Drug overdose among women in intimate relationships: The role of partner violence, adversity and relationship dependencies

English version

Autoři: Nabila El-Bassel ^aff001; Phillip L. Marotta ^aff002; Dawn Goddard-Eckrich ^aff001; Mingway Chang ^aff001; Tim Hunt ^aff001; Ewin Wu ^aff001; Louisa Gilbert ^aff001
Působiště autorů: Columbia University, School of Social Work, New York, New York, United States of America ^aff001; Yale University, School of Medicine, Department of Psychiatry, New Haven, Connecticut, United States of America ^aff002
Vyšlo v časopise: PLoS ONE 14(12)
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.pone.0225854

Souhrn

Background

This study examines the relationship between experiencing intimate partner violence (IPV), exposure to prior childhood adversity, lifetime adverse experiences, drug-related relationship dependencies with intimate partners and overdose, hospitalization for drug use, friends and family members who overdosed and witnessing overdose.

Methodology

This paper included a sample of 201 women who use drugs in heterosexual relationships with criminal justice-involved men in New York City. We included measures of experiencing overdose, hospitalization for drug use, witnessing overdose, and having friends and family who overdosed. Intimate partner violence consisted of either 1) none/verbal only, 2) moderate and 3) severe abuse. Dichotomous indicators of drug-related relationship dependencies included financial support, drug procurement, splitting and pooling drugs. A scale measured cumulative exposure to childhood adversity and lifetime exposures to adverse events. This paper hypothesized that experiencing moderate and severe IPV, drug-related dependencies and exposure to prior childhood and lifetime adversity would be associated with a greater risk of experiencing overdose, hospitalization for drug use, witnessing overdose and having friends and family members who overdosed. Generalized linear modeling with robust variance estimated relative risk ratios that accounted for potential bias in confidence intervals and adjusted for race, ethnicity, education and marital status.

Results

We found experiencing moderate or severe IPV was associated with ever being hospitalized for drug use and having a family member who experienced overdose. Experiencing moderate IPV was associated with increased risk of witnessing overdose, Partner drug dependencies were associated with overdose, ever being hospitalized for drug use, witnessing overdose, and having a family member or friend who experienced overdose. Childhood and lifetime adversity exposures were significantly associated with increased risk of overdose, ever being hospitalized for drug use, ever witnessing overdose and having a friend and family member who overdosed.

Conclusion

Findings underscore the intersection of experiencing IPV and drug-related relationship dependencies, childhood adversity and lifetime adversity in shaping experiences of and witnessing overdose among women who use drugs. They highlight the urgent need to address IPV, adversity experiences and drug-related relationship dependencies in overdose prevention for women who use drugs.

Klíčová slova:

Human families – Drug research and development – Finance – Drug dependence – Recreational drug use – Drug abuse – Child abuse – Intimate partner violence

Zdroje

1. Van Houten J. P., Rudd R. A., Ballesteros M. F., & Mack K. A. (2019). Drug overdose deaths among women aged 30–64 years—United States, 1999–2017. Morbidity and Mortality Weekly Report, 68(1), 1. doi: 10.15585/mmwr.mm6801a1 30629574

2. Mack Karin A., Jones Christopher M., and Paulozzi Leonard J. "Vital signs: overdoses of prescription opioid pain relievers and other drugs among women—United States, 1999–2010." MMWR. Morbidity and mortality weekly report62.26 (2013): 537.

3. Marsh J. C., Park K., Lin Y. A., & Bersamira C. (2018). Gender differences in trends for heroin use and nonmedical prescription opioid use, 2007–2014. Journal of Substance Abuse Treatment, 87, 79–85. doi: 10.1016/j.jsat.2018.01.001 29433788

4. Centers for Disease Control and Prevention. Analysis of the National Vital Statistics System Multiple Cause of Death data, Wide-ranging OnLine Data for Epidemiologic Research (WONDER). 2017

5. Office on Women's Health. Final report: Opioid use, misuse, and overdose in women. Retrieved from https://www.womenshealth.gov/files/documents/final-report-opioid-508.pdf (2017)

6. Spencer M. R., Warner M., Bastian B. A., Trinidad J. P., & Hedegaard H. (2019). Drug Overdose Deaths Involving Fentanyl, 2011–2016. National vital statistics reports: from the Centers for Disease Control and Prevention, National Center for Health Statistics, National Vital Statistics System, 68(3), 1–19.

7. Blankenship K. M., Friedman S. R., Dworkin S., & Mantell J. E. (2006). Structural interventions: concepts, challenges and opportunities for research. Journal of Urban Health, 83(1), 59–72. doi: 10.1007/s11524-005-9007-4 16736355

8. El-Bassel N., & Strathdee S. A. (2015). Women who use or inject drugs: an action agenda for women-specific, multilevel and combination HIV prevention and research. Journal of Acquired Immune Deficiency Syndromes (1999), 69(Suppl 2), S182.

9. Rhodes T. (2002). The ‘risk environment’: a framework for understanding and reducing drug-related harm. International Journal of Drug Policy, 13(2), 85–94.

10. Rhodes T., & Simic M. (2005). Transition and the HIV risk environment. BMJ, 331(7510), 220–223. doi: 10.1136/bmj.331.7510.220 16037463

11. El-Bassel N., Gilbert L., Witte S., Wu E., Gaeta T., Schilling R., & Wada T. (2003). Intimate partner violence and substance abuse among minority women receiving care from an inner-city emergency department. Women's Health Issues, 13(1), 16–22. doi: 10.1016/s1049-3867(02)00142-1 12598055

12. El-Bassel N., Gilbert L., Wu E., Go H., & Hill J. (2005). Relationship between drug abuse and intimate partner violence: a longitudinal study among women receiving methadone. American Journal of Public Health, 95(3), 465–470. doi: 10.2105/AJPH.2003.023200 15727978

13. El-Bassel N., Gilbert L., Golder S., Wu E., Chang M., Fontdevila J., & Sanders G. (2004). Deconstructing the relationship between intimate partner violence and sexual HIV risk among drug-involved men and their female partners. AIDS and Behavior, 8(4), 429–439. doi: 10.1007/s10461-004-7327-0 15690116

14. Gilbert L., Raj A., Hien D., Stockman J., Terlikbayeva A., & Wyatt G. (2015). Targeting the SAVA (substance abuse, violence and AIDS) syndemic among women and girls: a global review of epidemiology and integrated interventions. Journal of Acquired Immune Deficiency Syndromes (1999), 69(0 2), S118.

15. Smith P. H., Homish G. G., Leonard K. E., & Cornelius J. R. (2012). Intimate partner violence and specific substance use disorders: Findings from the National Epidemiologic Survey on Alcohol and Related Conditions. Psychology of Addictive Behaviors, 26(2), 236. doi: 10.1037/a0024855 21823768

16. Testa M., Livingston J. A., & Leonard K. E. (2003). Women's substance use and experiences of intimate partner violence: A longitudinal investigation among a community sample. Addictive Behaviors, 28(9), 1649–1664. doi: 10.1016/j.addbeh.2003.08.040 14656551

17. Papp J., & Schrock J. (2017). 1EMF Take-Home Naloxone Rescue Kits Following Heroin Overdose in the Emergency Department to Prevent Opioid Overdose-Related Repeat Emergency Department Visits, Hospitalization, and Death: A Pilot Study. Annals of Emergency Medicine, 70(4), S170.

18. Carbone-López K., Kruttschnitt C., & Macmillan R. (2006). Patterns of intimate partner violence and their associations with physical health, psychological distress, and substance use. Public Health Reports, 121(4), 382–392. doi: 10.1177/003335490612100406 16827439

19. El-Bassel N., Shaw S. A., Dasgupta A., & Strathdee S. A. (2014). People who inject drugs in intimate relationships: it takes two to combat HIV. Current HIV/AIDS Reports, 11(1), 45–51. doi: 10.1007/s11904-013-0192-6 24477931

20. Amaro H., Fried L. E., Cabral H., & Zuckerman B. (1990). Violence during pregnancy and substance use. American Journal of Public Health, 80(5), 575–579. doi: 10.2105/ajph.80.5.575 2327535

21. Burke J. G., Thieman L. K., Gielen A. C., O’Campo P., & McDonnell K. A. (2005). Intimate partner violence, substance use, and HIV among low-income women: taking a closer look. Violence Against Women, 11(9), 1140–1161. doi: 10.1177/1077801205276943 16049104

22. Martin S. L., Beaumont J. L., & Kupper L. L. (2003). Substance use before and during pregnancy: links to intimate partner violence. The American Journal of Drug and Alcohol Abuse, 29(3), 599–617 doi: 10.1081/ada-120023461 14510043

23. Roberts A., Mathers B., & Degenhardt L. (2010). Women who inject drugs: A review of their risks, experiences and needs. A report prepared on behalf of the Reference Group to the United Nations on HIV and Injecting Drug Use. Australia Sydney: National Drug and Alcohol Research Centre (NDARC), University of New South Wales.

24. Caldwell J. E., Swan S. C., & Woodbrown V. D. (2012). Gender differences in intimate partner violence outcomes. Psychology of Violence, 2(1), 42.

25. Simmons J., & Singer M. (2006). I love you … and heroin: care and collusion among drug-using couples. Substance Abuse Treatment, Prevention, and Policy, 1(1), 7.

26. Bair-Merritt M. H., Blackstone M., & Feudtner C. (2006). Physical health outcomes of childhood exposure to intimate partner violence: a systematic review. Pediatrics, 117(2), e278–e290. doi: 10.1542/peds.2005-1473 16452335

27. Lake S., Hayashi K., Milloy M. J., Wood E., Dong H., Montaner J., & Kerr T. (2015). Associations between childhood trauma and non-fatal overdose among people who inject drugs. Addictive Behaviors, 43, 83–88. doi: 10.1016/j.addbeh.2014.12.014 25588793

28. Hammersley R., Dalgarno P., McCollum S., Reid M., Strike Y., Smith A., & & Liddell D. (2016). Trauma in the childhood stories of people who have injected drugs. Addiction Research & Theory, 24(2), 135–151.

29. Davidson PJ, Ochoa KC, Hahn JA, Evans JL, Moss AR. Witnessing heroin-related overdoses: the experiences of young injectors in San Francisco. Addiction. 2002; 97: 1511–1516. doi: 10.1046/j.1360-0443.2002.00210.x 12472634

30. Somerville N. J., O’Donnell J., Gladden R. M., Zibbell J. E., Green T. C., Younkin M., & Kuramoto-Crawford J. (2017). Characteristics of fentanyl overdose—Massachusetts, 2014–2016. MMWR. Morbidity and Mortality Weekly Report, 66(14), 382. doi: 10.15585/mmwr.mm6614a2 28406883

31. Tracy M., Piper T. M., Ompad D., Bucciarelli A., Coffin P. O., Vlahov D., & Galea S. (2005). Circumstances of witnessed drug overdose in New York City: implications for intervention. Drug and Alcohol Dependence, 79(2), 181–190. doi: 10.1016/j.drugalcdep.2005.01.010 16002027

32. Kim D., Irwin K. S., & Khoshnood K. (2009). Expanded access to naloxone: options for critical response to the epidemic of opioid overdose mortality. American Journal of Public Health, 99(3), 402–407. doi: 10.2105/AJPH.2008.136937 19150908

33. Martins S. S., Sampson L., Cerdá M., & Galea S. (2015). Worldwide prevalence and trends in unintentional drug overdose: a systematic review of the literature. American Journal of Public Health, 105(11), e29–e49. doi: 10.2105/AJPH.2015.302843 26451760

34. Straus M. A., Hamby S. L., Boney-McCoy S., & Sugarman D. B. (1996). The revised conflict tactics scales (CTS2) development and preliminary psychometric data. Journal of family issues, 17(3), 283–316.

35. Goodman L. A., Corcoran C., Turner K., Yuan N., & Green B. L. (1998). Assessing traumatic event exposure: General issues and preliminary findings for the Stressful Life Events Screening Questionnaire. Journal of Traumatic Stress: Official Publication of The International Society for Traumatic Stress Studies, 11(3), 521–542.

36. El-Bassel N., Gilbert L., Goddard-Eckrich D., Chang M., Wu E., Goodwin S., & & Hunt T. (2019). Effectiveness of a Couple-Based HIV and Sexually Transmitted Infection Prevention Intervention for Men in Community Supervision Programs and Their Female Sexual Partners: A Randomized Clinical Trial. JAMA Network Open, 2(3), e191139–e191139. doi: 10.1001/jamanetworkopen.2019.1139 30924895

37. Finkelhor D., Shattuck A., Turner H., & Hamby S. (2015). A revised inventory of adverse childhood experiences. Child Abuse & Neglect, 48, 13–21.

38. Agresti A., & Kateri M. (2011). Categorical Data Analysis (pp. 206–208). Springer Berlin Heidelberg.

39. Cramer D. (2003). Advanced Quantitative Data Analysis. McGraw-Hill Education (UK).

40. Wilcoxon F., Katti S. K., & Wilcox R. A. (1970). Critical values and probability levels for the Wilcoxon rank sum test and the Wilcoxon signed rank test. Selected tables in mathematical statistics, 1, 171–259.

41. McCullagh P. (2019). Generalized Linear Models. Routledge.

42. Nelder J. A., & Wedderburn R. W. (1972). Generalized linear models. Journal of the Royal Statistical Society: Series A (General), 135(3), 370–384.

43. Cummings P. (2009). Methods for estimating adjusted risk ratios. The Stata Journal, 9(2), 175–196.

44. Dobson A. J., & Barnett A. G. (2008). An Introduction to Generalized Llinear Models. Chapman and Hall/CRC.

45. Lumley T., Kronmal R., & Ma S. (2006). Relative risk regression in medical research: models, contrasts, estimators, and algorithms.

46. StataCorp Reference Manual 13 (2019). glm postestimation—Postestimation tools for glm. Retrieved from https://www.stata.com/manuals13/rglmpostestimation.pdf

47. StataCorp, College Park, Texas.

48. Sacks J. Y., McKendrick K., & Banks S. (2008). The impact of early trauma and abuse on residential substance abuse treatment outcomes for women. Journal of Substance Abuse Treatment, 34(1), 90–100. doi: 10.1016/j.jsat.2007.01.010 17574799

49. Randhawa Gurdeeshpal, Azarbar Ataa, Dong Huiru, M. J. Milloy, Thomas Kerr, and Kanna Hayashi. "Childhood Trauma and the Inability to Access Hospital Care Among People who Inject Drugs." Journal of Traumatic Stress 31, no. 3 (2018): 383–390.

50. Van Dam D., Ehring T., Vedel E., & Emmelkamp P. M. (2013). Trauma-focused treatment for posttraumatic stress disorder combined with CBT for severe substance use disorder: a randomized controlled trial. BMC Psychiatry, 13(1), 172.

51. El-Bassel N., Gilbert L., Wu E., Chang M., Gomes C., Vinocur D., & Spevack T. (2007). Intimate partner violence prevalence and HIV risks among women receiving care in emergency departments: implications for IPV and HIV screening. Emergency Medicine Journal, 24(4), 255–259. doi: 10.1136/emj.2006.041541 17384378

52. Hankin A., Smith L. S., Daugherty J., & Houry D. (2010). Correlation between intimate partner violence victimization and risk of substance abuse and depression among African-American women in an urban emergency department. Western Journal of Emergency Medicine, 11(3), 252. 20882145

53. Jiwatram-Negrón T., & El-Bassel N. (2015). Correlates of sex trading among drug-involved women in committed intimate relationships: a risk profile. Women's Health Issues, 25(4), 420–428. doi: 10.1016/j.whi.2015.04.007 26092746

54. Salomon A., Bassuk S. S., & Huntington N. (2002). The relationship between intimate partner violence and the use of addictive substances in poor and homeless single mothers. Violence Against Women, 8(7), 785–815.

55. Cunradi C. B., Caetano R., & Schafer J. (2002). Alcohol‐related problems, drug use, and male intimate partner violence severity among US couples. Alcoholism: Clinical and Experimental Research, 26(4), 493–500.

56. Golinelli D., Longshore D., & Wenzel S. L. (2009). Substance use and intimate partner violence: Clarifying the relevance of women’s use and partners’ use. The Journal of Behavioral Health Services & Research, 36(2), 199.