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preLekára.sk / Odborné časopisy / PLOS One / 2019 - 11

How to design a dose-finding study on combined agents: Choice of design and development of R functions

English version

Autoři: Monia Ezzalfani aff001
Působiště autorů: Institut Curie, PSL Research University, Biometry Unit, Paris, France aff001
Vyšlo v časopise: PLoS ONE 14(11)
Kategorie: Research Article
prolekare.web.journal.doi_sk: https://doi.org/10.1371/journal.pone.0224940

Souhrn

Background

In oncology, the aim of dose-finding phase I studies is to find the maximum tolerated dose for further studies. The use of combinations of two or more agents is increasing. Several dose-finding designs have been proposed for this situation. Numerous publications have however pointed out the complexity of evaluating therapies in combination due to difficulties in choosing between different designs for an actual trial, as well as complications related to their implementation and application in practice.

Methods

In this work, we propose R functions for Wang and Ivanova’s approach. These functions compute the dose for the next patients enrolled and provide a simulation study in order to calibrate the design before it is applied and to assess the performance of the design in different scenarios of dose-toxicity relationships. This choice of the method was supported by a simulation study which the aim was to compare two designs in the context of an actual phase I trial: i) in 2005, Wang and Ivanova developed an empirical three-parameter model-based method in Bayesian inference, ii) in 2008, Yuan and Yin proposed a simple, adaptive two-dimensional dose-finding design. In particular, they converted the two-dimensional dose-finding trial to a series of one-dimensional dose-finding sub-trials by setting the dose of one drug at a fixed level. The performance assessment of Wang’s design was then compared with those of designs presented in the paper by Hirakawa et al. (2015) in their simulation context.

Results and conclusion

It is recommended to assess the performances of the designs in the context of the clinical trial before beginning the trial. The two-dimensional dose-finding design proposed by Wang and Ivanova is a comprehensive approach that yields good performances. The two R functions that we propose can facilitate the use of this design in practice.

Klíčová slova:

Simulation and modeling – Algorithms – Probability distribution – Toxic agents – Toxicity – Agent-based modeling – Probability density – Phase I clinical investigation

Zdroje

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2. Wang K. and Ivanova A. Two-dimensional dose finding in discrete dose space. Biometrics. 2005 Mar; 61 (1):217–222. doi: 10.1111/j.0006-341X.2005.030540.x 15737096

3. Yuan Y. and Yin G. Sequential continual reassessment method for two-dimensional dose finding. Stat Med. 2008 Nov; 27 (27):5664–5678. doi: 10.1002/sim.3372 18618901

4. Ivanova A. and Wang K. A non-parametric approach to the design and analysis of two-dimensional dose-finding trials. Stat Med. 2004 Jun; 23 (12):1861–1870. doi: 10.1002/sim.1796 15195320

5. Mandrekar S. J. and Cui Y. and Sargent D. J. An adaptive phase I design for identifying a biologically optimal dose for dual agent drug combinations. Stat Med. 2007 May; 26 (11):2317–2330. doi: 10.1002/sim.2707 17016867

6. Mandrekar S. J. and Qin R. and Sargent D. J. Model-based phase I designs incorporating toxicity and efficacy for single and dual agent drug combinations: methods and challenges. Stat Med. 2010 May; 29(10):1077–1083. doi: 10.1002/sim.3706 20419760

7. Wages N. A. and Conaway M. R. and O’Quigley J. Continual reassessment method for partial ordering. Biometrics. 2011 Dec; 67(4):1555–1563. doi: 10.1111/j.1541-0420.2011.01560.x 21361888

8. Riviere M-K and Dubois F and Zohar S. Competing designs for drug combination in phase I dose-finding clinical trials. Statistics in medicine. 2015; 34(1):1–12. doi: 10.1002/sim.6094 24464821

9. Ivanova A. and Kim S. H. Dose finding for continuous and ordinal outcomes with a monotone objective function: a unified approach. Biometrics. 2009 Mar; 65(1):307–315. doi: 10.1111/j.1541-0420.2008.01045.x 18479486

10. Yin Guosheng and Yuan Ying. Bayesian dose finding in oncology for drug combinations by copula regression. Journal of the Royal Statistical Society: Series C (Applied Statistics). 2009; 58(2):211–224. doi: 10.1111/j.1467-9876.2009.00649.x

11. Iasonos A. and Wilton A. S. and Riedel E. R. and Seshan V. E. and Spriggs D. R. A comprehensive comparison of the continual reassessment method to the standard 3 + 3 dose escalation scheme in Phase I dose-finding studies. Clin Trials. 2008; 5(5):465–477. doi: 10.1177/1740774508096474 18827039

12. Hirakawa A. and Wages N. A. and Sato H. and Matsui S. A comparative study of adaptive dose-finding designs for phase I oncology trials of combination therapies. Stat Med. 2015 Oct; 34(24):3194–3213. doi: 10.1002/sim.6533 25974405

13. Braun Thomas M and Wang Shufang. A hierarchical Bayesian design for phase I trials of novel combinations of cancer therapeutic agents. Biometrics. 2010; 66(3):805–812. doi: 10.1111/j.1541-0420.2009.01363.x 19995354

14. Hirakawa A. and Hamada C. and Matsui S. A dose-finding approach based on shrunken predictive probability for combinations of two agents in phase I trials. Stat Med. 2013 Nov; 32(26):4515–4525. doi: 10.1002/sim.5843 23650098

15. Wages N. A. and Conaway M. R. and O’Quigley J. Dose-finding design for multi-drug combinations”, Clin Trials. 2011 Aug; 8(4):380–389. doi: 10.1177/1740774511408748 21652689

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17. Riviere M. K. and Yuan Y. and Dubois F. and Zohar S. A Bayesian dose-finding design for drug combination clinical trials based on the logistic model. Pharm Stat. 2014; 13(4):247–257. doi: 10.1002/pst.1621 24828456

18. Yin G. and Lin R. Comments on Competing designs for drug combination in phase I dose‐finding clinical trials by M‐K. Riviere, F. Dubois, and S. Zohar. Stat Med. 2015 Jan; 34(1):13–17. doi: 10.1002/sim.6338 25492615

19. Hirakawa A. and Sato H. Authors’ Reply”. Stat Med. 2016 Feb; 35(3):479–480. doi: 10.1002/sim.6751 26757958

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Článek Synergistic immuno-modulatory activity in human macrophages of a medicinal mushroom formulation consisting of Reishi, Shiitake and Maitake
Článek Protein synthesis rates of muscle, tendon, ligament, cartilage, and bone tissue in vivo in humans
Článek “What gets measured better gets done better”: The landscape of validation of global maternal and newborn health indicators through key informant interviews
Článek Contactless monitoring of heart and respiratory rate in anesthetized pigs using infrared thermography
Článek Molecular characterisation of genital human papillomavirus among women in Southwestern, Nigeria
Článek Impact of negative tuberculin skin test on growth among disadvantaged Bangladeshi children
Článek Streptococcal phosphotransferase system imports unsaturated hyaluronan disaccharide derived from host extracellular matrices
Článek The clot thickens: Autologous and allogeneic fibrin sealants are mechanically equivalent in an ex vivo model of cartilage repair
Článek Variation in hybridogenetic hybrid emergence between populations of water frogs from the Pelophylax esculentus complex
Článek Breast cancer in Tanzanian, black American, and white American women: An assessment of prognostic and predictive features, including tumor infiltrating lymphocytes
Článek A global overview of cassava genetic diversity
Článek Whole body periodic acceleration in normal and reduced mucociliary clearance of conscious sheep
Článek Minimal effects of oyster aquaculture on local water quality: Examples from southern Chesapeake Bay
Článek High salinity tolerance of invasive blue catfish suggests potential for further range expansion in the Chesapeake Bay region
Článek From waste to food: Optimising the breakdown of oil palm waste to provide substrate for insects farmed as animal feed
Článek Quantitative assessment of interstitial lung disease in Sjögren’s syndrome
Článek Reference ranges for ultrasonographic renal dimensions as functions of age and body indices: A retrospective observational study in Taiwan
Článek Finding phrases: On the role of co-verbal facial information in learning word order in infancy
Článek Effects of forest management and roe deer impact on a mountain forest development in the Italian Apennines: A modelling approach using LANDIS-II
Článek Effect of caffeine on neuromuscular function following eccentric-based exercise
Článek The household economic costs associated with depression symptoms: A cross-sectional household study conducted in the North West province of South Africa
Článek Increased cell size, structural complexity and migration of cancer cells acquiring fibroblast organelles by cell-projection pumping
Článek Acute low- compared to high-load resistance training to failure results in greater energy expenditure during exercise in healthy young men
Článek Impact of body mass index and metabolically unhealthy status on mortality in the Japanese general population: The JMS cohort study
Článek Ecohydrology of urban trees under passive and active irrigation in a semiarid city
Článek Nonsteroidal anti-inflammatory drugs and acetaminophen ameliorate muscular mechanical hyperalgesia developed after lengthening contractions via cyclooxygenase-2 independent mechanisms in rats
Článek A popular Indian clove-based mosquito repellent is less effective against Culex quinquefasciatus and Aedes aegypti than DEET
Článek Yeasts affect tolerance of Drosophila melanogaster to food substrate with high NaCl concentration
Článek The effect of climate change on cholera disease: The road ahead using artificial neural network
Článek Micro-dislodgement during transcatheter aortic valve implantation with a contemporary self-expandable prosthesis
Článek Inflammatory cell infiltrates, hypoxia, vascularization, pentraxin 3 and osteoprotegerin in abdominal aortic aneurysms – A quantitative histological study
Článek Effects of virtual reality rehabilitation training on gait and balance in patients with Parkinson's disease: A systematic review
Článek Serum miR-33a is associated with steatosis and inflammation in patients with non-alcoholic fatty liver disease after liver transplantation
Článek Evaluation of upper limb superficial venous percussion as a sign of anatomical location and venous permeability. A comparative study of superficial venous percussion to ultrasound findings on non-renal patients and on chronic kidney disease patients
Článek An assessment of the Dutch experience with health insurers acting as healthcare advisors
Článek Perception of potential harm and benefits of HIV vaccine trial participation: A qualitative study from urban Tanzania
Článek Deep brain stimulation restores the glutamatergic and GABAergic synaptic transmission and plasticity to normal levels in kindled rats
Článek Metformin strongly affects transcriptome of peripheral blood cells in healthy individuals
Článek Histochemical quantification of collagen content in articular cartilage
Článek Prevalence and correlates of low serum calcium in late pregnancy: A cross sectional study in the Nkongsamba Regional Hospital; Littoral Region of Cameroon
Článek Home-cage monitoring ascertains signatures of ictal and interictal behavior in mouse models of generalized seizures
Článek Proton pump inhibitor use increases the risk of peritonitis in peritoneal dialysis patients
Článek Comparative distribution of extended-spectrum beta-lactamase–producing Escherichia coli from urine infections and environmental waters
Článek Sex differences in thigh muscle volumes, sprint performance and mechanical properties in national-level sprinters
Článek Maternal serum and cord blood leptin concentrations at delivery
Článek Winter nitrification in ice-covered lakes
Článek Monitoring exercise-induced muscle damage indicators and myoelectric activity during two weeks of knee extensor exercise training in young and old men
Článek Can adoption of pollution prevention techniques reduce pollution substitution?
Článek The association between self-efficacy and self-management behaviors among Chinese patients with type 2 diabetes
Článek Poly-arginine-18 peptides do not exacerbate bleeding, or improve functional outcomes following collagenase-induced intracerebral hemorrhage in the rat
Článek Maternal stress in Shank3ex4-9 mice increases pup-directed care and alters brain white matter in male offspring
Článek Long non-coding RNAs and latent HIV – A search for novel targets for latency reversal
Článek Clinical characteristics of neonatal fulminant necrotizing enterocolitis in a tertiary Children's hospital in the last 10 years
Článek Vasopressin SNP pain factors and stress in sickle cell disease
Článek Microbial metabolisms in an abyssal ferromanganese crust from the Takuyo-Daigo Seamount as revealed by metagenomics
Článek Incidence of chronic kidney disease hospitalisations and mortality in Espírito Santo between 1996 to 2017
Článek Blood metal levels and serum testosterone concentrations in male and female children and adolescents: NHANES 2011–2012
Článek Diversity, distribution and dynamics of large trees across an old-growth lowland tropical rain forest landscape
Článek Vaginal ring acceptability and related preferences among women in low- and middle-income countries: A systematic review and narrative synthesis
Článek UM171 induces a homeostatic inflammatory-detoxification response supporting human HSC self-renewal
Článek Positive selection and precipitation effects on the mitochondrial NADH dehydrogenase subunit 6 gene in brown hares (Lepus europaeus) under a phylogeographic perspective
Článek Evaluation of Minimum Inhibitory Concentrations for 154 Mycoplasma synoviae isolates from Italy collected during 2012-2017
Článek Enhancement of antibiotics antimicrobial activity due to the silver nanoparticles impact on the cell membrane
Článek Correction: Smoking, alcohol use disorder and tuberculosis treatment outcomes: A dual co-morbidity burden that cannot be ignored
Článek Correction: Effect of corruption on perceived difficulties in healthcare access in sub-Saharan Africa
Článek Pig farmers’ willingness to pay for management strategies to reduce aggression between pigs
Článek Metabolomic response of Euglena gracilis and its bleached mutant strain to light
Článek Grain filling of early-season rice cultivars grown under mechanical transplanting
Článek Correlative evidence for co-regulation of phosphorus and carbon exchanges with symbiotic fungus in the arbuscular mycorrhizal Medicago truncatula
Článek Trunk velocity-dependent Light Touch reduces postural sway during standing
Článek Evaluation of cytological diagnostic accuracy for canine splenic neoplasms: An investigation in 78 cases using STARD guidelines
Článek Assessment of energy expenditure during high intensity cycling and running using a heart rate and activity monitor in young active adults
Článek Evaluating rectal swab collection method for gut microbiome analysis in the common marmoset (Callithrix jacchus)
Článek The calcium sensor OsCBL1 modulates nitrate signaling to regulate seedling growth in rice
Článek Contingent negative variation during a modified cueing task in simulated driving
Článek Interaction between apolipoprotein E genotype and hypertension on cognitive function in older women in the Nurses’ Health Study
Článek Correction: Resistance profile of the HIV-1 maturation inhibitor GSK3532795 in vitro and in a clinical study
Článek Retrospective comparative analysis of intraocular lens calculation formulas after hyperopic refractive surgery
Článek Development and validation of exhaled breath condensate microRNAs to identify and endotype asthma in children
Článek Arthroscopic release for frozen shoulder: Does the timing of intervention and diabetes affect outcome?
Článek Risk factors affecting dairy cattle protective grouping behavior, commonly known as bunching, against Stomoxys calcitrans (L.) on California dairies
Článek Characterisation and microbial community analysis of lipid utilising microorganisms for biogas formation
Článek Artificial insemination with fresh, liquid stored and frozen thawed semen in dromedary camels
Článek Numerical study on the start and unstart phenomena in a scramjet inlet-isolator model
Článek Urban growth simulation in different scenarios using the SLEUTH model: A case study of Hefei, East China
Článek Chronic bronchitis without airflow obstruction, asthma and rhinitis are differently associated with cardiovascular risk factors and diseases
Článek The impact of leisure activities on older adults’ cognitive function, physical function, and mental health
Článek Association of serum leptin and adiponectin concentrations with echocardiographic parameters and pathophysiological states in patients with cardiovascular disease receiving cardiovascular surgery
Článek Synthesis, purification and crystallization of a putative critical bulge of HAR1 RNA
Článek Obesity is associated with an impaired survival in lymphoma patients undergoing autologous stem cell transplantation
Článek A new early Eocene deperetellid tapiroid illuminates the origin of Deperetellidae and the pattern of premolar molarization in Perissodactyla
Článek Longevity and marginal bone loss of narrow-diameter implants supporting single crowns: A systematic review
Článek Impact of UVC-sustained recirculating air filtration on airborne bacteria and dust in a pig facility
Článek Determinants of preterm birth among mothers who gave birth at public hospitals in the Amhara region, Ethiopia: A case-control study
Článek Unique transcriptomic landscapes identified in idiopathic spontaneous and infection related preterm births compared to normal term births
Článek Autophagy deficiency exacerbates colitis through excessive oxidative stress and MAPK signaling pathway activation
Článek The impacts of parity on lung function data (LFD) of healthy females aged 40 years and more issued from an upper middle income country (Algeria): A comparative study
Článek HIV prevalence and correlated factors among male clients of female sex workers in a border region of China
Článek Comparison of the fecal, cecal, and mucus microbiome in male and female mice after TNBS-induced colitis
Článek Complex alternative splicing of human Endonuclease V mRNA, but evidence for only a single protein isoform
Článek Correction: KML001 Induces Apoptosis and Autophagic Cell Death in Prostate Cancer Cells via Oxidative Stress Pathway
Článek Inactive USP14 and inactive UCHL5 cause accumulation of distinct ubiquitinated proteins in mammalian cells
Článek Correction: Comparison of the molecular properties of retinitis pigmentosa P23H and N15S amino acid replacements in rhodopsin
Článek Retraction: Regulation of gastric smooth muscle contraction via Ca2+-dependent and Ca2+-independent actin polymerization
Článek Correction: Good and Bad in the Hands of Politicians: Spontaneous Gestures during Positive and Negative Speech
Článek Correction: Long-term clinical outcomes in a cohort of patients with solitary plasmacytoma treated in the modern era
Článek Correction: Using remote sensing to detect whale strandings in remote areas: The case of sei whales mass mortality in Chilean Patagonia
Článek Correction: Habitat disturbance and the organization of bacterial communities in Neotropical hematophagous arthropods
Článek Correction: Antimicrobial resistance genotypes and phenotypes of Campylobacter jejuni isolated in Italy from humans, birds from wild and urban habitats, and poultry
Článek Correction: Establishing an infrastructure for collaboration in primate cognition research
Článek Correction: The impact of public health insurance on health care utilisation, financial protection and health status in low- and middle-income countries: A systematic review
Článek Correction: A novel association between relaxin receptor polymorphism and hematopoietic stem cell yield after mobilization
Článek Expression of Concern: Cooperativity of Oncogenic K-Ras and Downregulated p16/INK4A in Human Pancreatic Tumorigenesis
Článek Non-communicable diseases risk factors and their determinants: A cross-sectional state-wide STEPS survey, Haryana, North India
Článek Genotype-matched Newcastle disease virus vaccine confers improved protection against genotype XII challenge: The importance of cytoplasmic tails in viral replication and vaccine design
Článek Genetic and genomic analyses underpin the feasibility of concomitant genetic improvement of milk yield and mastitis resistance in dairy sheep
Článek Long-term exposure to daily ethanol injections in DBA/2J and Swiss mice: Lessons for the interpretation of ethanol sensitization
Článek Taxonomic and functional anuran beta diversity of a subtropical metacommunity respond differentially to environmental and spatial predictors
Článek A simple way to improve a conventional A/O-MBR for high simultaneous carbon and nutrient removal from synthetic municipal wastewater
Článek Knowledge and awareness of cervical cancer in Southwestern Ethiopia is lacking: A descriptive analysis
Článek Flat electrode contacts for vagus nerve stimulation
Článek Circulating Th17.1 cells as candidate for the prediction of therapeutic response to abatacept in patients with rheumatoid arthritis: An exploratory research
Článek A randomized controlled trial comparing isosorbide dinitrate-oxytocin versus misoprostol-oxytocin at management of foetal intrauterine death
Článek Use of latent class analysis to identify multimorbidity patterns and associated factors in Korean adults aged 50 years and older
Článek Dissemination and stakeholder engagement practices among dissemination & implementation scientists: Results from an online survey
Článek Comparative analysis of the accelerated aged seed transcriptome profiles of two maize chromosome segment substitution lines
Článek Left parietal tACS at alpha frequency induces a shift of visuospatial attention
Článek Predictive factors for unfavourable treatment in MDR-TB and XDR-TB patients in Rio de Janeiro State, Brazil, 2000-2016
Článek Development of a multi-locus typing scheme for an Enterobacteriaceae linear plasmid that mediates inter-species transfer of flagella
Článek The roles of MRI-based prostate volume and associated zone-adjusted prostate-specific antigen concentrations in predicting prostate cancer and high-risk prostate cancer
Článek Re-modeling of foliar membrane lipids in a seagrass allows for growth in phosphorus-deplete conditions
Článek Effect of calcium intake and the dietary cation-anion difference during early lactation on the bone mobilization dynamics throughout lactation in dairy cows
Článek Facilitators and barriers to linkage to HIV care and treatment among female sex workers in a community-based HIV prevention intervention in Tanzania: A qualitative study
Článek Tuberculosis treatment outcome: The case of women in Ethiopia and China, ten-years retrospective cohort study
Článek Protein:Protein interactions in the cytoplasmic membrane apparently influencing sugar transport and phosphorylation activities of the e. coli phosphotransferase system
Článek A digital collection of rare and endangered lemurs and other primates from the Duke Lemur Center
Článek Computational fluid dynamics simulation of changes in the morphology and airflow dynamics of the upper airways in OSAHS patients after treatment with oral appliances
Článek Resistome metagenomics from plate to farm: The resistome and microbial composition during food waste feeding and composting on a Vermont poultry farm
Článek Lower limb chronic edema management program: Perspectives of disengaged patients on challenges, enablers and barriers to program attendance and adherence
Článek Modelling vegetation understory cover using LiDAR metrics
Článek CRISPR-Cas9 modified bacteriophage for treatment of Staphylococcus aureus induced osteomyelitis and soft tissue infection
Článek Forecasting type-specific seasonal influenza after 26 weeks in the United States using influenza activities in other countries
Článek Chronic exercise modulates the cellular immunity and its cannabinoid receptors expression
Článek Characterization of the diverse plasmid pool harbored by the blaNDM-1-containing Acinetobacter bereziniae HPC229 clinical strain
Článek A cell-based evaluation of a non-essential amino acid formulation as a non-bioactive control for activation and stimulation of muscle protein synthesis using ex vivo human serum
Článek Conjugated linoleic acid as a novel insecticide targeting the agricultural pest Leptinotarsa decemlineata
Článek Depicting changes in land surface cover at Al-Hassa oasis of Saudi Arabia using remote sensing and GIS techniques
Článek Land snail dispersal, abundance and diversity on green roofs
Článek Fanconi-BRCA pathway mutations in childhood T-cell acute lymphoblastic leukemia
Článek Mesenchymal Stem/ Stromal Cells metabolomic and bioactive factors profiles: A comparative analysis on the umbilical cord and dental pulp derived Stem/ Stromal Cells secretome
Článek The association between caesarean section delivery and later life obesity in 21-24 year olds in an Urban South African birth cohort
Článek Toxicity and sublethal effects of two plant allelochemicals on the demographical traits of cotton aphid, Aphis gossypii Glover (Hemiptera: Aphididae)
Článek Protocol development for discovery of angiogenesis inhibitors via automated methods using zebrafish
Článek Friends with malefit. The effects of keeping dogs and cats, sustaining animal-related injuries and Toxoplasma infection on health and quality of life
Článek Trueness of digital intraoral impression in reproducing multiple implant position
Článek Norm values and psychometric properties of the short version of the Trier Inventory for Chronic Stress (TICS) in a representative German sample
Článek Maternal health and birth outcomes in a South African birth cohort study
Článek Structural characterization of scorpion peptides and their bactericidal activity against clinical isolates of multidrug-resistant bacteria
Článek Residential household yard care practices along urban-exurban gradients in six climatically-diverse U.S. metropolitan areas
Článek Evaluation of a global spring wheat panel for stripe rust: Resistance loci validation and novel resources identification
Článek The effect of bivalve filtration on eDNA-based detection of aquatic organisms
Článek Development and validation of rapid environmental DNA (eDNA) detection methods for bog turtle (Glyptemys muhlenbergii)
Článek Preference-based measure of health-related quality of life and its determinants in sickle cell disease in Nigeria
Článek Factors influencing participation dynamics in research for development interventions with multi-stakeholder platforms: A metric approach to studying stakeholder participation
Článek Contextual variation in young children’s acquisition of social-emotional skills
Článek A global assessment of street-network sprawl
Článek Mindfulness-Based Blood Pressure Reduction (MB-BP): Stage 1 single-arm clinical trial
Článek Behavioral response of naïve and non-naïve deer to wolf urine
Článek SNARE proteins rescue impaired autophagic flux in Down syndrome
Článek Change in left inferior frontal connectivity with less unexpected harmonic cadence by musical expertise
Článek How does open innovation lead competitive advantage? A dynamic capability view perspective
Článek Bull efficiency using dairy genetic traits
Článek Improved cortical boundary registration for locally distorted fMRI scans
Článek Extractive single document summarization using binary differential evolution: Optimization of different sentence quality measures
Článek Isolation and identification of an isoflavone reducing bacterium from feces from a pregnant horse
Článek Quantifying normal and parkinsonian gait features from home movies: Practical application of a deep learning–based 2D pose estimator
Článek Can visual interpretation of NucliSens graphs reduce the need for repeat viral load testing?
Článek Association between metabolic body composition status and risk for impaired renal function: A cross-sectional study
Článek Infective endocarditis and diabetes mellitus: Results from a single-center study from 1994 to 2017
Článek Measuring the complexity of directed graphs: A polynomial-based approach
Článek Publication rates in animal research. Extent and characteristics of published and non-published animal studies followed up at two German university medical centres
Článek Exploring critical factors of the perceived usefulness of blended learning for higher education students
Článek Direct transport vs secondary transfer to level I trauma centers in a French exclusive trauma system: Impact on mortality and determinants of triage on road-traffic victims
Článek Postoperative delirium after lung resection for primary lung cancer: Risk factors, risk scoring system, and prognosis
Článek The CSF-1-receptor inhibitor, JNJ-40346527 (PRV-6527), reduced inflammatory macrophage recruitment to the intestinal mucosa and suppressed murine T cell mediated colitis
Článek Antibacterial efficacy of cold atmospheric plasma against Enterococcus faecalis planktonic cultures and biofilms in vitro
Článek Mechanisms of African swine fever virus pathogenesis and immune evasion inferred from gene expression changes in infected swine macrophages
Článek Application of ensemble methods to analyse the decline of organochlorine pesticides in relation to the interactions between age, gender and time
Článek Mitogenomic diversity in Sacred Ibis Mummies sheds light on early Egyptian practices
Článek Inducible UCP1 silencing: A lentiviral RNA-interference approach to quantify the contribution of beige fat to energy homeostasis
Článek iCrotoK-PseAAC: Identify lysine crotonylation sites by blending position relative statistical features according to the Chou’s 5-step rule
Článek Raising the bar: Recovery ambition for species at risk in Canada and the US
Článek Management of locally advanced non-small cell lung cancer in the modern era: A national Italian survey on diagnosis, treatment and multidisciplinary approach
Článek Incidence of colorectal cancer in Eritrea: Data from the National Health Laboratory, 2011-2017
Článek Integrated analysis of miRNA landscape and cellular networking pathways in stage-specific prostate cancer
Článek Statistical determination of synergy based on Bliss definition of drugs independence
Článek Dispersion of Legionella bacteria in atmosphere: A practical source location estimation method
Článek Why are undergraduate emerging adults anxious and avoidant in their romantic relationships? The role of family relationships
Článek Moving system with action sport cameras: 3D kinematics of the walking and running in a large volume
Článek Factors influencing subclinical atherosclerosis in patients with biopsy-proven nonalcoholic fatty liver disease
Článek A new resolution function to evaluate tree shape statistics
Článek Thermostat wars? The roles of gender and thermal comfort negotiations in household energy use behavior
Článek Lifetime prevalence of intimate partner violence against women in an urban Brazilian city: A cross-sectional survey
Článek Quantifying pediatric patient need for second- and third-line HIV treatment: A tool for decision-making in resource-limited settings
Článek Discovery of actionable genetic alterations with targeted panel sequencing in children with relapsed or refractory solid tumors
Článek Iodine status of non-pregnant women and availability of food vehicles for fortification with iodine in a remote community in Gulf province, Papua New Guinea
Článek Psychology of personal data donation
Článek MARGO (Massively Automated Real-time GUI for Object-tracking), a platform for high-throughput ethology
Článek Visual detection of time-varying signals: Opposing biases and their timescales
Článek Results from a World Health Organization pilot of the Basic Emergency Care Course in Sub Saharan Africa
Článek Scientists’ opinions and attitudes towards citizens’ understanding of science and their role in public engagement activities
Článek Dacentrurine stegosaurs (Dinosauria): A new specimen of Miragaia longicollum from the Late Jurassic of Portugal resolves taxonomical validity and shows the occurrence of the clade in North America
Článek Morphology, phylogeny, and taxonomy of two species of colonial volvocine green algae from Lake Victoria, Tanzania
Článek Exploring local realities: Perceptions and experiences of healthcare workers on the management and control of drug-resistant tuberculosis in Addis Ababa, Ethiopia
Článek Barriers to integration of bioinformatics into undergraduate life sciences education: A national study of US life sciences faculty uncover significant barriers to integrating bioinformatics into undergraduate instruction
Článek Local unemployment changes the springboard effect of low pay: Evidence from England
Článek A comparison of body composition assessment methods in climbers: Which is better?
Článek Comparison of an in-house ‘home-brew’ and commercial ViroSeq integrase genotyping assays on HIV-1 subtype C samples
Článek Inducible microRNA-200c decreases motility of breast cancer cells and reduces filamin A
Článek Complex interaction networks of cytokines after transarterial chemotherapy in patients with hepatocellular carcinoma
Článek Gender essentialism in transgender and cisgender children
Článek Being there: A scoping review of grief support training in medical education
Článek Does the psychological profile influence the position of promising young futsal players?
Článek Correlates of leisure-time sedentary behavior among 181,793 adolescents aged 12-15 years from 66 low- and middle-income countries
Článek Spatiotemporal analysis of historical records (2001–2012) on dengue fever in Vietnam and development of a statistical model for forecasting risk
Článek Effect of community based health education on knowledge and attitude towards iron and folic acid supplementation among pregnant women in Kiambu County, Kenya: A quasi experimental study
Článek Impacts of risk and competition on the profitability of banks: Empirical evidence from Pakistan
Článek Molecular characterization of lung adenocarcinoma from Korean patients using next generation sequencing
Článek Joint image compression and encryption based on sparse Bayesian learning and bit-level 3D Arnold cat maps
Článek Urticating setae of tarantulas (Araneae: Theraphosidae): Morphology, revision of typology and terminology and implications for taxonomy
Článek Tributyltin chloride (TBT) induces RXRA down-regulation and lipid accumulation in human liver cells
Článek Amazon climatic factors driving terpene composition of Iryanthera polyneura Ducke in terra-firme forest: A statistical approach
Článek Differences in clinical features of cluster headache between drinkers and nondrinkers in Japan
Článek Distribution of macular ganglion cell layer thickness in foveal hypoplasia: A new diagnostic criterion for ocular albinism
Článek Polo-like kinase 1 (Plk1) inhibition synergizes with taxanes in triple negative breast cancer
Článek Automated content analysis across six languages
Článek The prognostic significance of tumor-infiltrating lymphocytes assessment with hematoxylin and eosin sections in resected primary lung adenocarcinoma
Článek Effectiveness of novel fabrics to resist punctures and lacerations from white shark (Carcharodon carcharias): Implications to reduce injuries from shark bites
Článek Serial block-face scanning electron microscopy reveals neuronal-epithelial cell fusion in the mouse cornea
Článek Salt or fish (or salted fish)? The Bronze Age specialised sites along the Tyrrhenian coast of Central Italy: New insights from Caprolace settlement
Článek Latitudinal gradient of cyanobacterial diversity in tidal flats
Článek Gene expression based survival prediction for cancer patients—A topic modeling approach
Článek Comparative analysis on Facebook post interaction using DNN, ELM and LSTM
Článek Omecamtiv mecarbil lowers the contractile deficit in a mouse model of nebulin-based nemaline myopathy
Článek Left-handed metamaterial bandpass filter for GPS, Earth Exploration-Satellite and WiMAX frequency sensing applications
Článek In-situ time resolved spectrographic measurement using an additively manufactured metallic micro-fluidic analysis platform
Článek Race disparity in blood sphingolipidomics associated with lupus cardiovascular comorbidity
Článek Characterization of the placental transcriptome through mid to late gestation in the mare
Článek Indirect violence exposure and mental health symptoms among an urban public-school population: Prevalence and correlates
Článek Study of the epidemiological behavior of malaria in the Darien Region, Panama. 2015–2017
Článek Neighborhood crime, disorder and substance use in the Caribbean context: Jamaica National Drug Use Prevalence Survey 2016
Článek Modeling of inter-organizational coordination dynamics in resilience planning of infrastructure systems: A multilayer network simulation framework
Článek Manipulating the odds: The effects of Machiavellianism and construal level on cheating behavior
Článek Early recognition of anorexia through patient-generated assessment predicts survival in patients with oesophagogastric cancer
Článek ITGAM is a risk factor to systemic lupus erythematosus and possibly a protection factor to rheumatoid arthritis in patients from Mexico
Článek Cluster tendency assessment in neuronal spike data
Článek Psychometric properties of the Korean version of the Health Literacy on Social Determinants of Health Questionnaire (K-HL-SDHQ)
Článek Flood hazard mapping and assessment in data-scarce Nyaungdon area, Myanmar
Článek Methods for the identification of farm escapees in feral mink (Neovison vison) populations
Článek Overcoming platinum resistance in ovarian cancer by targeting pregnancy-associated plasma protein-A
Článek Exploration of muscle loss and metabolic state during prolonged critical illness: Implications for intervention?
Článek Pan-caspase inhibitor F573 mitigates liver ischemia reperfusion injury in a murine model
Článek Early economic evaluation of MRI-guided laser interstitial thermal therapy (MRgLITT) and epilepsy surgery for mesial temporal lobe epilepsy
Článek Anterior tooth-use behaviors among early modern humans and Neandertals
Článek Association of thoracic spine deformity and cardiovascular disease in a mouse model for Marfan syndrome
Článek M3VR—A multi-stage, multi-resolution, and multi-volumes-of-interest volume registration method applied to 3D endovaginal ultrasound
Článek Fixation of genetic variation and optimization of gene expression: The speed of evolution in isolated lizard populations undergoing Reverse Island Syndrome
Článek Detection of Schistosoma japonicum and Oncomelania hupensis quadrasi environmental DNA and its potential utility to schistosomiasis japonica surveillance in the Philippines
Článek Does age influence the quality of life in children with atopic dermatitis?
Článek Identification of a novel monocytic phenotype in Classic Hodgkin Lymphoma tumor microenvironment
Článek Recent climate-driven ecological change across a continent as perceived through local ecological knowledge
Článek Effect of F1 and F2 generations on genetic variability and working steps of doubled haploid production in maize
Článek EPILAT-IRA Study: A contribution to the understanding of the epidemiology of acute kidney injury in Latin America
Článek 16S rDNA droplet digital PCR for monitoring bacterial DNAemia in bloodstream infections
Článek Diversity of endocervical microbiota associated with genital Chlamydia trachomatis infection and infertility among women visiting obstetrics and gynecology clinics in Malaysia
Článek Development of a novel automatable fabrication method based on electrospinning co electrospraying for rotator cuff augmentation patches
Článek Development of a quantitative PCR assay for the detection and enumeration of a potentially ciguatoxin-producing dinoflagellate, Gambierdiscus lapillus (Gonyaulacales, Dinophyceae)
Článek Association of clinical factors with survival outcomes in laryngeal squamous cell carcinoma (LSCC)
Článek Seasonal oyster harvesting recorded in a Late Archaic period shell ring
Článek Trends and predictors of mother-to-child transmission of HIV in an era of protocol changes: Findings from two large health facilities in North East Nigeria
Článek Genome-wide identification and gene expression analysis of SOS family genes in tuber mustard (Brassica juncea var. tumida)
Článek Molecular epidemiological characteristics of dengue virus carried by 34 patients in Guangzhou in 2018
Článek Association of uric acid in serum and urine with subclinical renal damage: Hanzhong Adolescent Hypertension Study
Článek The plasma metabolome of women in early pregnancy differs from that of non-pregnant women
Článek Diminuendo al bottom—Clarifying the semantics of music notation by re-modeling
Článek Structural analysis of the manganese transport regulator MntR from Bacillus halodurans in apo and manganese bound forms
Článek Serum uromodulin is associated with the severity of clinicopathological findings in ANCA-associated glomerulonephritis
Článek Male support for cervical cancer screening and treatment in rural Ghana
Článek ADAPTS: Automated deconvolution augmentation of profiles for tissue specific cells
Článek Comparison of shape quantification methods for genomic prediction, and genome-wide association study of sorghum seed morphology
Článek Video abstracts and plain language summaries are more effective than graphical abstracts and published abstracts
Článek Bioinformatic analysis of a novel Echinococcus granulosus nuclear receptor with two DNA binding domains
Článek Concurrent validity and discriminative ability of Dutch performance-based motor tests in 5 to 6 years old children
Článek Cumulative viral load as a predictor of CD4+ T-cell response to antiretroviral therapy using Bayesian statistical models
Článek Self-serving incentives impair collective decisions by increasing conformity
Článek Effects of Debaryomyces hansenii treatment on intestinal mucosa microecology in mice with antibiotic-associated diarrhea
Článek A novel wheat lodging resistance evaluation method and device based on the thrust force of the stalks
Článek Evolution of high tooth replacement rates in theropod dinosaurs
Článek Outpatient facility-based order variation in combined imaging
Článek Non-intubated anesthesia in patients undergoing video-assisted thoracoscopic surgery: A systematic review and meta-analysis
Článek Changes of serum pentraxin-3 and hypersensitive CRP levels during pregnancy and their relationship with gestational diabetes mellitus
Článek Investigating reindeer pastoralism and exploitation of high mountain zones in northern Mongolia through ice patch archaeology
Článek Diversity pattern of Plasmodium knowlesi merozoite surface protein 4 (MSP4) in natural population of Malaysia
Článek The impact of “male clinics” on health-seeking behaviors of adult men in rural Kenya
Článek Gene expression microarray public dataset reanalysis in chronic obstructive pulmonary disease
Článek Utility of the new cobas HCV test for viral load monitoring during direct-acting antiviral therapy
Článek Maternal diet modulates placental nutrient transporter gene expression in a mouse model of diabetic pregnancy
Článek Effects of an incremental theory of personality intervention on the reciprocity between bullying and cyberbullying victimization and perpetration in adolescents
Článek Reproducibility, stability, and accuracy of microbial profiles by fecal sample collection method in three distinct populations
Článek Cooperation with autonomous machines through culture and emotion
Článek Intramolecular tautomerization of the quercetin molecule due to the proton transfer: QM computational study
Článek Identifying resurrection genes through the differentially expressed genes between Selaginella tamariscina (Beauv.) spring and Selaginella moellendorffii Hieron under drought stress
Článek Impact of hemodialysis on the concentrations of sodium and potassium during infusion of sodium thiosulfate using an In Vitro hemodialysis model
Článek Suboptimal infant and young child feeding practices in rural Boucle du Mouhoun, Burkina Faso: Findings from a cross-sectional population-based survey
Článek Comparative efficacy of tenofovir and entecavir in nucleos(t)ide analogue-naive chronic hepatitis B: A systematic review and meta-analysis
Článek Mathematical modeling reveals the factors involved in the phenomena of cancer stem cells stabilization
Článek Evaluation of comprehensive improvement for mild and moderate soil salinization in arid zone
Článek Efficacy, acceptability and feasibility of daily text-messaging in promoting glycaemic control and other clinical outcomes in a low-resource setting of South Africa: A randomised controlled trial
Článek Magnitude and associated factors of postpartum depression among women in Nekemte town, East Wollega zone, west Ethiopia, 2019: A community-based study
Článek Comparison of continuous wave and cold lateral condensation filling techniques in 3D printed simulated C-shape canals instrumented with Reciproc Blue or Hyflex EDM
Článek AtUBL5 regulates growth and development through pre-mRNA splicing in Arabidopsis thaliana
Článek The gut microbiome of freshwater Unionidae mussels is determined by host species and is selectively retained from filtered seston
Článek Alcohol consumption and survival after breast cancer diagnosis in Japanese women: A prospective patient cohort study
Článek Selection of reference genes for normalization of cranberry (Vaccinium macrocarpon Ait.) gene expression under different experimental conditions
Článek Characterization of two thermophilic cellulases from Talaromyces leycettanus JCM12802 and their synergistic action on cellulose hydrolysis
Článek Cyclosporine A eyedrops with self-nanoemulsifying drug delivery systems have improved physicochemical properties and efficacy against dry eye disease in a murine dry eye model
Článek LFastqC: A lossless non-reference-based FASTQ compressor
Článek Highly accurate prediction of flammability limits of chemical compounds using novel integrated hybrid models
Článek Grit (effortful persistence) can be measured with a short scale, shows little variation across socio-demographic subgroups, and is associated with career success and career engagement
Článek Improving the antimicrobial efficacy against resistant Staphylococcus aureus by a combined use of conjugated oligoelectrolytes
Článek Kin discrimination and outer membrane exchange in Myxococcus xanthus: Experimental analysis of a natural population
Článek Association between housing tenure and self-rated health in Japan: Findings from a nationwide cross-sectional survey
Článek Investigation of biochemical and physiological parameters of the newborn Saiga antelope (Saiga tatarica) in Gansu Province, China
Článek One-year follow-up of changes in refraction and aberrations induced by corneal incision
Článek Veterans with Gulf War Illness exhibit distinct respiratory patterns during maximal cardiopulmonary exercise
Článek Cranberry extracts promote growth of Bacteroidaceae and decrease abundance of Enterobacteriaceae in a human gut simulator model
Článek Long-term retention on antiretroviral therapy among infants, children, adolescents and adults in Malawi: A cohort study
Článek Optogenetically transduced human ES cell-derived neural progenitors and their neuronal progenies: Phenotypic characterization and responses to optical stimulation
Článek Ion torrent high throughput mitochondrial genome sequencing (HTMGS)
Článek Outpatient antibiotic prescription rate and pattern in the private sector in India: Evidence from medical audit data
Článek Acute Influenza A virus outbreak in an enzootic infected sow herd: Impact on viral dynamics, genetic and antigenic variability and effect of maternally derived antibodies and vaccination
Článek CRISPR/Cas9 gene editing in the West Nile Virus vector, Culex quinquefasciatus Say
Článek Genetic susceptibility to angiotensin-converting enzyme-inhibitor induced angioedema: A systematic review and evaluation of methodological approaches
Článek Intolerance of uncertainty fuels depressive symptoms through rumination: Cross-sectional and longitudinal studies
Článek Affective disorders in the elderly in different European countries: Results from the MentDis_ICF65+ study
Článek Evaluation of forearm vascular resistance during orthostatic stress: Velocity is proportional to flow and size doesn’t matter
Článek Proton pencil minibeam irradiation of an in-vivo mouse ear model spares healthy tissue dependent on beam size
Článek Aspartate aminotransferase-to-platelet ratio index (APRI): A potential marker for diagnosis in patients at risk of severe malaria caused by Plasmodium vivax
Článek Exploiting open source 3D printer architecture for laboratory robotics to automate high-throughput time-lapse imaging for analytical microbiology
Článek Effects of neuromuscular electrical stimulation training on muscle size in collegiate track and field athletes
Článek Adaptive fuzzy flow rate control considering multifractal traffic modeling and 5G communications
Článek Evaluation of four commercial tests for detecting ceftiofur in waste milk bulk tank samples
Článek A smart tele-cytology point-of-care platform for oral cancer screening
Článek Carbonate production of Micronesian reefs suppressed by thermal anomalies and Acanthaster as sea-level rises
Článek The impact of short-term machine perfusion on the risk of cancer recurrence after rat liver transplantation with donors after circulatory death
Článek Proteomic profiling of the thrombin-activated canine platelet secretome (CAPS)
Článek The effects of prolonged single night session of videogaming on sleep and declarative memory
Článek Mapping developmental QTL for plant height in soybean [Glycine max (L.) Merr.] using a four-way recombinant inbred line population
Článek Knowledge-based best of breed approach for automated detection of clinical events based on German free text digital hospital discharge letters
Článek Importance of thorough tissue and cellular level characterization of targeted drugs in the evaluation of pharmacodynamic effects
Článek Integrated value-chain and risk assessment of Pig-Related Zoonoses in Ghana
Článek Failed sperm retrieval from severely oligospermic or non-obstructive azoospermic patients on oocyte retrieval day: Emergent oocyte cryopreservation is a feasible strategy
Článek Cassava yield traits predicted by genomic selection methods
Článek Verification of hub genes in the expression profile of aortic dissection
Článek Diagnostic value of ASVS for insulinoma localization: A systematic review and meta-analysis
Článek Newly educated care managers’ experiences of providing care for persons with stress-related mental disorders in the clinical primary care context
Článek Real-time telemetry monitoring of oxygen in the central complex of freely-walking Gromphadorhina portentosa
Článek Qualification programmes for immigrant health professionals: A systematic review
Článek An analytical model to minimize the latency in healthcare internet-of-things in fog computing environment
Článek Intercalation of small molecules into DNA in chromatin is primarily controlled by superhelical constraint
Článek Altered expression of Notch1 in Alzheimer's disease
Článek The ZJU index is a powerful surrogate marker for NAFLD in severely obese North American women
Článek Trade-offs in motivating volunteer effort: Experimental evidence on voluntary contributions to science
Článek Does caching strategy vary with microclimate in endangered Mt. Graham red squirrels?
Článek Implementation of a screening, brief intervention and referral to treatment programme for risky substance use in South African emergency centres: A mixed methods evaluation study
Článek Can the CalproQuest predict a positive Calprotectin test? A prospective diagnostic study
Článek Acceptability of and treatment preferences for recurrent bacterial vaginosis—Topical lactic acid gel or oral metronidazole antibiotic: Qualitative findings from the VITA trial
Článek Mathematical determination of the HIV-1 matrix shell structure and its impact on the biology of HIV-1
Článek CAMDI interacts with the human memory-associated protein KIBRA and regulates AMPAR cell surface expression and cognition
Článek Effect of feeding patterns on growth and nutritional status of children aged 0-24 months: A Chinese cohort study
Článek A fecal sequel: Testing the limits of a genetic assay for bat species identification
Článek Measuring the impact of chronic conditions and associated multimorbidity on health-related quality of life in the general population in Hong Kong SAR, China: A cross-sectional study
Článek Short and long-term clinical effectiveness and cost-effectiveness of a late-phase community-based balance and gait exercise program following hip fracture. The EVA-Hip Randomised Controlled Trial
Článek Vaccine cold chain in general practices: A prospective study in 75 refrigerators (Keep Cool study)
Článek Brazilian norms for the Bank of Standardized Stimuli (BOSS)
Článek Distinct varieties of aesthetic chills in response to multimedia
Článek New formulation of the Gompertz equation to describe the kinetics of untreated tumors
Článek Development of visual perception of others’ actions: Children’s judgment of lifted weight
Článek Human vitreous concentrations of citicoline following topical application of citicoline 2% ophthalmic solution
Článek Acceleration of chemical shift encoding-based water fat MRI for liver proton density fat fraction and T2* mapping using compressed sensing
Článek Sexuality in male partners of women with fibromyalgia syndrome: A qualitative study
Článek Exploring optimization strategies for improving explicit water models: Rigid n-point model and polarizable model based on Drude oscillator
Článek Moving into an urban drug scene among people who use drugs in Vancouver, Canada: Latent class growth analysis
Článek Effects of dietary supplementation with apple peel powder on the growth, blood and liver parameters, and transcriptome of genetically improved farmed tilapia (GIFT, Oreochromis niloticus)
Článek Factors associated with medication adherence among people with diabetes mellitus in poor urban areas of Cambodia: A cross-sectional study
Článek Mammary microbiome of lactating organic dairy cows varies by time, tissue site, and infection status
Článek Force field generalization and the internal representation of motor learning
Článek Polyphenism of visual and chemical secondary sexually-selected wing traits in the butterfly Bicyclus anynana: How different is the intermediate phenotype?
Článek Minimal genetic differentiation of the malaria vector Nyssorhynchus darlingi associated with forest cover level in Amazonian Brazil
Článek scafSLICR: A MATLAB-based slicing algorithm to enable 3D-printing of tissue engineering scaffolds with heterogeneous porous microarchitecture
Článek Operation of cognitive memory inhibition in adults with Down syndrome: Effects of maintenance load and material
Článek Influences on surgical antimicrobial prophylaxis decision making by surgical craft groups, anaesthetists, pharmacists and nurses in public and private hospitals
Článek Post-treatment Lyme disease symptoms score: Developing a new tool for research
Článek Expression of Concern: The Role of the RACK1 Ortholog Cpc2p in Modulating Pheromone-Induced Cell Cycle Arrest in Fission Yeast
Článek Equine bronchial fibroblasts enhance proliferation and differentiation of primary equine bronchial epithelial cells co-cultured under air-liquid interface
Článek Investigating cooperation with robotic peers
Článek Prosthetic push-off power in trans-tibial amputee level ground walking: A systematic review
Článek A case study of the use of verbal reports for talent identification purposes in soccer: A Messi affair!
Článek Transgenerational deep sequencing revealed hypermethylation of hippocampal mGluR1 gene with altered mRNA expression of mGluR5 and mGluR3 associated with behavioral changes in Sprague Dawley rats with history of prolonged febrile seizure
Článek Periodontal disease: Repercussions in pregnant woman and newborn health—A cohort study
Článek Origins of Chinese reindeer (Rangifer tarandus) based on mitochondrial DNA analyses
Článek Regional, racial, gender, and tumor biology disparities in breast cancer survival rates in Africa: A systematic review and meta-analysis
Článek How effective are films in inducing positive and negative emotional states? A meta-analysis
Článek 3D nanostructural characterisation of grain boundaries in atom probe data utilising machine learning methods
Článek An outbreak of tuberculosis in a middle school in Henan, China: Epidemiology and risk factors
Článek Initial clinical radiological findings and staging to predict prognosis of primary hepatic angiosarcoma: A retrospective analysis
Článek Cold-related Florida manatee mortality in relation to air and water temperatures
Článek Conceptual fluency in inductive reasoning
Článek Clinical outcomes and treatment patterns among Medicare patients with nonvalvular atrial fibrillation (NVAF) and chronic kidney disease
Článek Improvements in the learnability of smartphone haptic interfaces for visually impaired users
Článek Role of the malic enzyme in metabolism of the halotolerant methanotroph Methylotuvimicrobium alcaliphilum 20Z
Článek Cyclic loading test study on a new cast-in-situ insulated sandwich concrete wall
Článek Natural compounds as angiogenic enzyme thymidine phosphorylase inhibitors: In vitro biochemical inhibition, mechanistic, and in silico modeling studies
Článek Analysis of virulence potential of Escherichia coli O145 isolated from cattle feces and hide samples based on whole genome sequencing
Článek Pre-clinical medical student reflections on implicit bias: Implications for learning and teaching
Článek Prognostic significance of non-sustained ventricular tachycardia on stored electrograms in pacemaker recipients
Článek Real-world evidence of the effectiveness of ombitasvir-paritaprevir/r ± dasabuvir ± ribavirin in patients monoinfected with chronic hepatitis C or coinfected with human immunodeficiency virus-1 in Spain
Článek Restrained expansion of the recall germinal center response as biomarker of protection for influenza vaccination in mice
Článek Arabidopsis TRM5 encodes a nuclear-localised bifunctional tRNA guanine and inosine-N1-methyltransferase that is important for growth
Článek Achievement of weight loss in patients with overweight during dietetic treatment in primary health care
Článek Reorganization of spatial configurations in visual working memory: A matter of set size?
Článek Unravelling travellers’ route choice behaviour at full-scale urban network by focusing on representative OD pairs in computer experiments
Článek Evaluating the higher-order structure of the Profile of Emotional Competence (PEC): Confirmatory factor analysis and Bayesian structural equation modeling
Článek Next generation sequencing and RNA-seq characterization of adipose tissue in the Nile crocodile (Crocodylus niloticus) in South Africa: Possible mechanism(s) of pathogenesis and pathophysiology of pansteatitis
Článek Association between advanced maternal age and maternal and neonatal morbidity: A cross-sectional study on a Spanish population
Článek Ethnic differences in the prevalence, socioeconomic and health related risk factors of knee pain and osteoarthritis symptoms in older Malaysians
Článek Increasing knowledge of HIV status in a country with high HIV testing coverage: Results from the Botswana Combination Prevention Project
Článek Friends with benefits: The effects of vegetative shading on plant survival in a green roof environment
Článek Identifying candidate diagnostic markers for early stage of non-small cell lung cancer
Článek Unique developmental trajectories of risk behaviors in adolescence and associated outcomes in young adulthood
Článek Enhanced fibrinolysis detection in a natural occurring canine model with intracavitary effusions: Comparison and degree of agreement between thromboelastometry and FDPs, D-dimer and fibrinogen concentrations
Článek Overexpression of Saussurea involucrata dehydrin gene SiDHN promotes cold and drought tolerance in transgenic tomato plants
Článek Foxtail millet (Setaria italica (L.) P. Beauv) CIPKs are responsive to ABA and abiotic stresses
Článek Autonomous drone hunter operating by deep learning and all-onboard computations in GPS-denied environments
Článek Heterogeneity Diffusion Imaging of gliomas: Initial experience and validation
Článek Frequency cluster formation and slow oscillations in neural populations with plasticity
Článek DHP23002 as a next generation oral paclitaxel formulation for pancreatic cancer therapy
Článek Diagnostic accuracy of SOX11 immunohistochemistry in mantle cell lymphoma: A meta-analysis
Článek Analytical solution to swing equations in power grids
Článek Pathways to conspiracy: The social and linguistic precursors of involvement in Reddit’s conspiracy theory forum
Článek Spatiotemporally random and diverse grid cell spike patterns contribute to the transformation of grid cell to place cell in a neural network model
Článek Empathic concern and personal distress depend on situational but not dispositional factors
Článek Who is more susceptible to job stressors and resources? Sensory-processing sensitivity as a personal resource and vulnerability factor
Článek Cost-effectiveness of integrating postpartum antiretroviral therapy and infant care into maternal & child health services in South Africa
Článek A substitution mutation in a conserved domain of mammalian acetate-dependent acetyl CoA synthetase 2 results in destabilized protein and impaired HIF-2 signaling
Článek One step at a time: Physical activity is linked to positive interpretations of ambiguity
Článek Calreticulin regulates vascular endothelial growth factor-A mRNA stability in gastric cancer cells
Článek Evaluation of various methods of selection of B. subtilis strains capable of secreting surface-active compounds
Článek Association between US Pharmacopeia (USP) monograph standards, generic entry and prescription drug costs
Článek Molecular characterisation of the synovial fluid microbiome in rheumatoid arthritis patients and healthy control subjects
Článek On sorption hysteresis in wood: Separating hysteresis in cell wall water and capillary water in the full moisture range
Článek Inbreeding, Allee effects and stochasticity might be sufficient to account for Neanderthal extinction
Článek Reliability and construct validity of the stepping-forward affordance perception test for fall risk assessment in community-dwelling older adults
Článek Socioeconomic determinants of nutritional status among ‘Baiga’ tribal children In Balaghat district of Madhya Pradesh: A qualitative study
Článek Study on characteristics of fire plume in building facade window under lateral blow
Článek ‘When you talk to someone in a bad way or always put her under pressure, it is actually worse than beating her’: Conceptions and experiences of emotional intimate partner violence in Rwanda and South Africa
Článek Effects of 6-mercaptopurine in pressure overload induced right heart failure
Článek The association between haemoglobin levels in the first 20 weeks of pregnancy and pregnancy outcomes
Článek Implementation and evaluation of an antimicrobial stewardship programme in companion animal clinics: A stepped-wedge design intervention study
Článek Factors associated with persistently high-cost health care utilization for musculoskeletal pain
Článek Nitrogen and chlorophyll status determination in durum wheat as influenced by fertilization and soil management: Preliminary results
Článek Effect of repeated in vivo microCT imaging on the properties of the mouse tibia
Článek Coupling environment and physiology to predict effects of climate change on the taxonomic and functional diversity of fish assemblages in the Murray-Darling Basin, Australia
Článek Hematology and plasma biochemistries in the Blanding’s turtle (Emydoidea blandingii) in Lake County, Illinois
Článek CRISPR-Cas influences the acquisition of antibiotic resistance in Klebsiella pneumoniae
Článek Phosphorylation-dependent activity-based conformational changes in P21-activated kinase family members and screening of novel ATP competitive inhibitors
Článek Antidepressant prescriptions, discontinuation, depression and perinatal outcomes, including breastfeeding: A population cohort analysis
Článek Why men with a low-risk prostate cancer select and stay on active surveillance: A qualitative study
Článek Imported severe malaria and risk factors for intensive care: A single-centre retrospective analysis
Článek Combined treatment (image-guided thrombectomy and endovascular therapy with open femoral access) for acute lower limb ischemia: Clinical efficacy and outcomes
Článek Low-latency single channel real-time neural spike sorting system based on template matching
Článek Quantifying the scale effect in geospatial big data using semi-variograms
Článek Paper-and-pencil versus computerized administration mode: Comparison of data quality and risk behavior prevalence estimates in the European school Survey Project on Alcohol and other Drugs (ESPAD)
Článek Regression adjusted colocalisation colour mapping (RACC): A novel biological visual analysis method for qualitative colocalisation analysis of 3D fluorescence micrographs
Článek Ostrich eggshell bead diameter in the Holocene: Regional variation with the spread of herding in eastern and southern Africa
Článek Spatial and temporal variations in female size at maturity of a Southern Rock Lobster (Jasus edwardsii) population: A likely response to climate change
Článek Training rhesus macaques to take daily oral antiretroviral therapy for preclinical evaluation of HIV prevention and treatment strategies
Článek Left ventricular structural and functional changes in Friedreich ataxia – Relationship with body size, sex, age and genetic severity
Článek Magnitude and factors associated with anemia among pregnant women attending antenatal care in Bench Maji, Keffa and Sheka zones of public hospitals, Southwest, Ethiopia, 2018: A cross -sectional study
Článek Effectiveness of telerehabilitation in the management of adults with stroke: A systematic review
Článek Hydrogen sulphide-induced hypometabolism in human-sized porcine kidneys
Článek Evaluation of neutral oral contrast agents for assessment of the small bowel at abdominal staging CT
Článek Blood type and breed-associated differences in cell marker expression on equine bone marrow-derived mesenchymal stem cells including major histocompatibility complex class II antigen expression
Článek Induced abortion and future use of IVF treatment; A nationwide register study
Článek Psychosocial determinants of sustained maternal functional impairment: Longitudinal findings from a pregnancy-birth cohort study in rural Pakistan
Článek Measurement of finger joint angle using stretchable carbon nanotube strain sensor
Článek Determinants of mortality among patients with drug-resistant tuberculosis in northern Nigeria
Článek Drugs modulating stochastic gene expression affect the erythroid differentiation process
Článek Efficacy of UB0316, a multi-strain probiotic formulation in patients with type 2 diabetes mellitus: A double blind, randomized, placebo controlled study
Článek Prognostic value of des-γ-carboxy prothrombin in patients with hepatocellular carcinoma treated with transarterial chemotherapy: A systematic review and meta-analysis
Článek Avermectin induces the oxidative stress, genotoxicity, and immunological responses in the Chinese Mitten Crab, Eriocheir sinensis
Článek Antibiotic use in mandarin production (Citrus reticulata Blanco) in major mandarin-producing areas in Thailand: A survey assessment
Článek Application of CPI cutoff value based on parentage testing of duos and trios typed by four autosomal kits
Článek Adolescents with worse levels of oral health literacy have more cavitated carious lesions
Článek Effective methods for the inactivation of Francisella tularensis
Článek Detection of early-stage Alzheimer’s pathology using blood-based autoantibody biomarkers in elderly hip fracture repair patients
Článek Correlation between internal pudendal artery stenosis and erectile dysfunction in patients with suspected coronary artery disease
Článek Analysis of HER2 genomic binding in breast cancer cells identifies a global role in direct gene regulation
Článek Population productivity of shovelnose rays: Inferring the potential for recovery
Článek Effects of tetracycline on myocardial infarct size in obese rats with chemically-induced colitis
Článek Mineral absorption is an enriched pathway in a brain region of restless legs syndrome patients with reduced MEIS1 expression
Článek Changes in weight and body composition across five years at university: A prospective observational study
Článek Adeno-associated virus-mediated expression of human butyrylcholinesterase to treat organophosphate poisoning
Článek Effects of insulin signaling on mouse taste cell proliferation
Článek Patient-level cost of home- and facility-based child pneumonia treatment in Suba Sub County, Kenya
Článek TAP: A static analysis model for PHP vulnerabilities based on token and deep learning technology
Článek Cost-effectiveness of QuantiFERON-TB Gold In-Tube versus tuberculin skin test for diagnosis and treatment of Latent Tuberculosis Infection in primary health care workers in Brazil
Článek Multifaceted intervention for the prevention and management of musculoskeletal pain in nursing staff: Results of a cluster randomized controlled trial
Článek Changes over time in creatinine clearance and comparison of emergent adverse events for HIV-positive adults receiving standard doses (300 mg/day) of lamivudine-containing antiretroviral therapy with baseline creatinine clearance of 30–49 vs ≥50 mL/min
Článek Population dynamics of foxes during restricted-area culling in Britain: Advancing understanding through state-space modelling of culling records
Článek Impacts of experimental advisory exit speed sign on traffic speeds for freeway exit ramp
Článek In-hospital outcomes and 30-day readmission rates among ischemic and hemorrhagic stroke patients with delirium
Článek Monitoring quality indicators for the Xpert MTB/RIF molecular assay in Ethiopia
Článek Delivering genes across the blood-brain barrier: LY6A, a novel cellular receptor for AAV-PHP.B capsids
Článek Comparison of the inoculum size effects of antibiotics on IMP-6 β-lactamase-producing Enterobacteriaceae co-harboring plasmid-mediated quinolone resistance genes
Článek Contrast-enhanced computed tomography findings of canine primary renal tumors including renal cell carcinoma, lymphoma, and hemangiosarcoma
Článek Non-invasive in vivo imaging of UCP1 expression in live mice via near-infrared fluorescent protein iRFP720
Článek Overexpression of pink1 or parkin in indirect flight muscles promotes mitochondrial proteostasis and extends lifespan in Drosophila melanogaster
Článek Fiber stiffness, pore size and adhesion control migratory phenotype of MDA-MB-231 cells in collagen gels
Článek Comparison of two experimental ARDS models in pigs using electrical impedance tomography
Článek Are primary school children attending full-day school still engaged in sports clubs?
Článek Stroke risks in women with dysmenorrhea by age and stroke subtype
Článek Changes in patterns of mortality rates and years of life lost due to firearms in the United States, 1999 to 2016: A joinpoint analysis
Článek In vitro modeling of Batrachochytrium dendrobatidis infection of the amphibian skin
Článek Development and validation of LC-MS/MS method for imatinib and norimatinib monitoring by finger-prick DBS in gastrointestinal stromal tumor patients
Článek Characterisation of early metazoan secretion through associated signal peptidase complex subunits, prohormone convertases and carboxypeptidases of the marine sponge (Amphimedon queenslandica)
Článek Time trends between 2002 and 2017 in correlates of self-reported sitting time in European adults
Článek Performance of patient acuity rating by rapid response team nurses for predicting short-term prognosis
Článek Changes in HbA1c during the first six years after the diagnosis of Type 2 diabetes mellitus predict long-term microvascular outcomes
Článek Correction: Mental health and quality of life outcomes in family members of patients with chronic critical illness admitted to the intensive care units of two Brazilian hospitals serving the extremes of the socioeconomic spectrum
Článek Health provider and service-user experiences of sensory modulation rooms in an acute inpatient psychiatry setting
Článek Comparison of potential drug-drug interactions with metabolic syndrome medications detected by two databases
Článek The Polish version of the Cultural Intelligence Scale: Assessment of its reliability and validity among healthcare professionals and medical faculty students
Článek Selection of optimal reference genes for qRT-PCR analysis of shoot development and graviresponse in prostrate and erect chrysanthemums
Článek Metastasis risk prediction model in osteosarcoma using metabolic imaging phenotypes: A multivariable radiomics model
Článek Defining hospital community benefit activities using Delphi technique: A comparison between China and the United States
Článek Establishment of the experimental procedure for prediction of conjugation capacity in mutant UGT1A1
Článek A robust multi-objective optimization framework to capture both cellular and intercellular properties in cardiac cellular model tuning: Analyzing different regions of membrane resistance profile in parameter fitting
Článek Sea star wasting disease demography and etiology in the brooding sea star Leptasterias spp.
Článek Diagnostic plasma miRNA-profiles for ovarian cancer in patients with pelvic mass
Článek Genetic diversity and drug resistance of HIV-1 among infected pregnant women newly diagnosed in Luanda, Angola
Článek I’ve been robbed! – Can changes in floral traits discourage bee pollination?
Článek Visualising statistical models using dynamic nomograms
Článek Assessing the capacity of Malawi’s district and central hospitals to manage traumatic diaphyseal femoral fractures in adults
Článek Diagnostic performance of basal cortisol level at 0900-1300h in adrenal insufficiency
Článek The Mastery Rubric for Bioinformatics: A tool to support design and evaluation of career-spanning education and training
Článek Microdissection and whole chromosome painting confirm karyotype transformation in cryptic species of the Lariophagus distinguendus (Förster, 1841) complex (Hymenoptera: Pteromalidae)
Článek Quality of Kangaroo Mother Care services in Ethiopia: Implications for policy and practice
Článek Gemcitabine potentiates the anti-tumour effect of radiation on medullary thyroid cancer
Článek iTRAQ-based high-throughput proteomics analysis reveals alterations of plasma proteins in patients infected with human bocavirus
Článek The detection of a non-anemophilous plant species using airborne eDNA
Článek Perception and control of low cable operation forces in voluntary closing body-powered upper-limb prostheses
Článek Neoadjuvant chemotherapy plus surgery versus concurrent chemoradiotherapy in stage IB2-IIB cervical cancer: A systematic review and meta-analysis
Článek Randomized methods to characterize large-scale vortical flow networks
Článek Disentangling the coexistence strategies of mud-daubing wasp species through trophic analysis in oases of Baja California peninsula
Článek Front-of-pack nutritional labels: Understanding by low- and middle-income Mexican consumers
Článek Distress in patients with end-stage renal disease: Staff perceptions of barriers to the identification of mild-moderate distress and the provision of emotional support
Článek Pathways to antibiotics in Bangladesh: A qualitative study investigating how and when households access medicine including antibiotics for humans or animals when they are ill
Článek DOC export is exceeded by C fixation in May Creek: A late-successional watershed of the Copper River Basin, Alaska
Článek Behavioral observation of prosocial behavior and social initiative is related to preschoolers’ psychopathological symptoms
Článek Evaluating the impact of citations of articles based on knowledge flow patterns hidden in the citations
Článek Correction: Economic sanctions and academia: Overlooked impact and long-term consequences
Článek Price dispersion of generic medications
Článek Sex differences in body composition but not neuromuscular function following long-term, doxycycline-induced reduction in circulating levels of myostatin in mice
Článek The emotion regulation effect of cognitive control is related to depressive state through the mediation of rumination: An ERP study
Článek Comparison of SMS-EPI and 3D-EPI at 7T in an fMRI localizer study with matched spatiotemporal resolution and homogenized excitation profiles
Článek Left ventricular mass normalization for body size in children based on an allometrically adjusted ratio is as accurate as normalization based on the centile curves method
Článek Correction: Combining biophysical parameters, spectral indices and multivariate hyperspectral models for estimating yield and water productivity of spring wheat across different agronomic practices
Článek Correction: Flowers as viral hot spots: Honey bees (Apis mellifera) unevenly deposit viruses across plant species
Článek 'Small small quarrels bring about happiness or love in the relationships’: Exploring community perceptions and gendered norms contributing to male perpetrated intimate partner violence in the Central Region of Ghana
Článek The performance of practitioners conducting facial comparisons on images of children across age
Článek Increased amounts and stability of telomeric repeat-containing RNA (TERRA) following DNA damage induced by etoposide
Článek Patients with limitation or withdrawal of life supporting care admitted in a medico-surgical intermediate care unit: Prevalence, description and outcome over a six-month period
Článek Correction: Diverse radiofrequency sensitivity and radiofrequency effects of mobile or cordless phone near fields exposure in Drosophila melanogaster
Článek Predicting the performance of TV series through textual and network analysis: The case of Big Bang Theory
Článek Risk of temperature, humidity and concentrations of air pollutants on the hospitalization of AECOPD
Článek Mixed methods grant applications in the health sciences: An analysis of reviewer comments
Článek Renal abnormalities among children with sickle cell conditions in highly resource-limited setting in Ghana
Článek Size matters: How reaching and vergence movements are influenced by the familiar size of stereoscopically presented objects
Článek Willingness to receive institutional and community-based eldercare among the rural elderly in China
Článek An improved deep learning method for predicting DNA-binding proteins based on contextual features in amino acid sequences
Článek Beyond executive functions, creativity skills benefit academic outcomes: Insights from Montessori education
Článek A LAMP assay for the rapid and robust assessment of Wolbachia infection in Aedes aegypti under field and laboratory conditions
Článek Nonarteritic anterior ischemic optic neuropathy is associated with cerebral small vessel disease
Článek Fiber-tract localized diffusion coefficients highlight patterns of white matter disruption induced by proximity to glioma
Článek The fight against polio through the NO-DO newsreels during the Francoism period in Spain
Článek Ocean sound levels in the northeast Pacific recorded from an autonomous underwater glider
Článek Cost-consequence analysis of influenza vaccination among the staff of a large teaching hospital in Rome, Italy: A pilot study
Článek The relationship among the progression of inflammation in umbilical cord, fetal inflammatory response, early-onset neonatal sepsis, and chorioamnionitis
Článek How medical professional students view older people with dementia: Implications for education and practice
Článek An enhanced nonparametric EWMA sign control chart using sequential mechanism
Článek Land use change, carbon stocks and tree species diversity in green spaces of a secondary city in Myanmar, Pyin Oo Lwin
Článek Is there a difference in women’s experiences of care with medication vs. manual vacuum aspiration abortions? Determinants of person-centered care for abortion services
Článek Maternal complications in pregnancy and childbirth for women with epilepsy: Time trends in a nationwide cohort
Článek Adsorption of oxytetracycline on kaolinite
Článek Interdisciplinary stratified care for low back pain: A qualitative study on the acceptability, potential facilitators and barriers to implementation
Článek The role of resource transfer in positive, non-additive litter decomposition
Článek The impact of language on the interpretation of resuscitation clinical care plans by doctors. A mixed methods study
Článek Quantum dots reveal heterogeneous membrane diffusivity and dynamic surface density polarization of dopamine transporter
Článek Genomic analysis of Shiga toxin-producing Escherichia coli from patients and asymptomatic food handlers in Japan
Článek The heavy metals lead and cadmium are cytotoxic to human bone osteoblasts via induction of redox stress
Článek Anatomical, taxonomic, and phylogenetic reappraisal of a poorly known ghost knifefish, Tembeassu marauna (Ostariophysi: Gymnotiformes), using X-ray microcomputed tomography
Článek Matrix-assisted laser desorption/ionization time of flight mass spectrometry identification of Vibrio (Listonella) anguillarum isolated from sea bass and sea bream
Článek Recommendations of older adults on how to use the PROM ‘TOPICS-MDS’ in healthcare conversations: A Delphi study
Článek The winner takes it all—Competitiveness of single nodes in globalized supply networks
Článek Hamsters in the city: A study on the behaviour of a population of common hamsters (Cricetus cricetus) in urban environment
Článek Correction: Liquid biopsies for omics-based analysis in sentinel mussels
Článek Size matters! Association between journal size and longitudinal variability of the Journal Impact Factor
Článek Drug resistance and epidemiology characteristics of multidrug-resistant tuberculosis patients in 17 provinces of China
Článek A model-based framework for chronic hepatitis C prevalence estimation
Článek Adding rewards to regulation: The impacts of watershed conservation on land cover and household wellbeing in Moyobamba, Peru
Článek Clinical determinants of social media use in individuals with schizophrenia
Článek Arsenic and nutrient absorption characteristics and antioxidant response in different leaves of two ryegrass (Lolium perenne) species under arsenic stress
Článek An evolution of socioeconomic related inequality in teenage pregnancy and childbearing in Malawi
Článek A single plasmid based CRISPR interference in Synechocystis 6803 – A proof of concept
Článek Structural vulnerability to narcotics-driven firearm violence: An ethnographic and epidemiological study of Philadelphia’s Puerto Rican inner-city
Článek Temporal trends in intracerebral hemorrhage: Evidence from the Austrian Stroke Unit Registry
Článek Prevalence and risk factors for multi-drug resistant Escherichia coli among poultry workers in the Federal Capital Territory, Abuja, Nigeria
Článek Prediction of disease-related metabolites using bi-random walks
Článek Clinical use, efficacy, and durability of maraviroc for antiretroviral therapy in routine care: A European survey
Článek Biomarker discovery in inflammatory bowel diseases using network-based feature selection
Článek The Cinderella Complex: Word embeddings reveal gender stereotypes in movies and books
Článek Exoproteome profiling of Trypanosoma cruzi during amastigogenesis early stages
Článek Reproducible phenotype alteration due to prolonged cooling of the pupae of Polyommatus icarus butterflies
Článek Nutritional treatment with an immune-modulating enteral formula alleviates 5-fluorouracil-induced adverse effects in rats
Článek Pharmacy-based predictors of non-adherence, non-persistence and reinitiation of antihypertensive drugs among patients on oral diabetes drugs in the Netherlands
Článek Systematic review of the accuracy of plasma preparation tubes for HIV viral load testing
Článek Circadian clock regulates the shape and content of dendritic spines in mouse barrel cortex
Článek “Anybody can make kids; it takes a real man to look after your kids”: Aboriginal men’s discourse on parenting
Článek Correction: A 1D computer model of the arterial circulation in horses: An important resource for studying global interactions between heart and vessels under normal and pathological conditions
Článek Maternal interpregnancy weight change and premature birth: Findings from an English population-based cohort study
Článek Correction: Identifying performance benchmarks and determinants for reproductive performance and calf survival using a longitudinal field study of cow-calf herds in western Canada
Článek Prognostic value of the model for end-stage liver disease excluding INR score (MELD-XI) in patients with adult congenital heart disease
Článek Treatment of Urethral Pain Syndrome (UPS) in Sweden
Článek Migration and political polarization in the U.S.: An analysis of the county-level migration network
Článek Epidemiology and complications of late-onset sepsis: an Italian area-based study
Článek The relationship between women’s experience of intimate partner violence and other socio-demographic factors, and under-5 children’s health in South Africa
Článek Association between trunk and gluteus muscle size and long jump performance
Článek Multimorbidity and complex multimorbidity in Brazilian rural workers
Článek Correction: Interspecific Phylogenic Relationships within Genus Melilotus Based on Nuclear and Chloroplast DNA
Článek Insulin-like growth factor (IGF)-II- mediated fibrosis in pathogenic lung conditions
Článek Wolf diet and prey selection in the South-Eastern Carpathian Mountains, Romania
Článek In vitro activity of aryl-thiazole derivatives against Schistosoma mansoni schistosomula and adult worms
Článek Sample size issues in multilevel logistic regression models
Článek Seed germination ecology of Ageratum houstonianum: A major invasive weed in Nepal
Článek Experiences of lifestyle change among women with gestational diabetes mellitus (GDM): A behavioural diagnosis using the COM-B model in a low-income setting
Článek Pharmacologic management of HCV treatment in patients with HCV monoinfection vs. HIV/HCV coinfection: Does coinfection really matter?
Článek The association between cigarette smoking and serum thyroid stimulating hormone, thyroid peroxidase antibodies and thyroglobulin antibodies levels in Chinese residents: A cross-sectional study in 10 cities
Článek Mouse movement measures enhance the stop-signal task in adult ADHD assessment
Článek Ecosystem functioning in urban grasslands: The role of biodiversity, plant invasions and urbanization
Článek Correction: KETOS: Clinical decision support and machine learning as a service – A training and deployment platform based on Docker, OMOP-CDM, and FHIR Web Services
Článek Does craniofacial morphology affect third molars impaction? Results from a population-based study in northeastern Germany
Článek Hyperconnectivity during screen-based stories listening is associated with lower narrative comprehension in preschool children exposed to screens vs dialogic reading: An EEG study
Článek Weight loss is associated with improved quality of life among rural women completers of a web-based lifestyle intervention
Článek Long-term high-grain diet altered the ruminal pH, fermentation, and composition and functions of the rumen bacterial community, leading to enhanced lactic acid production in Japanese Black beef cattle during fattening
Článek Beyond detoxification: Pleiotropic functions of multiple glutathione S-transferase isoforms protect mice against a toxic electrophile
Článek Golgi reassembly and stacking protein 65 downregulation is required for the anti-cancer effect of dihydromyricetin on human ovarian cancer cells
Článek SSR marker development in Clerodendrum trichotomum using transcriptome sequencing
Článek Risk factors for the carriage of Streptococcus infantarius subspecies infantarius isolated from African fermented dairy products
Článek Development of an intervention tool for precision oral self-care: Personalized and evidence-based practice for patients with periodontal disease
Článek Personal values in adolescence and psychological distress in adults: A cross-sectional study based on a retrospective recall
Článek Overactive bladder and bladder pain syndrome/interstitial cystitis in primary Sjögren’s syndrome patients: A nationwide population-based study
Článek Clinical utility of combined preimplantation genetic testing methods in couples at risk of passing on beta thalassemia/hemoglobin E disease: A retrospective review from a single center
Článek Hip stress distribution - Predictor of dislocation in hip arthroplasties. A retrospective study of 149 arthroplasties
Článek Mortality, morbidity, and cardiac surgery in Injection Drug Use (IDU)-associated versus non-IDU infective endocarditis: The need to expand substance use disorder treatment and harm reduction services
Článek Pup mortality in New Zealand sea lions (Phocarctos hookeri) at Enderby Island, Auckland Islands, 2013-18
Článek In vitro endothelial cell migration from limbal edge-modified Quarter-DMEK grafts
Článek Liquid Chromatography/Mass Spectrometry based serum metabolomics study on recurrent abortion women with antiphospholipid syndrome
Článek Gut carriage of antimicrobial resistance genes among young children in urban Maputo, Mozambique: Associations with enteric pathogen carriage and environmental risk factors
Článek Prepubertal nutrition alters Leydig cell functional capacity and timing of puberty
Článek Reliability of the Swedish version of the Evidence-Based Practice Attitude Scale assessing physiotherapist’s attitudes to implementation of evidence-based practice
Článek Mitochondrial alarmins are tissue mediators of ventilator-induced lung injury and ARDS
Článek Complete Chloroplast Genomes of Vachellia nilotica and Senegalia senegal: Comparative Genomics and Phylogenomic Placement in a New Generic System
Článek Retraction: Over-Expression of Superoxide Dismutase Ameliorates Cr(VI) Induced Adverse Effects via Modulating Cellular Immune System of Drosophila melanogaster
Článek Effect of pre-season training phase on anthropometric, hormonal and fitness parameters in young soccer players
Článek Exosomes from conditioned media of bone marrow-derived mesenchymal stem cells promote bone regeneration by enhancing angiogenesis
Článek Outcome of patients with heart failure after transcatheter aortic valve implantation
Článek Fatty acid profile of Romanian’s common bean (Phaseolus vulgaris L.) lipid fractions and their complexation ability by β-cyclodextrin
Článek Appropriate empirical antibiotic therapy and mortality: Conflicting data explained by residual confounding
Článek Treatment of corneal endothelial damage in a rabbit model with a bioengineered graft using human decellularized corneal lamina and cultured human corneal endothelium
Článek Telbivudine on IgG-associated hypergammaglobulinemia and TGF-β1 hyperactivity in hepatitis B virus-related liver cirrhosis
Článek Correction: Axial variation of deoxyhemoglobin density as a source of the low-frequency time lag structure in blood oxygenation level-dependent signals
Článek Correction: Mobile health-based physical activity intervention for individuals with spinal cord injury in the community: A pilot study
Článek Retraction: Placental expression of CD100, CD72 and CD45 is dysregulated in human miscarriage
Článek Correction: Use of IoT sensing and occupant surveys for determining the resilience of buildings to forest fire generated PM2.5
Článek Correction: The modulation of facial mimicry by attachment tendencies and their underlying affiliation motives in 3-year-olds: An EMG study
Článek Correction: Cognitive impairment in multiple sclerosis: An exploratory analysis of environmental and lifestyle risk factors
Článek Discovering novel disease comorbidities using electronic medical records
Článek Glutathione contributes to efficient post-Golgi trafficking of incoming HPV16 genome
Článek Epidemiology and antimicrobial resistance of methicillin-resistant Staphylococcus aureus isolates colonizing pigs with different exposure to antibiotics
Článek Social information use in adolescents: The impact of adults, peers and household composition
Článek Public practices on antibiotic use: A cross-sectional study among Qatar University students and their family members
Článek Effects of Topper Training on psychosocial problems, self-esteem, and peer victimisation in Dutch children: A randomised trial
Článek Comparative studies of two generations of NanoString nCounter System
Článek General practitioners’ perceptions of delayed antibiotic prescription for respiratory tract infections: A phenomenographic study
Článek Can altered magnetic field affect the foraging behaviour of ants?
Článek Parasitic infections and medical expenses according to Health Insurance Review Assessment claims data in South Korea, 2011–2018
Článek A prospective observational study of on-treatment plasma homocysteine levels as a biomarker of toxicity, depression and vitamin supplementation lead-in time pre pemetrexed, in patients with non-small cell lung cancer and malignant mesothelioma
Článek A strategy to identify protein-N-myristoylation-dependent phosphorylation reactions of cellular proteins by using Phos-tag SDS-PAGE
Článek Expression profile of sonic hedgehog signaling-related molecules in basal cell carcinoma
Článek Seasonal alternation of the ontogenetic development of the moon jellyfish Aurelia coerulea in Maizuru Bay, Japan
Článek Reliability of measurement of active trunk movement in wheelchair basketball players
Článek Chinese SLE Treatment and Research group (CSTAR) registry: Clinical significance of thrombocytopenia in Chinese patients with systemic lupus erythematosus
Článek Does source credibility matter for point-of-decision prompts? A quasi-experimental field study to increase stair use
Článek Male-pattern baldness and incident coronary heart disease and risk factors in the Heinz Nixdorf Recall Study
Článek Quality and utilization patterns of maternity waiting homes at referral facilities in rural Zambia: A mixed-methods multiple case analysis of intervention and standard of care sites
Článek Determining an optimal pool size for testing beef herds for Johne’s disease in Australia
Článek Correction: Change in larval fish assemblage in a USA east coast estuary estimated from twenty-six years of fixed weekly sampling
Článek APOE-knockout in rabbits causes loss of cells in nucleus pulposus and enhances the levels of inflammatory catabolic cytokines damaging the intervertebral disc matrix
Článek Testing Species Assignments in Extant Terebratulide Brachiopods: A Three-dimensional Geometric Morphometric Analysis of Long-Looped Brachidia
Článek A daily diary study on maladaptive daydreaming, mind wandering, and sleep disturbances: Examining within-person and between-persons relations
Článek Improved chemotherapy modeling with RAG-based immune deficient mice
Článek Effect of tracheal antimicrobial peptide on the development of Mannheimia haemolytica pneumonia in cattle
Článek The internal realities of individuals with type 2 diabetes  – a functional framework of self-management practices via Grounded Theory approach
Článek Role of platelet parameters in early detection and prediction of severity of preeclampsia: A comparative cross-sectional study at Ayder comprehensive specialized and Mekelle general hospitals, Mekelle, Tigray, Ethiopia
Článek eIF4E and 4EBP1 are prognostic markers of head and neck squamous cell carcinoma recurrence after definitive surgery and adjuvant radiotherapy
Článek Smoking and other determinants of bone turnover
Článek Oxygen delivery, oxygen consumption and decreased kidney function after cardiopulmonary bypass
Článek School engagement of children in early grades: Psychometric, and gender comparisons
Článek Correction: A review of the elusive bicolored iris Snouted Treefrogs (Anura: Hylidae:Scinax uruguayus group)
Článek Perceived attractiveness of Czech faces across 10 cultures: Associations with sexual shape dimorphism, averageness, fluctuating asymmetry, and eye color
Článek Discovery of stable and prognostic CT-based radiomic features independent of contrast administration and dimensionality in oesophageal cancer
Článek Correction: Population-based dementia prediction model using Korean public health examination data: A cohort study
Článek Location, location, location: Close ties among older continuing care retirement community residents
Článek Correction: ISED: Constructing a high-resolution elevation road dataset from massive, low-quality in-situ observations derived from geosocial fitness tracking data
Článek Correction: Use of validated objective methods of locomotion characteristics and weight distribution for evaluating the efficacy of ketoprofen for alleviating pain in cows with limb pathologies
Článek Monitoring fine root growth to identify optimal fertilization timing in a forest plantation: A case study in Northeast Vietnam
Článek Metabolic costs of spontaneous swimming in Sprattus sprattus L., at different water temperatures
Článek Enterovirus 71 vaccine acceptance among parents of children < 5 years old and their knowledge of hand, foot and mouth disease, Chongqing, China, 2017
Článek Correction: Transcriptome profiling of mouse brain and lung under Dip2a regulation using RNA-sequencing
Článek Genetic diversity and antiretroviral resistance-associated mutation profile of treated and naive HIV-1 infected patients from the Northwest and Southwest regions of Cameroon
Článek Maximum parsimony interpretation of chromatin capture experiments
Článek Multiple innate antibacterial immune defense elements are correlated in diverse ungulate species
Článek Incidence and characteristics of ventricular tachycardia in patients after percutaneous coronary revascularization of chronic total occlusions
Článek Estimating measures of latent variables from m-alternative forced choice responses
Článek Clade F AAVHSCs cross the blood brain barrier and transduce the central nervous system in addition to peripheral tissues following intravenous administration in nonhuman primates
Článek First evidence of hepatitis E virus infection in a small mammal (yellow-necked mouse) from Croatia
Článek The inhibitory effects of polypyrrole on the biofilm formation of Streptococcus mutans
Článek Self-reported adverse drug effects and associated factors among H. pylori infected patients on standard triple therapy: Prospective follow up study
Článek Upregulation of ERK phosphorylation in rat dorsal root ganglion neurons contributes to oxaliplatin-induced chronic neuropathic pain
Článek Characterization of the relationship between neutron production and thermal load on a target material in an accelerator-based boron neutron capture therapy system employing a solid-state Li target
Článek Remote heart rate monitoring - Assessment of the Facereader rPPg by Noldus
Článek Seroprevalence of rubella virus antibodies among pregnant women in the Center and South-West regions of Cameroon
Článek Effectiveness of steam sterilization of reusable medical devices in primary and secondary care public hospitals in Nepal and factors associated with ineffective sterilization: A nation-wide cross-sectional study
Článek Relevance of HTLV-1 proviral load in asymptomatic and symptomatic patients living in endemic and non-endemic areas of Argentina
Článek Ritualized aggressive behavior reveals distinct social structures in native and introduced range tawny crazy ants
Článek The value of kinetic glomerular filtration rate estimation on medication dosing in acute kidney injury
Článek Screening and characterization of long noncoding RNAs involved in the albinism of Ananas comosus var. bracteatus leaves
Článek Visual attention to emotional faces in adolescents with social anxiety disorder receiving cognitive behavioral therapy
Článek A Q fever outbreak associated to courier transport of pets
Článek Antibodies against measles and rubella virus among different age groups in Thailand: A population-based serological survey
Článek Molecular diet analysis of Anguilliformes leptocephalus larvae collected in the western North Pacific
Článek Correction: The relationship between context, structure, and processes with outcomes of 6 regional diabetes networks in Europe
Článek Correction: The C-reactive protein/albumin ratio as an independent predictor of mortality in patients with severe sepsis or septic shock treated with early goal-directed therapy
Článek Interleukin 21 (IL-21) regulates chronic allograft vasculopathy (CAV) in murine heart allograft rejection
Článek Semantic computational analysis of anticoagulation use in atrial fibrillation from real world data
Článek The implementation of HTA in medicine pricing and reimbursement policies in Indonesia: Insights from multiple stakeholders
Článek International experiences during United States ophthalmology residency training: Current structure of international experiences and perspectives of faculty mentors at United States training institutions
Článek Questionable utility of digoxin in left-ventricular assist device recipients: A multicenter, retrospective analysis
Článek Genotyping and outcomes of presumptive second line ART failure cases switched to third line or maintained on second line ART in Mumbai, India
Článek A mathematical model of honey bee colony dynamics to predict the effect of pollen on colony failure
Článek Airway microbiome composition correlates with lung function and arterial stiffness in an age-dependent manner
Článek An odorant receptor from Anopheles gambiae that demonstrates enantioselectivity to the plant volatile, linalool
Článek Factors associated with full immunization of children 12–23 months of age in Ethiopia: A multilevel analysis using 2016 Ethiopia Demographic and Health Survey
Článek Additional evidence that the rat renal interstitium contracts in vivo
Článek Factors affecting acceptance of at-birth point of care HIV testing among providers and parents in Kenya: A qualitative study
Článek Removal efficiency of central vacuum system and protective masks to suspended particles from dental treatment
Článek Psychological well-being and distress in patients with generalized anxiety disorder: The roles of positive and negative functioning
Článek Conventional rotator cuff versus all-suture anchors—A biomechanical study focusing on the insertion angle in an unlimited cyclic model
Článek Are viral-infections associated with Ménière’s Disease? A systematic review and meta-analysis of molecular-markers of viral-infection in case-controlled observational studies of MD
Článek An evaluation of genetic causes and environmental risks for bilateral optic atrophy
Článek Comparative vector competence of the Afrotropical soft tick Ornithodoros moubata and Palearctic species, O. erraticus and O. verrucosus, for African swine fever virus strains circulating in Eurasia
Článek Effects of the solubility of yeast cell wall preparations on their potential prebiotic properties in dogs
Článek Carbogen gas-challenge BOLD fMRI in assessment of liver hypoxia after portal microcapsules implantation
Článek Socioeconomic determinants of cancer screening utilisation in Latin America: A systematic review
Článek Development of an easy-to-use questionnaire assessing critical care nursing competence in Japan: A cross-sectional study
Článek Towards successful business process improvement – An extension of change acceleration process model
Článek Correction: Dietary polyphenols as a safe and novel intervention for modulating pain associated with intervertebral disc degeneration in an in-vivo rat model
Článek Correction: Phylogenetic analysis of hepatitis C virus among HIV/ HCV co-infected patients in Nigeria
Článek Correction: Relationship between self-disclosure to first acquaintances and subjective well-being in people with schizophrenia spectrum disorders living in the community
Článek Impact of ATM rs1801516 on late skin reactions of radiotherapy for breast cancer: Evidences from a cohort study and a trial sequential meta-analysis
Článek Involvement of human and canine MRP1 and MRP4 in benzylpenicillin transport
Článek Soil organic matter rather than ectomycorrhizal diversity is related to urban tree health
Článek Clinical risk assessment in early pregnancy for preeclampsia in nulliparous women: A population based cohort study
Článek The relation between circulating levels of vitamin D and parathyroid hormone in children and adolescents with overweight or obesity: Quest for a threshold
Článek Behavioural evidence for segments as subordinate units in Chinese spoken word production: The form-preparation paradigm revisited
Článek Correction: Measuring the impact of an interdisciplinary learning project on nursing, architecture and landscape design students’ empathy
Článek Analysis of the characteristics of chemotherapy-resistant renal cell carcinomas based on global transcriptional analysis of their tissues and cell lines
Článek The characteristics and treatment patterns of patients with Parkinson’s disease in the United States and United Kingdom: A retrospective cohort study
Článek Sex differences in youth elite swimming
Článek Unconventional SCCmec types and low prevalence of the Panton-Valentine Leukocidin exotoxin in South African blood culture Staphylococcus aureus surveillance isolates, 2013-2016
Článek Prosocial perceptions of taxation predict support for taxes
Článek Correction: Clonality analysis of pulmonary tumors by genome-wide copy number profiling
Článek Improved oxygenation following methylprednisolone therapy and survival in paediatric acute respiratory distress syndrome
Článek Normative values for relative schoolbag weight in primary school children aged 6-14 from Czech Republic: A pilot study
Článek Correction: Intensive longitudinal modelling predicts diurnal activity of salivary alpha-amylase
Článek Correction: SNV discovery and functional candidate gene identification for milk composition based on whole genome resequencing of Holstein bulls with extremely high and low breeding values
Článek Monoclonal antibody anti-PBP2a protects mice against MRSA (methicillin-resistant Staphylococcus aureus) infections
Článek Diurnal variations of amplitude of accommodation in different age groups
Článek HHIP overexpression inhibits the proliferation, migration and invasion of non-small cell lung cancer
Článek Infusion of HIV-1 Nef-expressing astrocytes into the rat hippocampus induces enteropathy and interstitial pneumonitis and increases blood–brain-barrier permeability
Článek Correlation analysis of cold-related gene expression with physiological and biochemical indicators under cold stress in oil palm
Článek Student engagement and wellbeing over time at a higher education institution
Článek Gender-based differences in platelet function and platelet reactivity to P2Y12 inhibitors
Článek Influence of season and social context on male giant panda (Ailuropoda melanoleuca) vocal behaviour
Článek Development of an intravaginal ring for the topical delivery of Aurora kinase A inhibitor, MLN8237
Článek Differential phosphorylation determines the repressor and activator potencies of GLI1 proteins and their efficiency in modulating the HPV life cycle
Článek Polymorphisms of FDPS, LRP5, SOST and VKORC1 genes and their relation with osteoporosis in postmenopausal Romanian women
Článek Depression increases the risk of rotator cuff tear and rotator cuff repair surgery: A nationwide population-based study
Článek Interleukin-38 interacts with destrin/actin-depolymerizing factor in human keratinocytes
Článek Correction: Fast, quantitative, murine cardiac 19F MRI/MRS of PFCE-labeled progenitor stem cells and macrophages at 9.4T
Článek Persistent post-discharge opioid prescribing after traumatic brain injury requiring intensive care unit admission: A cross-sectional study with longitudinal outcome
Článek Genome-wide histone modification profiling of inner cell mass and trophectoderm of bovine blastocysts by RAT-ChIP
Článek Aerobic exercise increases post-exercise exogenous protein oxidation in healthy young males
Článek Selection for tandem stop codons in ciliate species with reassigned stop codons
Článek Research ethics in inter- and multi-disciplinary teams: Differences in disciplinary interpretations
Článek Correction: Analyzing data from the digital healthcare exchange platform for surveillance of antibiotic prescriptions in primary care in urban Kenya: A mixed-methods study
Článek Correction: People making deontological judgments in the Trapdoor dilemma are perceived to be more prosocial in economic games than they actually are
Článek LFRET, a novel rapid assay for anti-tissue transglutaminase antibody detection
Článek Effects of isotemporal substitution of sedentary behavior with light-intensity or moderate-to-vigorous physical activity on cardiometabolic markers in male adolescents
Článek Topical estrogen application to wounds promotes delayed cutaneous wound healing in 80-week-old female mice
Článek Correction: An international randomised placebo-controlled trial of a four-component combination pill (“polypill”) in people with raised cardiovascular risk
Článek Correction: Evaluation of lung toxicity risk with computed tomography ventilation image for thoracic cancer patients
Článek Retraction: Pathological Roles of Interleukin-22 in the Development of Recurrent Hepatitis C after Liver Transplantation
Článek Correction: Elevational Distribution and Ecology of Small Mammals on Tanzania's Second Highest Mountain
Článek Correction: Decreased breast cancer-specific mortality risk in patients with a history of thyroid cancer
Článek Correction: Fecal microbiota dysbiosis in macaques and humans within a shared environment
Článek Correction: The center of pressure and ankle muscle co-contraction in response to anterior-posterior perturbations
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2019 Číslo 11
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Aktuální možnosti diagnostiky a léčby litiáz
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Autori: MUDr. Tomáš Ürge, PhD.
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