Chronic bronchitis without airflow obstruction, asthma and rhinitis are differently associated with cardiovascular risk factors and diseases

English version

Autoři: Marcello Ferrari ^aff001; Elia Piccinno ^aff001; Alessandro Marcon ^aff002; Pierpaolo Marchetti ^aff002; Lucia Cazzoletti ^aff002; Pietro Pirina ^aff003; Salvatore Battaglia ^aff004; Amelia Grosso ^aff005; Giulia Squillacioti ^aff006; Leonardo Antonicelli ^aff007; Giuseppe Verlato ^aff002; Giancarlo Pesce ^aff008
Působiště autorů: Department of Medicine, Unit of Respiratory Medicine, University of Verona, Verona, Italy ^aff001; Unit of Epidemiology and Medical Statistics, Department of Diagnostics and Public Health, University of Verona, Verona, Italy ^aff002; Unità Operativa di Pneumologia, Dipartimento di Scienze Mediche, Chirurgiche e Sperimentali, Università degli Studi di Sassari, Sassari, Italy ^aff003; Dipartimento Universitario di Promozione della Salute, Materno Infantile, Medicina Interna e Specialistica di Eccellenza "G. D'Alessandro"(PROMISE), Università di Palermo, Palermo, Italy ^aff004; Division of Respiratory Diseases, IRCCS “San Matteo” Hospital Foundation, University of Pavia, Pavia, Italy ^aff005; Department of Public Health and Pediatrics, University of Turin, Turin, Italy ^aff006; Allergy Unit, Department of Internal Medicine, Azienda Ospedaliero-Universitaria Ospedali Riuniti, Ancona, Italy ^aff007; Epidemiology of Allergic and Respiratory Diseases Department (EPAR), Institut Pierre Louis d’Épidémiologie et de Santé Publique (IPLESP), Sorbonne Université, INSERM UMR-S 1136, Paris, France ^aff008
Vyšlo v časopise: PLoS ONE 14(11)
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.pone.0224999

Souhrn

Background and objectives

Cardiovascular and respiratory diseases can frequently coexist. Understanding their link may improve disease management. We aimed at assessing the associations of chronic bronchitis (CB), asthma and rhinitis with cardiovascular diseases and risk factors in the general population.

Methods

We used data collected in the Gene Environment Interactions in Respiratory Diseases study, an Italian multicentre, multicase-control study. Among 2463 participants (age 21–86, female 50%) who underwent standardized interviews, skin prick and lung function tests, we identified 254 cases of CB without airflow obstruction, 418 cases of asthma without CB, 959 cases of rhinitis alone, and 832 controls. The associations of respiratory diseases with reported cardiovascular risk factors (lifestyles, hypertension, dyslipidaemia), heart disorders (myocardial infarction, coronary thrombosis, angina, aorta or heart surgery) and intermittent claudication were estimated through relative risk ratios (RRR) by multinomial logistic regression models.

Results

Compared to controls, CB cases were more likely to be heavy smokers, alcohol consumers, physically inactive, and to suffer from hypertension or dyslipidaemia; rhinitis cases were less obese but more likely to have hypertension. Asthma was significantly associated with current smoking. After adjusting for cardiovascular risk factors, heart disorders were associated with CB (RRR[95%CI]: 1.58[1.12–2.22]) and rhinitis (1.35[0.98–1.85]) and intermittent claudication was associated with CB (3.43[2.52–4.67]), asthma (1.51[1.04–2.21]) and rhinitis (2.03[1.34–3.07]).

Conclusions

CB, asthma and rhinitis were associated with cardiovascular risk factors and diseases. In particular, CB shared with cardiovascular diseases almost all risk factors and was strongly associated with a higher risk of heart disorders and intermittent claudication.

Klíčová slova:

Alcohol consumption – Rhinitis – Hypertension – Medical risk factors – Cardiovascular diseases – Bronchitis – Asthma

Zdroje

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