in wild and cultivated barley
Článek Interdependence of balance mechanisms during bipedal locomotion
Článek A new finite element based parameter to predict bone fracture
Článek Clinical, imaging features and outcome in internal carotid artery versus middle cerebral artery disease
Článek The association of weight status and weight perception with number of confidants in adolescents
Článek Discoidin domain Receptor 2: A determinant of metabolic syndrome-associated arterial fibrosis in non-human primates
Článek Selection of appropriate reference genes for quantitative real-time reverse transcription PCR in Betula platyphylla under salt and osmotic stress conditions
Článek Bilateral Parkinson’s disease model rats exhibit hyperalgesia to subcutaneous formalin administration into the vibrissa pad
Článek Erastin, a ferroptosis-inducing agent, sensitized cancer cells to X-ray irradiation via glutathione starvation in vitro and in vivo
Článek Host-mediated microbiome engineering (HMME) of drought tolerance in the wheat rhizosphere
Článek Improving distribution models of riparian vegetation with mobile laser scanning and hydraulic modelling
Článek Skeletal muscle alterations in tachycardia-induced heart failure are linked to deficient natriuretic peptide signalling and are attenuated by RAS-/NEP-inhibition
Článek Leisure-time physical activity and sports in the Brazilian population: A social disparity analysis
Článek Robot-assisted unicompartmental knee arthroplasty can reduce radiologic outliers compared to conventional techniques
Článek Autosomal-dominant hypotrichosis with woolly hair: Novel gene locus on chromosome 4q35.1-q35.2
Článek Personality traits and risky behavior among motorcyclists: An exploratory study
Článek Human-nature relationships in context. Experiential, psychological, and contextual dimensions that shape children’s desire to protect nature
Článek The spatio-temporal patterns of the topsoil organic carbon density and its influencing factors based on different estimation models in the grassland of Qinghai-Tibet Plateau
Článek Helicobacter pylori antibody and pepsinogen testing for predicting gastric microbiome abundance
Článek Outcome of bimodality definitive chemoradiation does not differ from that of trimodality upfront neck dissection followed by adjuvant treatment for >6 cm lymph node (N3) head and neck cancer
Článek Belief in conspiracy theories: The predictive role of schizotypy, Machiavellianism, and primary psychopathy
Článek First-4-week erythrocyte sedimentation rate variability predicts erythrocyte sedimentation rate trajectories and clinical course among patients with pyogenic vertebral osteomyelitis
Článek Walking with head-mounted virtual and augmented reality devices: Effects on position control and gait biomechanics
Článek Cohort Profile: The Dutch Perined-Lifelines birth cohort
Článek Accelerated development of rice stripe virus-resistant, near-isogenic rice lines through marker-assisted backcrossing
Článek Physical determinants of vault performance and their age-related differences across male junior and elite top-level gymnasts
Článek Overweight and obesity are associated with clustering of metabolic risk factors in early pregnancy and the risk of GDM
Článek Genome-wide association mapping of total antioxidant capacity, phenols, tannins, and flavonoids in a panel of Sorghum bicolor and S. bicolor × S. halepense populations using multi-locus models
Článek Reconstruction error based deep neural networks for coronary heart disease risk prediction
Článek Exploring the geography of serious mental illness and type 2 diabetes comorbidity in Illawarra—Shoalhaven, Australia (2010 -2017)
Článek Myalgic encephalomyelitis/chronic fatigue Syndrome (ME/CFS): Investigating care practices pointed out to disparities in diagnosis and treatment across European Union
Článek The effect of a curriculum-based physical activity intervention on accelerometer-assessed physical activity in schoolchildren: A non-randomised mixed methods controlled before-and-after study
Článek In vivo ultrasound thermal ablation control using echo decorrelation imaging in rabbit liver and VX2 tumor
Článek What effort is required in retrieving self-defining memories? Specific autonomic responses for integrative and non-integrative memories
Článek Influence of pre-pregnancy body mass index (p-BMI) and gestational weight gain (GWG) on DNA methylation and protein expression of obesogenic genes in umbilical vein
Článek Early recovery after endoscopic totally extraperitoneal (TEP) hernia repair in athletes with inguinal disruption: A prospective cohort study
Článek Gaze direction reveals implicit item and source memory in older adults
Článek Eavesdropping on dolphins: Investigating the habits of bottlenose dolphins (Tursiops truncatus) through fixed acoustic stations
Článek Modeling narrative structure and dynamics with networks, sentiment analysis, and topic modeling
Článek Screening colonoscopy and flexible sigmoidoscopy for reduction of colorectal cancer incidence: A case-control study
Článek Child protection, domestic violence, and ethnic minorities: Narrative results from a mixed methods study in Australia
Článek Prediction of early C-reactive protein levels after non-cardiac surgery under general anesthesia
Článek Snord94 expression level alters methylation at C62 in snRNA U6
Článek The relation between local and distal muscle fat infiltration in chronic whiplash using magnetic resonance imaging
Článek Serotonin modulates behavior-related neural activity of RID interneuron in Caenorhabditis elegans
Článek Risk factors of post-discharge under-five mortality among Danish children 1997-2016: A register-based study
Článek Correction: Modeling the natural history of fatty liver using lifestyle–related risk factors: Effects of body mass index (BMI) on the life–course of fatty liver
Článek Effects of acupuncture at Pericardium-6 and Stomach-36 on nausea, sedation and gastrointestinal motility in healthy dogs administered intravenous lidocaine infusions
Článek Short-term treatment with a peroxisome proliferator-activated receptor α agonist influences plasma one-carbon metabolites and B-vitamin status in rats
Článek Elevation, an emotion for prosocial contagion, is experienced more strongly by those with greater expectations of the cooperativeness of others
Článek Efficient delipidation of a recombinant lung surfactant lipopeptide analogue by liquid-gel chromatography
Článek Increasing sika deer population density may change resource use by larval dung beetles
Článek The fertile grounds of reproductive activism in The Gambia: A qualitative study of local key stakeholders’ understandings and heterogeneous actions related to infertility
Článek Molecular identification of Ehrlichia, Anaplasma, Babesia and Theileria in African elephants and their ticks
Článek Reproductive life-history strategies in a species-rich assemblage of Amazonian electric fishes
Článek Cattle intestinal microbiota shifts following Escherichia coli O157:H7 vaccination and colonizationtravel
Článek The genetic diversity and population structure of Sophora alopecuroides (Faboideae) as determined by microsatellite markers developed from transcriptome
Článek Establishment and characterization of transformed goat primary cells by expression of simian virus 40 large T antigen for orf virus propagations
Článek Sharing of gut microbial strains between selected individual sets of twins cohabitating for decades
Článek Characterization and quantitative trait locus mapping of late-flowering from a Thai soybean cultivar introduced into a photoperiod-insensitive genetic background
Článek Plasmodium falciparum infection dysregulates placental autophagy
Článek Intraocular pressure elevation after subtenon triamcinolone acetonide injection; Multicentre retrospective cohort study in Japan
Článek Expression of Concern: Synthesized multiple antigenic polypeptide vaccine based on B-cell epitopes of human heparanase could elicit a potent antimetastatic effect on human hepatocellular carcinoma in vivo
Článek Correction: Effective methods for the inactivation of Francisella tularensis
Článek Spatial patterns of tuberculosis and HIV co-infection in Ethiopia
Článek Retraction: Circulating FoxP3+ regulatory T and interleukin17-producing Th17 cells actively influence HBV clearance in de novo Hepatitis B virus infected patients after orthotopic liver transplantation
Článek Correction: Data in question: A survey of European biobank professionals on ethical, legal and societal challenges of biobank research
Článek A scalable culturing system for the marine annelid Platynereis dumerilii
Článek Identification of novel non-myelin biomarkers in multiple sclerosis using an improved phage-display approach
Článek Micro-RNA signatures in monozygotic twins discordant for congenital heart defects
Článek Selection and validation of reference genes desirable for gene expression analysis by qRT-PCR in MeJA-treated ginseng hairy roots
Článek Retraction: Is insulin resistance the cause of fibromyalgia? A preliminary report
Článek Correction: Synanthropic Mammals as Potential Hosts of Tick-Borne Pathogens in Panama
Článek Correction: Incidence of sexually transmitted infections in men who have sex with men and who are at substantial risk of HIV infection – A meta-analysis of data from trials and observational studies of HIV pre-exposure prophylaxis
Článek Retraction: Multidrug-Resistance Related Long Non-Coding RNA Expression Profile Analysis of Gastric Cancer
Článek Correction: Quantitative CT analysis of honeycombing area predicts mortality in idiopathic pulmonary fibrosis with definite usual interstitial pneumonia pattern: A retrospective cohort study
Článek Correction: Improving the impact of HIV pre-exposure prophylaxis implementation in small urban centers among men who have sex with men: An agent-based modelling study
Článek Correction: Examining the relationship between socio-economic status, WASH practices and wasting
Článek Correction: Change in left inferior frontal connectivity with less unexpected harmonic cadence by musical expertise
Článek Expression of Concern: Activation of Notch Signaling Is Required for Cholangiocarcinoma Progression and Is Enhanced by Inactivation of p53 In Vivo
Článek Correction: Calorie information and dieting status modulate reward and control activation during the evaluation of food images
Článek Correction: Intraperitoneal administration of follistatin promotes adipocyte browning in high-fat diet-induced obese mice
Článek Correction: Heart rate recovery and morbidity after noncardiac surgery: Planned secondary analysis of two prospective, multi-centre, blinded observational studies
Článek Correction: May the change of platelet to lymphocyte ratio be a prognostic factor for T3-T4 laryngeal squamous cell carcinoma: A retrospective study
Článek Correction: Assessment of lung function in successfully treated tuberculosis reveals high burden of ventilatory defects and COPD
Článek Palliative care for people living with HIV/AIDS: Factors influencing healthcare workers’ knowledge, attitude and practice in public health facilities, Abuja, Nigeria
Článek Batrachochytrium dendrobatidis infection in amphibians predates first known epizootic in Costa Rica
Článek Epidemiological scenarios for human rabies exposure notified in Colombia during ten years: A challenge to implement surveillance actions with a differential approach on vulnerable populations
Článek Human recombinant erythropoietin improves motor function in rats with spinal cord compression-induced cervical myelopathy
Článek Generation of models from existing models composition: An application to agrarian sciences
Článek Genetic mapping of morpho-physiological traits involved during reproductive stage drought tolerance in rice
Článek Heroin type, injecting behavior, and HIV transmission. A simulation model of HIV incidence and prevalence
Článek Proposal for a Global Adherence Scale for Acute Conditions (GASAC): A prospective cohort study in two emergency departments
Článek Seasonal Change in Microbial Diversity and Its Relationship with Soil Chemical Properties in an Orchard
Článek Epidemiology of drug-resistant tuberculosis in Chongqing, China: A retrospective observational study from 2010 to 2017
Článek Use of an automated pyrosequencing technique for confirmation of sickle cell disease
Článek Beta-caryophyllene enhances wound healing through multiple routes
Článek Modelling tick bite risk by combining random forests and count data regression models
Článek Differences of endogenous polyamines and putative genes associated with paraquat resistance in goosegrass (Eleusine indica L.)
Článek HIV chromatin is a preferred target for drugs that bind in the DNA minor groove
Článek Oregano powder reduces Streptococcus and increases SCFA concentration in a mixed bacterial culture assay
Článek Ocular vestibular evoked myogenic potential (VEMP) reveals mesencephalic HTLV-1-associated neurological disease
Článek Using virtual reality and thermal imagery to improve statistical modelling of vulnerable and protected species
Článek Children’s reliance on the non-verbal cues of a robot versus a human
Článek Diaphragmatic motor cortex hyperexcitability in patients with chronic obstructive pulmonary disease
Článek Persistence of Burkholderia thailandensis E264 in lung tissue after a single binge alcohol episode
Článek Candida utilis yeast as a functional protein source for Atlantic salmon (Salmo salar L.): Local intestinal tissue and plasma proteome responses
Článek Health conditions associated with overweight in climacteric women
Článek The effects of arm swing amplitude and lower-limb asymmetry on gait stability
Článek High throughput, efficacious gene editing & genome surveillance in Chinese hamster ovary cells
Článek Identification and characterization of compounds from Chrysosporium multifidum, a fungus with moderate antimicrobial activity isolated from Hermetia illucens gut microbiota
Článek A framework for the development of a global standardised marine taxon reference image database (SMarTaR-ID) to support image-based analyses
Článek Cluster analysis on high dimensional RNA-seq data with applications to cancer research - An evaluation study
Článek Comparative in silico analysis of ftsZ gene from different bacteria reveals the preference for core set of codons in coding sequence structuring and secondary structural elements determination
Článek Exploring thematic structure and predicted functionality of 16S rRNA amplicon data
Článek Plant-mediated community structure of spring-fed, coastal rivers
Článek The epidemiology of childhood intussusception in South Korea: An observational study
Článek Gaze and Movement Assessment (GaMA): Inter-site validation of a visuomotor upper limb functional protocol
Článek Effects of treatment with enrofloxacin or tulathromycin on fecal microbiota composition and genetic function of dairy calves
Článek Predicting long-term type 2 diabetes with support vector machine using oral glucose tolerance test
Článek Multiscale, multimodal analysis of tumor heterogeneity in IDH1 mutant vs wild-type diffuse gliomas
Článek Assessment of Phenotype Microarray plates for rapid and high-throughput analysis of collateral sensitivity networks
Článek Overexpressing GH3.1 and GH3.1L reduces susceptibility to Xanthomonas citri subsp. citri by repressing auxin signaling in citrus (Citrus sinensis Osbeck)
Článek High prevalence and incidence of rectal Chlamydia infection among men who have sex with men in Japan
Článek A low-cost fluorescence reader for in vitro transcription and nucleic acid detection with Cas13a
Článek Changes in endolysosomal organization define a pre-degenerative state in the crumbs mutant Drosophila retina
Článek The burden of antimicrobial resistance among urinary tract isolates of Escherichia coli in the United States in 2017
Článek Multiple cyanotoxin congeners produced by sub-dominant cyanobacterial taxa in riverine cyanobacterial and algal mats
Článek BIN overlap confirms transcontinental distribution of pest aphids (Hemiptera: Aphididae)
Článek Sexual behaviour in a murine model of mucopolysaccharidosis type I (MPS I)
Článek Platelet thrombus formation in eHUS is prevented by anti-MBL2
Článek CPO Complete, a novel test for fast, accurate phenotypic detection and classification of carbapenemases
Článek Temporal microstructure of dyadic social behavior during relationship formation in mice
Článek Root and shoot competition lead to contrasting competitive outcomes under water stress: A systematic review and meta-analysis
Článek Divulging diazotrophic bacterial community structure in Kuwait desert ecosystems and their N2-fixation potential
Článek Development of the mandibular curve of spee and maxillary compensating curve: A finite element model
Článek Quantitative assessment of fecal contamination in multiple environmental sample types in urban communities in Dhaka, Bangladesh using SaniPath microbial approach
Článek The effect of overnight consolidation in the perceptual learning of non-native tonal contrasts
Článek Perceptions and practices related to birthweight in rural Bangladesh: Implications for neonatal health programs in low- and middle-income settings
Článek Regulation of amino acid and nucleotide metabolism by crustacean hyperglycemic hormone in the muscle and hepatopancreas of the crayfish Procambarus clarkia
Článek The D-dimer level predicts the postoperative prognosis in patients with non-small cell lung cancer
Článek Ligand-induced conformational selection predicts the selectivity of cysteine protease inhibitors
Článek Protein, dietary fiber, minerals, antioxidant pigments and phytochemicals, and antioxidant activity in selected red morph Amaranthus leafy vegetable
Článek A submerged 7000-year-old village and seawall demonstrate earliest known coastal defence against sea-level rise
Článek Annual replication is essential in evaluating the response of the soil microbiome to the genetic modification of maize in different biogeographical regions
Článek Brettanomyces bruxellensis wine isolates show high geographical dispersal and long persistence in cellars
Článek Effects of the replacement of fishmeal by soy protein concentrate on growth performance, apparent digestibility, and retention of protein and amino acid in juvenile pearl gentian grouper
Článek Energy expenditure and body composition changes after an isocaloric ketogenic diet in overweight and obese men: A secondary analysis of energy expenditure and physical activity
Článek Dyslipidemias and cardiovascular risk scores in urban and rural populations in north-western Tanzania and southern Uganda
Článek Demographic characteristics, site and phylogenetic distribution of dogs with appendicular osteosarcoma: 744 dogs (2000-2015)
Článek Distinctive tasks of different cyanobacteria and associated bacteria in carbon as well as nitrogen fixation and cycling in a late stage Baltic Sea bloom
Článek Genome wide DNA methylation profiling identifies specific epigenetic features in high-risk cutaneous squamous cell carcinoma
Článek The effect of dietary supplementation with Clostridium butyricum on the growth performance, immunity, intestinal microbiota and disease resistance of tilapia (Oreochromis niloticus)
Článek De novo identification of satellite DNAs in the sequenced genomes of Drosophila virilis and D. americana using the RepeatExplorer and TAREAN pipelines
Článek Comprehensive analysis of chromosomal mobile genetic elements in the gut microbiome reveals phylum-level niche-adaptive gene pools
Článek Mood and behavioral problems are important predictors of quality of life of nursing home residents with moderate to severe dementia: A cross-sectional study
Článek Goniozus omanensis (Hymenoptera: Bethylidae) an important parasitoid of the lesser date moth Batrachedra amydraula Meyrick (Lepidoptera: Batrachedridae) in Oman
Článek Prevalence and epidemiological characteristics of patients with diabetic retinopathy in Slovakia: 12-month results from the DIARET SK study
Článek Historical record of Corallium rubrum and its changing carbon sequestration capacity: A meta-analysis from the North Western Mediterranean
Článek Having pity on our victims to save ourselves: Compassion reduces self-critical emotions and self-blame about past harmful behavior among those who highly identify with their past self
Článek Fuzzy jump wavelet neural network based on rule induction for dynamic nonlinear system identification with real data applications
Článek Patterns of serial rib fractures after blunt chest trauma: An analysis of 380 cases
Článek Strategic rule breaking: Time wasting to win soccer games
Článek Visual body form and orientation cues do not modulate visuo-tactile temporal integration
Článek Early succession on slag compared to urban soil: A slower recovery
Článek Informing, simulating experience, or both: A field experiment on phishing risks
Článek Agronomic performance of lettuce cultivars submitted to different irrigation depths
Článek Development of a high throughput human stool specimen processing method for a molecular Helicobacter pylori clarithromycin resistance assay
Článek MSP-N: Multiple selection procedure with ‘N’ possible growth mechanisms
Článek Are census data accurate for estimating coverage of a lymphatic filariasis MDA campaign? Results of a survey in Sierra Leone
Článek Biological control of Erwinia mallotivora, the causal agent of papaya dieback disease by indigenous seed-borne endophytic lactic acid bacteria consortium
Článek Comparison of a novel algorithm quantitatively estimating epifascial fibrosis in three-dimensional computed tomography images to other clinical lymphedema grading methods
Článek Monitoring hunted species of cultural significance: Estimates of trends, population sizes and harvesting rates of flying-fox (Pteropus sp.) in New Caledonia
Článek Flexible employment policies, temporal control and health promoting practices: A qualitative study in two Australian worksites
Článek Olfactory bulb volume changes associated with trans-sphenoidal pituitary surgery
Článek Integrin αDβ2 influences cerebral edema, leukocyte accumulation and neurologic outcomes in experimental severe malaria
Článek Robust, automated sleep scoring by a compact neural network with distributional shift correction
Článek Clinical characterization and prognosis of T cell acute lymphoblastic leukemia with high CRLF2 gene expression in children
Článek Seasonal changes of the diurnal variation of precipitation in the upper Río Chagres basin, Panamá
Článek A quantum chemical approach representing a new perspective concerning agonist and antagonist drugs in the context of schizophrenia and Parkinson’s disease
Článek The effect of extra-osseous talotarsal stabilization (EOTTS) to reduce medial knee compartment forces – An in vivo study
Článek Whole brain polarity regime dynamics are significantly disrupted in schizophrenia and correlate strongly with network connectivity measures
Článek Risk of infection in the first year of life in preterm children: An Austrian observational study
Článek Influence of post-partum BMI change on childhood obesity and energy intake
Článek m6A minimally impacts the structure, dynamics, and Rev ARM binding properties of HIV-1 RRE stem IIB
Článek Trait self-control does not predict attentional control: Evidence from a novel attention capture paradigm
Článek Early changes in pulmonary function and intrarenal haemodynamics and the correlation between these sets of parameters in patients with T2DM
Článek Gender and neglected tropical disease front-line workers: Data from 16 countries
Článek Integrating long noncoding RNAs and mRNAs expression profiles of response to Plasmodiophora brassicae infection in Pakchoi (Brassica campestris ssp. chinensis Makino)
Článek Survey on antimicrobial usage in local dairy cows in North-central Nigeria: Drivers for misuse and public health threats
Článek Report on a large animal study with Göttingen Minipigs where regenerates and controls for articular cartilage were created in a large number. Focus on the conditions of the operated stifle joints and suggestions for standardized procedures
Článek Assessing gastro-intestinal related quality of life in cystic fibrosis: Validation of PedsQL GI in children and their parents
Článek Autosomal recessive congenital cataracts linked to HSF4 in a consanguineous Pakistani family
Článek Replacing murine insulin 1 with human insulin protects NOD mice from diabetes
Článek Long-term gait measurements in daily life: Results from the Berlin Aging Study II (BASE-II)
Článek A novel image encryption technique using hybrid method of discrete dynamical chaotic maps and Brownian motion
Článek Possible link between dental diseases and arteriosclerosis in patients on hemodialysis
Článek Significant hearing loss in Fabry disease: Study of the Danish nationwide cohort prior to treatment
Článek Establishment of chemosensitivity tests in triple-negative and BRCA-mutated breast cancer patient-derived xenograft models
Článek An epidemiological study of visceral leishmaniasis in North East Ethiopia using serological and leishmanin skin tests
Článek Dissociations of oral foci of infections with infectious complications and survival after haematopoietic stem cell transplantation
Článek Latin American consumption of major food groups: Results from the ELANS study
Článek The seroconversion rate of QuantiFERON-TB Gold In-Tube test in psoriatic patients receiving secukinumab and ixekizumab, the anti-interleukin-17A monoclonal antibodies
Článek Bridge to neuroscience workshop: An effective educational tool to introduce principles of neuroscience to Hispanics students
Článek Investigating gene expression profiles of whole blood and peripheral blood mononuclear cells using multiple collection and processing methods
Článek “My mother in-law forced my husband to divorce me”: Experiences of women with infertility in Zamfara State of Nigeria
Článek The technological, organizational and environmental determinants of adoption of mobile health applications (m-health) by hospitals in Kenya
Článek The computational analyses of handwriting in individuals with psychopathic personality disorder
Článek The properties and formation mechanism of oat β-glucan mixed gels with different molecular weight composition induced by high-pressure processing
Článek Abundance of ethnically biased microsatellites in human gene regions
Článek Malaria screening at the workplace in Cameroon
Článek Genetic and morphological divergence in the warm-water planktonic foraminifera genus Globigerinoides
Článek The association between chronic periodontitis and oral Helicobacter pylori: A meta-analysis
Článek Using species distribution models to predict potential hot-spots for Rift Valley Fever establishment in the United Kingdom
Článek Vernonia polysphaera Baker: Anti-inflammatory activity in vivo and inhibitory effect in LPS-stimulated RAW 264.7 cells
Článek Prevalence of drug–drug interaction in atrial fibrillation patients based on a large claims data
Článek Diversity and distribution of microbial communities in floral nectar of two night-blooming plants of the Sonoran Desert
Článek Examining differences in cigarette smoking prevalence among young adults across national surveillance surveys
Článek Reversed metabolic reprogramming as a measure of cancer treatment efficacy in rat C6 glioma model
Článek Effect of diabetes on incidence of peritoneal dialysis-associated peritonitis
Článek Alligators in the abyss: The first experimental reptilian food fall in the deep ocean
Článek A novel power-driven fractional accumulated grey model and its application in forecasting wind energy consumption of China
Článek Chronic unexplained nausea in adults: Prevalence, impact on quality of life, and underlying organic diseases in a cohort of 5096 subjects comprehensively investigated
Článek Evaluation of a nanophosphor lateral-flow assay for self-testing for herpes simplex virus type 2 seropositivity
Článek Normal and altered masticatory load impact on the range of craniofacial shape variation: An analysis of pre-Hispanic and modern populations of the American Southern Cone
Článek An examination of the association between early initiation of substance use and interrelated multilevel risk and protective factors among adolescents
Článek Pelagic tunicates at shallow hydrothermal vents of Kueishantao
Článek Aegicetus gehennae, a new late Eocene protocetid (Cetacea, Archaeoceti) from Wadi Al Hitan, Egypt, and the transition to tail-powered swimming in whales
Článek Changing landscape configuration demands ecological planning: Retrospect and prospect for megaherbivores of North Bengal
Článek Analyzing linguistic variation and change using gamification web apps: The case of German-speaking Europe
Článek Factors associated with condom use among HIV-positive women living in Atlanta, Georgia
Článek Watered-down biodiversity? A comparison of metabarcoding results from DNA extracted from matched water and bulk tissue biomonitoring samples
Článek Identification and impact of stable prognostic biochemical markers for cold-induced sweetening resistance on selection efficiency in potato (Solanum tuberosum L.) breeding programs
Článek Naïve/Effector CD4 T cell ratio as a useful predictive marker of immune reconstitution in late presenter HIV patients: A multicenter study
Článek C5aR agonist enhances phagocytosis of fibrillar and non-fibrillar Aβ amyloid and preserves memory in a mouse model of familial Alzheimer’s disease
Článek Channel-spatial attention network for fewshot classification
Článek The evolution and genetic diversity of avian influenza A(H9N2) viruses in Cambodia, 2015 – 2016
Článek Healing The Past By Nurturing The Future: A qualitative systematic review and meta-synthesis of pregnancy, birth and early postpartum experiences and views of parents with a history of childhood maltreatment
Článek Seeking snow and breathing hard – Behavioral tactics in high elevation mammals to combat warming temperatures
Článek Application of enhanced assimilable organic carbon method across operational drinking water systems
Článek New fossils of Elateridae (Insecta, Coleoptera) from Early Cretaceous Jinju Formation (South Korea) with their implications to evolutionary diversity of extinct Protagrypninae
Článek Establishment of normative ranges of the healthy human immune system with comprehensive polychromatic flow cytometry profiling
Článek NF-κB-mediated regulation of rat CYP2E1 by two independent signaling pathways
Článek Effectiveness of integrative medicine group visits in chronic pain and depressive symptoms: A randomized controlled trial
Článek Comparative analysis of the vaginal microbiome of pregnant women with either Trichomonas vaginalis or Chlamydia trachomatis
Článek Diet and feeding strategy of Northeast Atlantic mackerel (Scombrus scomber) in Icelandic waters
Článek Agricultural intensification was associated with crop diversification in India (1947-2014)
Článek IL-18/IL-37/IP-10 signalling complex as a potential biomarker for discriminating active and latent TB
Článek Immuno-metabolic profile of human macrophages after Leishmania and Trypanosoma cruzi infection
Článek Association between cardiovascular diseases and pregnancy-induced hypertensive disorders in a population of Cameroonian women at Yaoundé: A case-control study
Článek Four months vitamin D supplementation to vitamin D insufficient individuals does not improve muscular strength: A randomized controlled trial
Článek Preoperative and operation-related risk factors for postoperative nosocomial infections in pediatric patients: A retrospective cohort study
Článek Differences between individuals with schizophrenia or obsessive-compulsive disorder and healthy controls in social cognition and mindfulness skills: A controlled study
Článek Variations by sex and age in the association between alcohol use and depressed mood among Thai adolescents
Článek Undernutrition is associated with perturbations in T cell-, B cell-, monocyte- and dendritic cell- subsets in latent Mycobacterium tuberculosis infection
Článek RNA-sequencing reveals that STRN, ZNF484 and WNK1 add to the value of mitochondrial MT-COI and COX10 as markers of unstable coronary artery disease
Článek Human gut microbiota is associated with HIV-reactive immunoglobulin at baseline and following HIV vaccination
Článek Is un stylo sharper than une épée? Investigating the interaction of sound symbolism and grammatical gender in English and French speakers
Článek Effects of continuity of care on the postradiotherapy survival of working-age patients with oral cavity cancer: A nationwide population-based cohort study in Taiwan
Článek Self-reported attitudes, knowledge and skills of using evidence-based medicine in daily health care practice: A national survey among students of medicine and health sciences in Hungary
Článek Up on the roof and down in the dirt: Differences in substrate properties (SOM, potassium, phosphorus and pH) and their relationships to each other between sedum and wildflower green roofs
Článek Combination treatment of berberine and solid lipid curcumin particles increased cell death and inhibited PI3K/Akt/mTOR pathway of human cultured glioblastoma cells more effectively than did individual treatments
Článek HR-pQCT imaging in children, adolescents and young adults: Systematic review and subgroup meta-analysis of normative data
Článek 4D perfusion CT of prostate cancer for image-guided radiotherapy planning: A proof of concept study
Článek Rapid wound healing in a reef manta ray masks the extent of vessel strike
Článek BPRF: Blockchain-based privacy-preserving reputation framework for participatory sensing systems
Článek Hidden dynamics of soccer leagues: The predictive ‘power’ of partial standings
Článek Diet of the brown bear in Himalaya: Combining classical and molecular genetic techniques
Článek Multiscale analysis for patterns of Zika virus genotype emergence, spread, and consequence
Článek Association between circulating neuregulin4 levels and diabetes mellitus: A meta-analysis of observational studies
Článek Impact of relational leadership on employees’ unethical pro-organizational behavior: A survey based on tourism companies in four countries
Článek Using morphological attributes for the fast assessment of nutritional responses of Buddhist pine (Podocarpus macrophyllus [Thunb.] D. Don) seedlings to exponential fertilization
Článek Direct costs of illness of patients with chronic cough in rural Malawi—Experiences from Dowa and Ntchisi districts
Článek Bone spoons for prehistoric babies: Detection of human teeth marks on the Neolithic artefacts from the site Grad-Starčevo (Serbia)
Článek Identifying and characterizing extrapolation in multivariate response data
Článek Clinically-defined preoperative serum phosphorus abnormalities and outcomes of coronary artery bypass grafting: Retrospective analysis using inverse probability weighting adjustment
Článek My experiences with kidney care: A qualitative study of adults in the Northern Territory of Australia living with chronic kidney disease, dialysis and transplantation
Článek Evaluation of upconverting nanoparticles towards heart theranostics
Článek Cashew nuts (Anacardium occidentale L.) decrease visceral fat, yet augment glucose in dyslipidemic rats
Článek Pathways to care and outcomes among hospitalised HIV-seropositive persons with cryptococcal meningitis in South Africa
Článek Fungicides, herbicides and bees: A systematic review of existing research and methods
Článek The risk of active tuberculosis among individuals living in tuberculosis-affected households in the Republic of Korea, 2015
Článek Factors affecting the spread of multiple information in social networks
Článek Network dynamics of Broca’s area during word selection
Článek Is less readable liked better? The case of font readability in poetry appreciation
Článek An expanded rating curve model to estimate river discharge during tidal influences across the progressive-mixed-standing wave systems
Článek Serum procalcitonin as an independent diagnostic markers of bacteremia in febrile patients with hematologic malignancies
Článek Polyvinylalcohol-carbazate (PVAC) reduces red blood cell hemolysis
Článek Single nucleotide polymorphisms associated with susceptibility for development of colorectal cancer: Case-control study in a Basque population
Článek Transient effect of melatonin treatment after neonatal hypoxic-ischemic brain injury in rats
Článek Housekeeping gene validation for RT-qPCR studies on synovial fibroblasts derived from healthy and osteoarthritic patients with focus on mechanical loading
Článek Does historical land use affect the regional distribution of fleshy-fruited woody plants?
Článek The diversity and abundance of fungi and bacteria on the healthy and dandruff affected human scalp
Článek Interferometric fluorescence cross correlation spectroscopy
Článek Evaluating the impact of setting delineators in tunnels based on drivers’ visual characteristics
Článek Influence of Debaryomyces hansenii on bacterial lactase gene diversity in intestinal mucosa of mice with antibiotic-associated diarrhea
Článek Food from faeces: Evaluating the efficacy of scat DNA metabarcoding in dietary analyses
Článek Toll-like receptor 7-adapter complex modulates interferon-α production in HIV-stimulated plasmacytoid dendritic cells
Článek Prediction model for dengue fever based on interactive effects between multiple meteorological factors in Guangdong, China (2008–2016)
Článek Circadian misalignment alters insulin sensitivity during the light phase and shifts glucose tolerance rhythms in female mice
Článek Commonly missed nursing cares in the obstetrics and gynecologic wards of Tigray general hospitals; Northern Ethiopia
Článek Preparedness for colorectal cancer surgery and recovery through a person-centred information and communication intervention – A quasi-experimental longitudinal design
Článek Detrended Fluctuation Analysis in the prediction of type 2 diabetes mellitus in patients at risk: Model optimization and comparison with other metrics
Článek A co-registration investigation of inter-word spacing and parafoveal preview: Eye movements and fixation-related potentials
Článek Sequence analyses at mitochondrial and nuclear loci reveal a novel Theileria sp. and aid in the phylogenetic resolution of piroplasms from Australian marsupials and ticks
Článek Plasmacytoid dendritic cell and myeloid dendritic cell function in ageing: A comparison between elderly and young adult women
Článek Lomax exponential distribution with an application to real-life data
Článek Territoriality and the organization of technology during the Last Glacial Maximum in southwestern Europe
Článek The evaluation of the Woman’s Condom marketing approach: What value did peer-led interpersonal communication add to the promotion of a new female condom in urban Lusaka?
Článek Discovery of genomic variations by whole-genome resequencing of the North American Araucana chicken
Článek A Bayesian Monte Carlo approach for predicting the spread of infectious diseases
Článek Orbit image analysis machine learning software can be used for the histological quantification of acute ischemic stroke blood clots
Článek Impact of oral probiotic Lactobacillus acidophilus vaccine strains on the immune response and gut microbiome of mice
Článek Backward compatibility of whole genome sequencing data with MLVA typing using a new MLVAtype shiny application for Vibrio cholerae
Článek Dynamics of essential interaction between firms on financial reports
Článek Drug overdose among women in intimate relationships: The role of partner violence, adversity and relationship dependencies
Článek California condor microbiomes: Bacterial variety and functional properties in captive-bred individuals
Článek Evaluation of the potential of a new ribavirin analog impairing the dissemination of ovarian cancer cells
Článek Molecular characterization of fowl adenovirus isolate of Malaysia attenuated in chicken embryo liver cells and its pathogenicity and immunogenicity in chickens
Článek Prolonged fasting followed by refeeding modifies proteome profile and parvalbumin expression in the fast-twitch muscle of pacu (Piaractus mesopotamicus)
Článek Expanded eligibility for HIV testing increases HIV diagnoses—A cross-sectional study in seven health facilities in western Kenya
Článek Clinically useful limited sampling strategy to estimate area under the concentration-time curve of once-daily tacrolimus in adult Japanese kidney transplant recipients
Článek Re-introduction of dengue virus serotype 2 in the state of Rio de Janeiro after almost a decade of epidemiological silence
Článek The salivary gland proteome of root-galling grape phylloxera (Daktulosphaira vitifoliae Fitch) feeding on Vitis spp.
Článek Efficacy of antimalarial drugs for treatment of uncomplicated falciparum malaria in Asian region: A network meta-analysis
Článek A study of the impact of data sharing on article citations using journal policies as a natural experiment
Článek Women with metabolic syndrome show similar health benefits from high-intensity interval training than men
Článek Long-term tracking demonstrates effectiveness of a partnership-led training program to advance the careers of biomedical researchers from underrepresented groups
Článek Serological evidence of arboviruses and coccidia infecting horses in the Amazonian region of Brazil
Článek Do cancer stem cells exist? A pilot study combining a systematic review with the hierarchy-of-hypotheses approach
Článek PyRates—A Python framework for rate-based neural simulations
Článek Ecological interdependencies and resource competition: The role of information and communication in promoting effective collaboration in complex management situations
Článek Quaking-induced conversion of prion protein on a thermal mixer accelerates detection in brains infected with transmissible spongiform encephalopathy agents
Článek Smoking trajectories and risk of stroke until age of 50 years – The Northern Finland Birth Cohort 1966
Článek L-lysine protects C2C12 myotubes and 3T3-L1 adipocytes against high glucose damages and stresses
Článek IGF-1-enhanced miR-513a-5p signaling desensitizes glioma cells to temozolomide by targeting the NEDD4L-inhibited Wnt/β-catenin pathway
Článek Performance, complexity and dynamics of force maintenance and modulation in young and older adults
Článek A method for complete plant taxon and site inventories in large forest areas with the help of orienteering maps, as exemplified by target forests in Switzerland
Článek Microbial diversity and mineral composition of weathered serpentine rock of the Khalilovsky massif
Článek Interaction strength in plant-pollinator networks: Are we using the right measure?
Článek Psychometric properties of the PERMA Profiler for measuring wellbeing in Australian adults
Článek Trust development as an expectancy-learning process: Testing contingency effects
Článek Mutation analysis of annual sediment discharge at Wu Long station in Wu Jiang River Basin from 1960 to 2016
Článek Comprehensive value assessment of drugs using a multi-criteria decision analysis: An example of targeted therapies for metastatic colorectal cancer treatment
Článek Causes of inferior relative survival after testicular germ cell tumor diagnosed 1953–2015: A population-based prospective cohort study
Článek Mystery or method? Evaluating claims of increased energy expenditure during a ketogenic diet
Článek Commentary on: Abundance and distribution of microplastics within surface sediments of a key shellfish growing region of Canada
Článek The genetic and environmental effects on school grades in late childhood and adolescence
Článek Metabolic power in hurling with respect to position and halves of match-play
Článek Local, nonlinear effects of cGMP and Ca2+ reduce single photon response variability in retinal rods
Článek The long-term arterial assist intermittent pneumatic compression generating venous flow obstruction is responsible for improvement of arterial flow in ischemic legs
Článek INT reduction is a valid proxy for eukaryotic plankton respiration despite the inherent toxicity of INT and differences in cell wall structure
Článek Gestational diabetes mellitus diagnosed at 24 to 28 weeks of gestation in older and obese Women: Is it too late?
Článek Hermetia illucens in diets for zebrafish (Danio rerio): A study of bacterial diversity by using PCR-DGGE and metagenomic sequencing
Článek Thermotolerant Campylobacter spp. in chicken and bovine meat in Italy: Prevalence, level of contamination and molecular characterization of isolates
Článek Prognostic value of maximum standard uptake value, metabolic tumor volume, and total lesion glycolysis of positron emission tomography/computed tomography in patients with breast cancer: A systematic review and meta-analysis
Článek Understanding the variability of handheld spectral-domain optical coherence tomography measurements in supine infants
Článek Does seed size mediate sex-specific reproduction costs in the Callosobruchus maculatus bean beetle?
Článek Characters matter: How narratives shape affective responses to risk communication
Článek The transcriptome analysis of the Arabidopsis thaliana in response to the Vibrio vulnificus by RNA-sequencing
Článek Stable depletion of RUNX1-ETO in Kasumi-1 cells induces expression and enhanced proteolytic activity of Cathepsin G and Neutrophil Elastase
Článek Choosing important health outcomes for comparative effectiveness research: 5th annual update to a systematic review of core outcome sets for research
Článek Balancing fire risk and human thermal comfort in fire-prone urban landscapes
Článek Low-rank graph optimization for multi-view dimensionality reduction
Článek Time optimal entrainment control for circadian rhythm
Článek Why do football clubs fail financially? A financial distress prediction model for European professional football industry
Článek To be or not to be an inclusive teacher: Are empathy and social dominance relevant factors to positive attitudes towards inclusive education?
Článek Seasonality of deaths with respect to age and cause in Chitral District Pakistan
Článek Poor nutrition for under-five children from poor households in Ethiopia: Evidence from 2016 Demographic and Health Survey
Článek Safety and immune cell kinetics after donor natural killer cell infusion following haploidentical stem cell transplantation in children with recurrent neuroblastoma
Článek On-site blood culture incubation shortens the time to knowledge of positivity and microbiological results in septic patients
Článek Genome wide identification and characterization of microsatellite markers in black pepper (Piper nigrum): A valuable resource for boosting genomics applications
Článek Child behaviour and subsequent changes in body weight, composition and shape
Článek RBM3 and CIRP expressions in targeted temperature management treated cardiac arrest patients—A prospective single center study
Článek Segmentation of distal airways using structural analysis
Článek A single intra-articular injection of 2.0% non-chemically modified sodium hyaluronate vs 0.8% hylan G-F 20 in the treatment of symptomatic knee osteoarthritis: A 6-month, multicenter, randomized, controlled non-inferiority trial
Článek Extending the information content of the MALDI analysis of biological fluids via multi-million shot analysis
Článek Effects of the performance parameters of a wheelchair on the changes in the position of the centre of gravity of the human body in dynamic condition
Článek An analysis of atmospheric water vapor variations over a complex agricultural region using airborne imaging spectrometry
Článek Factors influencing harmonized health data collection, sharing and linkage in Denmark and Switzerland: A systematic review
Článek Intracerebroventricular administration of the thyroid hormone analog TRIAC increases its brain content in the absence of MCT8
Článek Social influences on smoking cessation in mid-life: Prospective cohort of UK women
Článek Cord compression defined by MRI is the driving factor behind the decision to operate in Degenerative Cervical Myelopathy despite poor correlation with disease severity
Článek Characterization of testis-specific serine/threonine kinase 1-like (TSSK1-like) gene and expression patterns in diploid and triploid Pacific abalone (Haliotis discus hannai; Gastropoda; Mollusca) males
Článek Focal inputs are a potential origin of local field potential (LFP) in the brain regions without laminar structure
Článek Emergency Department visits due to intoxications in a Dutch university hospital: Occurrence, characteristics and health care costs
Článek The effects of isobaric and hyperbaric bupivacaine on maternal hemodynamic changes post spinal anesthesia for elective cesarean delivery: A prospective cohort study
Článek Long-term outcome in patients after treatment for Cushing’s disease in childhood
Článek The effects of diurnal intermittent fasting on proinflammatory cytokine levels while controlling for sleep/wake pattern, meal composition and energy expenditure
Článek Gender differences in the interaction effect of cumulative risk and problem-focused coping on depression among adult employees
Článek Prevalence of hypothermia on admission to recovery room remains high despite a large use of forced-air warming devices: Findings of a non-randomized observational multicenter and pragmatic study on perioperative hypothermia prevalence in France
Článek De novo transcriptome analysis and identification of genes associated with immunity, detoxification and energy metabolism from the fat body of the tephritid gall fly, Procecidochares utilis
Článek Linking surveillance and clinical data for evaluating trends in bloodstream infection rates in neonatal units in England
Článek Women’s decision-making power and undernutrition in their children under age five in the Democratic Republic of the Congo: A cross-sectional study
Článek Ocular surface and tear film changes in workers exposed to organic solvents used in the dry-cleaning industry
Článek The interferon-gamma pathway is selectively up-regulated in the liver of patients with secondary hemophagocytic lymphohistiocytosis
Článek Apologies as signals for change? Implicit theories of personality and reactions to apologies during the #MeToo movement
Článek Knee joint biomechanics in transtibial amputees in gait, cycling, and elliptical training
Článek The polarity protein Dlg5 regulates collective cell migration during Drosophila oogenesis
Článek Resolving fluorescent species by their brightness and diffusion using correlated photon-counting histograms
Článek Rapid loss of flight in the Aldabra white-throated rail
Článek Classification of flavors in cigarillos and little cigars and their variable cellular and acellular oxidative and cytotoxic responses
Článek Image denoising via a non-local patch graph total variation
Článek Chemogenomic profiling to understand the antifungal action of a bioactive aurone compound
Článek Isobaric mass tagging and triple quadrupole mass spectrometry to determine lipid biomarker candidates for Alzheimer's disease
Článek Awareness of polycystic ovary syndrome among obstetrician-gynecologists and endocrinologists in Northern Europe
Článek Maternal death review and surveillance: The case of Central Hospital, Benin City, Nigeria
Článek Assessing insomnia management in community pharmacy setting in Jordan: A simulated patient approach
Článek Mapping the EORTC QLQ-C30 and QLQ-H&N35 to the EQ-5D for head and neck cancer: Can disease-specific utilities be obtained?
Článek Subtle changes in striatal muscarinic M1 and M4 receptor expression in the DYT1 knock-in mouse model of dystonia
Článek Using evidence when planning for trial recruitment: An international perspective from time-poor trialists
Článek Does educational level predict hearing aid self-efficacy in experienced older adult hearing aid users from Latin America? Validation process of the Spanish version of the MARS-HA questionnaire
Článek Psychometric properties of the Portuguese version of the National Eye Institute Visual Function Questionnaire-25
Článek Chlamydiaceae in wild, feral and domestic pigeons in Switzerland and insight into population dynamics by Chlamydia psittaci multilocus sequence typing
Článek Longitudinal Doppler references for monochorionic twins and comparison with singletons
Článek Survey on Chlamydiaceae in cloacal swabs from Swiss turkeys demonstrates absence of Chlamydia psittaci and low occurrence of Chlamydia gallinacean
Článek Computational singular perturbation analysis of brain lactate metabolism
Článek Analyzing and interpreting spatial and temporal variability of the United States county population distributions using Taylor's law
Článek Direct comparison of retinal structure and function in retinitis pigmentosa by co-registering microperimetry and optical coherence tomography
Článek Significant reduction of vancomycin resistant E. faecium in the Norwegian broiler population coincided with measures taken by the broiler industry to reduce antimicrobial resistant bacteria
Článek Dual-hemispheric transcranial direct current stimulation (tDCS) over primary motor cortex does not affect movement selection
Článek Pharmacological or genetic targeting of Transient Receptor Potential (TRP) channels can disrupt the planarian escape response
Článek Flax rust infection transcriptomics reveals a transcriptional profile that may be indicative for rust Avr genes
Článek Optimizing sgRNA length to improve target specificity and efficiency for the GGTA1 gene using the CRISPR/Cas9 gene editing system
Článek Diversity of A(H5N1) clade 2.3.2.1c avian influenza viruses with evidence of reassortment in Cambodia, 2014-2016
Článek The effects of kinesiology taping on experimentally-induced thermal and mechanical pain in otherwise pain-free healthy humans: A randomised controlled repeated-measures laboratory study
Článek Tobacco and E-cigarette use among cancer survivors in the United States
Článek Loading… loading… The influence of download time on information search
Článek Crystal structures of p120RasGAP N-terminal SH2 domain in its apo form and in complex with a p190RhoGAP phosphotyrosine peptide
Článek Echolocation while drinking: Pulse-timing strategies by high- and low-frequency FM bats
Článek A novel one-class classification approach to accurately predict disease-gene association in acute myeloid leukemia cancer
Článek Generalized nonlinear Schrödinger equations describing the Second Harmonic Generation of femtosecond pulse, containing a few cycles, and their integrals of motion
Článek Community perception of abortion, women who abort and abortifacients in Kisumu and Nairobi counties, Kenya
Článek The Salmonella type III effector SpvC triggers the reverse transmigration of infected cells into the bloodstream
Článek Serum PCSK6 and corin levels are not associated with cardiovascular outcomes in patients undergoing coronary angiography
Článek On a remarkable sexual dimorphic trait in the Characiformes related to the olfactory organ and description of a new miniature species of Tyttobrycon Géry (Characiformes: Characidae)
Článek Effect of integrating a video intervention on parenting practices and related parental self-efficacy regarding health behaviours within the Feel4Diabetes-study in Belgian primary schoolchildren from vulnerable families: A cluster randomized trial
Článek Type 2 diabetes care: Improvement by standardization at a diabetes rehabilitation clinic. An observational report
Článek Regulating pharmacists as contraception providers: A qualitative study from Coastal Kenya on injectable contraception provision to youth
Článek The impact of familial risk and early life adversity on emotion and reward processing networks in youth at-risk for bipolar disorder
Článek Melanism evolution in the cat family is influenced by intraspecific communication under low visibility
Článek Gene expression profiles classifying clinical stages of tuberculosis and monitoring treatment responses in Ethiopian HIV-negative and HIV-positive cohorts
Článek Selection of valid reference genes for quantitative real-time PCR in Cotesia chilonis (Hymenoptera: Braconidae) exposed to different temperatures
Článek Magnitude of surgical site infection and its associated factors among patients who underwent a surgical procedure at Wolaita Sodo University Teaching and Referral Hospital, South Ethiopia
Článek Kyasanur Forest Disease vaccination coverage and its perceived barriers in Goa, India—A mixed methods operational research
Článek Maternal psychosocial risk factors and lower respiratory tract infection (LRTI) during infancy in a South African birth cohort
Článek Ameliorating effects of Gö6976, a pharmacological agent that inhibits protein kinase D, on collagen-induced arthritis
Článek Regional hypothermia improves gastric microcirculatory oxygenation during hemorrhage in dogs
Článek Dynamical comparison between Drosha and Dicer reveals functional motion similarities and dissimilarities
Článek Expression of HIF-1α is related to a poor prognosis and tamoxifen resistance in contralateral breast cancer
Článek Metabolic responses of wheat seedlings to osmotic stress induced by various osmolytes under iso-osmotic conditions
Článek A δ2H Isoscape of blackberry as an example application for determining the geographic origins of plant materials in New Zealand
Článek Fiber visualization for preoperative glioma assessment: Tractography versus local connectivity mapping
Článek Amiselimod (MT-1303), a novel sphingosine 1-phosphate receptor-1 functional antagonist, inhibits progress of chronic colitis induced by transfer of CD4+CD45RBhigh T cells
Článek Insights of organic fertilizer micro flora of bovine manure and their useful potentials in sustainable agriculture
Článek Is parity a cause of tooth loss? Perceptions of northern Nigerian Hausa women
Článek Low-diversity bacterial microbiota in Southern Ocean representatives of lanternfish genera Electrona, Protomyctophum and Gymnoscopelus (family Myctophidae)
Článek Bacteriologically-confirmed pulmonary tuberculosis in an Ethiopian prison: Prevalence from screening of entrant and resident prisoners
Článek Multi-objective AGV scheduling in an automatic sorting system of an unmanned (intelligent) warehouse by using two adaptive genetic algorithms and a multi-adaptive genetic algorithm
Článek PTH1-34 improves bone healing by promoting angiogenesis and facilitating MSCs migration and differentiation in a stabilized fracture mouse model
Článek Aspirin enhances sensitization to the egg-white allergen ovalbumin in rats
Článek HCV incidence is associated with injecting partner age and HCV serostatus mixing in young adults who inject drugs in San Francisco
Článek Adherence is associated with a favorable outcome after lung transplantation
Článek Availability, prices and affordability of essential medicines for treatment of diabetes and hypertension in private pharmacies in Zambia
Článek Amnestic mild cognitive impairment in Parkinson’s disease: White matter structural changes and mechanisms
Článek Menagerie: A text-mining tool to support animal-human translation in neurodegeneration research
Článek Profusion of G-quadruplexes on both subunits of metazoan ribosomes
Článek Analysis of genome-wide DNA arrays reveals the genomic population structure and diversity in autochthonous Greek goat breeds
Článek Impact of human-derived hemoglobin based oxygen vesicles as a machine perfusion solution for liver donation after cardiac death in a pig model
Článek Microbial diversity within the digestive tract contents of Dezhou donkeys
Článek Nexrutine and exercise similarly prevent high grade prostate tumors in transgenic mouse model
Článek Shannon entropy approach reveals relevant genes in Alzheimer’s disease
Článek Experimental hut evaluation of DawaPlus 3.0 LN and DawaPlus 4.0 LN treated with deltamethrin and PBO against free-flying populations of Anopheles gambiae s.l. in Vallée du Kou, Burkina Faso
Článek Induction of miR 21 impairs the anti-Leishmania response through inhibition of IL-12 in canine splenic leukocytes
Článek Ultra-deep massively parallel sequencing with unique molecular identifier tagging achieves comparable performance to droplet digital PCR for detection and quantification of circulating tumor DNA from lung cancer patients
Článek Pupillometry evaluation of melanopsin retinal ganglion cell function and sleep-wake activity in pre-symptomatic Alzheimer’s disease
Článek Sickness absence and disability pension before and after first childbirth and in nulliparous women by numerical gender segregation of occupations: A Swedish population-based longitudinal cohort study
Článek New insights into intranuclear inclusions in thyroid carcinoma: Association with autophagy and with BRAFV600E mutation
Článek Effects of medium chain triglycerides supplementation on insulin sensitivity and beta cell function: A feasibility study
Článek The impact of mental health recovery narratives on recipients experiencing mental health problems: Qualitative analysis and change model
Článek Not so unique to Primates: The independent adaptive evolution of TRIM5 in Lagomorpha lineage
Článek Distributed forecasting and ant colony optimization for the bike-sharing rebalancing problem with unserved demands
Článek Chronic dietary supplementation with kynurenic acid, a neuroactive metabolite of tryptophan, decreased body weight without negative influence on densitometry and mandibular bone biomechanical endurance in young rats
Článek Higher neuron densities in the cerebral cortex and larger cerebellums may limit dive times of delphinids compared to deep-diving toothed whales
Článek Individual variation in migratory movements of chinstrap penguins leads to widespread occupancy of ice-free winter habitats over the continental shelf and deep ocean basins of the Southern Ocean
Článek Correction: Anabolic steroids among resistance training practitioners
Článek The effect of emotional information from eyes on empathy for pain: A subliminal ERP study
Článek NKL homeobox gene activities in normal and malignant myeloid cells
Článek Personal distress as a mediator between self-esteem, self-efficacy, loneliness and problematic video gaming in female and male emerging adult gamers
Článek Prevalence of vitamin D deficiency in women from southern Brazil and association with vitamin D-binding protein levels and GC-DBP gene polymorphisms
Článek Balance control mechanisms do not benefit from successive stimulation of different sensory systems
Článek Measuring individual differences in cognitive abilities in the lab and on the web
Článek Objective sleep assessment in >80,000 UK mid-life adults: Associations with sociodemographic characteristics, physical activity and caffeine
Článek Self-reported traffic-related air pollution and respiratory symptoms among adults in an area with modest levels of traffic
Článek A hierarchical loss and its problems when classifying non-hierarchically
Článek Cross-cultural examination of the Big Five Personality Trait Short Questionnaire: Measurement invariance testing and associations with mental health
Článek A geographically weighted random forest approach for evaluate forest change drivers in the Northern Ecuadorian Amazon
Článek Spatial genetic structure and diversity of natural populations of Aesculus hippocastanum L. in Greece
Článek Anemia in patients with diabetic foot ulcer and its impact on disease outcome among Nigerians: Results from the MEDFUN study
Článek The effectiveness of physiotherapy interventions on pain and quality of life in adults with persistent post-surgical pain compared to usual care: A systematic review
Článek Association between anxiety and non-coding genetic variants of the galanin neuropeptide
Článek Evaluating the effectiveness of HOCl application on odor reduction and earthworm population growth during vermicomposting of food waste employing Eisenia fetida
Článek What is known about the quality of out-of-hospital emergency medical services in the Arabian Gulf States? A systematic review
Článek Impact of dietary patterns, individual and workplace characteristics on blood pressure status among civil servants in Bida and Wushishi communities of Niger State, Nigeria
Článek Robust detection of event-related potentials in a user-voluntary short-term imagery task
Článek Microbiota composition of the dorsal patch of reproductive male Leptonycteris yerbabuenae
Článek Characteristics of the gut microbiota in professional martial arts athletes: A comparison between different competition levels
Článek Interpreting social determinants: Emergent properties and adolescent risk behaviour
Článek Tulathromycin treatment does not affect bacterial dissemination or clearance of Brucella melitensis 16M following experimental infection of goats
Článek Hydrogenotrophic methanogens of the mammalian gut: Functionally similar, thermodynamically different—A modelling approach
Článek Gene delivery of a modified antibody to Aβ reduces progression of murine Alzheimer’s disease
Článek Flock sensitivity and specificity of pooled fecal qPCR and pooled serum ELISA for screening ovine paratuberculosis
Článek Disrupted resting-state brain functional network in methamphetamine abusers: A brain source space study by EEG
Článek Steady expression of high oleic acid in peanut bred by marker-assisted backcrossing for fatty acid desaturase mutant alleles and its effect on seed germination along with other seedling traits
Článek DNA metabarcoding-based diet survey for the Eurasian otter (Lutra lutra): Development of a Eurasian otter-specific blocking oligonucleotide for 12S rRNA gene sequencing for vertebrates
Článek Dynamics of photosynthetic responses in 10 rubber tree (Hevea brasiliensis) clones in Colombian Amazon: Implications for breeding strategies
Článek Inferring disease severity in rheumatoid arthritis using predictive modeling in administrative claims databases
Článek An evaluation of different classification algorithms for protein sequence-based reverse vaccinology prediction
Článek Detecting false intentions using unanticipated questions
Článek In vitro activity and In vivo efficacy of Isoliquiritigenin against Staphylococcus xylosus ATCC 700404 by IGPD target
Článek When risk becomes illness: The personal and social consequences of cervical intraepithelial neoplasia medical surveillance
Článek Sperm DNA integrity in adult survivors of paediatric leukemia and lymphoma: A pilot study on the impact of age and type of treatment
Článek Swaying slower reduces the destabilizing effects of a compliant surface on voluntary sway dynamics
Článek Dye diffusion during laparoscopic tubal patency tests may suggest a lymphatic contribution to dissemination in endometriosis: A prospective, observational study
Článek Intra-individual correlations between quantitative THK-5351 PET and MRI-derived cortical volume in Alzheimer’s disease differ according to disease severity and amyloid positivity
Článek Assessment of the role of Trichomonas tenax in the etiopathogenesis of human periodontitis: A systematic review
Článek Root and alveolar bone changes in first premolars adjacent to the traction of buccal versus palatal maxillary impacted canines
Článek Investigating multisite pain as a predictor of self-reported falls and falls requiring health care use in an older population: A prospective cohort study
Článek The socio-economic status gradient in median lifespan by birth cohorts: Evidence from Dutch Olympic athletes born between 1852 and 1947
Článek Identification of Plasmodium dipeptidyl aminopeptidase allosteric inhibitors by high throughput screening
Článek Brief group-delivered motivational interviewing is equally effective as brief group-delivered cognitive-behavioral therapy at reducing alcohol use in risky college drinkers
Článek Predicting the occurrence of surgical site infections using text mining and machine learning
Článek Organic carbon sequestration in sediments of subtropical Florida lakes
Článek Reliability of isokinetic knee strength measurements in children: A systematic review and meta-analysis
Článek Plasma concentration of neurofilament light chain protein decreases after switching from tenofovir disoproxil fumarate to tenofovir alafenamide fumarate
Článek Revealing the assembly of filamentous proteins with scanning transmission electron microscopy
Článek Effects of treated wastewater on the ecotoxicity of small streams – Unravelling the contribution of chemicals causing effects
Článek Air quality and obesity at older ages in China: The role of duration, severity and pollutants
Článek Breeding French bulldogs so that they breathe well—A long way to go
Článek A network-centric approach for estimating trust between open source software developers
Článek A novel scoring system to predict the requirement for surgical intervention in victims of motor vehicle crashes: Development and validation using independent cohorts
Článek Prediction of overt hepatic encephalopathy by the continuous reaction time method and the portosystemic encephalopathy syndrome test in clinically mentally unimpaired patients with cirrhosis
Článek Attentional capture by Pavlovian reward-signalling distractors in visual search persists when rewards are removed
Článek Validation of risk factors for recurrence of renal cell carcinoma: Results from a large single-institution series
Článek Real world, big data cost of pharmaceutical treatment for rheumatoid arthritis in Greece
Článek Does training with amplitude modulated tones affect tone-vocoded speech perception?
Článek Accuracy of the Cosmed K5 portable calorimeter
Článek Non-invasive diagnostic criteria of hepatocellular carcinoma: Comparison of diagnostic accuracy of updated LI-RADS with clinical practice guidelines of OPTN-UNOS, AASLD, NCCN, EASL-EORTC, and KLSCG-NCC
Článek Omentin-1 in diabetes mellitus: A systematic review and meta-analysis
Článek Immunological recovery, failure and factors associated with CD-4 T-cells progression over time, among adolescents and adults living with HIV on Antiretroviral Therapy in Northern Ethiopia: A retrospective cross sectional study
Článek Prediction of poor outcome after hypoxic-ischemic brain injury by diffusion-weighted imaging: A systematic review and meta-analysis
Článek Absence of posture-dependent and posture-congruent memory effects on the recall of action sentences
Článek Identifiability and numerical algebraic geometry
Článek Co-infection of cattle with Fasciola hepatica or F. gigantica and Mycobacterium bovis: A systematic review
Článek High maternal self-efficacy is associated with meeting Institute of Medicine gestational weight gain recommendations
Článek Isolation of endothelial cells, pericytes and astrocytes from mouse brain
Článek Effects of metformin administration on endocrine-metabolic parameters, visceral adiposity and cardiovascular risk factors in children with obesity and risk markers for metabolic syndrome: A pilot study
Článek Physiological impact of nanoporous acupuncture needles: Laser Doppler perfusion imaging in healthy volunteers
Článek A world map of evidence-based medicine: Density equalizing mapping of the Cochrane database of systematic reviews
Článek Common trust and personal safety issues: A systematic review on the acceptability of health and social interventions for persons with lived experience of homelessness
Článek Implications of monocular vision for racing drivers
Článek Effect of arteriovenous access closure and timing on kidney function in kidney transplant recipients
Článek Immune responses to a HSV-2 polynucleotide immunotherapy COR-1 in HSV-2 positive subjects: A randomized double blinded phase I/IIa trial
Článek What Twitter teaches us about patient-provider communication on pain
Článek Development of a computer-aided design software for the quantitative evaluation of aesthetic damage
Článek Microtubules are necessary for proper Reticulon localization during mitosis
Článek Human perception and biosignal-based identification of posed and spontaneous smiles
Článek State of household need for caregivers and determinants of psychological burden among caregivers of older people in Thailand: An analysis from national surveys on older persons
Článek Dietary habits of the black-necked swan Cygnus melancoryphus (Birds: Anatidae) and variability of the aquatic macrophyte cover in the Río Cruces wetland, southern Chile
Článek Improving emotional health and self-esteem of Malaysian adolescents living in orphanages through Life Skills Education program: A multi-centre randomized control trial
Článek Radiocarbon, Bayesian chronological modeling and early European metal circulation in the sixteenth-century AD Mohawk River Valley, USA
Článek Economic evaluation of HPV DNA test as primary screening method for cervical cancer: A health policy discussion in Greece
Článek Clonality testing in the lymph nodes from dogs with lymphadenomegaly due to Leishmania infantum infection
Článek Transcriptome landscape of Rafflesia cantleyi floral buds reveals insights into the roles of transcription factors and phytohormones in flower development
Článek Comparison of 6-week PMTCT outcomes for HIV-exposed and HIV-unexposed infants in the era of lifelong ART: Results from an observational prospective cohort study
Článek Sex differences in physical performance by age, educational level, ethnic groups and birth cohort: The Longitudinal Aging Study Amsterdam
Článek HIV-1 proteins gp120 and tat induce the epithelial–mesenchymal transition in oral and genital mucosal epithelial cells
Článek Inflammatory mediators and lung abnormalities in HIV: A systematic review
Článek An investigation of machine learning methods in delta-radiomics feature analysis
Článek Differences in receipt of opioid agonist treatment and time to enter treatment for opioid use disorder among specialty addiction programs in the United States, 2014-17
Článek Intensity-modulated ventricular irradiation for intracranial germ-cell tumors: Survival analysis and impact of salvage re-irradiation
Článek Personalized breast cancer screening strategies: A systematic review and quality assessment
Článek The shifting epidemiology and serotype distribution of invasive pneumococcal disease in Ontario, Canada, 2007-2017
Článek Backwashing performance of self-cleaning screen filters in drip irrigation systems
Článek Hierarchical cluster analysis to identify the homogeneous desertification management units
Článek MicroRNA-710 regulates multiple pathways of carcinogenesis in murine metastatic breast cancer
Článek MicroRNA profiling in canine multicentric lymphoma
Článek Early impact of agropastoral activities and climate on the littoral landscape of Corsica since mid-Holocene
Článek Barriers and facilitators for caregiver involvement in the home care of people with pressure injuries: A qualitative study
Článek Evaluating mob stocking for beef cattle in a temperate grassland
Článek Suicide among physicians and health-care workers: A systematic review and meta-analysis
Článek Survival kinetics of Listeria monocytogenes on chickpeas, sesame seeds, pine nuts, and black pepper as affected by relative humidity storage conditions
Článek Free thiol groups on poly(aspartamide) based hydrogels facilitate tooth-derived progenitor cell proliferation and differentiation
Článek Acute and chronic traumatic diaphragmatic hernia: 10 years’ experience
Článek Application of DArT seq derived SNP tags for comparative genome analysis in fishes; An alternative pipeline using sequence data from a non-traditional model species, Macquaria ambigua
Článek Dipole-wind interactions under gap wind jet conditions in the Gulf of Tehuantepec, Mexico: A surface drifter and satellite database analysis
Článek PfmPif97-like regulated by Pfm-miR-9b-5p participates in shell formation in Pinctada fucata martensii
Článek Synapsin 1 promotes Aβ generation via BACE1 modulation
Článek Predictive utility of the C-reactive protein to albumin ratio in early allograft dysfunction in living donor liver transplantation: A retrospective observational cohort study
Článek Effects of SCUBA bubbles on counts of roving piscivores in a large remote marine protected area
Článek Examining practice effects in repeated measurements of vibration perception thresholds on finger pulps of healthy individuals – Is it possible to improve your results over a clinically relevant test interval?
Článek Analysis of gut microbiota of obese individuals with type 2 diabetes and healthy individuals
Článek The evaluation of AMSR-E soil moisture data in atmospheric modeling using a suitable time series iteration to derive land surface fluxes over the Tibetan Plateau
Článek Comparison of plasma fatty acid binding protein 4 concentration in venous and capillary blood
Článek Nonalcoholic fatty liver disease and hepatic fibrosis among perinatally HIV-monoinfected Asian adolescents receiving antiretroviral therapy
Článek Environmental enrichment effects after early stress on behavior and functional brain networks in adult rats
Článek Developmental expression of human tau in Drosophila melanogaster glial cells induces motor deficits and disrupts maintenance of PNS axonal integrity, without affecting synapse formation
Článek TRPC3 determines osmosensitive [Ca2+]i signaling in the collecting duct and contributes to urinary concentration
Článek Awareness, willingness to use, and history of HIV PrEP use among gay, bisexual, and other men who have sex with men in Nigeria
Článek Odor quality profile is partially influenced by verbal cues
Článek A novel assessment for Readiness Evaluation during Simulated Dismounted Operations: A reliability study
Článek Cognitive bias modification for energy drink cues
Článek Contribution of ROS and metabolic status to neonatal and adult CD8+ T cell activation
Článek Verification of mesenchymal stem cell injection therapy for interstitial cystitis in a rat model
Článek Vertical transmission of HIV among pregnant women who initially had false–negative rapid HIV tests in four South African antenatal clinics
Článek Tapped out or barely tapped? Recommendations for how to harness the vast and largely unused potential of the Mechanical Turk participant pool
Článek Are lizards sensitive to anomalous seasonal temperatures? Long-term thermobiological variability in a subtropical species
Článek Mutation spectrums of TSC1 and TSC2 in Chinese women with lymphangioleiomyomatosis (LAM)
Článek “That’s all Fake”: Health professionals stigma and physical healthcare of people living with Serious Mental Illness
Článek On the interpretation of the atmospheric mechanism transporting the environmental trigger of Kawasaki Disease
Článek Comparison of the Panther Fusion and Allplex assays for the detection of respiratory viruses in clinical samples
Článek Acute kidney injury in Ugandan children with severe malaria is associated with long-term behavioral problems
Článek Rho-associated kinase and zipper-interacting protein kinase, but not myosin light chain kinase, are involved in the regulation of myosin phosphorylation in serum-stimulated human arterial smooth muscle cells
Článek Use of detailed family history data to improve risk prediction,with application to breast cancer screening
Článek The promise of open survey questions—The validation of text-based job satisfaction measures
Článek Measuring within-day cognitive performance using the experience sampling method: A pilot study in a healthy population
Článek Shifts in trait-based and taxonomic macrofauna community structure along a 27-year time-series in the south-eastern North Sea
Článek Plasma biomarkers of inflammation, coagulation, and brain injury as predictors of delirium duration in older hospitalized patients
Článek Factors associated with repeat rectal Neisseria gonorrhoeae and Chlamydia trachomatis screening following inconclusive nucleic acid amplification testing: A potential missed opportunity for screening
Článek Beyond Buddhism and animism: A psychometric test of the structure of Burmese Theravada Buddhism
Článek Determining the molecular drivers of species-specific interferon-stimulated gene product 15 interactions with nairovirus ovarian tumor domain proteases
Článek Assessment of the perceived safety culture in the petrochemical industry in Japan: A cross-sectional study
Článek The Intersection of Human Disturbance and Diel Activity, with Potential Consequences on Trophic Interactions
Článek Levels of caspase-3 and histidine-rich glycoprotein in the embryo secretome as biomarkers of good-quality day-2 embryos and high-quality blastocysts
Článek Improving accuracy for finite element modeling of endovascular coiling of intracranial aneurysm
Článek Drought stress and re-watering affect the abundance of TIP aquaporin transcripts in barley
Článek Intra- and inter-task reliability of spatial attention measures in healthy older adults
Článek Genome-wide comparisons of gene expression in adult versus elderly burn patients
Článek Challenges to generating political prioritization for adolescent sexual and reproductive health in Kenya: A qualitative study
Článek Chronic atrophic gastritis and intestinal metaplasia surrounding diffuse-type gastric cancer: Are they just bystanders in the process of carcinogenesis?
Článek GLAMbox: A Python toolbox for investigating the association between gaze allocation and decision behaviour
Článek Correction: Rapid visual categorization is not guided by early salience-based selection
Článek Oxygen inhalation improves postoperative survival in ketamine-xylazine anaesthetised rats: An observational study
Článek An inter-island comparison of Darwin’s finches reveals the impact of habitat, host phylogeny, and island on the gut microbiome
Článek The use of opioids in low acuity pediatric trauma patients
Článek The acute myeloid leukemia associated AML1-ETO fusion protein alters the transcriptome and cellular progression in a single-oncogene expressing in vitro induced pluripotent stem cell based granulocyte differentiation model
Článek Primary Epstein-Barr virus infection with and without infectious mononucleosis
Článek “Disruptive behavior” in the operating room: A prospective observational study of triggers and effects of tense communication episodes in surgical teams
Článek Measuring affect-related cognitive bias: Do mice in opposite affective states react differently to negative and positive stimuli?
Článek Impaired cardiac performance, protein synthesis, and mitochondrial function in tumor-bearing mice
Článek Determinants of speeding among new generations of car drivers from the Arabian Peninsula. An investigation based among Omani drivers using the theory of planned behaviour
Článek Modulation of protective reflex cough by acute immune driven inflammation of lower airways in anesthetized rabbits
Článek KRAS and NRAS mutational gene profile of metastatic colorectal cancer patients in Jordan
Článek Successional, spatial, and seasonal changes in seed rain in the Atlantic forest of southern Bahia, Brazil
Článek Ultrasound microbubble potentiated enhancement of hyperthermia-effect in tumours
Článek Introgression of a cry1Ab transgene into open pollinated maize and its effect on Cry protein concentration and target pest survival
Článek Benefits of VISION Max automated cross-matching in comparison with manual cross-matching: A multidimensional analysis
Článek An explorative study identifies miRNA signatures for the diagnosis of non-celiac wheat sensitivity
Článek Effects of long-term statin-treatment on coronary atherosclerosis in patients with inflammatory joint diseases
Článek Connectivity differences between Gulf War Illness (GWI) phenotypes during a test of attention
Článek Native speakers like affixes, L2 speakers like letters? An overt visual priming study investigating the role of orthography in L2 morphological processing
Článek A partial genome assembly of the miniature parasitoid wasp, Megaphragma amalphitanum
Článek Can we learn from the ecology of the Bohemian gentian and save another closely related species of Gentianella?
Článek Are we prepared? The development of performance indicators for public health emergency preparedness using a modified Delphi approach
Článek Racial discrimination in medical care settings and opioid pain reliever misuse in a U.S. cohort: 1992 to 2015
Článek Applying circuit theory and landscape linkage maps to reintroduction planning for California Condors
Článek An improved understanding of ungulate population dynamics using count data: Insights from western Montana
Článek Pediatric trainees systematically under-report duty hour violations compared to electronic health record defined shifts
Článek An exclusive human milk diet for very low birth weight newborns—A cost-effectiveness and EVPI study for Germany
Článek Investigating unexplained genetic variation and its expression in the arbuscular mycorrhizal fungus Rhizophagus irregularis: A comparison of whole genome and RAD sequencing data
Článek Disease activity and damage in patients with primary Sjogren’s syndrome: Prognostic value of salivary gland ultrasonography
Článek A low-loss and compact single-layer butler matrix for a 5G base station antenna
Článek Response of rhizosphere bacterial community of Taxus chinensis var. mairei to temperature changes
Článek Choosing and enjoying violence in narratives
Článek Phylogeography, genetic diversity, and population structure of Nile crocodile populations at the fringes of the southern African distribution
Článek Association between workplace bullying and burnout, professional quality of life, and turnover intention among clinical nurses
Článek Factors predictive of the success of tuberculosis treatment: A systematic review with meta-analysis
Článek Area extraction and spatiotemporal characteristics of winter wheat–summer maize in Shandong Province using NDVI time series
Článek Caring for the elderly: A person-centered segmentation approach for exploring the association between health care needs, mental health care use, and costs in Germany
Článek Potentially inappropriate medication in older participants of the Berlin Aging Study II (BASE-II) – Sex differences and associations with morbidity and medication use
Článek Previously implanted mitral surgical prosthesis in patients undergoing transcatheter aortic valve implantation: Procedural outcome and morphologic assessment using multidetector computed tomography
Článek Towards elimination of measles and rubella in Italy: Progress and challenges
Článek Molecular characterization of pulmonary defenses against bacterial invasion in allergic asthma: The role of Foxa2 in regulation of β-defensin 1
Článek A validation of machine learning-based risk scores in the prehospital setting
Článek Early life starvation has stronger intra-generational than transgenerational effects on key life-history traits and consumption measures in a sawfly
Článek Longitudinal changes in plasma hemopexin and alpha-1-microglobulin concentrations in women with and without clinical risk factors for pre-eclampsia
Článek Feasibility of thin-slice abdominal CT in overweight patients using a vendor neutral image-based denoising algorithm: Assessment of image noise, contrast, and quality
Článek Women's abortion seeking behavior under restrictive abortion laws in Mexico
Článek Understanding the combining ability for physiological traits in soybean
Článek Second language learning induces grey matter volume increase in people with multiple sclerosis
Článek Increased performance of DNA metabarcoding of macroinvertebrates by taxonomic sorting
Článek Hybrid denture acrylic composites with nanozirconia and electrospun polystyrene fibers
Článek Predictive sampling effort and species-area relationship models for estimating richness in fragmented landscapes
Článek The mixture toxicity of heavy metals on Photobacterium phosphoreum and its modeling by ion characteristics-based QSAR
Článek Exogenous melatonin reduces the inhibitory effect of osmotic stress on photosynthesis in soybean
Článek Comparative analysis of ascorbate peroxidases (APXs) from selected plants with a special focus on Oryza sativa employing public databases
Článek The microbiota composition of the offspring of patients with gestational diabetes mellitus (GDM)
Článek Analysis of 13,312 benthic invertebrate samples from German streams reveals minor deviations in ecological status class between abundance and presence/absence data
Článek Extending the use of the World Health Organisations’  water sanitation and hygiene assessment tool for surveys in hospitals – from WASH-FIT to WASH-FAST
Článek Measuring subjective social status in children of diverse societies
Článek The effect of gut passage by waterbirds on the seed coat and pericarp of diaspores lacking “external flesh”: Evidence for widespread adaptation to endozoochory in angiosperms
Článek Cost effectiveness of therapeutic drug monitoring for imatinib administration in chronic myeloid leukemia
Článek Tissue ACE phenotyping in lung cancer
Článek Risk factors in the illness-death model: Simulation study and the partial differential equation about incidence and prevalence
Článek Association of cord blood methylation with neonatal leptin: An epigenome wide association study
Článek Clonality, spatial structure, and pathogenic variation in Fusarium fujikuroi from rain-fed rice in southern Laos
Článek Effect of Iodine treatments on Ocimum basilicum L.: Biofortification, phenolics production and essential oil composition
Článek In Vitro detection of Chronic Wasting Disease (CWD) prions in semen and reproductive tissues of white tailed deer bucks (Odocoileus virginianus)
Článek Thermodilution vs estimated Fick cardiac output measurement in an elderly cohort of patients: A single-centre experience
Článek Association between depressive symptoms and poor sleep quality among Han and Manchu ethnicities in a large, rural, Chinese population
Článek Application of pharmacogenomics and bioinformatics to exemplify the utility of human ex vivo organoculture models in the field of precision medicine
Článek Adherence to dietary guidelines for the Spanish population and risk of overweight/obesity in the SUN cohort
Článek Impact on mortality of being seropositive for hepatitis C virus antibodies among blood donors in Brazil: A twenty-year study
Článek Dietary intake as a predictor for all-cause mortality in hemodialysis subjects (NUGE-HD study)
Článek Rats’ (Rattus norvegicus) tool manipulation ability exceeds simple patterned behavior
Článek Luminescent and fluorescent triple reporter plasmid constructs for Wnt, Hedgehog and Notch pathway
Článek A lab-on-a-chip for rapid miRNA extraction
Článek Ghost hunting in the nonlinear dynamic machine
Článek Dysregulation of sterol regulatory element-binding protein 2 gene in HIV treatment-experienced individuals
Článek Evaluation of bacteriophage as an adjunct therapy for treatment of peri-prosthetic joint infection caused by Staphylococcus aureus
Článek Neuronal and glial DNA methylation and gene expression changes in early epileptogenesis
Článek Kinetics of the thermal inactivation and the refolding of bacterial luciferases in Bacillus subtilis and in Escherichia coli differ
Článek The use of back propagation neural networks and 18F-Florbetapir PET for early detection of Alzheimer’s disease using Alzheimer’s Disease Neuroimaging Initiative database
Článek Refinement of metabolite detection in cystic fibrosis sputum reveals heme correlates with lung function decline
Článek Labeling surface proteins with high specificity: Intrinsic limitations of phosphopantetheinyl transferase systems
Článek Irradiation dose response under hypoxia for the application of the sterile insect technique in Drosophila suzukii
Článek Neutrophils remain detrimentally active in hydroxyurea-treated patients with sickle cell disease
Článek Correction: Enhancing genomic selection by fitting large-effect SNPs as fixed effects and a genotype-by-environment effect using a maize BC1F3:4population
Článek Binding and functional profiling of antibody mutants guides selection of optimal candidates as antibody drug conjugates
Článek DUSTBot: A duplex and stealthy P2P-based botnet in the Bitcoin network
Článek Force-stabilizing synergies can be retained by coordinating sensory-blocked and sensory-intact digits
Článek Temperature time series analysis at Yucatan using natural and horizontal visibility algorithms
Článek Genome-wide identification and expression profile of the MADS-box gene family in Erigeron breviscapus
Článek Evaluating the international standards gap for the use of acupuncture needles by physiotherapists and chiropractors: A policy analysis
Článek Analyses with double knockouts of the Bmpr1a and Bmpr1b genes demonstrate that BMP signaling is involved in the formation of precerebellar mossy fiber nuclei derived from the rhombic lip
Článek The protein architecture in Bacteria and Archaea identifies a set of promiscuous and ancient domains
Článek Utility of preoperative electrophysiological testing of the facial nerve in patients with vestibular schwannoma
Článek Dynamics of plasma micronutrient concentrations and their correlation with serum proteins and thyroid hormones in patients with paracoccidioidomycosis
Článek Equity in aid allocation and distribution: A qualitative study of key stakeholders in Northern Uganda
Článek Health-related quality of life and intensity-specific physical activity in high-risk adults attending a behavior change service within primary care
Článek Syphilis among adult males with a history of male-to-male sexual contact living with diagnosed HIV in New York State (excluding New York City): The challenge of intersecting epidemics
Článek Entropy of human leukocyte antigen and killer-cell immunoglobulin-like receptor systems in immune-mediated disorders: A pilot study on multiple sclerosis
Článek Insights into fungal diversity of a shallow-water hydrothermal vent field at Kueishan Island, Taiwan by culture-based and metabarcoding analyses
Článek Predicting Abundances of Aedes mcintoshi, a primary Rift Valley fever virus mosquito vector
Článek Self-association of human beta-galactocerebrosidase: Dependence on pH, salt, and surfactant
Článek Lowbush blueberry fruit yield and growth response to inorganic and organic N-fertilization when competing with two common weed species
Článek Copy number-based quantification assay for non-invasive detection of PVT1-derived transcripts
Článek Association between religiosity and depression varies with age and sex among adults in South America: Evidence from the CESCAS I study
Článek Recall accuracy of weekly automated surveys of health care utilization and infectious disease symptoms among infants over the first year of life
Článek Physiological response of North China red elder container seedlings to inoculation with plant growth-promoting rhizobacteria under drought stress
Článek Acute kidney injury – A frequent and serious complication after primary percutaneous coronary intervention in patients with ST-segment elevation myocardial infarction
Článek Neurotherapeutic effects of Ginkgo biloba extract and its terpene trilactone, ginkgolide B, on sciatic crush injury model: A new evidence
Článek Clinical utility of mono-exponential model diffusion weighted imaging using two b-values compared to the bi- or stretched exponential model for the diagnosis of biliary atresia in infant liver MRI
Článek Optical coherence tomography angiography reveals progressive worsening of retinal vascular geometry in diabetic retinopathy and improved geometry after panretinal photocoagulation
Článek Comparison of standard and alternative methods for chest compressions in a single rescuer infant CPR: A prospective simulation study
Článek Characterization of the physical properties of electron-beam-irradiated white rice and starch during short-term storage
Článek Colonic bacterial composition is sex-specific in aged CD-1 mice fed diets varying in fat quality
Článek The nature of the ligand’s side chain interacting with the S1'-subsite of metallocarboxypeptidase T (from Thermoactinomyces vulgaris) determines the geometry of the tetrahedral transition complex
Článek Clarithromycin use and the risk of mortality and cardiovascular events: A systematic review and meta-analysis
Článek Droplet digital PCR assays for the quantification of brown trout (Salmo trutta) and Arctic char (Salvelinus alpinus) from environmental DNA collected in the water of mountain lakes
Článek Vitamin E TPGS based transferosomes augmented TAT as a promising delivery system for improved transdermal delivery of raloxifene
Článek Estimation of membrane bending modulus of stiffness tuned human red blood cells from micropore filtration studies
Článek Retrospective analysis of central venous catheters in elective intracranial surgery - Is there any benefit?
Článek Clinical impact of visceral-to-subcutaneous fat ratio in patients with acute aortic dissection
Článek Correction: Are viral-infections associated with Ménière’s Disease? A systematic review and meta-analysis of molecular-markers of viral-infection in case-controlled observational studies of MD
Článek Epidemiology of cardiovascular diseases related admissions in a referral hospital in the South West region of Cameroon: A cross-sectional study in sub-Saharan Africa
Článek Tankyrase inhibition sensitizes cells to CDK4 blockade
Článek Spelling performance on the web and in the lab
Článek Heteroxanthin as a pigment biomarker for Gonyostomum semen (Raphidophyceae)
Článek Sexually transmitted founder HIV-1 viruses are relatively resistant to Langerhans cell-mediated restriction
Článek High-glucose diets induce mitochondrial dysfunction in Caenorhabditis elegans
Článek Correction: Safety and efficacy of tacrolimus-coated silicone plates as an alternative to mitomycin C in a rabbit model of conjunctival fibrosis
Článek Correction: Uncertainty analysis of species distribution models
Článek Correction: Testosterone deficiency reduces the effects of late cardiac remodeling after acute myocardial infarction in rats
Článek Correction: Trends and predictors of mother-to-child transmission of HIV in an era of protocol changes: Findings from two large health facilities in North East Nigeria
Článek Habitat quality, configuration and context effects on roe deer fecundity across a forested landscape mosaic
Článek Recording behaviour of indoor-housed farm animals automatically using machine vision technology: A systematic review
Článek Correction: Influence of three artificial light sources on oviposition and half-life of the Black Soldier Fly, Hermetia illucens (Diptera: Stratiomyidae): Improving small-scale indoor rearing
Článek Lead-I ECG for detecting atrial fibrillation in patients attending primary care with an irregular pulse using single-time point testing: A systematic review and economic evaluation
Článek External validation of clinical prediction rules for complications and mortality following Clostridioides difficile infection
Článek Vitamin D deficiency at the time of delivery – Prevalence and risk of postpartum infections
Článek Changing perioperative prophylaxis during antibiotic therapy and iterative debridement for orthopedic infections?
Článek Tyrphostin AG490 reduces inflammation and fibrosis in neonatal obstructive nephropathy
Článek Evaluation of antibiotic susceptibility patterns of pathogens isolated from routine laboratory specimens at Ndola Teaching Hospital: A retrospective study
Článek Age-period-cohort analysis with a constant-relative-variation constraint for an apportionment of period and cohort slopes
Článek Early neonatal outcomes of very-low-birth-weight infants in Turkey: A prospective multicenter study of the Turkish Neonatal Society
Článek Improving graphs of cycles approach to structural similarity of molecules
Článek Heterotrimeric G-alpha subunits Gpa11 and Gpa12 define a transduction pathway that control spore size and virulence in Mucor circinelloides
Článek Clinical outcome of admitted HIV/AIDS patients in Ethiopian tertiary care settings: A prospective cohort study
Článek How the size of the to-be-learned material influences the encoding and later retrieval of associative memories: A pupillometric assessment
Článek "Tremendous financial burden": Crowdfunding for organ transplantation costs in Canada
Článek Stochastically modeling multiscale stationary biological processes
Článek Distribution of aerophilous diatom communities associated with terrestrial green macroalgae in the South Shetland Islands, Maritime Antarctica
Článek An eye-tracking approach to Autonomous sensory meridian response (ASMR): The physiology and nature of tingles in relation to the pupil
Článek Structural diversity in the atomic resolution 3D fingerprint of the titin M-band segment
Článek AlleleProfileR: A versatile tool to identify and profile sequence variants in edited genomes
Článek Spike culture derived wheat (Triticum aestivum L.) variants exhibit improved resistance to multiple chemotypes of Fusarium graminearum
Článek N-acetyl cysteine attenuates oxidative stress and glutathione-dependent redox imbalance caused by high glucose/high palmitic acid treatment in pancreatic Rin-5F cells
Článek Neurofilaments in blood is a new promising preclinical biomarker for the screening of natural scrapie in sheep
Článek Comparative transcriptome reveals the potential modulation mechanisms of estradiol affecting ovarian development of female Portunus trituberculatus
Článek Determinants of Group B streptococcal virulence potential amongst vaginal clinical isolates from pregnant women
Článek Identification of QTLs for resistance to maize rough dwarf disease using two connected RIL populations in maize
Článek Retraction: Ramentaceone, a Naphthoquinone Derived from Drosera sp., Induces Apoptosis by Suppressing PI3K/Akt Signaling in Breast Cancer Cells
Článek Correction: Differences in energy and nutritional content of menu items served by popular UK chain restaurants with versus without voluntary menu labelling: A cross-sectional study
Článek Correction: Cross-presentation of a spread-defective MCMV is sufficient to prime the majority of virus-specific CD8+ T cells
Článek Correction: An observational study comparing HPV prevalence and type distribution between HPV-vaccinated and -unvaccinated girls after introduction of school-based HPV vaccination in Norway
Článek Aortic pressure and forward and backward wave components in children, adolescents and young-adults: Agreement between brachial oscillometry, radial and carotid tonometry data and analysis of factors associated with their differences
Článek Clinical ethics consultation among Italian ethics committee: A mixed method study
Článek Epidemiology of tick-borne encephalitis in China, 2007- 2018
Článek Narrative warmth and quantitative competence: Message type affects impressions of a speaker
Článek Murine models for familial pancreatic cancer: Histopathology, latency and drug sensitivity among cancers of Palb2, Brca1 and Brca2 mutant mouse strains
Článek Comparison of quality control methods for automated diffusion tensor imaging analysis pipelines
Článek Self-efficacy, procrastination, and burnout in post-secondary faculty: An international longitudinal analysis
Článek Should social disconnectedness be included in primary-care screening for cardiometabolic disease? A systematic review of the relationship between everyday stress, social connectedness, and allostatic load
Článek Fast and accurate quantification of insertion-site specific transgene levels from raw seed samples using solid-state nanopore technology
Článek Maternal employment and child nutritional status in Uganda
Článek Correction: Saiga horn user characteristics, motivations, and purchasing behaviour in Singapore
Článek Disparities in survival by stage after surgery between pancreatic head and body/tail in patients with nonmetastatic pancreatic cancer
Článek Acknowledgements are not just thank you notes: A qualitative analysis of acknowledgements content in scientific articles and reviews published in 2015
Článek Interocular asymmetry of the superonasal retinal nerve fibre layer thickness and blood vessel diameter in healthy subjects
Článek Does it still fit? – Adapting affordance judgments to altered body properties in young and older adults
Článek Health-related quality of life in patients with atrial fibrillation: The role of symptoms, comorbidities, and the type of atrial fibrillation
Článek A systems approach identifies Enhancer of Zeste Homolog 2 (EZH2) as a protective factor in epilepsy
Článek Statistical learning and the uncertainty of melody and bass line in music
Článek The association between childhood maltreatment and empathic perspective taking is moderated by the 5-HTT linked polymorphic region: Another example of “differential susceptibility”
Článek Household air pollution and arthritis in low-and middle-income countries: Cross-sectional evidence from the World Health Organization’s study on Global Ageing and Adult Health
Článek Firefighters’ occupational stress and its correlations with cardiorespiratory fitness, arterial stiffness, heart rate variability, and sleep quality
Článek Diagnostic utility of CT for small bowel obstruction: Systematic review and meta-analysis
Článek Clinical nurses’ beliefs, knowledge, organizational readiness and level of implementation of evidence-based practice: The first step to creating an evidence-based practice culture
Článek Attitude and behaviour of Dutch Otorhinolaryngologists to Evidence Based Medicine
Článek Electronic cigarettes and insulin resistance in animals and humans: Results of a controlled animal study and the National Health and Nutrition Examination Survey (NHANES 2013-2016)
Článek Cytogenetics of the small-sized fish, Copeina guttata (Characiformes, Lebiasinidae): Novel insights into the karyotype differentiation of the family
Článek Infant rhesus macaque (Macaca mulatta) personality and subjective well-being
Článek Potential effects of ursodeoxycholic acid on accelerating cutaneous wound healing
Článek Healthcare utilization and costs of cardiopulmonary complications following cardiac surgery in the United States
Článek Prediction of train wheel diameter based on Gaussian process regression optimized using a fast simulated annealing algorithm
Článek Comparative de novo transcriptomics and untargeted metabolomic analyses elucidate complicated mechanisms regulating celery (Apium graveolens L.) responses to selenium stimuli
Článek Cognitive dysfunction in mice lacking proper glucocorticoid receptor dimerization
Článek Prevalence, awareness, treatment and control of hypertension and sodium intake in Zhejiang Province, China: A cross-sectional survey in 2017
Článek Autofluorescence spectroscopy in redox monitoring across cell confluencies
Článek Impact of mycoplasma pneumonia infection on urticaria: A nationwide, population-based retrospective cohort study in Taiwan
Článek Correction: Dual pathway for metabolic engineering of Escherichia coli to produce the highly valuable hydroxytyrosol
Článek Rapid label-free analysis of Opisthorchis viverrini eggs in fecal specimens using confocal Raman spectroscopy
Článek Associations of systemic, serum lipid and lipoprotein metabolic pathway gene variations with polypoidal choroidal vasculopathy in China
Článek MRI-guided, transrectal, intraprostatic steam application as potential focal therapeutic modality for prostatic diseases in a large animal translational model: A feasibility follow-up study
Článek Predicting breast cancer risk using personal health data and machine learning models
Článek External validation of the relative fat mass (RFM) index in adults from north-west Mexico using different reference methods
Článek A study on separation of the protein structural types in amino acid sequence feature spaces
Článek α-Lipoic acid prevents against cisplatin cytotoxicity via activation of the NRF2/HO-1 antioxidant pathway
Článek A phenome-wide association study (PheWAS) in the Population Architecture using Genomics and Epidemiology (PAGE) study reveals potential pleiotropy in African Americans
Článek The effect of prioritization over cognitive-motor interference in people with relapsing-remitting multiple sclerosis and healthy controls
Článek Ionomic and transcriptomic analyses of two cotton cultivars (Gossypium hirsutum L.) provide insights into the ion balance mechanism of cotton under salt stress
Článek Soluble lytic transglycosylase SLT of Francisella novicida is involved in intracellular growth and immune suppression
Článek Glucocorticoid and dietary effects on mucosal microbiota in canine inflammatory bowel disease
Článek Zoonotic Babesia: A scoping review of the global evidence
Článek Utility of citizen science data: A case study in land-based shark fishing
Článek Response of cassava cultivars to African cassava mosaic virus infection across a range of inoculum doses and plant ages
Článek Correction: Risk factors for tooth loss in adults: A population-based prospective cohort study
Článek Dynamic deformation of femur during medial compartment knee osteoarthritis
Článek A novel ε-sensitive correlation indistinguishable scheme for publishing location data
Článek Interaction between BDNF val66met polymorphism and personality on long-term cardiac outcomes in patients with acute coronary syndrome
Článek What factors do make quality improvement work in primary health care? Experiences of maternal health quality improvement teams in three Puskesmas in Indonesia
Článek Social anxiety changes the way we move—A social approach-avoidance task in a virtual reality CAVE system
Článek Evaluation of a savings-led family-based economic empowerment intervention for AIDS-affected adolescents in Uganda: A four-year follow-up on efficacy and cost-effectiveness
Článek From sea monsters to charismatic megafauna: Changes in perception and use of large marine animals
Článek Association between IQ and FMR1 protein (FMRP) across the spectrum of CGG repeat expansions
Článek Impact of sports activity on Polish adults: Self-reported health, social capital & attitudes
Článek Hold your breath – Differential behavioral and sensory acuity of mosquitoes to acetone and carbon dioxide
Článek Comparative analysis of eight DNA extraction methods for molecular research in mealybugs
Článek Age-dependent survival rate of the colonial Little Tern (Sternula albifrons)
Článek The metabotropic glutamate receptor subtype 1 regulates development and maintenance of lemniscal synaptic connectivity in the somatosensory thalamus
Článek Impact of HFE variants and sex in lung cancer
Článek Study of congenital Morgagnian cataracts in Holstein calves
Článek Decreasing prevalence of contamination with extended-spectrum beta-lactamase-producing Enterobacteriaceae (ESBL-E) in retail chicken meat in the Netherlands
Článek Screening of differentially expressed immune-related genes from spleen of broilers fed with probiotic Bacillus cereus PAS38 based on suppression subtractive hybridization
Článek Factors governing the performance of Auxiliary Nurse Midwives in India: A study in Pune district
Článek Writing in the air: Facilitative effects of finger writing in older adults
Článek Enzymatic production of bioactive peptides from scotta, an exhausted by-product of ricotta cheese processing
Článek Effect of endometriosis on the fecal bacteriota composition of mice during the acute phase of lesion formation
Článek Experimental infection of lambs with tick-borne encephalitis virus and co-infection with Anaplasma phagocytophilum
Článek Leishmania amazonensis resistance in murine macrophages: Analysis of possible mechanisms
Článek Comparison between the induced membrane technique and distraction osteogenesis in treating segmental bone defects: An experimental study in a rat model
Článek A dengue fever predicting model based on Baidu search index data and climate data in South China
Článek Revierparks as an integrated green network in Germany: An option for Amman?
Článek Detection and analysis of pulse waves during sleep via wrist-worn actigraphy
Článek From dangerous branches to urban banyan: Facilitating aerial root growth of Ficus rubiginosa
Článek Unilateral versus bilateral pedicle screw fixation in lumbar fusion: A systematic review of overlapping meta-analyses
Článek Edible ectomycorrhizal fungi and Cistaceae. A study on compatibility and fungal ecological strategies
Článek Physical space interacts with clonal fragmentation and nutrient availability to affect the growth of Salvinia natans
Článek Odd haemoglobins in odd-toed ungulates: Impact of selected haemoglobin characteristics of the white rhinoceros (Ceratotherium simum) on the monitoring of the arterial oxygen saturation of haemoglobin
Článek Somatic mutations in intracranial arteriovenous malformations
Článek Clinical feasibility of NGS liquid biopsy analysis in NSCLC patients
Článek Thrombospondin-I is a critical modulator in non-alcoholic steatohepatitis (NASH)
Článek Chemical analysis of Hg0-containing Hindu religious objects
Článek Hipk is required for JAK/STAT activity during development and tumorigenesis
Článek Transfer of skin microbiota between two dissimilar autologous microenvironments: A pilot study
Článek Correction: MiR-4524b-5p/WTX/β-catenin axis functions as a regulator of metastasis in cervical cancer
Článek Complete chloroplast genomes of two Siraitia Merrill species: Comparative analysis, positive selection and novel molecular marker development
Článek Lower levels of proteinuria are associated with elevated mortality in incident dialysis patients
Článek Optimising medication data collection in a large-scale clinical trial
Článek Personal response to immune checkpoint inhibitors of patients with advanced melanoma explained by a computational model of cellular immunity, tumor growth, and drug
Článek Hypofibrinolysis induced by tranexamic acid does not influence inflammation and mortality in a polymicrobial sepsis model
Článek Correction: Dose-dependent adverse effects of salinomycin on male reproductive organs and fertility in mice
Článek Endocrine profile of the VCD-induced perimenopausal model rat
Článek Inhibition of complement activation, myeloperoxidase, NET formation and oxidant activity by PIC1 peptide variants
Článek Domestication may affect the maternal mRNA profile in unfertilized eggs, potentially impacting the embryonic development of Eurasian perch (Perca fluviatilis)
Článek Intrauterine growth patterns in rural Ethiopia compared with WHO and INTERGROWTH-21st growth standards: A community-based longitudinal study
Článek Remote ischaemic conditioning and early changes in plasma creatinine as markers of one year kidney graft function—A follow-up of the CONTEXT study
Článek Validation of Plasmodium vivax centromere and promoter activities using Plasmodium yoelii
Článek Variation in neophobia among cliff swallows at different colonies
Článek Soil C, N, and P distribution as affected by plant communities in the Yellow River Delta, China
Článek Community-based sero-prevalence of hepatitis B and C infections in South Omo Zone, Southern Ethiopia
Článek Birth asphyxia and its associated factors among newborns in public hospital, northeast Amhara, Ethiopia
Článek Enhancement in dopamine reduces generous behaviour in women
Článek Correction: Risk factors for postoperative meningitis after microsurgery for vestibular schwannoma
Článek Correction: Evolution of high tooth replacement rates in theropod dinosaurs
Článek Hepatic sinusoidal hemophagocytosis with and without hemophagocytic lymphohistiocytosis
Článek Efficient intra mode decision for low complexity HEVC screen content compression
Článek Feature selection for helpfulness prediction of online product reviews: An empirical study
Článek Structure and age-dependent growth of the chicken liver together with liver fat quantification: A comparison between a dual-purpose and a broiler chicken line
Článek Important features of retail shoes for women with rheumatoid arthritis: A Delphi consensus survey
Článek The impact of gut microbiota manipulation with antibiotics on colon tumorigenesis in a murine model
Článek The characteristic of patulous eustachian tube patients diagnosed by the JOS diagnostic criteria
Článek Nine years of in situ soil warming and topography impact the temperature sensitivity and basal respiration rate of the forest floor in a Canadian boreal forest
Článek A novel model for malaria prediction based on ensemble algorithms
Článek “Because at school, you can become somebody” – The perceived health and economic returns on secondary schooling in rural Burkina Faso
Článek Experiences of health services and unmet care needs of people with late-stage Parkinson’s in England: A qualitative study
Článek Electrochemical analysis of uric acid excretion to the intestinal lumen: Effect of serum uric acid-lowering drugs and 5/6 nephrectomy on intestinal uric acid levels
Článek Does completion of sputum smear monitoring have an effect on treatment success and cure rate among adult tuberculosis patients in rural Eastern Uganda? A propensity score-matched analysis
Článek Identifying fetal yawns based on temporal dynamics of mouth openings: A preterm neonate model using support vector machines (SVMs)
Článek Hepatitis B virus seromarkers among HIV infected adults on ART: An unmet need for HBV screening in eastern Ethiopia
Článek Assessment of knowledge and practice of breast self-examination among reproductive age women in Akatsi South district of Volta region of Ghana
Článek Evaluation of quantitative biosensor for glucose-6-phosphate dehydrogenase activity detection
Článek Antibiotic treatment adequacy and death among patients with Pseudomonas aeruginosa airway infection
Článek Effects of experimentally induced fatigue on healthy older adults’ gait: A systematic review
Článek Monounsaturated fatty acids protect against palmitate-induced lipoapoptosis in human umbilical vein endothelial cells
Článek An assessment of the utility and repeatability of the renal resistive index in horses
Článek Analysis of center of mass acceleration and muscle activation in hemiplegic paralysis during quiet standing
Článek The association between dengue incidences and provincial-level weather variables in Thailand from 2001 to 2014
Článek Asylum seekers’ perspectives on vaccination and screening policies after their arrival in Greece and The Netherlands
Článek A new, fast method to search for morphological convergence with shape data
Článek Zinc thiazole enhances defense enzyme activities and increases pathogen resistance to Ralstonia solanacearum in peanut (Arachis hypogaea) under salt stress
Článek Effect of thermal control of dry fomites on regulating the survival of human pathogenic bacteria responsible for nosocomial infections
Článek Spatial dynamics in the classroom: Does seating choice matter?
Článek Hematologic profile of Amazon river dolphins Inia geoffrensis and its variation during acute capture stress
Článek Association between body mass index and asthma severity in Arab pediatric population: A retrospective study
Článek Toxic trajectories under future climate conditions
Článek Bioassay- and metabolomics-guided screening of bioactive soil actinomycetes from the ancient city of Ihnasia, Egypt
Článek Awareness of treatment: A source of bias in subjective grading of ocular complications
Článek Genome-wide identification and expression analysis of the PHD-finger gene family in Solanum tuberosum
Článek Exploring functional core bacteria in fermentation of a traditional Chinese food, Aspergillus-type douchi
Článek Folk theories of gender and anti-transgender attitudes: Gender differences and policy preferences
Článek Lower S-adenosylmethionine levels and DNA hypomethylation of placental growth factor (PlGF) in placental tissue of early-onset preeclampsia-complicated pregnancies
Článek Simulating the route of the Tang-Tibet Ancient Road for one branch of the Silk Road across the Qinghai-Tibet Plateau
Článek Evaluation of the ecological niche model approach in spatial conservation prioritization
Článek Important gene–gene interaction of TNF-α and VDR on osteoporosis in community-dwelling elders
Článek Traffic light labelling could prevent mortality from noncommunicable diseases in Canada: A scenario modelling study
Článek Choice-induced inter-trial inhibition is modulated by idiosyncratic choice-consistency
Článek HomeSTEAD’s physical activity and screen media practices and beliefs survey: Instrument development and integrated conceptual model
Článek What nature separated, and human joined together: About a spontaneous hybridization between two allopatric dogwood species (Cornus controversa and C. alternifolia)
Článek Cell sources of inflammatory mediators present in bone marrow areas inside the meniscus
Článek The effects of exercise variation in muscle thickness, maximal strength and motivation in resistance trained men
Článek High prevalence of abnormal menstruation among women living with HIV in Canada
Článek A quantitative engineering study of ecosystem robustness using thermodynamic power cycles as case studies
Článek External morphology and developmental changes of tarsal tips and mouthparts of the invasive spotted lanternfly, Lycorma delicatula (Hemiptera: Fulgoridae)
Článek Small joint arthrodesis technique using a dowel bone graft in a rabbit model
Článek An investigation of far and near transfer in a gamified visual learning paradigm
Článek Isolation and characterization of fowl aviadenovirus serotype 11 from chickens with inclusion body hepatitis in Morocco
Článek Translocation of Mycobacterium tuberculosis after experimental ingestion
Článek Health literacy as a mediator of the relationship between socioeconomic status and health: A cross-sectional study in a population-based sample in Florence
Článek Genomic insights on heterogeneous resistance to vancomycin and teicoplanin in Methicillin-resistant Staphylococcus aureus: A first report from South India
Článek “I am alive; my baby is alive”: Understanding reasons for satisfaction and dissatisfaction with maternal health care services in the context of user fee removal policy in Nigeria
Článek A systems biology approach uncovers a gene co-expression network associated with cell wall degradability in maize
Článek Correction: DNA barcodes corroborating identification of mosquito species and multiplex real-time PCR differentiating Culex pipiens complex and Culex torrentium in Iran
Článek Heterogeneous root zone salinity mitigates salt injury to Sorghum bicolor (L.) Moench in a split-root system
Článek Effects and cost-effectiveness of postoperative oral analgesics for additional postoperative pain relief in children and adolescents undergoing dental treatment: Health technology assessment including a systematic review
Článek Spatial ecology of coyotes in the urbanizing landscape of the Cuyahoga Valley, Ohio
Článek The role of gadolinium in magnetic resonance imaging for early prostate cancer diagnosis: A diagnostic accuracy study
Článek Modeling succinate dehydrogenase loss disorders in C. elegans through effects on hypoxia-inducible factor
Článek The association of parents’ behaviors related to salt with 24 h urinary sodium excretion of their children: A Spanish cross-sectional study
Článek Transcriptional changes during hepatic ischemia-reperfusion in the rat
Článek NAT2 gene polymorphisms and endometriosis risk: A PRISMA-compliant meta-analysis
Článek Effects of lutein supplementation in age-related macular degeneration
Článek Correction: Genetic susceptibility to angiotensin-converting enzyme-inhibitor induced angioedema: A systematic review and evaluation of methodological approaches
Článek Recovery cycles of posterior root-muscle reflexes evoked by transcutaneous spinal cord stimulation and of the H reflex in individuals with intact and injured spinal cord
Článek Virulence beneath the fleece; a tale of foot-and-mouth disease virus pathogenesis in sheep
Článek The delay of motherhood: Reasons, determinants, time used to achieve pregnancy, and maternal anxiety level
Článek Glycated albumin as a diagnostic tool in diabetes: An alternative or an additional test?
Článek Quantification of circulating cell-free DNA (cfDNA) in urine using a newborn piglet model of asphyxia
Článek Correction: Elevated levels of eEF1A2 protein expression in triple negative breast cancer relate with poor prognosis
Článek Inhibiting the copper efflux system in microbes as a novel approach for developing antibiotics
Článek Rapid pathogen identification and antimicrobial susceptibility testing in in vitro endophthalmitis with matrix assisted laser desorption-ionization Time-of-Flight Mass Spectrometry and VITEK 2 without prior culture
Článek Identification of loci of functional relevance to Barrett’s esophagus and esophageal adenocarcinoma: Cross-referencing of expression quantitative trait loci data from disease-relevant tissues with genetic association data
Článek Inter- and intraspecific diversity of food legumes among households and communities in Ethiopia
Článek Walking-speed estimation using a single inertial measurement unit for the older adults
Článek The relationship between glutathione levels in leukocytes and ocular clinical parameters in glaucoma
Článek The home field advantage of modern plant breeding
Článek High concentrations of middle ear antimicrobial peptides and proteins and proinflammatory cytokines are associated with detection of middle ear pathogens in children with recurrent acute otitis media
Článek A modern approach to identifying and characterizing child asthma and wheeze phenotypes based on clinical data
Článek Validation of a novel time-to-event nest density estimator on passerines: An example using Brewer’s sparrows (Spizella breweri)
Článek Use of GeneXpert and the role of an expert panel in improving clinical diagnosis of smear-negative tuberculosis cases
Článek Heat-induced hyperthermia impacts the follicular fluid proteome of the periovulatory follicle in lactating dairy cows
Článek One-shot phase-recovery using a cellphone RGB camera on a Jamin-Lebedeff microscope
Článek Change of surfactant protein D and A after renal ischemia reperfusion injury
Článek Antibiotic saving effect of combination therapy through synergistic interactions between well-characterized chito-oligosaccharides and commercial antifungals against medically relevant yeasts
Článek Impact of the change in the antitubercular regimen from three to four drugs on cure and frequency of adverse reactions in tuberculosis patients from Brazil: A retrospective cohort study
Článek Ontogenic mRNA expression of RNA modification writers, erasers, and readers in mouse liver
Článek Intrinsic and extrinsic factors associated with sputum characteristics of presumed tuberculosis patients
Článek Vaccination with a live-attenuated small-colony variant improves the humoral and cell-mediated responses against Staphylococcus aureus
Článek A versatile modular vector set for optimizing protein expression among bacterial, yeast, insect and mammalian hosts
Článek Rapid evolution of prey maintains predator diversity
Článek Correction: Consumption of rice, acceptability and sensory qualities of fortified rice amongst consumers of social safety net rice in Nepal
Článek Indicators to distinguish symptom accentuators from symptom producers in individuals with a diagnosed adjustment disorder: A pilot study on inconsistency subtypes using SIMS and MMPI-2-RF
Článek Postural stability of 5-year-old girls and boys with different body heights
Článek The association between exposure to interferon-beta during pregnancy and birth measurements in offspring of women with multiple sclerosis
Článek Variations in neurotoxicity and proteome profile of Malayan krait (Bungarus candidus) venoms
Článek Altered functional connectivity density in the brains of hemodialysis end-stage renal disease patients: An in vivo resting-state functional MRI study
Článek Transboundary movements of foot-and-mouth disease from India to Sri Lanka: A common pattern is shared by serotypes O and C
Článek Medical and productivity costs after trauma
Článek Defining pharmacists' roles in disasters: A Delphi study
Článek Comprehensive assessment of tissue and serum parameters of bone metabolism in a series of orthopaedic patients
Článek Predictors of alcohol use transitions among drug-using youth presenting to an urban emergency department
Článek Longitudinal changes in structural lung abnormalities using MDCT in chronic obstructive pulmonary disease with asthma-like features
Článek Endocannabinoid 2-arachidonoylglycerol is elevated in the coronary circulation during acute coronary syndrome
Článek Contextual factors and sporting success: The relationship between birth date and place of early development on the progression of Jamaican track and field athletes from junior to senior level
Článek Potential application of Aloe Vera-derived plant-based cell in powering wireless device for remote sensor activation
Článek Retraction: Inhibition of reactive gliosis prevents neovascular growth in the mouse model of oxygen-induced retinopathy
Článek Measuring and addressing the childhood tuberculosis reporting gaps in Pakistan: The first ever national inventory study among children
Článek Arterial blood gas analysis in dogs with bronchomalacia
Článek Trends in the incidence of thymoma, thymic carcinoma, and thymic neuroendocrine tumor in the United States
Článek Optogenetic inhibition of ventral hippocampal neurons alleviates associative motor learning dysfunction in a rodent model of schizophrenia
Článek Safe and effective subcutaneous adipolysis in minipigs by a collagenase derivative
Článek The correlation between optical coherence tomography retinal shape irregularity and axial length
Článek Length of gestation and birth weight are associated with indices of combined kidney biomarkers in early childhood
Článek Essential oil-incorporated carbon nanotubes filters for bacterial removal and inactivation
Článek Domiciliary high-flow treatment in patients with COPD and chronic hypoxic failure: In whom can we reduce exacerbations and hospitalizations?
Článek Comprehensive analysis of putative dihydroflavonol 4-reductase gene family in tea plant
Článek Comparative proteomic analysis of mitochondria isolated from Euglena gracilis under aerobic and hypoxic conditions
Článek Secreted metabolite-mediated interactions between rhizosphere bacteria and Trichoderma biocontrol agents
Článek Experimental evidence of subtle victim blame in the absence of explicit blame
Článek Effects of different fatigue locations on upper body kinematics and inter-joint coordination in a repetitive pointing task
Článek Cannula and circuit management in peripheral extracorporeal membrane oxygenation: An international survey of 45 countries
Článek Economic evaluations of screening strategies for the early detection of colorectal cancer in the average-risk population: A systematic literature review
Článek Vitreous levels of Lipocalin-2 on patients with primary rhegmatogenous retinal detachment
Článek Light intensity and spectrum affect metabolism of glutathione and amino acids at transcriptional level
Článek The potential role of acrolein in plant ferroptosis-like cell death
Článek General practitioners’ consultation counts and associated factors in Swiss primary care – A retrospective observational study
Článek Potential of mesenchymal- and cardiac progenitor cells for therapeutic targeting of B-cells and antibody responses in end-stage heart failure
Článek Correction: Constitutive expression of an A-5 subgroup member in the DREB transcription factor subfamily from Ammopiptanthus mongolicus enhanced abiotic stress tolerance and anthocyanin accumulation in transgenic Arabidopsis
Článek A single institution experience of the treatment of pancreatic ductal carcinoma: The demand and the role of radiation therapy
Článek Correction: Intestinal mucosal injury induced by obstructive jaundice is associated with activation of TLR4/TRAF6/NF-κB pathways
Článek Relationship between scapular initial position and scapular movement during dynamic motions
Článek Correction: The circadian rhythm of bladder clock genes in the spontaneously hypersensitive rat
Článek Applications of machine learning in decision analysis for dose management for dofetilide
Článek Retraction: Nuclear factor kappa-B signaling is integral to ocular neovascularization in ischemia-independent microenvironment
Článek Using archaeological and geomorphological evidence for the establishment of a relative chronology and evolution pattern for Holocene landslides
Článek Who reported having a high-strain job, low-strain job, active job and passive job? The WIRUS Screening study
Článek Longitudinal monitoring of KRAS-mutated circulating tumor DNA enables the prediction of prognosis and therapeutic responses in patients with pancreatic cancer
Článek Retraction: Epigenetic Silencing of Peroxisome Proliferator-Activated Receptor γ Is a Biomarker for Colorectal Cancer Progression and Adverse Patients’ Outcome
Článek Correction: Severe cases of seasonal influenza in Russia in 2017-2018
Článek Differences between occupational and non-occupational-related motor vehicle collisions in West Virginia: A cross-sectional and spatial analysis
Článek Expression of concern: Zinc transporter 8 (ZnT8) expression is reduced by ischemic insults: A potential therapeutic target to prevent ischemic retinopathy
Článek Correction: Cattle intestinal microbiota shifts following Escherichia coli O157:H7 vaccination and colonization
Článek Correction: Development of UV spectrophotometry methods for concurrent quantification of amlodipine and celecoxib by manipulation of ratio spectra in pure and pharmaceutical formulation
Článek Correction: Modelling of the breadth of expression from promoter architectures identifies pro-housekeeping transcription factors
Článek Correction: Development of rice conidiation media for Ustilaginoidea virens
Článek Retraction: The Nexus between VEGF and NFκB Orchestrates a Hypoxia-Independent Neovasculogenesis
Článek Correction: Foraging strategies are maintained despite workforce reduction: A multidisciplinary survey on the pollen collected by a social pollinator
Článek Retraction: MicroRNA-493 Suppresses Tumor Growth, Invasion and Metastasis of Lung cancer by Regulating E2F1
Článek Correction: On the trail of Scandinavia’s early metallurgy: Provenance, transfer and mixing
Článek Correction: Novel insights into the morphology of Plesiochelys bigleri from the early Kimmeridgian of Northwestern Switzerland
Článek Correction: Supplementation of diet with non-digestible oligosaccharides alters the intestinal microbiota, but not arthritis development, in IL-1 receptor antagonist deficient mice
Článok vyšiel v časopise

PLOS One

2019 Číslo 12
Najčítanejšie tento týždeň
Najčítanejšie v tomto čísle
Kurzy

Zvýšte si kvalifikáciu online z pohodlia domova

Aktuální možnosti diagnostiky a léčby litiáz
nový kurz
Autori: MUDr. Tomáš Ürge, PhD.
Všetky kurzy
Prihlásenie
Zabudnuté heslo

Zadajte e-mailovú adresu, s ktorou ste vytvárali účet. Budú Vám na ňu zasielané informácie k nastaveniu nového hesla.

Prihlásenie

Nemáte účet?  Registrujte sa

#ADS_BOTTOM_SCRIPTS#