Management of locally advanced non-small cell lung cancer in the modern era: A national Italian survey on diagnosis, treatment and multidisciplinary approach
Autoři:
Alessio Bruni aff001; Niccolò Giaj-Levra aff002; Patrizia Ciammella aff003; Virginia Maragna aff004; Katia Ferrari aff005; Viola Bonti aff005; Francesco Grossi aff006; Stefania Greco aff007; Carlo Greco aff008; Paolo Borghetti aff009; Davide Franceschini aff010; Enrica Capelletto aff011; Marco Perna aff004; Giuseppe Banna aff012; Stefano Vagge aff013; Editta Baldini aff014; Emilio Bria aff015; Andrea Botti aff016; Marcello Tiseo aff017; Massimiliano Paci aff018; Maria Taraborrelli aff019; Venerino Poletti aff020; Pierluigi Granone aff022; Umberto Ricardi aff023; Silvia Novello aff011; Vieri Scotti aff004
Působiště autorů:
Radiotherapy Unit, Department of Oncology and Hematology, University Hospital of Modena, Modena, Italy
aff001; Department of Advanced Radiation Oncology, IRCCS Sacro Cuore–Don Calabria Hospital, Negrar, Verona, Italy
aff002; Radiation Therapy Unit, Department of Oncology and Advanced Technology, AUSL-IRCCS, Reggio Emilia, Italy
aff003; Radiation Therapy Unit, Department of Oncology, Careggi University Hospital, Firenze, Italy
aff004; Section of Respiratory Medicine, Careggi University Hospital, Firenze, Italy
aff005; UOC Oncologia Medica Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy
aff006; UOSD of Oncologic Pneumology, San Camillo Forlanini Hospital, Rome, Italy
aff007; Department of Radiation Oncology, Campus Bio-Medico University, Rome, Italy
aff008; Radiation Oncology Department University and Spedali Civili, Brescia, Italy
aff009; Department of Radiotherapy and Radiosurgery, Humanitas Cancer Center and Research Hospital, Rozzano, Milan, Italy
aff010; Oncology Department, University of Turin, AOU San Luigi, Orbassano (TO), Italy
aff011; Oncology Department, Ospedale Cannizzaro, Catania, Italy
aff012; Department of Radiation Oncology, Azienda Ospedaliera Universitaria San Martino di Genova—IST, Istituto Nazionale Ricerca sul Cancro, Genoa, Italy
aff013; UOC Oncologia Medica Ospedale San Luca, Lucca, Italy
aff014; U.O.C. Oncologia Medica, Comprehensive Cancer Center—Fondazione Policlinico Universitario A. Gemelli, IRCCS—Università Cattolica del Sacro Cuore, Roma, Italy
aff015; Medical Physics Unit, Department of Oncology and Advanced Technology, AUSL-IRCCS, Reggio Emilia, Italy
aff016; Department of Medicine and Surgery, University of Parma and Medical Oncology Unit, University Hospital of Parma, Parma, Italy
aff017; Division of Thoracic Surgery, Azienda USL-IRCCS of Reggio Emilia, Italy
aff018; Radiotherapy Unit, SS Annunziata Hospital—G. D'annunzio University, Chieti, Italy
aff019; Department of Diseases of the Thorax, Ospedale GB Morgagni, Forlì (I), Italy
aff020; Department of Respiratory Diseases & Allergy, Aarhus University Hospital, Aarhus, Denmark
aff021; Department of General Thoracic Surgery, Catholic University, Rome, Italy
aff022; Department of Oncology, University of Turin, Torino, Italy
aff023
Vyšlo v časopise:
PLoS ONE 14(11)
Kategorie:
Research Article
prolekare.web.journal.doi_sk:
https://doi.org/10.1371/journal.pone.0224027
Souhrn
Concurrent chemotherapy and radiotherapy (cCRT) is considered the standard treatment of locally advanced non-small cell lung cancer (LA-NSCLC). Unfortunately, management is still heterogeneous across different specialists. A multidisciplinary approach is needed in this setting due to recent, promising results obtained by consolidative immunotherapy. The aim of this survey is to assess current LA-NSCLC management in Italy. From January to April 2018, a 15-question survey focusing on diagnostic/therapeutic LA-NSCLC management was sent to 1,478 e-mail addresses that belonged to pneumologists, thoracic surgeons, and radiation and medical oncologists. 421 answers were analyzed: 176 radiation oncologists, 86 medical oncologists, 92 pneumologists, 64 thoracic surgeons and 3 other specialists. More than a half of the respondents had been practicing for >10 years after completing residency training. Some discrepancies were observed in clinical LA-NSCLC management: the lack of a regularly planned multidisciplinary tumor board, the use of upfront surgery in multistation stage IIIA, and territorial diffusion of cCRT in unresectable LA-NSCLC. Our analysis demonstrated good compliance with international guidelines in the diagnostic workup of LA-NSCLC. We observed a relationship between high clinical experience and good clinical practice. A multidisciplinary approach is mandatory for managing LA-NSCLC.
Klíčová slova:
Physicians – Diagnostic medicine – Oncology – Cancer treatment – Cancer detection and diagnosis – Surgical and invasive medical procedures – Lung and intrathoracic tumors – Non-small cell lung cancer
Zdroje
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