Decreased retinal thickness in patients with Alzheimer’s disease is correlated with disease severity
Autoři:
Jae-Il Kim aff001; Bong-Hui Kang aff001
Působiště autorů:
Department of Neurology, Dankook University College of Medicine, Dankook University Hospital, Cheonan, Korea
aff001
Vyšlo v časopise:
PLoS ONE 14(11)
Kategorie:
Research Article
prolekare.web.journal.doi_sk:
https://doi.org/10.1371/journal.pone.0224180
Souhrn
Background and purpose
The loss of retinal ganglion cells observed in Alzheimer’s disease (AD) may be attributable to a neurodegeneration of the neuro-retinal structure. Amnestic mild cognitive impairment (aMCI) has been considered a prodromal stage of AD. We evaluated retinal thicknesses in patients with aMCI and AD compared to healthy controls using spectral-domain optical coherence tomography (OCT) to investigate whether changes in retinal thickness are correlated with the clinical severity of dementia.
Methods
Patients with aMCI (n = 14), mild to moderate AD (n = 7), severe AD (n = 9), and age-matched controls (n = 17) underwent neuro-ophthalmologic examinations. Global deterioration scale (GDS), clinical dementia rating (CDR), and mini-mental status examination (MMSE) were used to evaluate the clinical overall severity of dementia. The thicknesses of the peripapillary retinal nerve fiber layer (RNFL), total macula, and macular ganglion cell-inner plexiform layer (GC-IPL) were measured using Cirrus HD-OCT.
Results
The severe AD group had overall significantly thinner GC-IPL, total macula, and peripapillary RNFL compared to the controls (p<0.05). In the mild to moderate AD group, the total macula, average RNFL, and superior RNFL thickness were each significantly reduced compared to controls (p<0.05). The aMCI group had reduced total macula, average RNFL, and inferior RNFL thickness, but there were no significant differences compared to the controls. The GDS and CDR scores had a negative correlation with the thickness of the GC-IPL and the total macula. The MMSE scores had a positive correlation with both the total macular and average RNFL thickness, when adjusted for age (p<0.05).
Conclusions
This study confirmed that retinal thickness is decreased in AD patients. There is a correlation between reduced retinal thickness and the clinical severity of dementia.
Klíčová slova:
Diagnostic medicine – Cognitive impairment – Dementia – Alzheimer's disease – Eyes – Tomography – Retina – Retinal ganglion cells
Zdroje
1. Koronyo-Hamaoui M, Koronyo Y, Ljubimov AV, Miller CA, Ko MK, Black KL, et al. Identification of amyloid plaques in retinas from Alzheimer's patients and noninvasive in vivo optical imaging of retinal plaques in a mouse model. Neuroimage. 2011;54(suppl 1):S204–S217. http://doi.org/10.1016/j.neuroimage.2010.06.020
2. Lanks JC, Torigoe Y, Hinton DR, Blanks RH. Retinal pathology in Alzheimer’s disease I. Ganglion cell loss in foveal/parafoveal retina. Neurobiol Aging. 1996;17:377–384. doi: 10.1016/0197-4580(96)00010-3 8725899
3. Guo L, Duggan J, Cordeiro MF. Alzheimer's disease and retinal neurodegeneration. Curr Alzheimer Res. 2010; 7:3–14. doi: 10.2174/156720510790274491 20205667
4. Petersen RC, Roberts RO, Knopman DS, Boeve BF, Geda YE, Ivnik RJ, et al. Mild cognitive impairment: ten years later. Arch Neurol. 2009;66:1447–1455. https://doi.org/10.1001/archneurol.2009.266 20008648
5. Albert MS, DeKosky ST, Dickson D, Dubois B, Feldman HH, Fox NC, et al. The diagnosis of mild cognitive impairment due to Alzheimer’s disease: Recommendations from the National Institute on Aging and Alzheimer’s Association workgroup. Alzheimer’s & Dementia. 2011; 7:270–279. https://doi.org/10.1016/j.jalz.2011.03.008
6. Greenberg BM, Frohman E. Optical coherence tomography as a potential readout in clinical trials. Ther Adv Neurol Disord. 2010;3: 153–160. https://doi.org/10.1177/1756285610368890 21179607
7. Coppola G, Di Renzo A, Ziccardi L, Martelli F, Fadda A, Manni G, et al. Optical Coherence Tomography in Alzheimer's Disease: A Meta-Analysis. PLoS One. 2015;7:10. https://doi.org/10.1371/journal.pone.0134750
8. Thomson KL, Yeo JM, Waddell B, Cameron JR, Pal S. A systematic review and meta-analysis of retinal nerve fiber layer change in dementia, using optical coherence tomography. Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring. 2015;1:136–143. https://doi.org/10.1016/j.dadm.2015.03.001
9. Kesler A, Vakhapova V, Korczyn AD, Naftaliev E, Neudorfer M. Retinal thickness in patients with mild cognitive impairment and Alzheimer's disease. Clin Neurol Neurosurg. 2011;113:523–526. https://doi.org/10.1016/j.clineuro.2011.02.014 21454010
10. Paquet C, Boissonnot M, Roger F, Dighiero P, Gil R, Hugon J. Abnormal retinal thickness in patients with mild cognitive impairment and Alzheimer's disease. Neurosci Lett. 2007;420:97–99. https://doi.org/10.1016/j.neulet.2007.02.090 17543991
11. Ascaso FJ, Cruz N, Modrego PJ, Lopez-Anton R, Santaba´ rbara J, Pascual LF, et al. Retinal alterations in mild cognitive impairment and Alzheimer’s disease: An optical coherence tomography study. Journal of Neurology 2014;261:1522–1530. https://doi.org/10.1007/s00415-014-7374-z 24846203
12. Gao LY, Liu Y, Li XH, Bai QH, Liu P. Abnormal retinal nerve fiber layer thickness and macula lutea in patients with mild cognitive impairment and Alzheimer’s disease. Archives of Gerontology and Geriatrics. 2015;60:162–167. https://doi.org/10.1016/j.archger.2014.10.011 25459918
13. Kang BH, Kim JI. Decreased retinal thickness in patients with Alzheimer's disease. J Korean Neurol Assoc. 2013;31:173–177.
14. McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology. 1984,34:939–944. doi: 10.1212/wnl.34.7.939 6610841
15. Sheehan B. Assessment scales in dementia. Ther Adv Neurol Disord. 2012; 5: 349–358. https://doi.org/10.1177/1756285612455733 23139705
16. Kouros NM, Sara N, Nariman N, Cirineo N, Knipping S, Giaconi J, et al. Macular ganglion cell/Inner plexiform layer measurements by spectral domain optical coherence tomography for detection of early glaucoma and comparison to retinal nerve fiber layer measurements. Am J Ophthalmol. 2013;156:1297–1307. https://doi.org/10.1016/j.ajo.2013.08.001 24075422
17. Wostyn P, Audenaert K, DeDeyn PP. Alzheimer’s disease and glaucoma: Is there a causal relationship. British Journal of Ophthalmology. 2009;93:1557–1559. https://doi.org/10.1136/bjo.2008.148064 19286688
18. Whitwell JL, Shiung MM, Przybelski SA, Weigand SD, Knopman DS, Boeve BF, et al. MRI patterns of atrophy associated with progression to AD in amnestic mild cognitive impairment. Neurology. 2008;70:512–520. https://doi.org/10.1212/01.wnl.0000280575.77437.a2 17898323
19. Jack CRJ, Lowe VJ, Senjem ML, Weigand SD, Kemp BJ, Shiung MM, et al. 11C PiB and structural MRI provide complementary information in imaging of Alzheimer's disease and amnestic mild cognitive impairment. Brain. 2008;131:665–680. https://doi.org/10.1093/brain/awm336 18263627
20. Weiner MW, Veitch DP, Aisen PS, Beckett LA, Cairns NJ, Cedarbaum J, et al. 2014 Update of the Alzheimer’s Disease Neuroimaging Initiative: A review of papers published since its inception Alzheimers Dement. 2015 Jun; 11(6): e1–120. https://doi.org/10.1016/j.jalz.2014.11.001 26073027
21. Lee JY, Hwang YH, Lee SM, Kim YY. Age and retinal nerve fiber layer thickness measured by spectral domain optical coherence tomography. Korean J Ophthalmol. 2012;26:163–168. https://doi.org/10.3341/kjo.2012.26.3.163 22670071
22. Jicha GA, Parisi JE, Dickson DW, Johnson K, Cha R, Ivnik RJ, et al. Neuropathologic outcome of mild cognitive impairment following progression to clinical dementia. Arch Neurol. 2006;63:674–81. doi: 10.1001/archneur.63.5.674 16682537
23. Lashley T, Schott JM, Weston P, Murray CE, Wellington H, Keshavan A, et al. Molecular biomarkers of Alzheimer's disease: progress and prospects. Dis Model Mech. 2018;8;11(5). https://doi.org/10.1242/dmm.031781
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