Intraocular pressure elevation after subtenon triamcinolone acetonide injection; Multicentre retrospective cohort study in Japan

English version

Autoři: Yuki Maeda ^aff001; Hiroto Ishikawa ^aff001; Hiroki Nishikawa ^aff003; Miho Shimizu ^aff001; Takamasa Kinoshita ^aff001; Rie Ogihara ^aff001; Shigehiko Kitano ^aff001; Chihiro Yamanaka ^aff001; Yoshinori Mitamura ^aff001; Masahiko Sugimoto ^aff001; Mineo Kondo ^aff001; Yoshihiro Takamura ^aff001; Nahoko Ogata ^aff001; Tomohiro Ikeda ^aff001; Fumi Gomi ^aff001
Působiště autorů: J-CREST (Japan Clinical REtina STudy group), Kagoshima, Japan ^aff001; Department of Ophthalmology, Hyogo College of Medicine, Nishinomiya, Japan ^aff002; Center for Clinical Research and Education, Hyogo College of Medicine, Nishinomiya, Japan ^aff003; Department of Ophthalmology, Sapporo City General Hospital, Sapporo, Japan ^aff004; Department of Ophthalmology, Diabetes Center, Tokyo Women's Medical University School of Medicine, Shinjuku-ku, Japan ^aff005; Department of Ophthalmology, Tokushima University, Tokushima, Japan ^aff006; Department of Ophthalmology, Mie University, Tsu, Japan ^aff007; Department of Ophthalmology, Fukui University, Yoshida, Japan ^aff008; Department of Ophthalmology, Nara Medical University School of Medicine, Kashihara, Japan ^aff009
Vyšlo v časopise: PLoS ONE 14(12)
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.pone.0226118

Souhrn

Purpose

To evaluate real-world evidence for intraocular pressure (IOP) elevation after subtenon triamcinolone acetonide injection (STTA) in 1252 Japanese patients (1406 eyes) in the Japan Clinical REtina STudy group (J-CREST).

Methods

This was a multicentre retrospective study of the medical records of 1252 patients (676 men (758 eyes); mean age: 63.8 ± 12.9 years) who received STTA in participating centres between April 2013 and July 2017.

Results

IOP elevation was observed in 206 eyes (14.7%) and IOP increase ≥ 6 mmHg was found in 328 eyes (23.3%). In total, 106 eyes (7.5%) needed medication and two eyes (0.14%) needed surgical procedures. Younger age, higher baseline IOP, and steroid dose were risk factors associated with IOP elevation. Risk factors associated with IOP increase ≥ 6 mmHg were younger age, lower baseline IOP, steroid dose, and higher incidences of diabetic macular oedema (DME) and uveitis. In contrast, with steroid dose fixed at 20 mg, a lower incidence of DME was a risk factor for increased IOP, suggesting that STTA had dose-dependent effects on IOP increase, especially in patients with DME.

Conclusion

Our real-world evidence from a large sample of Japanese patients who received STTA showed that the incidence of IOP elevation after STTA was 14.7%, and was associated with younger age, higher baseline IOP, and steroid dose. Thus, IOP should be monitored, especially in patients with younger age, higher baseline IOP, and higher incidences of DME and uveitis.

Klíčová slova:

Surgical and invasive medical procedures – Eye diseases – Glaucoma – Eyes – Steroids – Medical risk factors – Ophthalmic procedures – Uveitis

Zdroje

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