Maternal serum and cord blood leptin concentrations at delivery
Autoři:
Małgorzata Stefaniak aff001; Ewa Dmoch-Gajzlerska aff001; Barbara Mazurkiewicz aff001; Wanda Gajzlerska-Majewska aff002
Působiště autorů:
Department of Obstetrics and Gynecology Didactics, Faculty of Health Sciences, Medical University of Warsaw, Warsaw, Poland
aff001; Department of Obstetrics and Gynecology, First Faculty of Medicine, Medical University of Warsaw, Warsaw, Poland
aff002
Vyšlo v časopise:
PLoS ONE 14(11)
Kategorie:
Research Article
prolekare.web.journal.doi_sk:
https://doi.org/10.1371/journal.pone.0224863
Souhrn
Introduction
Studies have demonstrated leptin involvement in the physiology and pathophysiology of pregnancy and suggest that leptin may be a prognostic marker for some complications of pregnancy although the association remains unclear. To date no studies have reported leptin reference intervals established in normal pregnancy, which could be used for interpreting the differences in leptin levels found in normal and pathological pregnancies.
Objective
To determine leptin concentrations at delivery, in maternal serum in normal pregnancy and in cord blood and to establish reference intervals for leptin.
Material and methods
The study was performed in 194 pregnant women without any comorbid health conditions. Leptin concentrations in maternal serum and in cord blood were measured by ELISA and subsequently analyzed by gestational age (weeks), maternal Body Mass Index (BMI), mode of delivery and infant gender and birth weight. For comparative analyses of normally distributed variables, parametric tests such as the Student–t were used to test the assumption of homogeneity or non-homogeneity of variance and a One-Way ANOVA when more than two groups were compared. The Pearson correlation coefficient was calculated to assess the correlation between normally distributed variables (p<0.05). The reference intervals for leptin were obtained by referring to the central 95% of laboratory test values.
Results
In normal pregnant women, the mean serum leptin concentration at delivery was 37.17 ± 28.07 ng/mL and the established reference interval was 33.19–41.14 ng/mL. The mean leptin concentration in cord blood was 14.78 ± 15.97 ng/mL and the established reference interval was 12.32–17.67 ng/mL. There was a statistically significant positive correlation between maternal serum and cord blood leptin concentrations (r = 0.37; p = 0.00). Mean leptin concentrations in cord blood increased with gestational age (p = 0.00). No statistically significant differences in maternal serum and cord blood leptin concentrations were found in regard to mode of delivery and neonatal gender. A statistically significant correlation was found between maternal serum leptin and third-trimester BMI (r = 0.22; p = 0.00), but there was no association between maternal BMI and cord blood leptin concentration. There was a statistically significant positive correlation between cord blood leptin concentration and birth weight (r = 0.23; p = 0.00).
Conclusions
Reference intervals for leptin in maternal serum and in cord blood established in normal pregnancy could be used in clinical practice for interpreting the differences in leptin concentrations found in normal pregnancy and in complications of pregnancy. The results indicate a strong association between maternal serum leptin levels and obesity and between cord blood leptin levels and birth weight.
Klíčová slova:
leptin – Labor and delivery – Pregnancy – Blood – Birth weight – Obesity – Infants – Pregnancy complications
Zdroje
1. WHO. World Health Organization: The WHO Global InfoBase. Prevalence of overweight & obesity map 2016 [27.04.2019]; Available fromhttp://gamapserver.who.int/mapLibrary/app/searchResults.aspx
2. Stang J, Huffman LG. Position of the Academy of Nutrition and Dietetics: Obesity, Reproduction, and Pregnancy Outcomes. J Acad Nutr Diet. 2016;116(4): 677–691. doi: 10.1016/j.jand.2016.01.008 27017177
3. Misra VK, Trudeau S. The influence of overweight and obesity on longitudinal trends in maternal serum leptin levels during pregnancy. Obesity. 2011;19(2): 416–421. doi: 10.1038/oby.2010.172 20725059
4. Pérez-Pérez A, Toro A, Vilariño-García T, Maymó J, Guadix P, Dueñas JL, et al. Leptin action in normal and pathological pregnancies. J Cell Mol Med. 2018;22(2): 716–727. doi: 10.1111/jcmm.13369 29160594
5. Weiss JL, Malone FD, Emig D, Ball RH, Nyberg DA, Comstock CH, et al. FASTER Research Consortium, obesity, obstetric complications and cesarean delivery rate–a population-based screening study. Am J Obstet Gynecol. 2004;190: 1091–1097. doi: 10.1016/j.ajog.2003.09.058 15118648
6. Cedergren MI. Maternal morbid obesity and the risk of adverse pregnancy outcome. Obstet Gynecol. 2004;103: 219–224. doi: 10.1097/01.AOG.0000107291.46159.00 14754687
7. Arendas K, Qiu Q, Gruslin A. Obesity in pregnancy: pre-conceptional to postpartum consequences. J Obstet Gynaecol Can. 2008;30: 477–488. doi: 10.1016/S1701-2163(16)32863-8 18611299
8. Gardosi J. Intrauterine growth restriction: new standards for assessing adverse outcome. Best Pract Res Clin Obstet Gynaecol. 2009;23: 741–749. doi: 10.1016/j.bpobgyn.2009.09.001 19854681
9. Gluckman PD, Hanson MA, Cooper C, Thornburg KL. Effect of in utero and early-life conditions on adult health and disease. N Engl J Med. 2008;359: 61–73. doi: 10.1056/NEJMra0708473 18596274
10. Briffa JF, McAinch AJ, Romano T, Wlodek ME, Hryciw DH. Leptin in pregnancy and development: a contributor to adulthood disease? Am J Physiol Endocrinol Metab. 2015;1:308(5): E335–50. doi: 10.1152/ajpendo.00312.2014 25516549
11. Hardiel L, Trayhurn P, Abramovich D, Fowler P. Circulating leptin in women: a longitudinal study in the menstrual cycle and during pregnancy. Clin Endocrinol. 1997;47: 101–106.
12. Al-Atawi FS, Addar MH, Warsy AS, Babay ZA. Leptin concentration during different trimesters of pregnancy and its relation to other pregnancy hormones. Saudi Med J. 2004;25(11): 1617–1622. 15573188
13. Tamura T, Goldenberg RL, Johnston KE, Cliver SP. Serum leptin concentrations during pregnancy and their relationship to fetal growth. Obstet Gynecol. 1998;91(3): 389–395. doi: 10.1016/s0029-7844(97)00670-4 9491866
14. Lepercq J, Challier JC, Guerre-Millo M, Cauzac M, Vidal H, Hauguel-de Mouzon S. Prenatal leptin production: evidence that fetaladipose tissue produces leptin. J Clin Endocrinol Metab. 2001;86: 2409–2413. doi: 10.1210/jcem.86.6.7529 11397832
15. Franco-Sena AB, de Oliveira LC, de Jesus Pereira Pinto T, Farias DR, Vaz Jdos S, Kac G. Factors associated with prospective leptin concentrations throughout pregnancy in pregestational normal weight, overweight and obese women. Clin Endocrinol (Oxf). 2015;82(1): 127–135.
16. Tessier DR, Ferraro ZM, Gruslin A. Role of leptin in pregnancy: consequences of maternal obesity. Placenta. 2013;34(3): 205–211. doi: 10.1016/j.placenta.2012.11.035 23332215
17. Horovitz GL, Altaie S, Boyd JC, Ceriott F, Garg U, Horn P, et al.: Defining, Establishing and Verifying Reference Intervals in the Clinical Laboratory; Approvied Guideline-Third Edition. Clinical and Laboratory Standard Institute. 2010;(28): 30.
18. Schubring C, Englaro P, Siebler T, Blum WF, Demirakca T, Kratzsch J, et al.: Longitudinal analysis of maternal serum leptin levels during pregnancy, at birth and up to six weeks after birth: relation to body mass index, skinfolds, sex steroids and umbilical cord blood leptin levels. Horm Res. 1998;50(5): 276–283. doi: 10.1159/000023290 9873196
19. Ishrat S, Rahman M, Rahman M, Hussain M, Jahan S. Leptin Concentrations in Maternal and Umbilical Cord Blood in Relation to Maternal Weight, Birth Weight and Weight of the Placenta. Bangladesh J Obstet Gynaecol. 2008;23(1): 3–7.
20. Carlhäll S, Källén K, Thorsell A, Blomberg M. Maternal plasma leptin levels in relation to the duration of the active phase of labor. Acta Obstet Gynecol Scand. 2018;97: 1248‐1256. doi: 10.1111/aogs.13380 29772056
21. Weyermann M, Beermann Ch, Brenner H, Rothenbacher D. Adiponectin and leptin in maternal serum, cord blood, and breast milk. Clin Chem. 2006;52(11): 2095–2102. doi: 10.1373/clinchem.2006.071019 16990422
22. Laml T, Hartmann BW, Ruecklinger E, Preyer O, Soeregi G, Wagenbichler P. Maternal serum leptin concentrations do not correlate with cord blood leptin concentrations in normal pregnancy. J Soc Gynecol Investig. 2001;8(1): 43–47. 11223357
23. Marino-Ortega LA, Molina-Bello A, Polanco-García JC, Muñoz-Valle JF, Salgado-Bernabé AB, Guzmán-Guzmán IP, et al. Correlation of leptin and soluble leptin receptor levels with anthropometric parameters in mother-newborn pairs. Int J Clin Exp Med. 2015;15:8(7): 11260–11267. 26379933
24. Yoshimitsu N, Douchi T, Kamio M, Nagata Y. Differences in umbilical venous and arterial leptin levels by mode of delivery. Obstet Gynecol. 2000;96(3): 342–345. doi: 10.1016/s0029-7844(00)00927-3 10960623
25. Logan CA, Thiel L, Bornemann R, Koenig W, Reister F, Brenner H, et al. Delivery mode, duration of labor, and cord blood adiponectin, leptin, and c-reactive protein: results of the population-based ulm birth cohort studies. PLoS ONE. 2016;11(2): e0149918. doi: 10.1371/journal.pone.0149918 26900695
26. Mellati AA, Mazloomzadeh S, Anjomshoaa A, Alipour M, Karimi F, Mazloomi S, et al. Multiple correlations between cord blood leptin concentration and indices of neonatal growth. Arch Med Res. 2010;41(1): 26–32. doi: 10.1016/j.arcmed.2009.12.001 20430251
27. Tamura T, Goldenberg RL, Johnston KE, Cliver SP. Serum leptin concentrations during pregnancy and their relationship to fetal growth. Obstet Gynecol. 1998;91(3): 389–395. doi: 10.1016/s0029-7844(97)00670-4 9491866
28. Butte NF, Hopkinson JM, Nicolson MA. Leptin in human reproduction: serum leptin levels in pregnant and lactating women. J Clin Endocrinol Metab. 1997;82: 1480–1483. doi: 10.1210/jcem.82.5.3935 9141537
29. Schubring C, Kiess W, Englaro P, Rascher W, Dötsch J, Hanitsch S, et al. Levels of leptin in maternal serum, amniotic fluid and arterial and venous cord blood: relation to neonatal and placental weight. J Clin End Metab. 1997;82: 480–483.
30. Catov JM, Patrick TE, Powers RW, Ness RB, Harger G, Roberts JM. Maternal leptin across pregnancy in women with small-for-gestational-age infants. Am J Obstet Gynecol. 2007;196(6): 558.e1–8.
31. Mantzoros CS, Rifas-Shiman SL, Williams CJ, Fargnoli JL, Kelesidis T, Gillman MW. Cord blood leptin and adiponectin as predictors of adiposity in children at 3 years of age: a prospective cohort study. Pediatrics. 2009;123: 682–689. doi: 10.1542/peds.2008-0343 19171638
32. Su PH, Wang SL, Chen JY, Lai CP, Jian SH. Serum leptin levels in preterm, healthy and sick-term newborns. Acta Paediatr Taiwan. 2002;43(5): 249–254. 12607479
33. Garanty-Bogacka B, Czeszyńska MB, Syrenicz M. Immaturity or hypotrophy? The cord blood leptin levels in preterm and small for gestational age neonates. Gin Pol. 2003;74: 356–361.
34. Po-Jung Tsai, Chun-Hsien Yu, Shih-Penn Hsu. Cord plasma concentrations of adiponectin and leptin in healthy term neonates: positive correlation with birthweight and neonatal adiposity. Clin Endocrinol (Oxf). 2004;61(1): 88–93.
35. Valūniene M, Verkauskiene R, Boguszewski M, Dahlgren J, Lasiene D, Lasas L, et al. Leptin levels at birth and in early postnatal life in small- and appropriate-for-gestational-age infants. Medicina (Kaunas). 2007;43(10): 784–791.
36. Shroff MR, Holzman C, Tian Y, Evans RW, Sikorskii A. Mid-pregnancy maternal leptin levels, birthweight for gestational age and preterm delivery. Clin Endocrinol (Oxf). 2013;78(4): 607–613.
37. Nuamah MA, Yura S, Sagawa N, Itoh H, Mise H, Korita D, et al. Significant increase in maternal plasma leptin concentration in induced delivery: a possible contribution of pro-inflammatory cytokines to placental leptin secretion. Endocr J. 2004;51(2): 177–187. doi: 10.1507/endocrj.51.177 15118268
Článok vyšiel v časopise
PLOS One
2019 Číslo 11
- Metamizol jako analgetikum první volby: kdy, pro koho, jak a proč?
- Nejasný stín na plicích – kazuistika
- Masturbační chování žen v ČR − dotazníková studie
- Úspěšná resuscitativní thorakotomie v přednemocniční neodkladné péči
- Dlouhodobá recidiva a komplikace spojené s elektivní operací břišní kýly
Najčítanejšie v tomto čísle
- A daily diary study on maladaptive daydreaming, mind wandering, and sleep disturbances: Examining within-person and between-persons relations
- A 3’ UTR SNP rs885863, a cis-eQTL for the circadian gene VIPR2 and lincRNA 689, is associated with opioid addiction
- A substitution mutation in a conserved domain of mammalian acetate-dependent acetyl CoA synthetase 2 results in destabilized protein and impaired HIF-2 signaling
- Molecular validation of clinical Pantoea isolates identified by MALDI-TOF