#PAGE_PARAMS# #ADS_HEAD_SCRIPTS# #MICRODATA#
preLekára.sk / Odborné časopisy / PLOS One / 2019 - 11

Infusion of HIV-1 Nef-expressing astrocytes into the rat hippocampus induces enteropathy and interstitial pneumonitis and increases blood–brain-barrier permeability

English version

Autoři: Jocelyn Rivera aff001;  Raymond A. Isidro aff002;  Raisa Y. Loucil-Alicea aff002;  Myrella L. Cruz aff002;  Caroline B. Appleyard aff002;  Angel A. Isidro aff002;  Gladys Chompre aff003;  Krystal Colon-Rivera aff001;  Richard J. Noel, Jr. aff002
Působiště autorů: HIV-1 Immunopathogenesis Laboratory, The Wistar Institute, Philadelphia, PA, United States of America aff001;  Department of Basic Sciences, Ponce Health Sciences University, Ponce Research Institute, Ponce, Puerto Rico, United States of America aff002;  Department of Biology, Pontifical Catholic University of Puerto Rico, Ponce, Puerto Rico, United States of America aff003
Vyšlo v časopise: PLoS ONE 14(11)
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.pone.0225760

Souhrn

Even though HIV-1 replication can be suppressed by combination antiretroviral therapy (cART) inflammatory processes still occur, contributing to comorbidities. Comorbidities are attributed to variety of factors, including HIV-1 mediated inflammation. Several HIV-1 proteins mediate central nervous system (CNS) inflammation, including Nef. Nef is an early HIV-1 protein, toxic to neurons and glia and is sufficient to cause learning impairment similar to some deficits observed in HIV-1 associated neurocognitive disorders. To determine whether hippocampal Nef expression by astrocytes contributes to comorbidities, specifically peripheral inflammation, we infused Sprague Dawley rats with GFP- (control) or Nef-transfected astrocytes into the right hippocampus. Brain, lung, and ileum were collected postmortem for the measurement of inflammatory markers. Increased blood-brain-barrier permeability and serum IL-1β levels were detected in the Nef-treated rats. The lungs of Nef-treated rats demonstrated leukocyte infiltration, macrophage upregulation, and enhanced vascular permeability. Ileal tissue showed reactive follicular lymphoid hyperplasia, increased permeability and macrophage infiltration. The intracerebroventricular application of IL-1 receptor antagonist reduced infiltration of immune cells into ileum and lung, indicating the important role of IL-1β in mediating the spread of inflammation from the brain to other tissues. This suggests that localized expression of a single viral protein, HIV-1 Nef, can contribute to a broader inflammatory response by upregulation of IL-1β. Further, these results suggest that Nef contributes to the chronic inflammation seen in HIV patients, even in those whose viremia is controlled by cART.

Klíčová slova:

Inflammation – HIV-1 – Gastrointestinal tract – Macrophages – Ileum – Hippocampus – Astrocytes – Tight junctions

Zdroje

1. Gupta RK, Wainberg MA, Brun-Vezinet F, Gatell JM, Albert J, Sonnerborg A, et al. Oral antiretroviral drugs as public health tools for HIV prevention: global implications for adherence, drug resistance, and the success of HIV treatment programs. J Infect Dis. 2013;207 Suppl 2:S101–6. Epub 2013/05/25. doi: 10.1093/infdis/jit108 23687287; PubMed Central PMCID: PMC3708737.

2. Kaul M, Zheng J, Okamoto S, Gendelman HE, Lipton SA. HIV-1 infection and AIDS: consequences for the central nervous system. Cell Death Differ. 2005;12 Suppl 1:878–92. Epub 2005/04/16. doi: 10.1038/sj.cdd.4401623 15832177.

3. Churchill MJ, Wesselingh SL, Cowley D, Pardo CA, McArthur JC, Brew BJ, et al. Extensive astrocyte infection is prominent in human immunodeficiency virus-associated dementia. Annals of neurology. 2009;66(2):253–8. Epub 2009/09/11. doi: 10.1002/ana.21697 19743454.

4. Huang Z, Nair M. A CRISPR/Cas9 guidance RNA screen platform for HIV provirus disruption and HIV/AIDS gene therapy in astrocytes. Scientific Reports. 2017;7(1):5955. doi: 10.1038/s41598-017-06269-x 28729655

5. Barat C, Proust A, Deshiere A, Leboeuf M, Drouin J, Tremblay MJ. Astrocytes sustain long-term productive HIV-1 infection without establishment of reactivable viral latency. Glia. 2018;66(7):1363–81. doi: 10.1002/glia.23310 29464785

6. Al-Harthi L, Nath A. Letter to Editor. Journal of neuroimmune pharmacology: the official journal of the Society on NeuroImmune Pharmacology. 2019;14(1):6. Epub 2018/12/14. doi: 10.1007/s11481-018-09827-w 30542907.

7. Henderson LJ, Narasipura SD, Adarichev V, Kashanchi F, Al-Harthi L. Identification of Novel T Cell Factor 4 (TCF-4) Binding Sites on the HIV Long Terminal Repeat Which Associate with TCF-4, β-Catenin, and SMAR1 To Repress HIV Transcription. Journal of Virology. 2012;86(17):9495–503. doi: 10.1128/JVI.00486-12 22674979

8. Narasipura SD, Kim S, Al-Harthi L. Epigenetic Regulation of HIV-1 Latency in Astrocytes. Journal of Virology. 2014;88(5):3031–8. doi: 10.1128/JVI.03333-13 24352441

9. Li GH, Henderson L, Nath A. Astrocytes as an HIV Reservoir: Mechanism of HIV Infection. Curr HIV Res. 2016;14(5):373–81. Epub 2016/10/11. doi: 10.2174/1570162x14666161006121455 27719663.

10. Prevedel L, Ruel N, Castellano P, Smith C, Malik S, Villeux C, et al. Identification, Localization, and Quantification of HIV Reservoirs Using Microscopy. Current protocols in cell biology. 2019;82(1):e64. Epub 2018/09/29. doi: 10.1002/cpcb.64 30265439; PubMed Central PMCID: PMC6386609.

11. Rao VR, Eugenin EA, Prasad VR. Evaluating the Role of Viral Proteins in HIV-Mediated Neurotoxicity Using Primary Human Neuronal Cultures. Methods in molecular biology (Clifton, NJ). 2016;1354:367–76. Epub 2015/12/31. doi: 10.1007/978-1-4939-3046-3_25 26714725; PubMed Central PMCID: PMC5050920.

12. Eugenin EA, Clements JE, Zink MC, Berman JW. Human immunodeficiency virus infection of human astrocytes disrupts blood-brain barrier integrity by a gap junction-dependent mechanism. The Journal of neuroscience: the official journal of the Society for Neuroscience. 2011;31(26):9456–65. Epub 2011/07/01. doi: 10.1523/jneurosci.1460-11.2011 21715610; PubMed Central PMCID: PMC3132881.

13. Luo X, He JJ. Cell-cell contact viral transfer contributes to HIV infection and persistence in astrocytes. Journal of neurovirology. 2015;21(1):66–80. Epub 2014/12/19. doi: 10.1007/s13365-014-0304-0 25522787.

14. Li GH, Anderson C, Jaeger L, Do T, Major EO, Nath A. Cell-to-cell contact facilitates HIV transmission from lymphocytes to astrocytes via CXCR4. Aids. 2015;29(7):755–66. Epub 2015/05/20. doi: 10.1097/QAD.0000000000000605 25985398; PubMed Central PMCID: PMC4438861.

15. Asahchop EL, Meziane O, Mamik MK, Chan WF, Branton WG, Resch L, et al. Reduced antiretroviral drug efficacy and concentration in HIV-infected microglia contributes to viral persistence in brain. Retrovirology. 2017;14(1):47. Epub 2017/10/19. doi: 10.1186/s12977-017-0370-5 29037245; PubMed Central PMCID: PMC5644262.

16. Khan MB, Lang MJ, Huang M-B, Raymond A, Bond VC, Shiramizu B, et al. Nef exosomes isolated from the plasma of individuals with HIV-associated dementia (HAD) can induce Aβ1–42 secretion in SH-SY5Y neural cells. Journal of neurovirology. 2016;22(2):179–90. doi: 10.1007/s13365-015-0383-6 26407718

17. Raymond AD, Diaz P, Chevelon S, Agudelo M, Yndart-Arias A, Ding H, et al. Microglia-derived HIV Nef+ exosome impairment of the blood-brain barrier is treatable by nanomedicine-based delivery of Nef peptides. Journal of neurovirology. 2016;22(2):129–39. Epub 2015/12/04. doi: 10.1007/s13365-015-0397-0 26631079.

18. Xu W, Santini PA, Sullivan JS, He B, Shan M, Ball SC, et al. HIV-1 evades virus-specific IgG2 and IgA responses by targeting systemic and intestinal B cells via long-range intercellular conduits. Nature immunology. 2009;10:1008–17. doi: 10.1038/ni.1753 19648924.

19. Uhl J, Gujarathi S, Waheed AA, Gordon A, Freed EO, Gousset K. Myosin-X is essential to the intercellular spread of HIV-1 Nef through tunneling nanotubes. Journal of cell communication and signaling. 2018. Epub 2018/11/18. doi: 10.1007/s12079-018-0493-z 30443895.

20. Wang T, Green LA, Gupta SK, Kim C, Wang L, Almodovar S, et al. Transfer of intracellular HIV Nef to endothelium causes endothelial dysfunction. PLoS ONE. 2014;9(3):e91063. Epub 2014/03/13. doi: 10.1371/journal.pone.0091063 24608713; PubMed Central PMCID: PMC3946685.

21. Ferdin J, Goričar K, Dolžan V, Plemenitaš A, Martin JN, Peterlin BM, et al. Viral protein Nef is detected in plasma of half of HIV-infected adults with undetectable plasma HIV RNA. PloS one. 2018;13(1):e0191613. doi: 10.1371/journal.pone.0191613 29364927

22. Chaudhuri R, Lindwasser OW, Smith WJ, Hurley JH, Bonifacino JS. Downregulation of CD4 by human immunodeficiency virus type 1 Nef is dependent on clathrin and involves direct interaction of Nef with the AP2 clathrin adaptor. Journal of virology. 2007;81:3877–90. doi: 10.1128/JVI.02725-06 17267500.

23. Garcia JV, Miller AD. Serine phosphorylation-independent downregulation of cell-surface CD4 by nef. Nature. 1991;350:508–11. doi: 10.1038/350508a0 2014052.

24. Le Gall S, Erdtmann L, Benichou S, Berlioz-Torrent C, Liu L, Benarous R, et al. Nef interacts with the mu subunit of clathrin adaptor complexes and reveals a cryptic sorting signal in MHC I molecules. Immunity. 1998;8:483–95. doi: 10.1016/s1074-7613(00)80553-1 9586638.

25. Schwartz O, Maréchal V, Le Gall S, Lemonnier F, Heard JM. Endocytosis of major histocompatibility complex class I molecules is induced by the HIV-1 Nef protein. Nature medicine. 1996;2:338–42. doi: 10.1038/nm0396-338 8612235.

26. Pužar Dominkuš P, Ferdin J, Plemenitaš A, Peterlin BM, Lenassi M. Nef is secreted in exosomes from Nef.GFP-expressing and HIV-1-infected human astrocytes. Journal of neurovirology. 2017;23(5):713–24. Epub 2017/08/02. doi: 10.1007/s13365-017-0552-x 28762184; PubMed Central PMCID: PMC6010353.

27. Sami Saribas A, Cicalese S, Ahooyi TM, Khalili K, Amini S, Sariyer IK. HIV-1 Nef is released in extracellular vesicles derived from astrocytes: evidence for Nef-mediated neurotoxicity. Cell Death Dis. 2017;8:e2542. doi: 10.1038/cddis.2016.467 28079886

28. Liu X, Shah A, Gangwani MR, Silverstein PS, Fu M, Kumar A. HIV-1 Nef induces CCL5 production in astrocytes through p38-MAPK and PI3K/Akt pathway and utilizes NF-kB, CEBP and AP-1 transcription factors. Scientific reports. 2014;4:4450. Epub 2014/03/25. doi: 10.1038/srep04450 24658403; PubMed Central PMCID: PMC3963078.

29. Nitkiewicz J, Borjabad A, Morgello S, Murray J, Chao W, Emdad L, et al. HIV induces expression of complement component C3 in astrocytes by NF-κB-dependent activation of interleukin-6 synthesis. J Neuroinflammation. 2017;14(1):23. Epub 2017/01/27. doi: 10.1186/s12974-017-0794-9 28122624; PubMed Central PMCID: PMC5267445.

30. Gallo P, Frei K, Rordorf C, Lazdins J, Tavolato B, Fontana A. Human immunodeficiency virus type 1 (HIV-1) infection of the central nervous system: an evaluation of cytokines in cerebrospinal fluid. Journal of neuroimmunology. 1989;23:109–16. doi: 10.1016/0165-5728(89)90029-5 2656753.

31. Lau LT, Yu AC-H. Astrocytes Produce and Release Interleukin-1, Interleukin-6, Tumor Necrosis Factor Alpha and Interferon-Gamma Following Traumatic and Metabolic Injury. Journal of Neurotrauma. 2001;18(3):351–9. doi: 10.1089/08977150151071035 11284554.

32. Parnet P, Kelley KW, Bluthe RM, Dantzer R. Expression and regulation of interleukin-1 receptors in the brain. Role in cytokines-induced sickness behavior. J Neuroimmunol. 2002;125(1–2):5–14. Epub 2002/04/19. doi: 10.1016/s0165-5728(02)00022-x 11960635.

33. Lampa J, Westman M, Kadetoff D, Agreus AN, Le Maitre E, Gillis-Haegerstrand C, et al. Peripheral inflammatory disease associated with centrally activated IL-1 system in humans and mice. Proc Natl Acad Sci U S A. 2012;109(31):12728–33. Epub 2012/07/18. doi: 10.1073/pnas.1118748109 22802629; PubMed Central PMCID: PMC3411968.

34. Schenk M, Fabri M, Krutzik SR, Lee DJ, Vu DM, Sieling PA, et al. Interleukin-1β triggers the differentiation of macrophages with enhanced capacity to present mycobacterial antigen to T cells. Immunology. 2014;141(2):174–80. Epub 2013/09/17. doi: 10.1111/imm.12167 24032597; PubMed Central PMCID: PMC3904238.

35. Lu J, Goh SJ, Tng PYL, Deng YY, Ling E-A, Moochhala S. Systemic inflammatory response following acute traumatic brain injury. Frontiers in bioscience (Landmark edition). 2009;14:3795–813. doi: 10.2741/3489 19273311.

36. Eng LF, Ghirnikar RS. GFAP and astrogliosis. Brain Pathol. 1994;4(3):229–37. doi: 10.1111/j.1750-3639.1994.tb00838.x 7952264

37. Lu J, Goh SJ, Tng PY, Deng YY, Ling EA, Moochhala S. Systemic inflammatory response following acute traumatic brain injury. Frontiers in bioscience. 2009;14:3795–813. Epub 2009/03/11. doi: 10.2741/3489 19273311.

38. Sato M, Chang E, Igarashi T, Noble LJ. Neuronal injury and loss after traumatic brain injury: time course and regional variability. Brain Res. 2001;917(1):45–54. Epub 2001/10/17. doi: 10.1016/s0006-8993(01)02905-5 11602228.

39. Akay C, Lindl KA, Shyam N, Nabet B, Goenaga-Vazquez Y, Ruzbarsky J, et al. Activation status of integrated stress response pathways in neurons and astrocytes of HAND cortex. Neuropathology and Applied Neurobiology. 2011:no-no. doi: 10.1111/j.1365-2990.2011.01215.x 21883374

40. Bansal V, Costantini T, Kroll L, Peterson C, Loomis W, Eliceiri B, et al. Traumatic brain injury and intestinal dysfunction: uncovering the neuro-enteric axis. Journal of neurotrauma. 2009;26:1353–9. doi: 10.1089/neu.2008-0858 19344293.

41. Hang C-H, Shi J-X, Li J-S, Wu W, Yin H-X. Alterations of intestinal mucosa structure and barrier function following traumatic brain injury in rats. World journal of gastroenterology. 2003;9:2776–81. doi: 10.3748/wjg.v9.i12.2776 14669332.

42. Kao CH, ChangLai SP, Chieng PU, Yen TC. Gastric emptying in head-injured patients. The American journal of gastroenterology. 1998;93:1108–12. doi: 10.1111/j.1572-0241.1998.00338.x 9672339.

43. Chompre G, Cruz E, Maldonado L, Rivera-Amill V, Porter JT, Noel RJ. Astrocytic expression of HIV-1 Nef impairs spatial and recognition memory. Neurobiology of disease. 2013;49:128–36. doi: 10.1016/j.nbd.2012.08.007 22926191.

44. Mascia L. Acute lung injury in patients with severe brain injury: a double hit model. Neurocritical care. 2009;11:417–26. doi: 10.1007/s12028-009-9242-8 19548120.

45. Pelosi P, Rocco PR. The lung and the brain: a dangerous cross-talk. Crit Care. 2011;15(3):168. doi: 10.1186/cc10259 21722336; PubMed Central PMCID: PMC3219008.

46. Ichinohe T, Pang IK, Kumamoto Y, Peaper DR, Ho JH, Murray TS, et al. Microbiota regulates immune defense against respiratory tract influenza A virus infection. Proceedings of the National Academy of Sciences of the United States of America. 2011;108:5354–9. doi: 10.1073/pnas.1019378108 21402903.

47. Keely S, Talley NJ, Hansbro PM. Pulmonary-intestinal cross-talk in mucosal inflammatory disease. Mucosal immunology. 2012;5:7–18. doi: 10.1038/mi.2011.55 22089028.

48. Crothers K, Thompson BW, Burkhardt K, Morris A, Flores SC, Diaz PT, et al. HIV-associated lung infections and complications in the era of combination antiretroviral therapy. Proceedings of the American Thoracic Society. 2011;8:275–81. doi: 10.1513/pats.201009-059WR 21653528.

49. Plata-Salaman CR, Ffrench-Mullen JM. Intracerebroventricular administration of a specific IL-1 receptor antagonist blocks food and water intake suppression induced by interleukin-1 beta. Physiology & behavior. 1992;51(6):1277–9. Epub 1992/06/01. doi: 10.1016/0031-9384(92)90321-r 1386466.

50. Isidro RA, Isidro AA, Cruz ML, Hernandez S, Appleyard CB. Double immunofluorescent staining of rat macrophages in formalin-fixed paraffin-embedded tissue using two monoclonal mouse antibodies. Histochemistry and Cell Biology. 2015;144(6):613–21. doi: 10.1007/s00418-015-1364-9 26403093.

51. Gavet O, Pines J. Activation of cyclin B1-Cdk1 synchronizes events in the nucleus and the cytoplasm at mitosis. J Cell Biol. 2010;189(2):247–59. doi: 10.1083/jcb.200909144 20404109; PubMed Central PMCID: PMC2856909.

52. Appleyard CB, Alvarez A, Percy WH. Temporal changes in colonic vascular architecture and inflammatory mediator levels in animal models of colitis. Dig Dis Sci. 2002;47(9):2007–14. doi: 10.1023/a:1019660526241 12353846.

53. Appleyard CB, Morales M, Percy WH. Regional variations in neurokinin receptor subtype contributions to muscularis mucosae and epithelial function in rat colon. Dig Dis Sci. 2006;51(3):506–16. doi: 10.1007/s10620-006-3163-6 16614960.

54. Li H, Sheppard DN, Hug MJ. Transepithelial electrical measurements with the Ussing chamber. J Cyst Fibros. 2004;3 Suppl 2:123–6. doi: 10.1016/j.jcf.2004.05.026 15463943.

55. Saria A, Lundberg JM. Evans blue fluorescence: quantitative and morphological evaluation of vascular permeability in animal tissues. J Neurosci Methods. 1983;8(1):41–9. doi: 10.1016/0165-0270(83)90050-x 6876872.

56. de Vries HE, Kuiper J, de Boer AG, Van Berkel TJ, Breimer DD. The blood-brain barrier in neuroinflammatory diseases. Pharmacological reviews. 1997;49:143–55. 9228664.

57. Elices MJ. Neuroinflammatory diseases and the importance of a healthy blood-brain barrier. Current opinion in investigational drugs (London, England: 2000). 2008;9:1149–50. 18951292.

58. Lepe-Zuniga JL, Mansell PW, Hersh EM. Idiopathic production of interleukin-1 in acquired immune deficiency syndrome. Journal of clinical microbiology. 1987;25:1695–700. 3498739.

59. Machowska A, Brzozowski T, Sliwowski Z, Pawlik M, Konturek PC, Pajdo R, et al. Gastric secretion, proinflammatory cytokines and epidermal growth factor (EGF) in the delayed healing of lingual and gastric ulcerations by testosterone. Inflammopharmacology. 2008;16(1):40–7. doi: 10.1007/s10787-007-1600-6 18046513.

60. Spindler-Vesel A, Wraber B, Vovk I, Kompan L. Intestinal permeability and cytokine inflammatory response in multiply injured patients. J Interferon Cytokine Res. 2006;26(10):771–6. doi: 10.1089/jir.2006.26.771 17032171.

61. Gasbarrini G, Montalto M. Structure and function of tight junctions. Role in intestinal barrier. Italian journal of gastroenterology and hepatology. 31:481–8. 10575567.

62. Brack-Werner R. Astrocytes: HIV cellular reservoirs and important participants in neuropathogenesis. Aids. 1999;13(1):1–22. Epub 1999/04/20. doi: 10.1097/00002030-199901140-00003 10207540.

63. Brack-Werner R, Kleinschmidt A, Ludvigsen A, Mellert W, Neumann M, Herrmann R, et al. Infection of human brain cells by HIV-1: restricted virus production in chronically infected human glial cell lines. Aids. 1992;6(3):273–85. Epub 1992/03/01. 1373627.

64. Acheampong EA, Parveen Z, Muthoga LW, Kalayeh M, Mukhtar M, Pomerantz RJ. Human Immunodeficiency virus type 1 Nef potently induces apoptosis in primary human brain microvascular endothelial cells via the activation of caspases. J Virol. 2005;79(7):4257–69. doi: 10.1128/JVI.79.7.4257-4269.2005 15767427

65. Sporer B, Koedel U, Paul R, Kohleisen B, Erfle V, Fontana A, et al. Human immunodeficiency virus type-1 Nef protein induces blood-brain barrier disruption in the rat: role of matrix metalloproteinase-9. J Neuroimmunol. 2000;102(2):125–30. doi: 10.1016/s0165-5728(99)00170-8 10636480

66. Van Marle G, Henry S, Todoruk T, Sullivan A, Silva C, Rourke SB, et al. Human immunodeficiency virus type 1 Nef protein mediates neural cell death: a neurotoxic role for IP-10. Virology. 2004;329(2):302–18. doi: 10.1016/j.virol.2004.08.024 15518810

67. Acharjee S, Branton WG, Vivithanaporn P, Maingat F, Paul AM, Dickie P, et al. HIV-1 Nef expression in microglia disrupts dopaminergic and immune functions with associated mania-like behaviors. Brain, behavior, and immunity. 2014;40:74–84. doi: 10.1016/j.bbi.2014.02.016 24607605

68. Mordelet E, Kissa K, Cressant A, Gray F, Ozden S, Vidal C, et al. Histopathological and cognitive defects induced by Nef in the brain. Faseb J. 2004;18(15):1851–61. doi: 10.1096/fj.04-2308com 15576488

69. Lamers SL, Fogel GB, Liu ES, Barbier AE, Rodriguez CW, Singer EJ, et al. Brain-specific HIV Nef identified in multiple patients with neurological disease. Journal of neurovirology. 2018;24(1):1–15. Epub 2017/10/25. doi: 10.1007/s13365-017-0586-0 29063512; PubMed Central PMCID: PMC5792318.

70. Lamers SL, Poon AFY, McGrath MS. HIV-1 Nef Protein Structures Associated with Brain Infection and Dementia Pathogenesis. PLoS ONE. 2011;6(2):e16659. doi: 10.1371/journal.pone.0016659 21347424

71. Churchill MJ, Wesselingh SL, Cowley D, Pardo CA, McArthur JC, Brew BJ, et al. Extensive astrocyte infection is prominent in human immunodeficiency virus-associated dementia. Annals of neurology. 2009;66:253–8. doi: 10.1002/ana.21697 19743454.

72. Conant K, Tornatore C, Atwood W, Meyers K, Traub R, Major EO. In vivo and in vitro infection of the astrocyte by HIV-1. Advances in neuroimmunology. 1994;4:287–9. doi: 10.1016/s0960-5428(06)80269-x 7874397.

73. Ranki A, Nyberg M, Ovod V, Haltia M, Elovaara I, Raininko R, et al. Abundant expression of HIV Nef and Rev proteins in brain astrocytes in vivo is associated with dementia. AIDS (London, England). 1995;9:1001–8. doi: 10.1097/00002030-199509000-00004 8527071.

74. Torres-Muñoz J, Stockton P, Tacoronte N, Roberts B, Maronpot RR, Petito CK. Detection of HIV-1 gene sequences in hippocampal neurons isolated from postmortem AIDS brains by laser capture microdissection. Journal of neuropathology and experimental neurology. 2001;60:885–92. doi: 10.1093/jnen/60.9.885 11556545.

75. Speth C, Schabetsberger T, Mohsenipour I, Stöckl G, Würzner R, Stoiber H, et al. Mechanism of human immunodeficiency virus-induced complement expression in astrocytes and neurons. Journal of virology. 2002;76:3179–88. doi: 10.1128/JVI.76.7.3179-3188.2002 11884542.

76. Trillo-Pazos G, McFarlane-Abdulla E, Campbell IC, Pilkington GJ, Everall IP. Recombinant nef HIV-IIIB protein is toxic to human neurons in culture. Brain research. 2000;864:315–26. doi: 10.1016/s0006-8993(00)02213-7 10802040.

77. Werner T, Ferroni S, Saermark T, Brack-Werner R, Banati RB, Mager R, et al. HIV-1 Nef protein exhibits structural and functional similarity to scorpion peptides interacting with K+ channels. AIDS (London, England). 1991;5:1301–8. doi: 10.1097/00002030-199111000-00003 1768378.

78. Almodovar S, Hsue PY, Morelli J, Huang L, Flores SC. Pathogenesis of HIV-associated pulmonary hypertension: potential role of HIV-1 Nef. Proceedings of the American Thoracic Society. 2011;8:308–12. doi: 10.1513/pats.201006-046WR 21653533.

79. Marecki JC, Cool CD, Parr JE, Beckey VE, Luciw PA, Tarantal AF, et al. HIV-1 Nef is associated with complex pulmonary vascular lesions in SHIV-nef-infected macaques. American journal of respiratory and critical care medicine. 2006;174:437–45. doi: 10.1164/rccm.200601-005OC 16728715.

80. Sehgal PB, Mukhopadhyay S, Patel K, Xu F, Almodóvar S, Tuder RM, et al. Golgi dysfunction is a common feature in idiopathic human pulmonary hypertension and vascular lesions in SHIV-nef-infected macaques. American journal of physiology Lung cellular and molecular physiology. 2009;297:L729–37. doi: 10.1152/ajplung.00087.2009 19648286.

81. Quaranta MG, Vincentini O, Felli C, Spadaro F, Silano M, Moricoli D, et al. Exogenous HIV-1 Nef Upsets the IFN-γ-Induced Impairment of Human Intestinal Epithelial Integrity. PLoS ONE. 2011;6(8):e23442. doi: 10.1371/journal.pone.0023442 21858117

82. Brenchley JM, Schacker TW, Ruff LE, Price DA, Taylor JH, Beilman GJ, et al. CD4+ T cell depletion during all stages of HIV disease occurs predominantly in the gastrointestinal tract. The Journal of experimental medicine. 2004;200:749–59. doi: 10.1084/jem.20040874 15365096.

83. Mehandru S, Poles MA, Tenner-Racz K, Horowitz A, Hurley A, Hogan C, et al. Primary HIV-1 infection is associated with preferential depletion of CD4+ T lymphocytes from effector sites in the gastrointestinal tract. The Journal of experimental medicine. 2004;200:761–70. doi: 10.1084/jem.20041196 15365095.

84. Sankaran S, George MD, Reay E, Guadalupe M, Flamm J, Prindiville T, et al. Rapid onset of intestinal epithelial barrier dysfunction in primary human immunodeficiency virus infection is driven by an imbalance between immune response and mucosal repair and regeneration. Journal of virology. 2008;82:538–45. doi: 10.1128/JVI.01449-07 17959677.

85. Swingler S, Mann A, Jacqué J, Brichacek B, Sasseville VG, Williams K, et al. HIV-1 Nef mediates lymphocyte chemotaxis and activation by infected macrophages. Nature medicine. 1999;5:997–103. doi: 10.1038/12433 10470075.

86. Vérollet C, Souriant S, Bonnaud E, Jolicoeur P, Raynaud-Messina B, Kinnaer C, et al. HIV-1 reprograms the migration of macrophages. Blood. 2015;125:1611–22. doi: 10.1182/blood-2014-08-596775 25527710.

87. Choe EY, Schoenberger ES, Groopman JE, Park I-W. HIV Nef inhibits T cell migration. The Journal of biological chemistry. 2002;277:46079–84. doi: 10.1074/jbc.M204698200 12354773.

88. Nobile C, Rudnicka D, Hasan M, Aulner N, Porrot F, Machu C, et al. HIV-1 Nef inhibits ruffles, induces filopodia, and modulates migration of infected lymphocytes. Journal of virology. 2010;84:2282–93. doi: 10.1128/JVI.02230-09 20015995.

89. Park I-W, He JJ. HIV-1 Nef-mediated inhibition of T cell migration and its molecular determinants. Journal of leukocyte biology. 2009;86:1171–8. doi: 10.1189/jlb.0409261 19641037.

90. Kotler DP, Gaetz HP, Lange M, Klein EB, Holt PR. Enteropathy associated with the acquired immunodeficiency syndrome. Annals of internal medicine. 1984;101:421–8. doi: 10.7326/0003-4819-101-4-421 6476631.

91. Kotler DP, Shimada T, Snow G, Winson G, Chen W, Zhao M, et al. Effect of combination antiretroviral therapy upon rectal mucosal HIV RNA burden and mononuclear cell apoptosis. AIDS (London, England). 1998;12:597–604. doi: 10.1097/00002030-199806000-00008 9583599.

92. Vitkovic L, Konsman JP, Bockaert J, Dantzer R, Homburger V, Jacque C. Cytokine signals propagate through the brain. Molecular psychiatry. 2000;5:604–15. doi: 10.1038/sj.mp.4000813 11126391.

93. Blamire AM, Anthony DC, Rajagopalan B, Sibson NR, Perry VH, Styles P. Interleukin-1beta -induced changes in blood-brain barrier permeability, apparent diffusion coefficient, and cerebral blood volume in the rat brain: a magnetic resonance study. The Journal of neuroscience: the official journal of the Society for Neuroscience. 2000;20:8153–9. doi: 10.1523/JNEUROSCI.20-21-08153.2000 11050138.

94. Oliveira SHP, Canetti C, Ribeiro RA, Cunha FQ. Neutrophil migration induced by IL-1beta depends upon LTB4 released by macrophages and upon TNF-alpha and IL-1beta released by mast cells. Inflammation. 2008;31:36–46. doi: 10.1007/s10753-007-9047-x 17874178.

95. Russell RA, Chojnacki J, Jones DM, Johnson E, Do T, Eggeling C, et al. Astrocytes Resist HIV-1 Fusion but Engulf Infected Macrophage Material. Cell Rep. 2017;18(6):1473–83. Epub 2017/02/09. doi: 10.1016/j.celrep.2017.01.027 28178524; PubMed Central PMCID: PMC5316642.

96. Guan-Han L, Lisa H, Avindra N. Astrocytes as an HIV Reservoir: Mechanism of HIV Infection. Current HIV Research. 2016;14(5):373–81. doi: 10.2174/1570162x14666161006121455 27719663

97. Hoxie JA, LaBranche CC, Endres MJ, Turner JD, Berson JF, Doms RW, et al. CD4-independent utilization of the CXCR4 chemokine receptor by HIV-1 and HIV-2. Journal of reproductive immunology. 1998;41(1–2):197–211. Epub 1999/04/23. doi: 10.1016/s0165-0378(98)00059-x 10213311.

98. Liu Y, Liu H, Kim BO, Gattone VH, Li J, Nath A, et al. CD4-Independent Infection of Astrocytes by Human Immunodeficiency Virus Type 1: Requirement for the Human Mannose Receptor. J Virol. 2004;78(8):4120–33. doi: 10.1128/JVI.78.8.4120-4133.2004 15047828

99. Gray LR, Roche M, Flynn JK, Wesselingh SL, Gorry PR, Churchill MJ. Is the central nervous system a reservoir of HIV-1? Current opinion in HIV and AIDS. 2014;9(6):552–8. Epub 2014/09/10. doi: 10.1097/COH.0000000000000108 25203642; PubMed Central PMCID: PMC4215931.

100. Eugenin EA, Berman JW. Gap Junctions Mediate Human Immunodeficiency Virus-Bystander Killing in Astrocytes. J Neurosci. 2007;27(47):12844–50. doi: 10.1523/JNEUROSCI.4154-07.2007 18032656

101. Ton H, Xiong H. Astrocyte Dysfunctions and HIV-1 Neurotoxicity. Journal of AIDS & clinical research. 2013;4(11):255. Epub 2014/03/04. doi: 10.4172/2155-6113.1000255 24587966; PubMed Central PMCID: PMC3938291.

102. Mediouni S, Marcondes MC, Miller C, McLaughlin JP, Valente ST. The cross-talk of HIV-1 Tat and methamphetamine in HIV-associated neurocognitive disorders. Frontiers in microbiology. 2015;6:1164. Epub 2015/11/12. doi: 10.3389/fmicb.2015.01164 26557111; PubMed Central PMCID: PMC4615951.

103. Liu X, Kumar A. Differential signaling mechanism for HIV-1 Nef-mediated production of IL-6 and IL-8 in human astrocytes. Scientific reports. 2015;5:9867. Epub 2015/06/16. doi: 10.1038/srep09867 26075907; PubMed Central PMCID: PMC4467202.

Článek Wild Steps in a semi-wild setting? Habitat selection and behavior of European bison reintroduced to an enclosure in an anthropogenic landscape
Článek The effect of facial expression on contrast sensitivity: A behavioural investigation and extension of Hedger, Adams & Garner (2015)
Článek Non-communicable diseases risk factors and their determinants: A cross-sectional state-wide STEPS survey, Haryana, North India
Článek Genotype-matched Newcastle disease virus vaccine confers improved protection against genotype XII challenge: The importance of cytoplasmic tails in viral replication and vaccine design
Článek Combined transcriptomics and proteomics forecast analysis for potential genes regulating the Columbian plumage color in chickens
Článek Persistence of traditional and emergence of new structural drivers and factors for the HIV epidemic in rural Uganda; A qualitative study
Článek Competency assessment of the medical interns and nurses and documenting prevailing practices to provide family planning services in teaching hospitals in three states of India
Článek Choice of birth place among antenatal clinic attendees in rural mission hospitals in Ebonyi State, South-East Nigeria
Článek Dual pathway for metabolic engineering of Escherichia coli to produce the highly valuable hydroxytyrosol
Článek Genetic and genomic analyses underpin the feasibility of concomitant genetic improvement of milk yield and mastitis resistance in dairy sheep
Článek Long-term exposure to daily ethanol injections in DBA/2J and Swiss mice: Lessons for the interpretation of ethanol sensitization
Článek Taxonomic and functional anuran beta diversity of a subtropical metacommunity respond differentially to environmental and spatial predictors
Článek A simple way to improve a conventional A/O-MBR for high simultaneous carbon and nutrient removal from synthetic municipal wastewater
Článek Knowledge and awareness of cervical cancer in Southwestern Ethiopia is lacking: A descriptive analysis
Článek Flat electrode contacts for vagus nerve stimulation
Článek Circulating Th17.1 cells as candidate for the prediction of therapeutic response to abatacept in patients with rheumatoid arthritis: An exploratory research
Článek Prevalence and socioeconomic determinants of development delay among children in Ceará, Brazil: A population-based study
Článek Characterizing macroinvertebrate community composition and abundance in freshwater tidal wetlands of the Sacramento-San Joaquin Delta
Článek A randomized controlled trial comparing isosorbide dinitrate-oxytocin versus misoprostol-oxytocin at management of foetal intrauterine death
Článek Hello, is that me you are looking for? A re-examination of the role of the DMN in social and self relevant aspects of off-task thought
Článek Lactobacillus rhamnosus Lcr35 as an effective treatment for preventing Candida albicans infection in the invertebrate model Caenorhabditis elegans: First mechanistic insights
Článek Use of latent class analysis to identify multimorbidity patterns and associated factors in Korean adults aged 50 years and older
Článek A study of psychological pain in substance use disorder and its relationship to treatment outcome
Článek Effects of artificially introduced Enterococcus faecalis strains in experimental necrotizing enterocolitis
Článek Treatment-seeking for vaginal fistula in sub-Saharan Africa
Článek Dissemination and stakeholder engagement practices among dissemination & implementation scientists: Results from an online survey
Článek Comparative analysis of the accelerated aged seed transcriptome profiles of two maize chromosome segment substitution lines
Článek Transactional sex among men who have sex with men participating in the CohMSM prospective cohort study in West Africa
Článek Addiction of mesenchymal phenotypes on the FGF/FGFR axis in oral squamous cell carcinoma cells
Článek Left parietal tACS at alpha frequency induces a shift of visuospatial attention
Článek Microtranscriptome analysis of sugarcane cultivars in response to aluminum stress
Článek The role of alien species on plant-floral visitor network structure in invaded communities
Článek Predictive factors for unfavourable treatment in MDR-TB and XDR-TB patients in Rio de Janeiro State, Brazil, 2000-2016
Článek Agricultural impacts on streams near Nitrate Vulnerable Zones: A case study in the Ebro basin, Northern Spain
Článek Development of a multi-locus typing scheme for an Enterobacteriaceae linear plasmid that mediates inter-species transfer of flagella
Článek The roles of MRI-based prostate volume and associated zone-adjusted prostate-specific antigen concentrations in predicting prostate cancer and high-risk prostate cancer
Článek Re-modeling of foliar membrane lipids in a seagrass allows for growth in phosphorus-deplete conditions
Článek Effect of sampling frequency on fractal fluctuations during treadmill walking
Článek Effect of calcium intake and the dietary cation-anion difference during early lactation on the bone mobilization dynamics throughout lactation in dairy cows
Článek Facilitators and barriers to linkage to HIV care and treatment among female sex workers in a community-based HIV prevention intervention in Tanzania: A qualitative study
Článek Tuberculosis treatment outcome: The case of women in Ethiopia and China, ten-years retrospective cohort study
Článek Protein:Protein interactions in the cytoplasmic membrane apparently influencing sugar transport and phosphorylation activities of the e. coli phosphotransferase system
Článek A digital collection of rare and endangered lemurs and other primates from the Duke Lemur Center
Článek Computational fluid dynamics simulation of changes in the morphology and airflow dynamics of the upper airways in OSAHS patients after treatment with oral appliances
Článek Resistome metagenomics from plate to farm: The resistome and microbial composition during food waste feeding and composting on a Vermont poultry farm
Článek Lower limb chronic edema management program: Perspectives of disengaged patients on challenges, enablers and barriers to program attendance and adherence
Článek Discovery of powdery mildew resistance gene candidates from Aegilops biuncialis chromosome 2Mb based on transcriptome sequencing
Článek Modelling vegetation understory cover using LiDAR metrics
Článek Assessing the impact of the “one-child policy” in China: A synthetic control approach
Článek CRISPR-Cas9 modified bacteriophage for treatment of Staphylococcus aureus induced osteomyelitis and soft tissue infection
Článek Forecasting type-specific seasonal influenza after 26 weeks in the United States using influenza activities in other countries
Článek Chronic exercise modulates the cellular immunity and its cannabinoid receptors expression
Článek Characterization of the diverse plasmid pool harbored by the blaNDM-1-containing Acinetobacter bereziniae HPC229 clinical strain
Článek What does mitogenomics tell us about the evolutionary history of the Drosophila buzzatii cluster (repleta group)?
Článek A cell-based evaluation of a non-essential amino acid formulation as a non-bioactive control for activation and stimulation of muscle protein synthesis using ex vivo human serum
Článek Conjugated linoleic acid as a novel insecticide targeting the agricultural pest Leptinotarsa decemlineata
Článek Relationship between pattern electroretinogram and optic disc morphology in glaucoma
Článek Depicting changes in land surface cover at Al-Hassa oasis of Saudi Arabia using remote sensing and GIS techniques
Článek Land snail dispersal, abundance and diversity on green roofs
Článek Fanconi-BRCA pathway mutations in childhood T-cell acute lymphoblastic leukemia
Článek Mesenchymal Stem/ Stromal Cells metabolomic and bioactive factors profiles: A comparative analysis on the umbilical cord and dental pulp derived Stem/ Stromal Cells secretome
Článek The association between caesarean section delivery and later life obesity in 21-24 year olds in an Urban South African birth cohort
Článek Diagnosis and treatment of acute respiratory illness in children under five in primary care in low-, middle-, and high-income countries: A descriptive FRESH AIR study
Článek Quality control of cervical cytology using a 3-type HPV mRNA test increases screening program sensitivity of cervical intraepithelial neoplasia grade 2+ in young Norwegian women—A cohort study
Článek Toxicity and sublethal effects of two plant allelochemicals on the demographical traits of cotton aphid, Aphis gossypii Glover (Hemiptera: Aphididae)
Článek Protocol development for discovery of angiogenesis inhibitors via automated methods using zebrafish
Článek Friends with malefit. The effects of keeping dogs and cats, sustaining animal-related injuries and Toxoplasma infection on health and quality of life
Článek Trueness of digital intraoral impression in reproducing multiple implant position
Článek Comparison of drug safety data obtained from the monitoring system, literature, and social media: An empirical proof from a Chinese patent medicine
Článek Norm values and psychometric properties of the short version of the Trier Inventory for Chronic Stress (TICS) in a representative German sample
Článek Maternal health and birth outcomes in a South African birth cohort study
Článek Structural characterization of scorpion peptides and their bactericidal activity against clinical isolates of multidrug-resistant bacteria
Článek Molecular evolution of genes encoding allergen proteins in the peanuts genus Arachis: Structural and functional implications
Článek Structural characterization of the saxitoxin-targeting APTSTX1 aptamer using optical tweezers and molecular dynamics simulations
Článek Residential household yard care practices along urban-exurban gradients in six climatically-diverse U.S. metropolitan areas
Článek Formal comment on “Assessing the impact of the ‘one-child policy’ in China: A synthetic control approach”
Článek Evaluation of a global spring wheat panel for stripe rust: Resistance loci validation and novel resources identification
Článek “Big men” in the office: The gender-specific influence of weight upon persuasiveness
Článek Modification of everyday activities and its association with self-awareness in cognitively diverse older adults
Článek The effect of bivalve filtration on eDNA-based detection of aquatic organisms
Článek Selective culture enrichment and sequencing of feces to enhance detection of antimicrobial resistance genes in third-generation cephalosporin resistant Enterobacteriaceae
Článek Development and validation of rapid environmental DNA (eDNA) detection methods for bog turtle (Glyptemys muhlenbergii)
Článek Average and time-specific maternal prenatal inflammatory biomarkers and the risk of labor epidural associated fever
Článek Preference-based measure of health-related quality of life and its determinants in sickle cell disease in Nigeria
Článek Factors influencing participation dynamics in research for development interventions with multi-stakeholder platforms: A metric approach to studying stakeholder participation
Článek Contextual variation in young children’s acquisition of social-emotional skills
Článek Prokaryotic and eukaryotic microbiomes associated with blooms of the ichthyotoxic dinoflagellate Cochlodinium (Margalefidinium) polykrikoides in New York, USA, estuaries
Článek Reconciling the statistics of spectral reflectance and colour
Článek Temporal weights in loudness: Investigation of the effects of background noise and sound level
Článek A global assessment of street-network sprawl
Článek Correction: KRIT1 Regulates the Homeostasis of Intracellular Reactive Oxygen Species
Článek Mindfulness-Based Blood Pressure Reduction (MB-BP): Stage 1 single-arm clinical trial
Článek Measurement of abortion safety using community-based surveys: Findings from three countries
Článek Behavioral response of naïve and non-naïve deer to wolf urine
Článek SNARE proteins rescue impaired autophagic flux in Down syndrome
Článek Negative impact of gestational diabetes mellitus on progress of pelvic floor muscle electromyography activity: Cohort study
Článek Change in left inferior frontal connectivity with less unexpected harmonic cadence by musical expertise
Článek Structural mechanism for regulation of DNA binding of BpsR, a Bordetella regulator of biofilm formation, by 6-hydroxynicotinic acid
Článek How does open innovation lead competitive advantage? A dynamic capability view perspective
Článek Bull efficiency using dairy genetic traits
Článek Improved cortical boundary registration for locally distorted fMRI scans
Článek Extractive single document summarization using binary differential evolution: Optimization of different sentence quality measures
Článek Measuring the tilt and slant of Chinese handwriting in primary school students: A computerized approach
Článek Isolation and identification of an isoflavone reducing bacterium from feces from a pregnant horse
Článek Sugar labeling: How numerical information of sugar content influences healthiness and tastiness expectations
Článek Optimally adjusted last cluster for prediction based on balancing the bias and variance by bootstrapping
Článek Quantifying normal and parkinsonian gait features from home movies: Practical application of a deep learning–based 2D pose estimator
Článek Heterogeneity of porcine bone marrow-derived dendritic cells induced by GM-CSF
Článek Can visual interpretation of NucliSens graphs reduce the need for repeat viral load testing?
Článek Manganese levels in infant formula and young child nutritional beverages in the United States and France: Comparison to breast milk and regulations
Článek Association between metabolic body composition status and risk for impaired renal function: A cross-sectional study
Článek Toddler skills predict moderate-to-late preterm born children’s cognition and behaviour at 6 years of age
Článek The bacterial community in potato is recruited from soil and partly inherited across generations
Článek Infective endocarditis and diabetes mellitus: Results from a single-center study from 1994 to 2017
Článek Patient satisfaction with HIV services in Vietnam: Status, service models and association with treatment outcome
Článek Ion concentration polarization (ICP) of proteins at silicon micropillar nanogaps
Článek The trajectory of patterns of light and sedentary physical activity among females, ages 14-23
Článek Coadministration of kla peptide with HPRP-A1 to enhance anticancer activity
Článek Measuring the complexity of directed graphs: A polynomial-based approach
Článek Estimation of maize evapotraspiration under drought stress - A case study of Huaibei Plain, China
Článek Publication rates in animal research. Extent and characteristics of published and non-published animal studies followed up at two German university medical centres
Článek Developmental conservation of microRNA gene localization at the nuclear periphery
Článek Exploring critical factors of the perceived usefulness of blended learning for higher education students
Článek Anti-Alzheimer potential, metabolomic profiling and molecular docking of green synthesized silver nanoparticles of Lampranthus coccineus and Malephora lutea aqueous extracts
Článek Protective effect of Platymiscium floribundum Vog. in tree extract on periodontitis inflammation in rats
Článek Direct transport vs secondary transfer to level I trauma centers in a French exclusive trauma system: Impact on mortality and determinants of triage on road-traffic victims
Článek Honey bee microbiome associated with different hive and sample types over a honey production season
Článek Bacterial communities in the rhizosphere, phyllosphere and endosphere of tomato plants
Článek Sildenafil citrate long-term treatment effects on cardiovascular reactivity in a SHR experimental model of metabolic syndrome
Článek Postoperative delirium after lung resection for primary lung cancer: Risk factors, risk scoring system, and prognosis
Článek The CSF-1-receptor inhibitor, JNJ-40346527 (PRV-6527), reduced inflammatory macrophage recruitment to the intestinal mucosa and suppressed murine T cell mediated colitis
Článek Using Er:YAG laser to remove lithium disilicate crowns from zirconia implant abutments: An in vitro study
Článek Antibacterial efficacy of cold atmospheric plasma against Enterococcus faecalis planktonic cultures and biofilms in vitro
Článek Mechanisms of African swine fever virus pathogenesis and immune evasion inferred from gene expression changes in infected swine macrophages
Článek Application of ensemble methods to analyse the decline of organochlorine pesticides in relation to the interactions between age, gender and time
Článek Mitogenomic diversity in Sacred Ibis Mummies sheds light on early Egyptian practices
Článek Automated detection of a nonperfusion area caused by retinal vein occlusion in optical coherence tomography angiography images using deep learning
Článek Characterisation of a novel SCCmec VI element harbouring fusC in an emerging Staphylococcus aureus strain from the Arabian Gulf region
Článek Inducible UCP1 silencing: A lentiviral RNA-interference approach to quantify the contribution of beige fat to energy homeostasis
Článek iCrotoK-PseAAC: Identify lysine crotonylation sites by blending position relative statistical features according to the Chou’s 5-step rule
Článek Emerging practices supporting diabetes self-management among food insecure adults and families: A scoping review
Článek Does aneurysm side influence the infarction side and patients´ outcome after subarachnoid hemorrhage?
Článek Raising the bar: Recovery ambition for species at risk in Canada and the US
Článek Management of locally advanced non-small cell lung cancer in the modern era: A national Italian survey on diagnosis, treatment and multidisciplinary approach
Článek Foraging strategies are maintained despite workforce reduction: A multidisciplinary survey on the pollen collected by a social pollinator
Článek Incidence of colorectal cancer in Eritrea: Data from the National Health Laboratory, 2011-2017
Článek Integrated analysis of miRNA landscape and cellular networking pathways in stage-specific prostate cancer
Článek Evaluation of the reactogenicity, adjuvanticity and antigenicity of LT(R192G) and LT(R192G/L211A) by intradermal immunization in mice
Článek Role of rhesus macaque IFITM3(2) in simian immunodeficiency virus infection of macaques
Článek Variation in the LRR region of Pi54 protein alters its interaction with the AvrPi54 protein revealed by in silico analysis
Článek Evolutionarily conserved susceptibility of the mitochondrial respiratory chain to SDHI pesticides and its consequence on the impact of SDHIs on human cultured cells
Článek Statistical determination of synergy based on Bliss definition of drugs independence
Článek The association between sleep problems and academic performance in primary school-aged children: Findings from a Norwegian longitudinal population-based study
Článek Estimating the national cost burden of in-hospital needlestick injuries among healthcare workers in Japan
Článek Assessing reliability of intra-tumor heterogeneity estimates from single sample whole exome sequencing data
Článek Dispersion of Legionella bacteria in atmosphere: A practical source location estimation method
Článek Integrative proteomic and phosphoproteomic profiling of prostate cell lines
Článek Treatment paths for localised prostate cancer in Italy: The results of a multidisciplinary, observational, prospective study (Pros-IT CNR)
Článek Why are undergraduate emerging adults anxious and avoidant in their romantic relationships? The role of family relationships
Článek Barriers to implementation of emergency obstetric and neonatal care in rural Pakistan
Článek Testosterone supplementation improves insulin responsiveness in HFD fed male T2DM mice and potentiates insulin signaling in the skeletal muscle and C2C12 myocyte cell line
Článek Ang-(1-7)/ MAS1 receptor axis inhibits allergic airway inflammation via blockade of Src-mediated EGFR transactivation in a murine model of asthma
Článek Factors influencing bird-building collisions in the downtown area of a major North American city
Článek Collembola laterally move biochar particles
Článek Decreased retinal thickness in patients with Alzheimer’s disease is correlated with disease severity
Článek Moving system with action sport cameras: 3D kinematics of the walking and running in a large volume
Článek Factors influencing subclinical atherosclerosis in patients with biopsy-proven nonalcoholic fatty liver disease
Článek Boundary violations and adolescent drinking: Observational evidence that symbolic boundaries moderate social influence
Článek Inadequate conflict of interest policies at most French teaching hospitals: A survey and website analysis
Článek A new resolution function to evaluate tree shape statistics
Článek Thermostat wars? The roles of gender and thermal comfort negotiations in household energy use behavior
Článek Patients undergoing surgery for lumbar spinal stenosis experience unique courses of pain and disability: A group-based trajectory analysis
Článek Lifetime prevalence of intimate partner violence against women in an urban Brazilian city: A cross-sectional survey
Článek The factors associated with being left-behind children in China: Multilevel analysis with nationally representative data
Článek High heat tolerance in plants from the Andean highlands: Implications for paramos in a warmer world
Článek Quantifying pediatric patient need for second- and third-line HIV treatment: A tool for decision-making in resource-limited settings
Článek Discovery of actionable genetic alterations with targeted panel sequencing in children with relapsed or refractory solid tumors
Článek Iodine status of non-pregnant women and availability of food vehicles for fortification with iodine in a remote community in Gulf province, Papua New Guinea
Článek Fibre and extracellular matrix contributions to passive forces in human skeletal muscles: An experimental based constitutive law for numerical modelling of the passive element in the classical Hill-type three element model
Článek The status of imported Barremian-Bedoulian flint in north-eastern Iberia during the Middle Neolithic. Insights from the variscite mines of Gavà (Barcelona)
Článek Psychology of personal data donation
Článek Radiocarbon dating and cultural dynamics across Mongolia’s early pastoral transition
Článek MARGO (Massively Automated Real-time GUI for Object-tracking), a platform for high-throughput ethology
Článek Visual detection of time-varying signals: Opposing biases and their timescales
Článek Results from a World Health Organization pilot of the Basic Emergency Care Course in Sub Saharan Africa
Článek Scientists’ opinions and attitudes towards citizens’ understanding of science and their role in public engagement activities
Článek Dacentrurine stegosaurs (Dinosauria): A new specimen of Miragaia longicollum from the Late Jurassic of Portugal resolves taxonomical validity and shows the occurrence of the clade in North America
Článek Integrated pan-cancer gene expression and drug sensitivity analysis reveals SLFN11 mRNA as a solid tumor biomarker predictive of sensitivity to DNA-damaging chemotherapy
Článek Does membrane feeding compromise the quality of Aedes aegypti mosquitoes?
Článek Morphology, phylogeny, and taxonomy of two species of colonial volvocine green algae from Lake Victoria, Tanzania
Článek Metabolomics profiles associated with HbA1c levels in patients with type 2 diabetes
Článek Exploring local realities: Perceptions and experiences of healthcare workers on the management and control of drug-resistant tuberculosis in Addis Ababa, Ethiopia
Článek Sex differences in the treatment and outcome of emergency general surgery
Článek Comorbidities and costs in HIV patients: A retrospective claims database analysis in Germany
Článek Barriers to integration of bioinformatics into undergraduate life sciences education: A national study of US life sciences faculty uncover significant barriers to integrating bioinformatics into undergraduate instruction
Článek Local unemployment changes the springboard effect of low pay: Evidence from England
Článek A comparison of body composition assessment methods in climbers: Which is better?
Článek Comparison of an in-house ‘home-brew’ and commercial ViroSeq integrase genotyping assays on HIV-1 subtype C samples
Článek Elucidating genetic variability and population structure in Venturia inaequalis associated with apple scab diseaseusing SSR markers
Článek Clustering via hypergraph modularity
Článek Indomethacin enhances anti-tumor efficacy of a MUC1 peptide vaccine against breast cancer in MUC1 transgenic mice
Článek Multistage fuzzy comprehensive evaluation of landslide hazards based on a cloud model
Článek Inducible microRNA-200c decreases motility of breast cancer cells and reduces filamin A
Článek Pharmacological signatures of the reduced incidence and the progression of cognitive decline in ageing populations suggest the protective role of beneficial polypharmacy
Článek Continuous influenza virus production in a tubular bioreactor system provides stable titers and avoids the “von Magnus effect”
Článek Complex interaction networks of cytokines after transarterial chemotherapy in patients with hepatocellular carcinoma
Článek Gender essentialism in transgender and cisgender children
Článek Insertional mutagenesis in the zoonotic pathogen Chlamydia caviae
Článek Being there: A scoping review of grief support training in medical education
Článek Does the psychological profile influence the position of promising young futsal players?
Článek Effect of self-rated health status on functioning difficulties among older adults in Ghana: Coarsened exact matching method of analysis of the World Health Organization’s study on global AGEing and adult health, Wave 2
Článek Olfactory screening of Parkinson’s Disease patients and healthy subjects in China and Germany: A study of cross-cultural adaptation of the Sniffin’ Sticks 12-identification test
Článek Molecular evolution of cytochrome C oxidase-I protein of insects living in Saudi Arabia
Článek Correlates of leisure-time sedentary behavior among 181,793 adolescents aged 12-15 years from 66 low- and middle-income countries
Článek Cost-effectiveness analysis of Mucosal Leishmaniasis diagnosis with PCR-based vs parasitological tests in Colombia
Článek Spatiotemporal analysis of historical records (2001–2012) on dengue fever in Vietnam and development of a statistical model for forecasting risk
Článek Resilience assessment of Puerto Rico’s coral reefs to inform reef management
Článek Effect of community based health education on knowledge and attitude towards iron and folic acid supplementation among pregnant women in Kiambu County, Kenya: A quasi experimental study
Článek Implementation and effectiveness of non-specialist mediated interventions for children with Autism Spectrum Disorder: A systematic review and meta-analysis
Článek A tailored cognitive behavioral program for juvenile justice-referred females at risk of substance use and delinquency: A pilot quasi-experimental trial
Článek Impact of adjusted kidney volume measured in the bench surgery on one-year renal function in kidney transplantation
Článek Machine learning algorithm validation with a limited sample size
Článek The magnitude of suicidal ideation, attempts and associated factors of HIV positive youth attending ART follow ups at St. Paul’s hospital Millennium Medical College and St. Peter’s specialized hospital, Addis Ababa, Ethiopia, 2018
Článek The nonlinear effect of financial and fiscal policies on poverty alleviation in China—An empirical analysis of Chinese 382 impoverished counties with PSTR models
Článek Impacts of risk and competition on the profitability of banks: Empirical evidence from Pakistan
Článek Molecular characterization of lung adenocarcinoma from Korean patients using next generation sequencing
Článek An expansin-like protein expands forage cell walls and synergistically increases hydrolysis, digestibility and fermentation of livestock feeds by fibrolytic enzymes
Článek Joint image compression and encryption based on sparse Bayesian learning and bit-level 3D Arnold cat maps
Článek Urticating setae of tarantulas (Araneae: Theraphosidae): Morphology, revision of typology and terminology and implications for taxonomy
Článek Live observation of the oviposition process in Daphnia magna
Článek On the accuracy of displacement-based wave intensity analysis: Effect of vessel wall viscoelasticity and nonlinearity
Článek Nodosilinea signiensis sp. nov. (Leptolyngbyaceae, Synechococcales), a new terrestrial cyanobacterium isolated from mats collected on Signy Island, South Orkney Islands, Antarctica
Článek A 3’ UTR SNP rs885863, a cis-eQTL for the circadian gene VIPR2 and lincRNA 689, is associated with opioid addiction
Článek Characterizing the Randot Preschool stereotest: Testability, norms, reliability, specificity and sensitivity in children aged 2-11 years
Článek Tributyltin chloride (TBT) induces RXRA down-regulation and lipid accumulation in human liver cells
Článek Amazon climatic factors driving terpene composition of Iryanthera polyneura Ducke in terra-firme forest: A statistical approach
Článek Differences in clinical features of cluster headache between drinkers and nondrinkers in Japan
Článek Distribution of macular ganglion cell layer thickness in foveal hypoplasia: A new diagnostic criterion for ocular albinism
Článek Polo-like kinase 1 (Plk1) inhibition synergizes with taxanes in triple negative breast cancer
Článek Effect of mechanochemical activation of natural phosphorite structure as well as phosphorus solubility
Článek Automated content analysis across six languages
Článek A deep learning reconstruction framework for X-ray computed tomography with incomplete data
Článek Integrating interconception care in preventive child health care services: The Healthy Pregnancy 4 All program
Článek The prognostic significance of tumor-infiltrating lymphocytes assessment with hematoxylin and eosin sections in resected primary lung adenocarcinoma
Článek Effectiveness of novel fabrics to resist punctures and lacerations from white shark (Carcharodon carcharias): Implications to reduce injuries from shark bites
Článek Bacillus Calmette-Guérin (BCG) therapy lowers the incidence of Alzheimer’s disease in bladder cancer patients
Článek Serial block-face scanning electron microscopy reveals neuronal-epithelial cell fusion in the mouse cornea
Článek Salt or fish (or salted fish)? The Bronze Age specialised sites along the Tyrrhenian coast of Central Italy: New insights from Caprolace settlement
Článek Pragmatic language dysfunction in systemic lupus erythematosus patients: Results from a single center Italian study
Článek Association between cerebral atrophy and osteoporotic vertebral compression fractures
Článek Latitudinal gradient of cyanobacterial diversity in tidal flats
Článek Gene expression based survival prediction for cancer patients—A topic modeling approach
Článek Understanding allergic multimorbidity within the non-eosinophilic interactome
Článek The association between psychological distress and angina pectoris: A population-based study
Článek Comparative analysis on Facebook post interaction using DNN, ELM and LSTM
Článek Cerebellum-mediated trainability of eye and head movements for dynamic gazing
Článek Psychological and physiological effects of applying self-control to the mobile phone
Článek Omecamtiv mecarbil lowers the contractile deficit in a mouse model of nebulin-based nemaline myopathy
Článek Genome-wide SNP analyses reveal population structure of Portunus pelagicus along Vietnam coastline
Článek Modulating transcription through development of semi-synthetic yeast core promoters
Článek Left-handed metamaterial bandpass filter for GPS, Earth Exploration-Satellite and WiMAX frequency sensing applications
Článek Cost-effectiveness analysis of PSA-based mass screening: Evidence from a randomised controlled trial combined with register data
Článek A good tennis player does not lose matches. The effects of valence congruency in processing stance-argument pairs
Článek Validation of the group tasks uncertainty model (MITAG) in a German sample
Článek Parent psychological wellbeing in a single-family room versus an open bay neonatal intensive care unit
Článek Optimizing the procedure of grain nutrient predictions in barley via hyperspectral imaging
Článek In-situ time resolved spectrographic measurement using an additively manufactured metallic micro-fluidic analysis platform
Článek Race disparity in blood sphingolipidomics associated with lupus cardiovascular comorbidity
Článek Characterization of the placental transcriptome through mid to late gestation in the mare
Článek Diagnostic ability of multifocal electroretinogram in early multiple sclerosis using a new signal analysis method
Článek Predictors of never having a mammogram among Chinese, Vietnamese, and Korean immigrant women in the U.S.
Článek The impact of hepatic steatosis on portal hypertension
Článek How do and could clinical guidelines support patient-centred care for women: Content analysis of guidelines
Článek Study of the epidemiological behavior of malaria in the Darien Region, Panama. 2015–2017
Článek School-based obesity prevention for busy low-income families—Organisational and personal barriers and facilitators to implementation
Článek Neighborhood crime, disorder and substance use in the Caribbean context: Jamaica National Drug Use Prevalence Survey 2016
Článek Genomic comparison of diverse Salmonella serovars isolated from swine
Článek Significance of the lobe-specific emphysema index to predict prolonged air leak after anatomical segmentectomy
Článek Modeling of inter-organizational coordination dynamics in resilience planning of infrastructure systems: A multilayer network simulation framework
Článek Manipulating the odds: The effects of Machiavellianism and construal level on cheating behavior
Článek Early recognition of anorexia through patient-generated assessment predicts survival in patients with oesophagogastric cancer
Článek Identifying publications in questionable journals in the context of performance-based research funding
Článek ITGAM is a risk factor to systemic lupus erythematosus and possibly a protection factor to rheumatoid arthritis in patients from Mexico
Článek Nurses’ and patients’ experiences and preferences of the ankle-brachial pressure index and multi-site photoplethysmography for the diagnosis of peripheral arterial disease: A qualitative study
Článek Cluster tendency assessment in neuronal spike data
Článek Voluntary medical male circumcision for HIV prevention among adolescents in Kenya: Unintended consequences of pursuing service-delivery targets
Článek Primary care in five European countries: A citizens’ perspective on the quality of care for children
Článek High Order Profile Expansion to tackle the new user problem on recommender systems
Článek Psychometric properties of the Korean version of the Health Literacy on Social Determinants of Health Questionnaire (K-HL-SDHQ)
Článek Flood hazard mapping and assessment in data-scarce Nyaungdon area, Myanmar
Článek Methods for the identification of farm escapees in feral mink (Neovison vison) populations
Článek Transcriptional analysis of amino acid, metal ion, vitamin and carbohydrate uptake in butanol-producing Clostridium beijerinckii NRRL B-598
Článek Long-term vancomycin use had low risk of ototoxicity
Článek Overcoming platinum resistance in ovarian cancer by targeting pregnancy-associated plasma protein-A
Článek Exploration of muscle loss and metabolic state during prolonged critical illness: Implications for intervention?
Článek Pan-caspase inhibitor F573 mitigates liver ischemia reperfusion injury in a murine model
Článek Efficacy of interleukin 10 gene hydrofection in pig liver vascular isolated ‘in vivo’ by surgical procedure with interest in liver transplantation
Článek Molecular characteristics of segment 5, a unique fragment encoding two partially overlapping ORFs in the genome of rice black-streaked dwarf virus
Článek Early economic evaluation of MRI-guided laser interstitial thermal therapy (MRgLITT) and epilepsy surgery for mesial temporal lobe epilepsy
Článek GLADS: A gel-less approach for detection of STMS markers in wheat and rice
Článek Anterior tooth-use behaviors among early modern humans and Neandertals
Článek Incidence patterns of orofacial clefts in purebred dogs
Článek Capacity of the medullary cavity of tibia and femur for intra-bone marrow transplantation in mice
Článek Association of thoracic spine deformity and cardiovascular disease in a mouse model for Marfan syndrome
Článek Predicting atrial fibrillation in primary care using machine learning
Článek M3VR—A multi-stage, multi-resolution, and multi-volumes-of-interest volume registration method applied to 3D endovaginal ultrasound
Článek A developmental trajectory supporting the evaluation and achievement of competencies: Articulating the Mastery Rubric for the nurse practitioner (MR-NP) program curriculum
Článek Mobile medication manager application to improve adherence with immunosuppressive therapy in renal transplant recipients: A randomized controlled trial
Článek Default Mode Network structural alterations in Kocher-Monro trajectory white matter transection: A 3 and 7 tesla simulation modeling approach
Článek Phylogenetic revision of Gymnotidae (Teleostei: Gymnotiformes), with descriptions of six subgenera
Článek Population genetic analysis of 36 Y-chromosomal STRs yields comprehensive insights into the forensic features and phylogenetic relationship of Chinese Tai-Kadai-speaking Bouyei
Článek Prevention of suicidal behaviour: Results of a controlled community-based intervention study in four European countries
Článek An assessment of khat consumption habit and its linkage to household economies and work culture: The case of Harar city
Článek Fixation of genetic variation and optimization of gene expression: The speed of evolution in isolated lizard populations undergoing Reverse Island Syndrome
Článek One simple claudication question as first step in Peripheral Arterial Disease (PAD) screening: A meta-analysis of the association with reduced Ankle Brachial Index (ABI) in 27,945 subjects
Článek Direct cost of health care for individuals with community associated Clostridium difficile infections: A population-based cohort study
Článek Association between serum homocysteine level and cognitive function in middle-aged type 2 diabetes mellitus patients
Článek A qualitative research synthesis of contextual factors contributing to female overweight and obesity over the life course in sub-Saharan Africa
Článek Insight into the relationship between aryl-hydrocarbon receptor and β-catenin in human colon cancer cells
Článek Hidden noise in immunologic parameters might explain rapid progression in early-onset periodontitis
Článek The role of stigma in the acceptance and disclosure of HIV among recently diagnosed men who have sex with men in Australia: A qualitative study
Článek Detection of Schistosoma japonicum and Oncomelania hupensis quadrasi environmental DNA and its potential utility to schistosomiasis japonica surveillance in the Philippines
Článek Does age influence the quality of life in children with atopic dermatitis?
Článek Questioning the lasting effect of galvanic vestibular stimulation on postural control
Článek Identification of a novel monocytic phenotype in Classic Hodgkin Lymphoma tumor microenvironment
Článek Characterization of 20 complete plastomes from the tribe Laureae (Lauraceae) and distribution of small inversions
Článek Binding and dynamics of melatonin at the interface of phosphatidylcholine-cholesterol membranes
Článek Recent climate-driven ecological change across a continent as perceived through local ecological knowledge
Článek Nonalcoholic fatty liver disease is an early predictor of metabolic diseases in a metabolically healthy population
Článek Occurrence and multilocus genotyping of Giardia duodenalis from post-weaned dairy calves in Sichuan province, China
Článek Retinoic acid-stimulated ERK1/2 pathway regulates meiotic initiation in cultured fetal germ cells
Článek Gender disparities in scientific production: A nationwide assessment among physicians in Peru
Článek Effect of F1 and F2 generations on genetic variability and working steps of doubled haploid production in maize
Článek Mitochondrial dysfunction in rheumatoid arthritis: A comprehensive analysis by integrating gene expression, protein-protein interactions and gene ontology data
Článek A caspase-6-cleaved fragment of Glial Fibrillary Acidic Protein as a potential serological biomarker of CNS injury after cardiac arrest
Článek A handy method to remove bacterial contamination from fungal cultures
Článek The self-care profiles and its determinants among adults with hypertension in primary health care clinics in Selangor, Malaysia
Článek The mutational landscape of quinolone resistance in Escherichia coli
Článek Exploring the influence of self-perceptions on the relationship between motor competence and identity in adolescents
Článek Study on the damage characteristics of gas-bearing shale under different unloading stress paths
Článek EPILAT-IRA Study: A contribution to the understanding of the epidemiology of acute kidney injury in Latin America
Článek 16S rDNA droplet digital PCR for monitoring bacterial DNAemia in bloodstream infections
Článek Three-dimensional (3D) brain microphysiological system for organophosphates and neurochemical agent toxicity screening
Článek Diversity of endocervical microbiota associated with genital Chlamydia trachomatis infection and infertility among women visiting obstetrics and gynecology clinics in Malaysia
Článek Health impact of hepatic-venous-occlusive disease in a small town in Ethiopia—Case study from Tahtay koraro district in Tigray region, 2017
Článek Development of a novel automatable fabrication method based on electrospinning co electrospraying for rotator cuff augmentation patches
Článek Development of a quantitative PCR assay for the detection and enumeration of a potentially ciguatoxin-producing dinoflagellate, Gambierdiscus lapillus (Gonyaulacales, Dinophyceae)
Článek Association of clinical factors with survival outcomes in laryngeal squamous cell carcinoma (LSCC)
Článek Seasonal oyster harvesting recorded in a Late Archaic period shell ring
Článek Population preferences for breast cancer screening policies: Discrete choice experiment in Belarus
Článek Respiratory health and inflammatory markers - Exposure to respirable dust and quartz and chemical binders in Swedish iron foundries
Článek Trends and predictors of mother-to-child transmission of HIV in an era of protocol changes: Findings from two large health facilities in North East Nigeria
Článek Elevated Ki-67 (MIB-1) expression as an independent predictor for unfavorable pathologic outcomes and biochemical recurrence after radical prostatectomy in patients with localized prostate cancer: A propensity score matched study
Článek Genome-wide identification and gene expression analysis of SOS family genes in tuber mustard (Brassica juncea var. tumida)
Článek Carvedilol improves glucose tolerance and insulin sensitivity in treatment of adrenergic overdrive in high fat diet-induced obesity in mice
Článek Institutional differences in USMLE Step 1 and 2 CK performance: Cross-sectional study of 89 US allopathic medical schools
Článek Molecular epidemiological characteristics of dengue virus carried by 34 patients in Guangzhou in 2018
Článek Heteroplasmy in the complete chicken mitochondrial genome
Článek Candida blood stream infections observed between 2011 and 2016 in a large Italian University Hospital: A time-based retrospective analysis on epidemiology, biofilm production, antifungal agents consumption and drug-susceptibility
Článek Sixty years since the creation of Lake Kariba: Thermal and oxygen dynamics in the riverine and lacustrine sub-basins
Článek Association of uric acid in serum and urine with subclinical renal damage: Hanzhong Adolescent Hypertension Study
Článek Appropriate management of acute gastroenteritis in Australian children: A population-based study
Článek The plasma metabolome of women in early pregnancy differs from that of non-pregnant women
Článek Effectiveness of four types of neuraminidase inhibitors approved in Japan for the treatment of influenza
Článek More than just availability: Who has access and who administers take-home naloxone in Baltimore, MD
Článek Evaluating the cross-cultural validity of the Dutch version of the Social Exclusion Index for Health Surveys (SEI-HS): A mixed methods study
Článek Diminuendo al bottom—Clarifying the semantics of music notation by re-modeling
Článek Structural analysis of the manganese transport regulator MntR from Bacillus halodurans in apo and manganese bound forms
Článek Serum uromodulin is associated with the severity of clinicopathological findings in ANCA-associated glomerulonephritis
Článek Male support for cervical cancer screening and treatment in rural Ghana
Článek ADAPTS: Automated deconvolution augmentation of profiles for tissue specific cells
Článek Comparison of shape quantification methods for genomic prediction, and genome-wide association study of sorghum seed morphology
Článek An attempt to identify the issues underlying the lack of consistent conceptualisations in the field of student mathematics-related beliefs
Článek Video abstracts and plain language summaries are more effective than graphical abstracts and published abstracts
Článek Trophic structure of the macrofauna associated to deep-vents of the southern Gulf of California: Pescadero Basin and Pescadero Transform Fault
Článek Incomplete insertion of pedicle screws in a standard construct reduces the fatigue life: A biomechanical analysis
Článek Cost savings associated with timely treatment of botulism with botulism antitoxin heptavalent product
Článek Effects of light and nitrogen availability on photosynthetic efficiency and fatty acid content of three original benthic diatom strains
Článek Early signal detection of adverse events following influenza vaccination using proportional reporting ratio, Victoria, Australia
Článek Bioinformatic analysis of a novel Echinococcus granulosus nuclear receptor with two DNA binding domains
Článek Genome-wide identification and characterization, phylogenetic comparison and expression profiles of SPL transcription factor family in B. juncea (Cruciferae)
Článek Hypoxia inhibits TNF-α-induced TSLP expression in keratinocytes
Článek Conceptualising alcohol consumption in relation to long-term health conditions: Exploring risk in interviewee accounts of drinking and taking medications
Článek Elevated interleukin-25 and its association to Th2 cytokines in systemic lupus erythematosus with lupus nephritis
Článek Thrombocytopenia and thrombocytosis are associated with different outcome in atrial fibrillation patients on anticoagulant therapy
Článek Involvement of extracellular vesicles in the macrophage-tumor cell communication in head and neck squamous cell carcinoma
Článek Comparison of Humphrey Field Analyzer and imo visual field test results in patients with glaucoma and pseudo-fixation loss
Článek Out-of-pocket expenditure and catastrophic health expenditure for hospitalization due to injuries in public sector hospitals in North India
Článek Concurrent validity and discriminative ability of Dutch performance-based motor tests in 5 to 6 years old children
Článek Cumulative viral load as a predictor of CD4+ T-cell response to antiretroviral therapy using Bayesian statistical models
Článek Can General Practitioners manage mental disorders in primary care? A partially randomised, pragmatic, cluster trial
Článek Self-serving incentives impair collective decisions by increasing conformity
Článek Mutation and immune profiling of metaplastic breast cancer: Correlation with survival
Článek The clinicopathological significance of Thrombospondin-4 expression in the tumor microenvironment of gastric cancer
Článek Propofol-based total intravenous anesthesia did not improve survival compared to desflurane anesthesia in breast cancer surgery
Článek Association between ossification of the posterior longitudinal ligament and ossification of the nuchal ligament in the cervical spine
Článek Effects of Debaryomyces hansenii treatment on intestinal mucosa microecology in mice with antibiotic-associated diarrhea
Článek Molecular validation of clinical Pantoea isolates identified by MALDI-TOF
Článek A novel wheat lodging resistance evaluation method and device based on the thrust force of the stalks
Článek Evolution of high tooth replacement rates in theropod dinosaurs
Článek Outpatient facility-based order variation in combined imaging
Článek Ethnic-racial identity affirmation: Validation in Aboriginal Australian children
Článek Non-intubated anesthesia in patients undergoing video-assisted thoracoscopic surgery: A systematic review and meta-analysis
Článek Tissue-type plasminogen activator selectively inhibits multiple toll-like receptors in CSF-1-differentiated macrophages
Článek Changes of serum pentraxin-3 and hypersensitive CRP levels during pregnancy and their relationship with gestational diabetes mellitus
Článek Synergistic immuno-modulatory activity in human macrophages of a medicinal mushroom formulation consisting of Reishi, Shiitake and Maitake
Článek Investigating reindeer pastoralism and exploitation of high mountain zones in northern Mongolia through ice patch archaeology
Článek Diversity pattern of Plasmodium knowlesi merozoite surface protein 4 (MSP4) in natural population of Malaysia
Článek Protein synthesis rates of muscle, tendon, ligament, cartilage, and bone tissue in vivo in humans
Článek “What gets measured better gets done better”: The landscape of validation of global maternal and newborn health indicators through key informant interviews
Článek Contactless monitoring of heart and respiratory rate in anesthetized pigs using infrared thermography
Článek Molecular characterisation of genital human papillomavirus among women in Southwestern, Nigeria
Článek The impact of “male clinics” on health-seeking behaviors of adult men in rural Kenya
Článek Gene expression microarray public dataset reanalysis in chronic obstructive pulmonary disease
Článek Utility of the new cobas HCV test for viral load monitoring during direct-acting antiviral therapy
Článek Impact of negative tuberculin skin test on growth among disadvantaged Bangladeshi children
Článek Streptococcal phosphotransferase system imports unsaturated hyaluronan disaccharide derived from host extracellular matrices
Článek Maternal diet modulates placental nutrient transporter gene expression in a mouse model of diabetic pregnancy
Článek Effects of an incremental theory of personality intervention on the reciprocity between bullying and cyberbullying victimization and perpetration in adolescents
Článek The clot thickens: Autologous and allogeneic fibrin sealants are mechanically equivalent in an ex vivo model of cartilage repair
Článek Reproducibility, stability, and accuracy of microbial profiles by fecal sample collection method in three distinct populations
Článek Cooperation with autonomous machines through culture and emotion
Článek Variation in hybridogenetic hybrid emergence between populations of water frogs from the Pelophylax esculentus complex
Článek Breast cancer in Tanzanian, black American, and white American women: An assessment of prognostic and predictive features, including tumor infiltrating lymphocytes
Článek Intramolecular tautomerization of the quercetin molecule due to the proton transfer: QM computational study
Článek A global overview of cassava genetic diversity
Článek Whole body periodic acceleration in normal and reduced mucociliary clearance of conscious sheep
Článek Identifying resurrection genes through the differentially expressed genes between Selaginella tamariscina (Beauv.) spring and Selaginella moellendorffii Hieron under drought stress
Článek Impact of hemodialysis on the concentrations of sodium and potassium during infusion of sodium thiosulfate using an In Vitro hemodialysis model
Článek Minimal effects of oyster aquaculture on local water quality: Examples from southern Chesapeake Bay
Článek Suboptimal infant and young child feeding practices in rural Boucle du Mouhoun, Burkina Faso: Findings from a cross-sectional population-based survey
Článek High salinity tolerance of invasive blue catfish suggests potential for further range expansion in the Chesapeake Bay region
Článek From waste to food: Optimising the breakdown of oil palm waste to provide substrate for insects farmed as animal feed
Článek Quantitative assessment of interstitial lung disease in Sjögren’s syndrome
Článek Comparative efficacy of tenofovir and entecavir in nucleos(t)ide analogue-naive chronic hepatitis B: A systematic review and meta-analysis
Článek Reference ranges for ultrasonographic renal dimensions as functions of age and body indices: A retrospective observational study in Taiwan
Článek Finding phrases: On the role of co-verbal facial information in learning word order in infancy
Článek Mathematical modeling reveals the factors involved in the phenomena of cancer stem cells stabilization
Článek Effects of forest management and roe deer impact on a mountain forest development in the Italian Apennines: A modelling approach using LANDIS-II
Článek Evaluation of comprehensive improvement for mild and moderate soil salinization in arid zone
Článek Efficacy, acceptability and feasibility of daily text-messaging in promoting glycaemic control and other clinical outcomes in a low-resource setting of South Africa: A randomised controlled trial
Článek Magnitude and associated factors of postpartum depression among women in Nekemte town, East Wollega zone, west Ethiopia, 2019: A community-based study
Článek Comparison of continuous wave and cold lateral condensation filling techniques in 3D printed simulated C-shape canals instrumented with Reciproc Blue or Hyflex EDM
Článek Effect of caffeine on neuromuscular function following eccentric-based exercise
Článek AtUBL5 regulates growth and development through pre-mRNA splicing in Arabidopsis thaliana
Článek The gut microbiome of freshwater Unionidae mussels is determined by host species and is selectively retained from filtered seston
Článek Alcohol consumption and survival after breast cancer diagnosis in Japanese women: A prospective patient cohort study
Článek Selection of reference genes for normalization of cranberry (Vaccinium macrocarpon Ait.) gene expression under different experimental conditions
Článek The household economic costs associated with depression symptoms: A cross-sectional household study conducted in the North West province of South Africa
Článek Increased cell size, structural complexity and migration of cancer cells acquiring fibroblast organelles by cell-projection pumping
Článek Acute low- compared to high-load resistance training to failure results in greater energy expenditure during exercise in healthy young men
Článek Impact of body mass index and metabolically unhealthy status on mortality in the Japanese general population: The JMS cohort study
Článek Characterization of two thermophilic cellulases from Talaromyces leycettanus JCM12802 and their synergistic action on cellulose hydrolysis
Článek Ecohydrology of urban trees under passive and active irrigation in a semiarid city
Článek Cyclosporine A eyedrops with self-nanoemulsifying drug delivery systems have improved physicochemical properties and efficacy against dry eye disease in a murine dry eye model
Článek LFastqC: A lossless non-reference-based FASTQ compressor
Článek Highly accurate prediction of flammability limits of chemical compounds using novel integrated hybrid models
Článek Nonsteroidal anti-inflammatory drugs and acetaminophen ameliorate muscular mechanical hyperalgesia developed after lengthening contractions via cyclooxygenase-2 independent mechanisms in rats
Článek A popular Indian clove-based mosquito repellent is less effective against Culex quinquefasciatus and Aedes aegypti than DEET
Článek Yeasts affect tolerance of Drosophila melanogaster to food substrate with high NaCl concentration
Článek The effect of climate change on cholera disease: The road ahead using artificial neural network
Článek Grit (effortful persistence) can be measured with a short scale, shows little variation across socio-demographic subgroups, and is associated with career success and career engagement
Článek Micro-dislodgement during transcatheter aortic valve implantation with a contemporary self-expandable prosthesis
Článek Improving the antimicrobial efficacy against resistant Staphylococcus aureus by a combined use of conjugated oligoelectrolytes
Článek Kin discrimination and outer membrane exchange in Myxococcus xanthus: Experimental analysis of a natural population
Článek Inflammatory cell infiltrates, hypoxia, vascularization, pentraxin 3 and osteoprotegerin in abdominal aortic aneurysms – A quantitative histological study
Článek Effects of virtual reality rehabilitation training on gait and balance in patients with Parkinson's disease: A systematic review
Článek Serum miR-33a is associated with steatosis and inflammation in patients with non-alcoholic fatty liver disease after liver transplantation
Článek Association between housing tenure and self-rated health in Japan: Findings from a nationwide cross-sectional survey
Článek Investigation of biochemical and physiological parameters of the newborn Saiga antelope (Saiga tatarica) in Gansu Province, China
Článek One-year follow-up of changes in refraction and aberrations induced by corneal incision
Článek Evaluation of upper limb superficial venous percussion as a sign of anatomical location and venous permeability. A comparative study of superficial venous percussion to ultrasound findings on non-renal patients and on chronic kidney disease patients
Článek An assessment of the Dutch experience with health insurers acting as healthcare advisors
Článek Perception of potential harm and benefits of HIV vaccine trial participation: A qualitative study from urban Tanzania
Článek Veterans with Gulf War Illness exhibit distinct respiratory patterns during maximal cardiopulmonary exercise
Článek Deep brain stimulation restores the glutamatergic and GABAergic synaptic transmission and plasticity to normal levels in kindled rats
Článek Metformin strongly affects transcriptome of peripheral blood cells in healthy individuals
Článek Cranberry extracts promote growth of Bacteroidaceae and decrease abundance of Enterobacteriaceae in a human gut simulator model
Článek Long-term retention on antiretroviral therapy among infants, children, adolescents and adults in Malawi: A cohort study
Článek Histochemical quantification of collagen content in articular cartilage
Článek Optogenetically transduced human ES cell-derived neural progenitors and their neuronal progenies: Phenotypic characterization and responses to optical stimulation
Článek Ion torrent high throughput mitochondrial genome sequencing (HTMGS)
Článek Outpatient antibiotic prescription rate and pattern in the private sector in India: Evidence from medical audit data
Článek Acute Influenza A virus outbreak in an enzootic infected sow herd: Impact on viral dynamics, genetic and antigenic variability and effect of maternally derived antibodies and vaccination
Článek Prevalence and correlates of low serum calcium in late pregnancy: A cross sectional study in the Nkongsamba Regional Hospital; Littoral Region of Cameroon
Článek Home-cage monitoring ascertains signatures of ictal and interictal behavior in mouse models of generalized seizures
Článek CRISPR/Cas9 gene editing in the West Nile Virus vector, Culex quinquefasciatus Say
Článek Genetic susceptibility to angiotensin-converting enzyme-inhibitor induced angioedema: A systematic review and evaluation of methodological approaches
Článek Proton pump inhibitor use increases the risk of peritonitis in peritoneal dialysis patients
Článek Comparative distribution of extended-spectrum beta-lactamase–producing Escherichia coli from urine infections and environmental waters
Článek Sex differences in thigh muscle volumes, sprint performance and mechanical properties in national-level sprinters
Článek Maternal serum and cord blood leptin concentrations at delivery
Článek Winter nitrification in ice-covered lakes
Článek Intolerance of uncertainty fuels depressive symptoms through rumination: Cross-sectional and longitudinal studies
Článek Monitoring exercise-induced muscle damage indicators and myoelectric activity during two weeks of knee extensor exercise training in young and old men
Článek Can adoption of pollution prevention techniques reduce pollution substitution?
Článek The association between self-efficacy and self-management behaviors among Chinese patients with type 2 diabetes
Článek Poly-arginine-18 peptides do not exacerbate bleeding, or improve functional outcomes following collagenase-induced intracerebral hemorrhage in the rat
Článek Affective disorders in the elderly in different European countries: Results from the MentDis_ICF65+ study
Článek Evaluation of forearm vascular resistance during orthostatic stress: Velocity is proportional to flow and size doesn’t matter
Článek Proton pencil minibeam irradiation of an in-vivo mouse ear model spares healthy tissue dependent on beam size
Článek Maternal stress in Shank3ex4-9 mice increases pup-directed care and alters brain white matter in male offspring
Článek Aspartate aminotransferase-to-platelet ratio index (APRI): A potential marker for diagnosis in patients at risk of severe malaria caused by Plasmodium vivax
Článek Exploiting open source 3D printer architecture for laboratory robotics to automate high-throughput time-lapse imaging for analytical microbiology
Článek Long non-coding RNAs and latent HIV – A search for novel targets for latency reversal
Článek Clinical characteristics of neonatal fulminant necrotizing enterocolitis in a tertiary Children's hospital in the last 10 years
Článek Effects of neuromuscular electrical stimulation training on muscle size in collegiate track and field athletes
Článek Adaptive fuzzy flow rate control considering multifractal traffic modeling and 5G communications
Článek Evaluation of four commercial tests for detecting ceftiofur in waste milk bulk tank samples
Článek A smart tele-cytology point-of-care platform for oral cancer screening
Článek Vasopressin SNP pain factors and stress in sickle cell disease
Článek Carbonate production of Micronesian reefs suppressed by thermal anomalies and Acanthaster as sea-level rises
Článek Microbial metabolisms in an abyssal ferromanganese crust from the Takuyo-Daigo Seamount as revealed by metagenomics
Článek Incidence of chronic kidney disease hospitalisations and mortality in Espírito Santo between 1996 to 2017
Článek The impact of short-term machine perfusion on the risk of cancer recurrence after rat liver transplantation with donors after circulatory death
Článek Proteomic profiling of the thrombin-activated canine platelet secretome (CAPS)
Článek Blood metal levels and serum testosterone concentrations in male and female children and adolescents: NHANES 2011–2012
Článek The effects of prolonged single night session of videogaming on sleep and declarative memory
Článek Diversity, distribution and dynamics of large trees across an old-growth lowland tropical rain forest landscape
Článek Mapping developmental QTL for plant height in soybean [Glycine max (L.) Merr.] using a four-way recombinant inbred line population
Článek Vaginal ring acceptability and related preferences among women in low- and middle-income countries: A systematic review and narrative synthesis
Článek UM171 induces a homeostatic inflammatory-detoxification response supporting human HSC self-renewal
Článek Positive selection and precipitation effects on the mitochondrial NADH dehydrogenase subunit 6 gene in brown hares (Lepus europaeus) under a phylogeographic perspective
Článek Evaluation of Minimum Inhibitory Concentrations for 154 Mycoplasma synoviae isolates from Italy collected during 2012-2017
Článek Enhancement of antibiotics antimicrobial activity due to the silver nanoparticles impact on the cell membrane
Článek Correction: Smoking, alcohol use disorder and tuberculosis treatment outcomes: A dual co-morbidity burden that cannot be ignored
Článek Correction: Effect of corruption on perceived difficulties in healthcare access in sub-Saharan Africa
Článek Knowledge-based best of breed approach for automated detection of clinical events based on German free text digital hospital discharge letters
Článek Importance of thorough tissue and cellular level characterization of targeted drugs in the evaluation of pharmacodynamic effects
Článek Integrated value-chain and risk assessment of Pig-Related Zoonoses in Ghana
Článek Failed sperm retrieval from severely oligospermic or non-obstructive azoospermic patients on oocyte retrieval day: Emergent oocyte cryopreservation is a feasible strategy
Článek Cassava yield traits predicted by genomic selection methods
Článek Verification of hub genes in the expression profile of aortic dissection
Článek Pig farmers’ willingness to pay for management strategies to reduce aggression between pigs
Článek Metabolomic response of Euglena gracilis and its bleached mutant strain to light
Článek Diagnostic value of ASVS for insulinoma localization: A systematic review and meta-analysis
Článek Newly educated care managers’ experiences of providing care for persons with stress-related mental disorders in the clinical primary care context
Článek Real-time telemetry monitoring of oxygen in the central complex of freely-walking Gromphadorhina portentosa
Článek Qualification programmes for immigrant health professionals: A systematic review
Článek An analytical model to minimize the latency in healthcare internet-of-things in fog computing environment
Článek Grain filling of early-season rice cultivars grown under mechanical transplanting
Článek Intercalation of small molecules into DNA in chromatin is primarily controlled by superhelical constraint
Článek Correlative evidence for co-regulation of phosphorus and carbon exchanges with symbiotic fungus in the arbuscular mycorrhizal Medicago truncatula
Článek How to design a dose-finding study on combined agents: Choice of design and development of R functions
Článek Altered expression of Notch1 in Alzheimer's disease
Článek The ZJU index is a powerful surrogate marker for NAFLD in severely obese North American women
Článek Trunk velocity-dependent Light Touch reduces postural sway during standing
Článek Evaluation of cytological diagnostic accuracy for canine splenic neoplasms: An investigation in 78 cases using STARD guidelines
Článek Trade-offs in motivating volunteer effort: Experimental evidence on voluntary contributions to science
Článek Does caching strategy vary with microclimate in endangered Mt. Graham red squirrels?
Článek Assessment of energy expenditure during high intensity cycling and running using a heart rate and activity monitor in young active adults
Článek Evaluating rectal swab collection method for gut microbiome analysis in the common marmoset (Callithrix jacchus)
Článek Implementation of a screening, brief intervention and referral to treatment programme for risky substance use in South African emergency centres: A mixed methods evaluation study
Článek Can the CalproQuest predict a positive Calprotectin test? A prospective diagnostic study
Článek The calcium sensor OsCBL1 modulates nitrate signaling to regulate seedling growth in rice
Článek Acceptability of and treatment preferences for recurrent bacterial vaginosis—Topical lactic acid gel or oral metronidazole antibiotic: Qualitative findings from the VITA trial
Článek Mathematical determination of the HIV-1 matrix shell structure and its impact on the biology of HIV-1
Článek Contingent negative variation during a modified cueing task in simulated driving
Článek CAMDI interacts with the human memory-associated protein KIBRA and regulates AMPAR cell surface expression and cognition
Článek Effect of feeding patterns on growth and nutritional status of children aged 0-24 months: A Chinese cohort study
Článek A fecal sequel: Testing the limits of a genetic assay for bat species identification
Článek Measuring the impact of chronic conditions and associated multimorbidity on health-related quality of life in the general population in Hong Kong SAR, China: A cross-sectional study
Článek Short and long-term clinical effectiveness and cost-effectiveness of a late-phase community-based balance and gait exercise program following hip fracture. The EVA-Hip Randomised Controlled Trial
Článek Vaccine cold chain in general practices: A prospective study in 75 refrigerators (Keep Cool study)
Článek Brazilian norms for the Bank of Standardized Stimuli (BOSS)
Článek Distinct varieties of aesthetic chills in response to multimedia
Článek Interaction between apolipoprotein E genotype and hypertension on cognitive function in older women in the Nurses’ Health Study
Článek Correction: Resistance profile of the HIV-1 maturation inhibitor GSK3532795 in vitro and in a clinical study
Článek New formulation of the Gompertz equation to describe the kinetics of untreated tumors
Článek Development of visual perception of others’ actions: Children’s judgment of lifted weight
Článek Retrospective comparative analysis of intraocular lens calculation formulas after hyperopic refractive surgery
Článek Human vitreous concentrations of citicoline following topical application of citicoline 2% ophthalmic solution
Článek Development and validation of exhaled breath condensate microRNAs to identify and endotype asthma in children
Článek Arthroscopic release for frozen shoulder: Does the timing of intervention and diabetes affect outcome?
Článek Risk factors affecting dairy cattle protective grouping behavior, commonly known as bunching, against Stomoxys calcitrans (L.) on California dairies
Článek Acceleration of chemical shift encoding-based water fat MRI for liver proton density fat fraction and T2* mapping using compressed sensing
Článek Characterisation and microbial community analysis of lipid utilising microorganisms for biogas formation
Článek Sexuality in male partners of women with fibromyalgia syndrome: A qualitative study
Článek Exploring optimization strategies for improving explicit water models: Rigid n-point model and polarizable model based on Drude oscillator
Článek Artificial insemination with fresh, liquid stored and frozen thawed semen in dromedary camels
Článek Moving into an urban drug scene among people who use drugs in Vancouver, Canada: Latent class growth analysis
Článek Numerical study on the start and unstart phenomena in a scramjet inlet-isolator model
Článek Effects of dietary supplementation with apple peel powder on the growth, blood and liver parameters, and transcriptome of genetically improved farmed tilapia (GIFT, Oreochromis niloticus)
Článek Urban growth simulation in different scenarios using the SLEUTH model: A case study of Hefei, East China
Článek Chronic bronchitis without airflow obstruction, asthma and rhinitis are differently associated with cardiovascular risk factors and diseases
Článek Factors associated with medication adherence among people with diabetes mellitus in poor urban areas of Cambodia: A cross-sectional study
Článek Mammary microbiome of lactating organic dairy cows varies by time, tissue site, and infection status
Článek Force field generalization and the internal representation of motor learning
Článek Polyphenism of visual and chemical secondary sexually-selected wing traits in the butterfly Bicyclus anynana: How different is the intermediate phenotype?
Článek Minimal genetic differentiation of the malaria vector Nyssorhynchus darlingi associated with forest cover level in Amazonian Brazil
Článek The impact of leisure activities on older adults’ cognitive function, physical function, and mental health
Článek scafSLICR: A MATLAB-based slicing algorithm to enable 3D-printing of tissue engineering scaffolds with heterogeneous porous microarchitecture
Článek Association of serum leptin and adiponectin concentrations with echocardiographic parameters and pathophysiological states in patients with cardiovascular disease receiving cardiovascular surgery
Článek Operation of cognitive memory inhibition in adults with Down syndrome: Effects of maintenance load and material
Článek Influences on surgical antimicrobial prophylaxis decision making by surgical craft groups, anaesthetists, pharmacists and nurses in public and private hospitals
Článek Post-treatment Lyme disease symptoms score: Developing a new tool for research
Článek Expression of Concern: The Role of the RACK1 Ortholog Cpc2p in Modulating Pheromone-Induced Cell Cycle Arrest in Fission Yeast
Článek Equine bronchial fibroblasts enhance proliferation and differentiation of primary equine bronchial epithelial cells co-cultured under air-liquid interface
Článek Investigating cooperation with robotic peers
Článek Synthesis, purification and crystallization of a putative critical bulge of HAR1 RNA
Článek Prosthetic push-off power in trans-tibial amputee level ground walking: A systematic review
Článek A case study of the use of verbal reports for talent identification purposes in soccer: A Messi affair!
Článek Transgenerational deep sequencing revealed hypermethylation of hippocampal mGluR1 gene with altered mRNA expression of mGluR5 and mGluR3 associated with behavioral changes in Sprague Dawley rats with history of prolonged febrile seizure
Článek Obesity is associated with an impaired survival in lymphoma patients undergoing autologous stem cell transplantation
Článek Periodontal disease: Repercussions in pregnant woman and newborn health—A cohort study
Článek Origins of Chinese reindeer (Rangifer tarandus) based on mitochondrial DNA analyses
Článek Regional, racial, gender, and tumor biology disparities in breast cancer survival rates in Africa: A systematic review and meta-analysis
Článek How effective are films in inducing positive and negative emotional states? A meta-analysis
Článek 3D nanostructural characterisation of grain boundaries in atom probe data utilising machine learning methods
Článek An outbreak of tuberculosis in a middle school in Henan, China: Epidemiology and risk factors
Článek Initial clinical radiological findings and staging to predict prognosis of primary hepatic angiosarcoma: A retrospective analysis
Článek A new early Eocene deperetellid tapiroid illuminates the origin of Deperetellidae and the pattern of premolar molarization in Perissodactyla
Článek Longevity and marginal bone loss of narrow-diameter implants supporting single crowns: A systematic review
Článek Impact of UVC-sustained recirculating air filtration on airborne bacteria and dust in a pig facility
Článek Cold-related Florida manatee mortality in relation to air and water temperatures
Článek Conceptual fluency in inductive reasoning
Článek Clinical outcomes and treatment patterns among Medicare patients with nonvalvular atrial fibrillation (NVAF) and chronic kidney disease
Článek Improvements in the learnability of smartphone haptic interfaces for visually impaired users
Článek Role of the malic enzyme in metabolism of the halotolerant methanotroph Methylotuvimicrobium alcaliphilum 20Z
Článek Cyclic loading test study on a new cast-in-situ insulated sandwich concrete wall
Článek Natural compounds as angiogenic enzyme thymidine phosphorylase inhibitors: In vitro biochemical inhibition, mechanistic, and in silico modeling studies
Článek Analysis of virulence potential of Escherichia coli O145 isolated from cattle feces and hide samples based on whole genome sequencing
Článek Pre-clinical medical student reflections on implicit bias: Implications for learning and teaching
Článek Prognostic significance of non-sustained ventricular tachycardia on stored electrograms in pacemaker recipients
Článek Determinants of preterm birth among mothers who gave birth at public hospitals in the Amhara region, Ethiopia: A case-control study
Článek Real-world evidence of the effectiveness of ombitasvir-paritaprevir/r ± dasabuvir ± ribavirin in patients monoinfected with chronic hepatitis C or coinfected with human immunodeficiency virus-1 in Spain
Článek Unique transcriptomic landscapes identified in idiopathic spontaneous and infection related preterm births compared to normal term births
Článek Restrained expansion of the recall germinal center response as biomarker of protection for influenza vaccination in mice
Článek Arabidopsis TRM5 encodes a nuclear-localised bifunctional tRNA guanine and inosine-N1-methyltransferase that is important for growth
Článek Achievement of weight loss in patients with overweight during dietetic treatment in primary health care
Článek Autophagy deficiency exacerbates colitis through excessive oxidative stress and MAPK signaling pathway activation
Článek The impacts of parity on lung function data (LFD) of healthy females aged 40 years and more issued from an upper middle income country (Algeria): A comparative study
Článek Reorganization of spatial configurations in visual working memory: A matter of set size?
Článek Unravelling travellers’ route choice behaviour at full-scale urban network by focusing on representative OD pairs in computer experiments
Článek Evaluating the higher-order structure of the Profile of Emotional Competence (PEC): Confirmatory factor analysis and Bayesian structural equation modeling
Článek HIV prevalence and correlated factors among male clients of female sex workers in a border region of China
Článek Next generation sequencing and RNA-seq characterization of adipose tissue in the Nile crocodile (Crocodylus niloticus) in South Africa: Possible mechanism(s) of pathogenesis and pathophysiology of pansteatitis
Článek Association between advanced maternal age and maternal and neonatal morbidity: A cross-sectional study on a Spanish population
Článek Ethnic differences in the prevalence, socioeconomic and health related risk factors of knee pain and osteoarthritis symptoms in older Malaysians
Článek Increasing knowledge of HIV status in a country with high HIV testing coverage: Results from the Botswana Combination Prevention Project
Článek Friends with benefits: The effects of vegetative shading on plant survival in a green roof environment
Článek Comparison of the fecal, cecal, and mucus microbiome in male and female mice after TNBS-induced colitis
Článek Identifying candidate diagnostic markers for early stage of non-small cell lung cancer
Článek Complex alternative splicing of human Endonuclease V mRNA, but evidence for only a single protein isoform
Článek Correction: KML001 Induces Apoptosis and Autophagic Cell Death in Prostate Cancer Cells via Oxidative Stress Pathway
Článek Unique developmental trajectories of risk behaviors in adolescence and associated outcomes in young adulthood
Článek Enhanced fibrinolysis detection in a natural occurring canine model with intracavitary effusions: Comparison and degree of agreement between thromboelastometry and FDPs, D-dimer and fibrinogen concentrations
Článek Overexpression of Saussurea involucrata dehydrin gene SiDHN promotes cold and drought tolerance in transgenic tomato plants
Článek Foxtail millet (Setaria italica (L.) P. Beauv) CIPKs are responsive to ABA and abiotic stresses
Článek Autonomous drone hunter operating by deep learning and all-onboard computations in GPS-denied environments
Článek Heterogeneity Diffusion Imaging of gliomas: Initial experience and validation
Článek Frequency cluster formation and slow oscillations in neural populations with plasticity
Článek DHP23002 as a next generation oral paclitaxel formulation for pancreatic cancer therapy
Článek Diagnostic accuracy of SOX11 immunohistochemistry in mantle cell lymphoma: A meta-analysis
Článek Analytical solution to swing equations in power grids
Článek Pathways to conspiracy: The social and linguistic precursors of involvement in Reddit’s conspiracy theory forum
Článek Spatiotemporally random and diverse grid cell spike patterns contribute to the transformation of grid cell to place cell in a neural network model
Článek Empathic concern and personal distress depend on situational but not dispositional factors
Článek Who is more susceptible to job stressors and resources? Sensory-processing sensitivity as a personal resource and vulnerability factor
Článek Cost-effectiveness of integrating postpartum antiretroviral therapy and infant care into maternal & child health services in South Africa
Článek A substitution mutation in a conserved domain of mammalian acetate-dependent acetyl CoA synthetase 2 results in destabilized protein and impaired HIF-2 signaling
Článek One step at a time: Physical activity is linked to positive interpretations of ambiguity
Článek Calreticulin regulates vascular endothelial growth factor-A mRNA stability in gastric cancer cells
Článek Evaluation of various methods of selection of B. subtilis strains capable of secreting surface-active compounds
Článek Association between US Pharmacopeia (USP) monograph standards, generic entry and prescription drug costs
Článek Molecular characterisation of the synovial fluid microbiome in rheumatoid arthritis patients and healthy control subjects
Článek On sorption hysteresis in wood: Separating hysteresis in cell wall water and capillary water in the full moisture range
Článek Inbreeding, Allee effects and stochasticity might be sufficient to account for Neanderthal extinction
Článek Reliability and construct validity of the stepping-forward affordance perception test for fall risk assessment in community-dwelling older adults
Článek Socioeconomic determinants of nutritional status among ‘Baiga’ tribal children In Balaghat district of Madhya Pradesh: A qualitative study
Článek Study on characteristics of fire plume in building facade window under lateral blow
Článek ‘When you talk to someone in a bad way or always put her under pressure, it is actually worse than beating her’: Conceptions and experiences of emotional intimate partner violence in Rwanda and South Africa
Článek Effects of 6-mercaptopurine in pressure overload induced right heart failure
Článek The association between haemoglobin levels in the first 20 weeks of pregnancy and pregnancy outcomes
Článek Implementation and evaluation of an antimicrobial stewardship programme in companion animal clinics: A stepped-wedge design intervention study
Článek Factors associated with persistently high-cost health care utilization for musculoskeletal pain
Článek Nitrogen and chlorophyll status determination in durum wheat as influenced by fertilization and soil management: Preliminary results
Článek Effect of repeated in vivo microCT imaging on the properties of the mouse tibia
Článek Coupling environment and physiology to predict effects of climate change on the taxonomic and functional diversity of fish assemblages in the Murray-Darling Basin, Australia
Článek Hematology and plasma biochemistries in the Blanding’s turtle (Emydoidea blandingii) in Lake County, Illinois
Článek CRISPR-Cas influences the acquisition of antibiotic resistance in Klebsiella pneumoniae
Článek Phosphorylation-dependent activity-based conformational changes in P21-activated kinase family members and screening of novel ATP competitive inhibitors
Článek Antidepressant prescriptions, discontinuation, depression and perinatal outcomes, including breastfeeding: A population cohort analysis
Článek Why men with a low-risk prostate cancer select and stay on active surveillance: A qualitative study
Článek Imported severe malaria and risk factors for intensive care: A single-centre retrospective analysis
Článek Combined treatment (image-guided thrombectomy and endovascular therapy with open femoral access) for acute lower limb ischemia: Clinical efficacy and outcomes
Článek Low-latency single channel real-time neural spike sorting system based on template matching
Článek Quantifying the scale effect in geospatial big data using semi-variograms
Článek Paper-and-pencil versus computerized administration mode: Comparison of data quality and risk behavior prevalence estimates in the European school Survey Project on Alcohol and other Drugs (ESPAD)
Článek Regression adjusted colocalisation colour mapping (RACC): A novel biological visual analysis method for qualitative colocalisation analysis of 3D fluorescence micrographs
Článek Ostrich eggshell bead diameter in the Holocene: Regional variation with the spread of herding in eastern and southern Africa
Článek Spatial and temporal variations in female size at maturity of a Southern Rock Lobster (Jasus edwardsii) population: A likely response to climate change
Článek Inactive USP14 and inactive UCHL5 cause accumulation of distinct ubiquitinated proteins in mammalian cells
Článek Training rhesus macaques to take daily oral antiretroviral therapy for preclinical evaluation of HIV prevention and treatment strategies
Článek Left ventricular structural and functional changes in Friedreich ataxia – Relationship with body size, sex, age and genetic severity
Článek Magnitude and factors associated with anemia among pregnant women attending antenatal care in Bench Maji, Keffa and Sheka zones of public hospitals, Southwest, Ethiopia, 2018: A cross -sectional study
Článek Effectiveness of telerehabilitation in the management of adults with stroke: A systematic review
Článek Hydrogen sulphide-induced hypometabolism in human-sized porcine kidneys
Článek Correction: Comparison of the molecular properties of retinitis pigmentosa P23H and N15S amino acid replacements in rhodopsin
Článek Retraction: Regulation of gastric smooth muscle contraction via Ca2+-dependent and Ca2+-independent actin polymerization
Článek Evaluation of neutral oral contrast agents for assessment of the small bowel at abdominal staging CT
Článek Blood type and breed-associated differences in cell marker expression on equine bone marrow-derived mesenchymal stem cells including major histocompatibility complex class II antigen expression
Článek Induced abortion and future use of IVF treatment; A nationwide register study
Článek Psychosocial determinants of sustained maternal functional impairment: Longitudinal findings from a pregnancy-birth cohort study in rural Pakistan
Článek Measurement of finger joint angle using stretchable carbon nanotube strain sensor
Článek Determinants of mortality among patients with drug-resistant tuberculosis in northern Nigeria
Článek Drugs modulating stochastic gene expression affect the erythroid differentiation process
Článek Efficacy of UB0316, a multi-strain probiotic formulation in patients with type 2 diabetes mellitus: A double blind, randomized, placebo controlled study
Článek Prognostic value of des-γ-carboxy prothrombin in patients with hepatocellular carcinoma treated with transarterial chemotherapy: A systematic review and meta-analysis
Článek Avermectin induces the oxidative stress, genotoxicity, and immunological responses in the Chinese Mitten Crab, Eriocheir sinensis
Článek Antibiotic use in mandarin production (Citrus reticulata Blanco) in major mandarin-producing areas in Thailand: A survey assessment
Článek Application of CPI cutoff value based on parentage testing of duos and trios typed by four autosomal kits
Článek Correction: Good and Bad in the Hands of Politicians: Spontaneous Gestures during Positive and Negative Speech
Článek Adolescents with worse levels of oral health literacy have more cavitated carious lesions
Článek Effective methods for the inactivation of Francisella tularensis
Článek Detection of early-stage Alzheimer’s pathology using blood-based autoantibody biomarkers in elderly hip fracture repair patients
Článek Correlation between internal pudendal artery stenosis and erectile dysfunction in patients with suspected coronary artery disease
Článek Analysis of HER2 genomic binding in breast cancer cells identifies a global role in direct gene regulation
Článek Population productivity of shovelnose rays: Inferring the potential for recovery
Článek Correction: Long-term clinical outcomes in a cohort of patients with solitary plasmacytoma treated in the modern era
Článek Effects of tetracycline on myocardial infarct size in obese rats with chemically-induced colitis
Článek Mineral absorption is an enriched pathway in a brain region of restless legs syndrome patients with reduced MEIS1 expression
Článek Changes in weight and body composition across five years at university: A prospective observational study
Článek Adeno-associated virus-mediated expression of human butyrylcholinesterase to treat organophosphate poisoning
Článek Effects of insulin signaling on mouse taste cell proliferation
Článek Patient-level cost of home- and facility-based child pneumonia treatment in Suba Sub County, Kenya
Článek TAP: A static analysis model for PHP vulnerabilities based on token and deep learning technology
Článek Cost-effectiveness of QuantiFERON-TB Gold In-Tube versus tuberculin skin test for diagnosis and treatment of Latent Tuberculosis Infection in primary health care workers in Brazil
Článek Multifaceted intervention for the prevention and management of musculoskeletal pain in nursing staff: Results of a cluster randomized controlled trial
Článek Changes over time in creatinine clearance and comparison of emergent adverse events for HIV-positive adults receiving standard doses (300 mg/day) of lamivudine-containing antiretroviral therapy with baseline creatinine clearance of 30–49 vs ≥50 mL/min
Článek Population dynamics of foxes during restricted-area culling in Britain: Advancing understanding through state-space modelling of culling records
Článek Impacts of experimental advisory exit speed sign on traffic speeds for freeway exit ramp
Článek In-hospital outcomes and 30-day readmission rates among ischemic and hemorrhagic stroke patients with delirium
Článek Monitoring quality indicators for the Xpert MTB/RIF molecular assay in Ethiopia
Článek Delivering genes across the blood-brain barrier: LY6A, a novel cellular receptor for AAV-PHP.B capsids
Článek Correction: Using remote sensing to detect whale strandings in remote areas: The case of sei whales mass mortality in Chilean Patagonia
Článek Comparison of the inoculum size effects of antibiotics on IMP-6 β-lactamase-producing Enterobacteriaceae co-harboring plasmid-mediated quinolone resistance genes
Článek Contrast-enhanced computed tomography findings of canine primary renal tumors including renal cell carcinoma, lymphoma, and hemangiosarcoma
Článek Non-invasive in vivo imaging of UCP1 expression in live mice via near-infrared fluorescent protein iRFP720
Článek Overexpression of pink1 or parkin in indirect flight muscles promotes mitochondrial proteostasis and extends lifespan in Drosophila melanogaster
Článek Fiber stiffness, pore size and adhesion control migratory phenotype of MDA-MB-231 cells in collagen gels
Článek Comparison of two experimental ARDS models in pigs using electrical impedance tomography
Článek Are primary school children attending full-day school still engaged in sports clubs?
Článek Stroke risks in women with dysmenorrhea by age and stroke subtype
Článek Changes in patterns of mortality rates and years of life lost due to firearms in the United States, 1999 to 2016: A joinpoint analysis
Článek In vitro modeling of Batrachochytrium dendrobatidis infection of the amphibian skin
Článek Development and validation of LC-MS/MS method for imatinib and norimatinib monitoring by finger-prick DBS in gastrointestinal stromal tumor patients
Článek Correction: Habitat disturbance and the organization of bacterial communities in Neotropical hematophagous arthropods
Článek Characterisation of early metazoan secretion through associated signal peptidase complex subunits, prohormone convertases and carboxypeptidases of the marine sponge (Amphimedon queenslandica)
Článek Time trends between 2002 and 2017 in correlates of self-reported sitting time in European adults
Článek Performance of patient acuity rating by rapid response team nurses for predicting short-term prognosis
Článek Changes in HbA1c during the first six years after the diagnosis of Type 2 diabetes mellitus predict long-term microvascular outcomes
Článek Correction: Antimicrobial resistance genotypes and phenotypes of Campylobacter jejuni isolated in Italy from humans, birds from wild and urban habitats, and poultry
Článek Correction: Mental health and quality of life outcomes in family members of patients with chronic critical illness admitted to the intensive care units of two Brazilian hospitals serving the extremes of the socioeconomic spectrum
Článek Correction: Establishing an infrastructure for collaboration in primate cognition research
Článek Correction: The impact of public health insurance on health care utilisation, financial protection and health status in low- and middle-income countries: A systematic review
Článek Health provider and service-user experiences of sensory modulation rooms in an acute inpatient psychiatry setting
Článek Comparison of potential drug-drug interactions with metabolic syndrome medications detected by two databases
Článek The Polish version of the Cultural Intelligence Scale: Assessment of its reliability and validity among healthcare professionals and medical faculty students
Článek Selection of optimal reference genes for qRT-PCR analysis of shoot development and graviresponse in prostrate and erect chrysanthemums
Článek Metastasis risk prediction model in osteosarcoma using metabolic imaging phenotypes: A multivariable radiomics model
Článek Defining hospital community benefit activities using Delphi technique: A comparison between China and the United States
Článek Establishment of the experimental procedure for prediction of conjugation capacity in mutant UGT1A1
Článek A robust multi-objective optimization framework to capture both cellular and intercellular properties in cardiac cellular model tuning: Analyzing different regions of membrane resistance profile in parameter fitting
Článek Sea star wasting disease demography and etiology in the brooding sea star Leptasterias spp.
Článek Diagnostic plasma miRNA-profiles for ovarian cancer in patients with pelvic mass
Článek Genetic diversity and drug resistance of HIV-1 among infected pregnant women newly diagnosed in Luanda, Angola
Článek I’ve been robbed! – Can changes in floral traits discourage bee pollination?
Článek Visualising statistical models using dynamic nomograms
Článek Assessing the capacity of Malawi’s district and central hospitals to manage traumatic diaphyseal femoral fractures in adults
Článek Diagnostic performance of basal cortisol level at 0900-1300h in adrenal insufficiency
Článek The Mastery Rubric for Bioinformatics: A tool to support design and evaluation of career-spanning education and training
Článek Microdissection and whole chromosome painting confirm karyotype transformation in cryptic species of the Lariophagus distinguendus (Förster, 1841) complex (Hymenoptera: Pteromalidae)
Článek Quality of Kangaroo Mother Care services in Ethiopia: Implications for policy and practice
Článek Gemcitabine potentiates the anti-tumour effect of radiation on medullary thyroid cancer
Článek iTRAQ-based high-throughput proteomics analysis reveals alterations of plasma proteins in patients infected with human bocavirus
Článek The detection of a non-anemophilous plant species using airborne eDNA
Článek Perception and control of low cable operation forces in voluntary closing body-powered upper-limb prostheses
Článek Neoadjuvant chemotherapy plus surgery versus concurrent chemoradiotherapy in stage IB2-IIB cervical cancer: A systematic review and meta-analysis
Článek Randomized methods to characterize large-scale vortical flow networks
Článek Disentangling the coexistence strategies of mud-daubing wasp species through trophic analysis in oases of Baja California peninsula
Článek Front-of-pack nutritional labels: Understanding by low- and middle-income Mexican consumers
Článek Distress in patients with end-stage renal disease: Staff perceptions of barriers to the identification of mild-moderate distress and the provision of emotional support
Článek Pathways to antibiotics in Bangladesh: A qualitative study investigating how and when households access medicine including antibiotics for humans or animals when they are ill
Článek DOC export is exceeded by C fixation in May Creek: A late-successional watershed of the Copper River Basin, Alaska
Článek Behavioral observation of prosocial behavior and social initiative is related to preschoolers’ psychopathological symptoms
Článek Evaluating the impact of citations of articles based on knowledge flow patterns hidden in the citations
Článek Correction: Economic sanctions and academia: Overlooked impact and long-term consequences
Článek Correction: A novel association between relaxin receptor polymorphism and hematopoietic stem cell yield after mobilization
Článek Expression of Concern: Cooperativity of Oncogenic K-Ras and Downregulated p16/INK4A in Human Pancreatic Tumorigenesis
Článek Price dispersion of generic medications
Článek Sex differences in body composition but not neuromuscular function following long-term, doxycycline-induced reduction in circulating levels of myostatin in mice
Článek The emotion regulation effect of cognitive control is related to depressive state through the mediation of rumination: An ERP study
Článek Comparison of SMS-EPI and 3D-EPI at 7T in an fMRI localizer study with matched spatiotemporal resolution and homogenized excitation profiles
Článek Left ventricular mass normalization for body size in children based on an allometrically adjusted ratio is as accurate as normalization based on the centile curves method
Článek Correction: Combining biophysical parameters, spectral indices and multivariate hyperspectral models for estimating yield and water productivity of spring wheat across different agronomic practices
Článek Correction: Flowers as viral hot spots: Honey bees (Apis mellifera) unevenly deposit viruses across plant species
Článek 'Small small quarrels bring about happiness or love in the relationships’: Exploring community perceptions and gendered norms contributing to male perpetrated intimate partner violence in the Central Region of Ghana
Článek The performance of practitioners conducting facial comparisons on images of children across age
Článek Increased amounts and stability of telomeric repeat-containing RNA (TERRA) following DNA damage induced by etoposide
Článek Patients with limitation or withdrawal of life supporting care admitted in a medico-surgical intermediate care unit: Prevalence, description and outcome over a six-month period
Článek Correction: Diverse radiofrequency sensitivity and radiofrequency effects of mobile or cordless phone near fields exposure in Drosophila melanogaster
Článek Predicting the performance of TV series through textual and network analysis: The case of Big Bang Theory
Článek Risk of temperature, humidity and concentrations of air pollutants on the hospitalization of AECOPD
Článek Mixed methods grant applications in the health sciences: An analysis of reviewer comments
Článek Renal abnormalities among children with sickle cell conditions in highly resource-limited setting in Ghana
Článek Size matters: How reaching and vergence movements are influenced by the familiar size of stereoscopically presented objects
Článek Willingness to receive institutional and community-based eldercare among the rural elderly in China
Článek An improved deep learning method for predicting DNA-binding proteins based on contextual features in amino acid sequences
Článek Beyond executive functions, creativity skills benefit academic outcomes: Insights from Montessori education
Článek A LAMP assay for the rapid and robust assessment of Wolbachia infection in Aedes aegypti under field and laboratory conditions
Článek Nonarteritic anterior ischemic optic neuropathy is associated with cerebral small vessel disease
Článek Fiber-tract localized diffusion coefficients highlight patterns of white matter disruption induced by proximity to glioma
Článek The fight against polio through the NO-DO newsreels during the Francoism period in Spain
Článek Ocean sound levels in the northeast Pacific recorded from an autonomous underwater glider
Článek Cost-consequence analysis of influenza vaccination among the staff of a large teaching hospital in Rome, Italy: A pilot study
Článek The relationship among the progression of inflammation in umbilical cord, fetal inflammatory response, early-onset neonatal sepsis, and chorioamnionitis
Článek How medical professional students view older people with dementia: Implications for education and practice
Článek An enhanced nonparametric EWMA sign control chart using sequential mechanism
Článek Land use change, carbon stocks and tree species diversity in green spaces of a secondary city in Myanmar, Pyin Oo Lwin
Článek Is there a difference in women’s experiences of care with medication vs. manual vacuum aspiration abortions? Determinants of person-centered care for abortion services
Článek Maternal complications in pregnancy and childbirth for women with epilepsy: Time trends in a nationwide cohort
Článek Adsorption of oxytetracycline on kaolinite
Článek Interdisciplinary stratified care for low back pain: A qualitative study on the acceptability, potential facilitators and barriers to implementation
Článek The role of resource transfer in positive, non-additive litter decomposition
Článek The impact of language on the interpretation of resuscitation clinical care plans by doctors. A mixed methods study
Článek Quantum dots reveal heterogeneous membrane diffusivity and dynamic surface density polarization of dopamine transporter
Článek Genomic analysis of Shiga toxin-producing Escherichia coli from patients and asymptomatic food handlers in Japan
Článek The heavy metals lead and cadmium are cytotoxic to human bone osteoblasts via induction of redox stress
Článek Anatomical, taxonomic, and phylogenetic reappraisal of a poorly known ghost knifefish, Tembeassu marauna (Ostariophysi: Gymnotiformes), using X-ray microcomputed tomography
Článek Matrix-assisted laser desorption/ionization time of flight mass spectrometry identification of Vibrio (Listonella) anguillarum isolated from sea bass and sea bream
Článek Recommendations of older adults on how to use the PROM ‘TOPICS-MDS’ in healthcare conversations: A Delphi study
Článek The winner takes it all—Competitiveness of single nodes in globalized supply networks
Článek Hamsters in the city: A study on the behaviour of a population of common hamsters (Cricetus cricetus) in urban environment
Článek Correction: Liquid biopsies for omics-based analysis in sentinel mussels
Článek Size matters! Association between journal size and longitudinal variability of the Journal Impact Factor
Článek Drug resistance and epidemiology characteristics of multidrug-resistant tuberculosis patients in 17 provinces of China
Článek A model-based framework for chronic hepatitis C prevalence estimation
Článek Adding rewards to regulation: The impacts of watershed conservation on land cover and household wellbeing in Moyobamba, Peru
Článek Clinical determinants of social media use in individuals with schizophrenia
Článek Arsenic and nutrient absorption characteristics and antioxidant response in different leaves of two ryegrass (Lolium perenne) species under arsenic stress
Článek An evolution of socioeconomic related inequality in teenage pregnancy and childbearing in Malawi
Článek A single plasmid based CRISPR interference in Synechocystis 6803 – A proof of concept
Článek Structural vulnerability to narcotics-driven firearm violence: An ethnographic and epidemiological study of Philadelphia’s Puerto Rican inner-city
Článek Temporal trends in intracerebral hemorrhage: Evidence from the Austrian Stroke Unit Registry
Článek Prevalence and risk factors for multi-drug resistant Escherichia coli among poultry workers in the Federal Capital Territory, Abuja, Nigeria
Článek Prediction of disease-related metabolites using bi-random walks
Článek Clinical use, efficacy, and durability of maraviroc for antiretroviral therapy in routine care: A European survey
Článek Biomarker discovery in inflammatory bowel diseases using network-based feature selection
Článek The Cinderella Complex: Word embeddings reveal gender stereotypes in movies and books
Článek Exoproteome profiling of Trypanosoma cruzi during amastigogenesis early stages
Článek Reproducible phenotype alteration due to prolonged cooling of the pupae of Polyommatus icarus butterflies
Článek Nutritional treatment with an immune-modulating enteral formula alleviates 5-fluorouracil-induced adverse effects in rats
Článek Pharmacy-based predictors of non-adherence, non-persistence and reinitiation of antihypertensive drugs among patients on oral diabetes drugs in the Netherlands
Článek Systematic review of the accuracy of plasma preparation tubes for HIV viral load testing
Článek Circadian clock regulates the shape and content of dendritic spines in mouse barrel cortex
Článek “Anybody can make kids; it takes a real man to look after your kids”: Aboriginal men’s discourse on parenting
Článek Correction: A 1D computer model of the arterial circulation in horses: An important resource for studying global interactions between heart and vessels under normal and pathological conditions
Článek Maternal interpregnancy weight change and premature birth: Findings from an English population-based cohort study
Článek Correction: Identifying performance benchmarks and determinants for reproductive performance and calf survival using a longitudinal field study of cow-calf herds in western Canada
Článek Prognostic value of the model for end-stage liver disease excluding INR score (MELD-XI) in patients with adult congenital heart disease
Článek Treatment of Urethral Pain Syndrome (UPS) in Sweden
Článek Migration and political polarization in the U.S.: An analysis of the county-level migration network
Článek Epidemiology and complications of late-onset sepsis: an Italian area-based study
Článek The relationship between women’s experience of intimate partner violence and other socio-demographic factors, and under-5 children’s health in South Africa
Článek Association between trunk and gluteus muscle size and long jump performance
Článek Multimorbidity and complex multimorbidity in Brazilian rural workers
Článek Correction: Interspecific Phylogenic Relationships within Genus Melilotus Based on Nuclear and Chloroplast DNA
Článek Insulin-like growth factor (IGF)-II- mediated fibrosis in pathogenic lung conditions
Článek Wolf diet and prey selection in the South-Eastern Carpathian Mountains, Romania
Článek In vitro activity of aryl-thiazole derivatives against Schistosoma mansoni schistosomula and adult worms
Článek Sample size issues in multilevel logistic regression models
Článek Seed germination ecology of Ageratum houstonianum: A major invasive weed in Nepal
Článek Experiences of lifestyle change among women with gestational diabetes mellitus (GDM): A behavioural diagnosis using the COM-B model in a low-income setting
Článek Pharmacologic management of HCV treatment in patients with HCV monoinfection vs. HIV/HCV coinfection: Does coinfection really matter?
Článek The association between cigarette smoking and serum thyroid stimulating hormone, thyroid peroxidase antibodies and thyroglobulin antibodies levels in Chinese residents: A cross-sectional study in 10 cities
Článek Mouse movement measures enhance the stop-signal task in adult ADHD assessment
Článek Ecosystem functioning in urban grasslands: The role of biodiversity, plant invasions and urbanization
Článek Correction: KETOS: Clinical decision support and machine learning as a service – A training and deployment platform based on Docker, OMOP-CDM, and FHIR Web Services
Článek Does craniofacial morphology affect third molars impaction? Results from a population-based study in northeastern Germany
Článek Hyperconnectivity during screen-based stories listening is associated with lower narrative comprehension in preschool children exposed to screens vs dialogic reading: An EEG study
Článek Weight loss is associated with improved quality of life among rural women completers of a web-based lifestyle intervention
Článek Long-term high-grain diet altered the ruminal pH, fermentation, and composition and functions of the rumen bacterial community, leading to enhanced lactic acid production in Japanese Black beef cattle during fattening
Článek Beyond detoxification: Pleiotropic functions of multiple glutathione S-transferase isoforms protect mice against a toxic electrophile
Článek Golgi reassembly and stacking protein 65 downregulation is required for the anti-cancer effect of dihydromyricetin on human ovarian cancer cells
Článek SSR marker development in Clerodendrum trichotomum using transcriptome sequencing
Článek Risk factors for the carriage of Streptococcus infantarius subspecies infantarius isolated from African fermented dairy products
Článek Development of an intervention tool for precision oral self-care: Personalized and evidence-based practice for patients with periodontal disease
Článek Personal values in adolescence and psychological distress in adults: A cross-sectional study based on a retrospective recall
Článek Overactive bladder and bladder pain syndrome/interstitial cystitis in primary Sjögren’s syndrome patients: A nationwide population-based study
Článek Clinical utility of combined preimplantation genetic testing methods in couples at risk of passing on beta thalassemia/hemoglobin E disease: A retrospective review from a single center
Článek Hip stress distribution - Predictor of dislocation in hip arthroplasties. A retrospective study of 149 arthroplasties
Článek Mortality, morbidity, and cardiac surgery in Injection Drug Use (IDU)-associated versus non-IDU infective endocarditis: The need to expand substance use disorder treatment and harm reduction services
Článek Pup mortality in New Zealand sea lions (Phocarctos hookeri) at Enderby Island, Auckland Islands, 2013-18
Článek In vitro endothelial cell migration from limbal edge-modified Quarter-DMEK grafts
Článek Liquid Chromatography/Mass Spectrometry based serum metabolomics study on recurrent abortion women with antiphospholipid syndrome
Článek Gut carriage of antimicrobial resistance genes among young children in urban Maputo, Mozambique: Associations with enteric pathogen carriage and environmental risk factors
Článek Prepubertal nutrition alters Leydig cell functional capacity and timing of puberty
Článek Reliability of the Swedish version of the Evidence-Based Practice Attitude Scale assessing physiotherapist’s attitudes to implementation of evidence-based practice
Článek Mitochondrial alarmins are tissue mediators of ventilator-induced lung injury and ARDS
Článek Complete Chloroplast Genomes of Vachellia nilotica and Senegalia senegal: Comparative Genomics and Phylogenomic Placement in a New Generic System
Článek Retraction: Over-Expression of Superoxide Dismutase Ameliorates Cr(VI) Induced Adverse Effects via Modulating Cellular Immune System of Drosophila melanogaster
Článek Effect of pre-season training phase on anthropometric, hormonal and fitness parameters in young soccer players
Článek Exosomes from conditioned media of bone marrow-derived mesenchymal stem cells promote bone regeneration by enhancing angiogenesis
Článek Outcome of patients with heart failure after transcatheter aortic valve implantation
Článek Fatty acid profile of Romanian’s common bean (Phaseolus vulgaris L.) lipid fractions and their complexation ability by β-cyclodextrin
Článek Appropriate empirical antibiotic therapy and mortality: Conflicting data explained by residual confounding
Článek Treatment of corneal endothelial damage in a rabbit model with a bioengineered graft using human decellularized corneal lamina and cultured human corneal endothelium
Článek Telbivudine on IgG-associated hypergammaglobulinemia and TGF-β1 hyperactivity in hepatitis B virus-related liver cirrhosis
Článek Correction: Axial variation of deoxyhemoglobin density as a source of the low-frequency time lag structure in blood oxygenation level-dependent signals
Článek Correction: Mobile health-based physical activity intervention for individuals with spinal cord injury in the community: A pilot study
Článek Retraction: Placental expression of CD100, CD72 and CD45 is dysregulated in human miscarriage
Článek Correction: Use of IoT sensing and occupant surveys for determining the resilience of buildings to forest fire generated PM2.5
Článek Correction: The modulation of facial mimicry by attachment tendencies and their underlying affiliation motives in 3-year-olds: An EMG study
Článek Correction: Cognitive impairment in multiple sclerosis: An exploratory analysis of environmental and lifestyle risk factors
Článek Discovering novel disease comorbidities using electronic medical records
Článek Glutathione contributes to efficient post-Golgi trafficking of incoming HPV16 genome
Článek Epidemiology and antimicrobial resistance of methicillin-resistant Staphylococcus aureus isolates colonizing pigs with different exposure to antibiotics
Článek Social information use in adolescents: The impact of adults, peers and household composition
Článek Public practices on antibiotic use: A cross-sectional study among Qatar University students and their family members
Článek Effects of Topper Training on psychosocial problems, self-esteem, and peer victimisation in Dutch children: A randomised trial
Článek Comparative studies of two generations of NanoString nCounter System
Článek General practitioners’ perceptions of delayed antibiotic prescription for respiratory tract infections: A phenomenographic study
Článek Can altered magnetic field affect the foraging behaviour of ants?
Článek Parasitic infections and medical expenses according to Health Insurance Review Assessment claims data in South Korea, 2011–2018
Článek A prospective observational study of on-treatment plasma homocysteine levels as a biomarker of toxicity, depression and vitamin supplementation lead-in time pre pemetrexed, in patients with non-small cell lung cancer and malignant mesothelioma
Článek A strategy to identify protein-N-myristoylation-dependent phosphorylation reactions of cellular proteins by using Phos-tag SDS-PAGE
Článek Expression profile of sonic hedgehog signaling-related molecules in basal cell carcinoma
Článek Seasonal alternation of the ontogenetic development of the moon jellyfish Aurelia coerulea in Maizuru Bay, Japan
Článek Reliability of measurement of active trunk movement in wheelchair basketball players
Článek Chinese SLE Treatment and Research group (CSTAR) registry: Clinical significance of thrombocytopenia in Chinese patients with systemic lupus erythematosus
Článek Does source credibility matter for point-of-decision prompts? A quasi-experimental field study to increase stair use
Článek Male-pattern baldness and incident coronary heart disease and risk factors in the Heinz Nixdorf Recall Study
Článek Quality and utilization patterns of maternity waiting homes at referral facilities in rural Zambia: A mixed-methods multiple case analysis of intervention and standard of care sites
Článek Determining an optimal pool size for testing beef herds for Johne’s disease in Australia
Článek Correction: Change in larval fish assemblage in a USA east coast estuary estimated from twenty-six years of fixed weekly sampling
Článek APOE-knockout in rabbits causes loss of cells in nucleus pulposus and enhances the levels of inflammatory catabolic cytokines damaging the intervertebral disc matrix
Článek Testing Species Assignments in Extant Terebratulide Brachiopods: A Three-dimensional Geometric Morphometric Analysis of Long-Looped Brachidia
Článek A daily diary study on maladaptive daydreaming, mind wandering, and sleep disturbances: Examining within-person and between-persons relations
Článek Improved chemotherapy modeling with RAG-based immune deficient mice
Článek Effect of tracheal antimicrobial peptide on the development of Mannheimia haemolytica pneumonia in cattle
Článek The internal realities of individuals with type 2 diabetes  – a functional framework of self-management practices via Grounded Theory approach
Článek Role of platelet parameters in early detection and prediction of severity of preeclampsia: A comparative cross-sectional study at Ayder comprehensive specialized and Mekelle general hospitals, Mekelle, Tigray, Ethiopia
Článek eIF4E and 4EBP1 are prognostic markers of head and neck squamous cell carcinoma recurrence after definitive surgery and adjuvant radiotherapy
Článek Smoking and other determinants of bone turnover
Článek Oxygen delivery, oxygen consumption and decreased kidney function after cardiopulmonary bypass
Článek School engagement of children in early grades: Psychometric, and gender comparisons
Článek Correction: A review of the elusive bicolored iris Snouted Treefrogs (Anura: Hylidae:Scinax uruguayus group)
Článek Perceived attractiveness of Czech faces across 10 cultures: Associations with sexual shape dimorphism, averageness, fluctuating asymmetry, and eye color
Článek Discovery of stable and prognostic CT-based radiomic features independent of contrast administration and dimensionality in oesophageal cancer
Článek Correction: Population-based dementia prediction model using Korean public health examination data: A cohort study
Článek Location, location, location: Close ties among older continuing care retirement community residents
Článek Correction: ISED: Constructing a high-resolution elevation road dataset from massive, low-quality in-situ observations derived from geosocial fitness tracking data
Článek Correction: Use of validated objective methods of locomotion characteristics and weight distribution for evaluating the efficacy of ketoprofen for alleviating pain in cows with limb pathologies
Článek Monitoring fine root growth to identify optimal fertilization timing in a forest plantation: A case study in Northeast Vietnam
Článek Metabolic costs of spontaneous swimming in Sprattus sprattus L., at different water temperatures
Článek Enterovirus 71 vaccine acceptance among parents of children < 5 years old and their knowledge of hand, foot and mouth disease, Chongqing, China, 2017
Článek Correction: Transcriptome profiling of mouse brain and lung under Dip2a regulation using RNA-sequencing
Článek Genetic diversity and antiretroviral resistance-associated mutation profile of treated and naive HIV-1 infected patients from the Northwest and Southwest regions of Cameroon
Článek Maximum parsimony interpretation of chromatin capture experiments
Článek Multiple innate antibacterial immune defense elements are correlated in diverse ungulate species
Článek Incidence and characteristics of ventricular tachycardia in patients after percutaneous coronary revascularization of chronic total occlusions
Článek Estimating measures of latent variables from m-alternative forced choice responses
Článek Clade F AAVHSCs cross the blood brain barrier and transduce the central nervous system in addition to peripheral tissues following intravenous administration in nonhuman primates
Článek First evidence of hepatitis E virus infection in a small mammal (yellow-necked mouse) from Croatia
Článek Self-reported adverse drug effects and associated factors among H. pylori infected patients on standard triple therapy: Prospective follow up study
Článek Upregulation of ERK phosphorylation in rat dorsal root ganglion neurons contributes to oxaliplatin-induced chronic neuropathic pain
Článek Characterization of the relationship between neutron production and thermal load on a target material in an accelerator-based boron neutron capture therapy system employing a solid-state Li target
Článek Remote heart rate monitoring - Assessment of the Facereader rPPg by Noldus
Článek Seroprevalence of rubella virus antibodies among pregnant women in the Center and South-West regions of Cameroon
Článek Effectiveness of steam sterilization of reusable medical devices in primary and secondary care public hospitals in Nepal and factors associated with ineffective sterilization: A nation-wide cross-sectional study
Článek Relevance of HTLV-1 proviral load in asymptomatic and symptomatic patients living in endemic and non-endemic areas of Argentina
Článek Ritualized aggressive behavior reveals distinct social structures in native and introduced range tawny crazy ants
Článek The value of kinetic glomerular filtration rate estimation on medication dosing in acute kidney injury
Článek Screening and characterization of long noncoding RNAs involved in the albinism of Ananas comosus var. bracteatus leaves
Článek Visual attention to emotional faces in adolescents with social anxiety disorder receiving cognitive behavioral therapy
Článek A Q fever outbreak associated to courier transport of pets
Článek Antibodies against measles and rubella virus among different age groups in Thailand: A population-based serological survey
Článek Molecular diet analysis of Anguilliformes leptocephalus larvae collected in the western North Pacific
Článek Correction: The relationship between context, structure, and processes with outcomes of 6 regional diabetes networks in Europe
Článek Correction: The C-reactive protein/albumin ratio as an independent predictor of mortality in patients with severe sepsis or septic shock treated with early goal-directed therapy
Článek Interleukin 21 (IL-21) regulates chronic allograft vasculopathy (CAV) in murine heart allograft rejection
Článek Semantic computational analysis of anticoagulation use in atrial fibrillation from real world data
Článek The implementation of HTA in medicine pricing and reimbursement policies in Indonesia: Insights from multiple stakeholders
Článek International experiences during United States ophthalmology residency training: Current structure of international experiences and perspectives of faculty mentors at United States training institutions
Článek Questionable utility of digoxin in left-ventricular assist device recipients: A multicenter, retrospective analysis
Článek Genotyping and outcomes of presumptive second line ART failure cases switched to third line or maintained on second line ART in Mumbai, India
Článek A mathematical model of honey bee colony dynamics to predict the effect of pollen on colony failure
Článek Airway microbiome composition correlates with lung function and arterial stiffness in an age-dependent manner
Článek An odorant receptor from Anopheles gambiae that demonstrates enantioselectivity to the plant volatile, linalool
Článek Factors associated with full immunization of children 12–23 months of age in Ethiopia: A multilevel analysis using 2016 Ethiopia Demographic and Health Survey
Článek Factors affecting acceptance of at-birth point of care HIV testing among providers and parents in Kenya: A qualitative study
Článek Removal efficiency of central vacuum system and protective masks to suspended particles from dental treatment
Článek Psychological well-being and distress in patients with generalized anxiety disorder: The roles of positive and negative functioning
Článek Conventional rotator cuff versus all-suture anchors—A biomechanical study focusing on the insertion angle in an unlimited cyclic model
Článek Are viral-infections associated with Ménière’s Disease? A systematic review and meta-analysis of molecular-markers of viral-infection in case-controlled observational studies of MD
Článek An evaluation of genetic causes and environmental risks for bilateral optic atrophy
Článek Comparative vector competence of the Afrotropical soft tick Ornithodoros moubata and Palearctic species, O. erraticus and O. verrucosus, for African swine fever virus strains circulating in Eurasia
Článek Effects of the solubility of yeast cell wall preparations on their potential prebiotic properties in dogs
Článek Carbogen gas-challenge BOLD fMRI in assessment of liver hypoxia after portal microcapsules implantation
Článek Socioeconomic determinants of cancer screening utilisation in Latin America: A systematic review
Článek Development of an easy-to-use questionnaire assessing critical care nursing competence in Japan: A cross-sectional study
Článek Towards successful business process improvement – An extension of change acceleration process model
Článek Correction: Dietary polyphenols as a safe and novel intervention for modulating pain associated with intervertebral disc degeneration in an in-vivo rat model
Článek Correction: Phylogenetic analysis of hepatitis C virus among HIV/ HCV co-infected patients in Nigeria
Článek Correction: Relationship between self-disclosure to first acquaintances and subjective well-being in people with schizophrenia spectrum disorders living in the community
Článek Impact of ATM rs1801516 on late skin reactions of radiotherapy for breast cancer: Evidences from a cohort study and a trial sequential meta-analysis
Článek Involvement of human and canine MRP1 and MRP4 in benzylpenicillin transport
Článek Soil organic matter rather than ectomycorrhizal diversity is related to urban tree health
Článek Clinical risk assessment in early pregnancy for preeclampsia in nulliparous women: A population based cohort study
Článek The relation between circulating levels of vitamin D and parathyroid hormone in children and adolescents with overweight or obesity: Quest for a threshold
Článek Behavioural evidence for segments as subordinate units in Chinese spoken word production: The form-preparation paradigm revisited
Článek Correction: Measuring the impact of an interdisciplinary learning project on nursing, architecture and landscape design students’ empathy
Článek Analysis of the characteristics of chemotherapy-resistant renal cell carcinomas based on global transcriptional analysis of their tissues and cell lines
Článek The characteristics and treatment patterns of patients with Parkinson’s disease in the United States and United Kingdom: A retrospective cohort study
Článek Sex differences in youth elite swimming
Článek Unconventional SCCmec types and low prevalence of the Panton-Valentine Leukocidin exotoxin in South African blood culture Staphylococcus aureus surveillance isolates, 2013-2016
Článek Prosocial perceptions of taxation predict support for taxes
Článek Correction: Clonality analysis of pulmonary tumors by genome-wide copy number profiling
Článek Improved oxygenation following methylprednisolone therapy and survival in paediatric acute respiratory distress syndrome
Článek Normative values for relative schoolbag weight in primary school children aged 6-14 from Czech Republic: A pilot study
Článek Correction: Intensive longitudinal modelling predicts diurnal activity of salivary alpha-amylase
Článek Correction: SNV discovery and functional candidate gene identification for milk composition based on whole genome resequencing of Holstein bulls with extremely high and low breeding values
Článek Monoclonal antibody anti-PBP2a protects mice against MRSA (methicillin-resistant Staphylococcus aureus) infections
Článek Diurnal variations of amplitude of accommodation in different age groups
Článek HHIP overexpression inhibits the proliferation, migration and invasion of non-small cell lung cancer
Článek Correlation analysis of cold-related gene expression with physiological and biochemical indicators under cold stress in oil palm
Článek Student engagement and wellbeing over time at a higher education institution
Článek Gender-based differences in platelet function and platelet reactivity to P2Y12 inhibitors
Článek Influence of season and social context on male giant panda (Ailuropoda melanoleuca) vocal behaviour
Článek Development of an intravaginal ring for the topical delivery of Aurora kinase A inhibitor, MLN8237
Článek Differential phosphorylation determines the repressor and activator potencies of GLI1 proteins and their efficiency in modulating the HPV life cycle
Článek Polymorphisms of FDPS, LRP5, SOST and VKORC1 genes and their relation with osteoporosis in postmenopausal Romanian women
Článek Depression increases the risk of rotator cuff tear and rotator cuff repair surgery: A nationwide population-based study
Článek Interleukin-38 interacts with destrin/actin-depolymerizing factor in human keratinocytes
Článek Correction: Fast, quantitative, murine cardiac 19F MRI/MRS of PFCE-labeled progenitor stem cells and macrophages at 9.4T
Článek Persistent post-discharge opioid prescribing after traumatic brain injury requiring intensive care unit admission: A cross-sectional study with longitudinal outcome
Článek Genome-wide histone modification profiling of inner cell mass and trophectoderm of bovine blastocysts by RAT-ChIP
Článek Aerobic exercise increases post-exercise exogenous protein oxidation in healthy young males
Článek Selection for tandem stop codons in ciliate species with reassigned stop codons
Článek Research ethics in inter- and multi-disciplinary teams: Differences in disciplinary interpretations
Článek Correction: Analyzing data from the digital healthcare exchange platform for surveillance of antibiotic prescriptions in primary care in urban Kenya: A mixed-methods study
Článek Correction: People making deontological judgments in the Trapdoor dilemma are perceived to be more prosocial in economic games than they actually are
Článek LFRET, a novel rapid assay for anti-tissue transglutaminase antibody detection
Článek Effects of isotemporal substitution of sedentary behavior with light-intensity or moderate-to-vigorous physical activity on cardiometabolic markers in male adolescents
Článek Topical estrogen application to wounds promotes delayed cutaneous wound healing in 80-week-old female mice
Článek Correction: An international randomised placebo-controlled trial of a four-component combination pill (“polypill”) in people with raised cardiovascular risk
Článek Correction: Evaluation of lung toxicity risk with computed tomography ventilation image for thoracic cancer patients
Článek Retraction: Pathological Roles of Interleukin-22 in the Development of Recurrent Hepatitis C after Liver Transplantation
Článek Correction: Elevational Distribution and Ecology of Small Mammals on Tanzania's Second Highest Mountain
Článek Correction: Decreased breast cancer-specific mortality risk in patients with a history of thyroid cancer
Článek Correction: Fecal microbiota dysbiosis in macaques and humans within a shared environment
Článek Correction: The center of pressure and ankle muscle co-contraction in response to anterior-posterior perturbations
Článek Indirect violence exposure and mental health symptoms among an urban public-school population: Prevalence and correlates
Článek The inhibitory effects of polypyrrole on the biofilm formation of Streptococcus mutans
Článek Additional evidence that the rat renal interstitium contracts in vivo
Článok vyšiel v časopise

PLOS One

2019 Číslo 11
Najčítanejšie tento týždeň
Najčítanejšie v tomto čísle
Kurzy

Zvýšte si kvalifikáciu online z pohodlia domova

Aktuální možnosti diagnostiky a léčby litiáz
nový kurz
Autori: MUDr. Tomáš Ürge, PhD.
Všetky kurzy
Prihlásenie
Zabudnuté heslo

Zadajte e-mailovú adresu, s ktorou ste vytvárali účet. Budú Vám na ňu zasielané informácie k nastaveniu nového hesla.

Prihlásenie

Nemáte účet?  Registrujte sa

#ADS_BOTTOM_SCRIPTS#