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High prevalence and incidence of rectal Chlamydia infection among men who have sex with men in Japan


Autoři: Daisuke Mizushima aff001;  Misao Takano aff001;  Haruka Uemura aff001;  Yasuaki Yanagawa aff001;  Takahiro Aoki aff001;  Koji Watanabe aff001;  Hiroyuki Gatanaga aff001;  Yoshimi Kikuchi aff001;  Shinichi Oka aff001
Působiště autorů: AIDS Clinical Center, National Center for Global Health and Medicine, Tokyo, Japan aff001
Vyšlo v časopise: PLoS ONE 14(12)
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.pone.0220072

Souhrn

Background

Rectal Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG) infections have been neglected and epidemiological data are unavailable in Japan. Thus, we evaluated the prevalence and incidence of rectal CT/NG in a cohort of HIV-negative men who have sex with men (MSM), which was established at the National Center for Global Health and Medicine (NCGM), in Tokyo, Japan, in January 2017.

Methods

HIV-negative MSM aged ≥16 years old were included. The prevalence of rectal CT/NG among HIV-negative MSM was compared with that among an existing HIV-positive MSM cohort at NCGM. The HIV-negative MSM cohort was examined for rectal and pharyngeal CT/NG every 3 months. Urethral CT/NG was evaluated at the physician’s discretion. The incidences of CT/NG were evaluated in December 2018.

Results

Of 502 MSM initially included in this study, 13 men were diagnosed with HIV infection at enrollment and were subsequently excluded from the analysis. We evaluated 561 HIV-positive MSM for rectal CT/NG. The mean ages of the two cohorts were 33.6 and 46.2 years old, respectively (p<0.001). The prevalences of rectal CT were 16.4% and 15.9% (p = 0.707) and the prevalences of rectal NG were 4.1% and 2.3% (p = 0.101), for the HIV-negative and HIV-positive MSM cohorts, respectively. Of 489 HIV-negative MSM, 328 were followed at least twice, with 261.1 person-years during the study period. The incidences of rectal CT/NG were 17.2 and 3.8/100 person-years and the incidences of pharyngeal CT/NG were 2.0 and 11.0/100 person-years for the two cohorts, respectively. Approximately 37.9% of incident cases were attributed to recurrent infection.

Conclusions

The prevalence and incidence of rectal CT/NG were high among MSM in Tokyo, Japan, suggesting that urgent countermeasures for early diagnosis and treatment are necessary.

Klíčová slova:

Sexually transmitted diseases – Rectum – Chlamydia infection – Men who have sex with men – Pre-exposure prophylaxis – Japan


Zdroje

1. Bernstein KT, Marcus JL, Nieri G, Philip SS, Klausner JD (2010) Rectal gonorrhea and chlamydia reinfection is associated with increased risk of HIV seroconversion. J Acquir Immune Defic Syndr 53: 537–543. doi: 10.1097/QAI.0b013e3181c3ef29 19935075

2. Pathela P, Braunstein SL, Blank S, Schillinger JA (2013) HIV incidence among men with and those without sexually transmitted rectal infections: estimates from matching against an HIV case registry. Clin Infect Dis 57: 1203–1209. doi: 10.1093/cid/cit437 23800942

3. Jin F, Prestage GP, Imrie J, Kippax SC, Donovan B, Templeton DJ, et al. (2010) Anal sexually transmitted infections and risk of HIV infection in homosexual men. J Acquir Immune Defic Syndr 53: 144–149. doi: 10.1097/QAI.0b013e3181b48f33 19734801

4. Katz DA, Dombrowski JC, Bell TR, Kerani RP, Golden MR (2016) HIV Incidence Among Men Who Have Sex With Men After Diagnosis With Sexually Transmitted Infections. Sex Transm Dis 43: 249–254. doi: 10.1097/OLQ.0000000000000423 26967302

5. Patton ME, Kidd S, Llata E, Stenger M, Braxton J, Asbel L, et al. (2014) Extragenital gonorrhea and chlamydia testing and infection among men who have sex with men—STD Surveillance Network, United States, 2010–2012. Clin Infect Dis 58: 1564–1570. doi: 10.1093/cid/ciu184 24647015

6. Tao G, Hoover KW, Nye MB, Peters P, Gift TL, Peruvemba R, et al. (2016) Rectal Infection With Neisseria gonorrhoeae and Chlamydia trachomatis in Men in the United States. Clin Infect Dis 63: 1325–1331. doi: 10.1093/cid/ciw594 27572098

7. Dewart CM, Bernstein KT, DeGroote NP, Romaguera R, Turner AN (2018) Prevalence of Rectal Chlamydial and Gonococcal Infections: A Systematic Review. Sex Transm Dis 45: 287–293. doi: 10.1097/OLQ.0000000000000754 29465688

8. Tao G, Hoover KW, Nye MB, Peters PJ, Gift TL, Body BA. (2018) Infrequent Testing of Women for Rectal Chlamydia and Gonorrhea in the United States. Clin Infect Dis 66: 570–575. doi: 10.1093/cid/cix857 29028971

9. van Liere G, Dukers-Muijrers N, Levels L, Hoebe C (2017) High Proportion of Anorectal Chlamydia trachomatis and Neisseria gonorrhoeae After Routine Universal Urogenital and Anorectal Screening in Women Visiting the Sexually Transmitted Infection Clinic. Clin Infect Dis 64: 1705–1710. doi: 10.1093/cid/cix243 28369227

10. Traeger MW, Schroeder SE, Wright EJ, Hellard ME, Cornelisse VJ, Doyle JS, et al. (2018) Effects of Pre-exposure Prophylaxis for the Prevention of Human Immunodeficiency Virus Infection on Sexual Risk Behavior in Men Who Have Sex With Men: A Systematic Review and Meta-analysis. Clin Infect Dis 67: 676–686. doi: 10.1093/cid/ciy182 29509889

11. Marcus JL, Bernstein KT, Kohn RP, Liska S, Philip SS (2011) Infections missed by urethral-only screening for chlamydia or gonorrhea detection among men who have sex with men. Sex Transm Dis 38: 922–924. doi: 10.1097/OLQ.0b013e31822a2b2e 21934565

12. Kent CK, Chaw JK, Wong W, Liska S, Gibson S, Hubbard G, et al. (2005) Prevalence of rectal, urethral, and pharyngeal chlamydia and gonorrhea detected in 2 clinical settings among men who have sex with men: San Francisco, California, 2003. Clin Infect Dis 41: 67–74. doi: 10.1086/430704 15937765

13. Barbee LA, Dombrowski JC, Kerani R, Golden MR (2014) Effect of nucleic acid amplification testing on detection of extragenital gonorrhea and chlamydial infections in men who have sex with men sexually transmitted disease clinic patients. Sex Transm Dis 41: 168–172. doi: 10.1097/OLQ.0000000000000093 24521722

14. Sultan B, White JA, Fish R, Carrick G, Brima N, Copas A, et al. (2016) The "3 in 1" Study: Pooling Self-Taken Pharyngeal, Urethral, and Rectal Samples into a Single Sample for Analysis for Detection of Neisseria gonorrhoeae and Chlamydia trachomatis in Men Who Have Sex with Men. J Clin Microbiol 54: 650–656. doi: 10.1128/JCM.02460-15 26719439

15. Chan PA, Robinette A, Montgomery M, Almonte A, Cu-Uvin S, Lonks JR, et al. (2016) Extragenital Infections Caused by Chlamydia trachomatis and Neisseria gonorrhoeae: A Review of the Literature. Infect Dis Obstet Gynecol 2016: 5758387. doi: 10.1155/2016/5758387 27366021

16. Dudareva-Vizule S, Haar K, Sailer A, Wisplinghoff H, Wisplinghoff F, Marcus U, et al. (2014) Prevalence of pharyngeal and rectal Chlamydia trachomatis and Neisseria gonorrhoeae infections among men who have sex with men in Germany. Sex Transm Infect 90: 46–51. doi: 10.1136/sextrans-2012-050929 23920398

17. Rieg G, Lewis RJ, Miller LG, Witt MD, Guerrero M, Daar ES. (2008) Asymptomatic sexually transmitted infections in HIV-infected men who have sex with men: prevalence, incidence, predictors, and screening strategies. AIDS Patient Care STDS 22: 947–954. doi: 10.1089/apc.2007.0240 19072101

18. Chow EP, Tabrizi SN, Phillips S, Lee D, Bradshaw CS, Chen MY, et al. (2016) Neisseria gonorrhoeae Bacterial DNA Load in the Pharynges and Saliva of Men Who Have Sex with Men. J Clin Microbiol 54: 2485–2490. doi: 10.1128/JCM.01186-16 27413195

19. Chow EP, Lee D, Tabrizi SN, Phillips S, Snow A, Cook S, et al. (2016) Detection of Neisseria gonorrhoeae in the pharynx and saliva: implications for gonorrhoea transmission. Sex Transm Infect 92: 347–349. doi: 10.1136/sextrans-2015-052399 26622046

20. Dunne EF, Chapin JB, Rietmeijer CA, Kent CK, Ellen JM, Gaydos CA, et al. (2008) Rate and predictors of repeat Chlamydia trachomatis infection among men. Sex Transm Dis 35: S40–44.


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