Evaluation of cytological diagnostic accuracy for canine splenic neoplasms: An investigation in 78 cases using STARD guidelines
Autoři:
Marco Tecilla aff001; Matteo Gambini aff001; Annalisa Forlani aff001; Mario Caniatti aff001; Gabriele Ghisleni aff001; Paola Roccabianca aff001
Působiště autorů:
Diagnostic Pathology Service, Dipartimento di Medicina Veterinaria (DIMEVET), Università degli Studi di Milano, Lodi, Italy
aff001
Vyšlo v časopise:
PLoS ONE 14(11)
Kategorie:
Research Article
prolekare.web.journal.doi_sk:
https://doi.org/10.1371/journal.pone.0224945
Souhrn
Cytology represents a useful diagnostic tool in the preliminary clinical approach to canine splenic lesions, and may prevent unnecessary splenectomy. However, few studies have evaluated diagnostic accuracy of cytology in the diagnosis of canine splenic neoplasms. The aim of this study was to determine overall accuracy, sensitivity, specificity, positive and negative predictive values (i.e. diagnostic accuracy indexes) of cytology for canine splenic neoplasms following Standards for the Reporting of Diagnostic Accuracy Studies (STARD) guidelines. A consecutive series of canine splenic cytological samples was retrospectively retrieved from the database of the Diagnostic Pathology Service of the Department of Veterinary Medicine (DIMEVET—University of Milan). Histopathology was set as the diagnostic reference standard. Cytological cases were enrolled when slides were available for review and when the same lesion was submitted for histopathology. Seventy-eight (78) lesions were included in the study. By histopathology, 56 were neoplastic and 22 were non-neoplastic. Cytology had an overall accuracy of 73.08% (95% C.I. 61.84%-82.50%), sensitivity of 64.29% (95% C.I. 50.36%-76.64%), specificity of 95.45% (95% C.I. 77.16%-99.88%), and positive and negative predictive values of 97.3% (95% C.I. 84.01%-99.60%) and 51.22% (95% C.I. 42.21%-60.15%), respectively. Low sensitivity and negative predictive value were balanced by very high specificity and positive predictive value. When positive for neoplasia, cytology represents a useful diagnostic tool to rule in splenic neoplasia, prompting surgery independently from other diagnostic tests. Conversely, a negative cytological result requires additional investigations to confirm the dog to be disease free.
Klíčová slova:
Dogs – Cytology – Cancer detection and diagnosis – Histopathology – Histology – Veterinary diagnostics – Neoplasms – Angiosarcoma
Zdroje
1. Lee M, Park J, Choi H, Lee H, Jeong SM. Presurgical assessment of splenic tumors in dogs: a retrospective study of 57 cases (2012–2017). J Vet Sci. 2018;19: 827–834. Available: http://synapse.koreamed.org/DOIx.php?id=10.4142%2Fjvs.2018.19.6.827 30173499
2. Spangler WL, Culbertson MR. Prevalence, type, and importance of splenic diseases in dogs: 1,480 cases (1985–1989). J Am Vet Med Assoc. 1992;200: 829–34. Available: http://www.ncbi.nlm.nih.gov/pubmed/1568933 1568933
3. Spangler WL, Kass PH. Pathologic factors affecting postsplenectomy survival in dogs. J Vet Intern Med. 1997;11: 166–71. Available: http://www.ncbi.nlm.nih.gov/pubmed/9183768 9183768
4. Bertazzolo W, Dell’Orco M, Bonfanti U, Ghisleni G, Caniatti M, Masserdotti C, et al. Canine angiosarcoma: cytologic, histologic, and immunohistochemical correlations. Vet Clin Pathol. 2005;34: 28–34. Available: http://www.ncbi.nlm.nih.gov/pubmed/15732014 15732014
5. Eberle N, von Babo V, Nolte I, Baumgartner W, Betz D. Splenic masses in dogs. Part 1: Epidemiologic, clinical characteristics as well as histopathologic diagnosis in 249 cases (2000–2011). Tierarztl Prax Ausg K Kleintiere Heimtiere. 2012;40: 250–260. 22911256
6. Fossum TW, Caplan ER. Chapter 24—Surgery of the Hemolymphatic System. In: Fossum TW, editor. Small animal surgery. Fourth Ed. St. Louis, Missouri: Elsevier Mosby; 2013. pp. 685–704.
7. Cleveland MJ, Casale S. Incidence of malignancy and outcomes for dogs undergoing splenectomy for incidentally detected nonruptured splenic nodules or masses: 105 cases (2009–2013). J Am Vet Med Assoc. 2016;248: 1267–1273. doi: 10.2460/javma.248.11.1267 27172343
8. Watson AT, Penninck D, Knoll JS, Keating JH, Sutherland-Smith J. Safety and correlation of test results of combined ultrasound-guided fine-needle aspiration and needle core biopsy of the canine spleen. Vet Radiol Ultrasound. 2011;52: 317–322. doi: 10.1111/j.1740-8261.2010.01778.x 21554481
9. Wendelburg KM, O’Toole TE, McCobb E, Price LL, Lyons JA, Berg J. Risk factors for perioperative death in dogs undergoing splenectomy for splenic masses: 539 cases (2001–2012). J Am Vet Med Assoc. 2014;245: 1382–1390. doi: 10.2460/javma.245.12.1382 25459483
10. Marino DJ, Matthiesen DT, Fox PR, Lesser MB, Stamoulis ME. Ventricular Arrhythmias in Dogs Undergoing Splenectomy : Vet Surg. 1994;23: 101–106. doi: 10.1111/j.1532-950x.1994.tb00453.x 8191668
11. Pastarapatee N, Kijtawornrat A, Buranakarl C. Imbalance of autonomic nervous systems involved in ventricular arrhythmia after splenectomy in dogs. J Vet Med Sci. 2017;79: 2002–2010. doi: 10.1292/jvms.17-0482 29070771
12. Miko I, Nemeth N, Sogor V, Kiss F, Toth E, Peto K, et al. Comparative erythrocyte deformability investigations by filtrometry, slit-flow and rotational ektacytometry in a long-term follow-up animal study on splenectomy and different spleen preserving operative techniques: Partial or subtotal spleen resection and spleen autotransplantation. Clin Hemorheol Microcirc. 2017;66: 83–96. doi: 10.3233/CH-160231 28128749
13. Miko I, Nemeth N, Peto K, Furka A, Toth L, Furka I. Changes of red blood cell aggregation parameters in a long-term follow-up of splenectomy, spleen-autotransplantation and partial or subtotal spleen resections in a canine model. Clin Hemorheol Microcirc. 2017;67: 91–100. doi: 10.3233/CH-170264 28598833
14. Kaltreider HB, Barth E, Pellegrini C. The effect of splenectomy on the appearance of specific antibody-forming cells in lungs of dogs after intravenous immunization with sheep erythrocytes. Exp Lung Res. 1981;2: 231–238. doi: 10.3109/01902148109052318 6975209
15. Richardson EF, Brown NO. Hematological and biochemical changes and results of aerobic bacteriological culturing in dogs undergoing splenectomy. J Am Anim Hosp Assoc. 1996;32: 199–210. doi: 10.5326/15473317-32-3-199 8731133
16. Tiškina V, Capligina V, Must K, Berzina I, Ranka R, Jokelainen P. Fatal Babesia canis canis infection in a splenectomized Estonian dog. Acta Vet Scand. 2016;58: 1–6.
17. Kawamura M, Maede Y, Namioka S. Mitogenic responsibilities of lymphocytes in canine babesiosis and the effects of splenectomy on it. Jpn J Vet Res. 1987;35: 1–10. 3599600
18. Kemming G, Messick JB, Mueller W, Enders G, Meisner F, Muenzing S, et al. Can we continue research in splenectomized dogs? Mycoplasma haemocanis: Old problem—New insight. Eur Surg Res. 2004;36: 198–205. doi: 10.1159/000078853 15263824
19. Lester SJ, Hume JB, Phipps B. Haemobartonella canis infection following splenectomy and transfusion. Can Vet J. 1995;36: 444–445. 7585424
20. Sartor AJ, Bentley AM, Brown DC. Association between previous splenectomy and gastric dilatation-volvulus in dogs: 453 cases (2004–2009). J Am Vet Med Assoc. 2013;242: 1381–1384. doi: 10.2460/javma.242.10.1381 23634682
21. Allen P, Paul A. Gastropexy for Prevention of Gastric Dilatation-Volvulus in Dogs: History and Techniques. Top Companion Anim Med. 2014;29: 77–80. doi: 10.1053/j.tcam.2014.09.001 25496925
22. Maki LC, Males KN, Byrnes MJ, El-Saad AA, Coronado GS. Incidence of gastric dilatation-volvulus following a splenectomy in 238 dogs. Can Vet J. 2017;58: 1275–1280. 29203936
23. Christensen NI, Canfield PJ, Martin PA, Krockenberger MB, Spielman DS, Bosward KL. Cytopathological and histopathological diagnosis of canine splenic disorders. Aust Vet J. 2009;87: 175–181. doi: 10.1111/j.1751-0813.2009.00421.x 19382924
24. Ballegeer EA, Forrest LJ, Dickinson RM, Schutten MM, Delaney FA, Young KM. Correlation of ultrasonographic appearance of lesions and cytologic and histologic diagnoses in splenic aspirates from dogs and cats: 32 cases (2002–2005). J Am Vet Med Assoc. 2007;230: 690–696. doi: 10.2460/javma.230.5.690 17331053
25. O’Keefe DA, Couto CG. FNA of the spleen as an aid in the diagnosis of splenomegaly. J Vet Intern Med. 1987;1: 102–109.
26. Spangler WL, Kass PH. Pathologic factors affecting postsplenectomy survival in dogs. J Vet Intern Med. 1997;11: 166–171. doi: 10.1111/j.1939-1676.1997.tb00085.x 9183768
27. Gochhait D, Dey P, Rajwanshi A, Nijhawan R, Gupta N, Radhika S, et al. Role of Fine needle aspiration cytology of spleen. APMIS. 2015;123: 190–193. doi: 10.1111/apm.12339 25469450
28. Gómez-Rubio M, López-Cano A, Rendón P, Muñoz-Benvenuty A, Macías M, Garre C, et al. Safety and diagnostic accuracy of percutaneous ultrasound-guided biopsy of the spleen: A multicenter study. J Clin Ultrasound. 2009;37: 445–450. doi: 10.1002/jcu.20608 19582827
29. Barone S, Baer MR, Sait SNJ, Lawrence D, Block AW, Wetzler M. Ultrasound-guided fine needle biopsy of the spleen: High clinical efficacy and low risk in a multicenter Italian study. Am J Hematol. 2001;67: 93–99. doi: 10.1002/ajh.1085 11343380
30. Christopher MM. Cytology of the spleen. Veterinary Clinics of North America—Small Animal Practice. 2003. pp. 135–152. doi: 10.1016/S0195-5616(02)00082-7
31. Cohen M, Bohling MW, Wright JC, Welles EA, Spano JS. Evaluation of sensitivity and specificity of cytologic examination: 269 cases (1999–2000). J Am Vet Med Assoc. 2003;222: 964–7. Available: http://www.ncbi.nlm.nih.gov/pubmed/12685787 12685787
32. Eich C, Whitehair J, Moroff S, Heeb L. The accuracy of intraoperative cytopathological diagnosis compared with conventional histopathological diagnosis. J Am Anim Hosp Assoc. 2014;36: 16–18. doi: 10.5326/15473317-36-1-16 10667401
33. Braun AO, Hauser B. Korrelation zwischen zytologischen und histologischen Haut-, Lymphknoten- Und Milzbefunden bei 500 Hunden und Katzen. Schweiz Arch Tierheilkd. 2007;149: 249–257.
34. Bossuyt PM, Reitsma JB, Bruns DE, Gatsonis CA, Glasziou PP, Irwig L, et al. STARD 2015: An updated list of essential items for reporting diagnostic accuracy studies [Internet]. Clinical Chemistry. 2015. pp. 1446–1452. doi: 10.1373/clinchem.2015.246280 26510957
35. Caniatti M, da Cunha NP, Avallone G, Romussi S, Mortellaro CM, Tranquillo V, et al. Diagnostic accuracy of brush cytology in canine chronic intranasal disease. Vet Clin Pathol. 2012;41: 133–140. doi: 10.1111/j.1939-165X.2011.00388.x 22250805
36. Fournier Q, Cazzini P, Bavcar S, Pecceu E, Ballber C, Elders R. Investigation of the utility of lymph node fine-needle aspiration cytology for the staging of malignant solid tumors in dogs. Vet Clin Pathol. 2018;47: 489–500. doi: 10.1111/vcp.12636 30011068
37. Berzina I, Sharkey LC, Matise I, Kramek B. Correlation between cytologic and histopathologic diagnoses of bone lesions in dogs: a study of the diagnostic accuracy of bone cytology. Vet Clin Pathol. 2008;37: 332–338. doi: 10.1111/j.1939-165X.2008.00050.x 18761529
38. Raskin RE. Chapter 4—Hemolymphatic System. In: Raskin RE, Meyer DJBT, editors. Canine and Feline Cytology—A Color Atlas and Interpretation Guide. Third Ed. St. Louis, Missouri: W.B. Saunders; 2016. pp. 91–137. https://doi.org/10.1016/B978-1-4557-4083-3.00004-8
39. Ménard M, Fontaine M, Morin M. Fine needle aspiration biopsy of malignant tumors in dogs and cats: a report of 102 cases. Can Vet J = La Rev Vet Can. 1986;27: 504–10. Available: http://www.ncbi.nlm.nih.gov/pubmed/17422728
40. Valli VE. Chapter 3—B-Cell Neoplasms. In: Valli VE, editor. Veterinary Comparative Hematology. First Ed. Ames, Iowa: Blackwell Publishing; 2007. pp. 119–274.
41. Valli VE. Chapter 4—T-Cell and NK-Cell Neoplasms. In: Valli VE, editor. Veterinary Comparative Hematology. First Ed. Ames, Iowa: Blackwell Publishing; 2007. pp. 275–366.
42. Valli VE. Chapter 5—Acute Myeloid Leukemias. In: Valli VE, editor. Veterinary Comparative Hematology. First Ed. Ames, Iowa: Blackwell Publishing; 2007. pp. 367–424.
43. Valli VE. Chapter 6—Chronic Myeloproliferative Diseases. In: Valli VE, editor. Veterinary Comparative Hematology. First Ed. Ames, Iowa: Blackwell Publishing; 2007. pp. 425–460.
44. Valli VE. Chapter 7—Myeloproliferative/Myelodysplastic Diseases. In: Valli VE, editor. Veterinary Comparative Hematology. First Ed. Ames, Iowa: Blackwell Publishing; 2007. pp. 461–467.
45. Valli VE. Chapter 9—Hodgkin’s Lymphoma. In: Valli VE, editor. Veterinary Comparative Hematology. First Ed. Ames, Iowa: Blackwell Publishing; 2007. pp. 491–504.
46. Hendrick MJ. Chapter 5—Mesenchymal Tumors of the Skin and Soft Tissues. In: Meuten DJ, editor. Tumors in domestic animals. Fifth Ed. Ames, Iowa: Wiley/Blackwell; 2017. pp. 142–175. http://ez.statsbiblioteket.dk:2048/login?url=https://ebookcentral.proquest.com/lib/asb/detail.action?docID=4737344
47. Valli VE, Bienzle D, Meuten DJ, Linder KE. Chapter 7—Tumors of the Hemolymphatic System. In: Meuten DJ, editor. Tumors in domestic animals. Fifth Ed. Ames, Iowa: Wiley/Blackwell; 2017. pp. 203–321. http://ez.statsbiblioteket.dk:2048/login?url=https://ebookcentral.proquest.com/lib/asb/detail.action?docID=4737344
48. Moore PF. Chapter 8—Canine and Feline Histiocytic Diseases. In: Meuten DJ, editor. Tumors in domestic animals. Fifth Ed. Ames, Iowa: Wiley/Blackwell; 2017. pp. 322–336. http://ez.statsbiblioteket.dk:2048/login?url=https://ebookcentral.proquest.com/lib/asb/detail.action?docID=4737344
49. Valli VE, Vernau W, De Lorimier LP, Graham PS, Moore PF. Canine indolent nodular lymphoma. Vet Pathol. 2006;43: 241–256. doi: 10.1354/vp.43-3-241 16672571
50. Valli VE, Myint M, Barthel A, Bienzle D, Caswell J, Colbatzky F, et al. Classification of canine malignant lymphomas according to the world health organization criteria. Vet Pathol. 2011;48: 198–211. doi: 10.1177/0300985810379428 20861499
51. Moore PF. A Review of Histiocytic Diseases of Dogs and Cats. Vet Pathol. 2014;51: 167–184. doi: 10.1177/0300985813510413 24395976
52. Moore AS, Frimberger AE, Sullivan N, Moore PF. Histologic and Immunohistochemical Review of Splenic Fibrohistiocytic Nodules in Dogs. J Vet Intern Med. 2012;26: 1164–1168. doi: 10.1111/j.1939-1676.2012.00986.x 22882592
53. Vos JH, van den Ingh TS, van Mil FN. Non-exfoliative canine cytology: the value of fine needle aspiration and scraping cytology. Vet Q. 1989;11: 222–231. doi: 10.1080/01652176.1989.9694228 2690456
54. Bonfanti U, Bertazzolo W, Gracis M, Roccabianca P, Romanelli G, Palermo G, et al. Diagnostic value of cytological analysis of tumours and tumour-like lesions of the oral cavity in dogs and cats: A prospective study on 114 cases. Vet J. 2015;205: 322–327. doi: 10.1016/j.tvjl.2014.10.022 25466576
55. Ku CK, Kass PH, Christopher MM. Cytologic–histologic concordance in the diagnosis of neoplasia in canine and feline lymph nodes: a retrospective study of 367 cases. Vet Comp Oncol. 2017;15: 1206–1217. doi: 10.1111/vco.12256 27523399
56. Clifford CA, Pretorius ES, Weisse C, Sorenmo KU, Drobatz KJ, Siegelman ES, et al. Magnetic resonance imaging of focal splenic and hepatic lesions in the dog. J Vet Intern Med. 2004;18: 330–338. doi: 10.1892/0891-6640(2004)18<330:mriofs>2.0.co;2 15188820
57. Sharkey LC, Dial SM, Matz ME. Maximizing the Diagnostic Value of Cytology in Small Animal Practice. Vet Clin North Am—Small Anim Pract. 2007;37: 351–372. doi: 10.1016/j.cvsm.2006.11.004 17336679
58. Valli VE, Kass PH, Myint MS, Scott F. Canine Lymphomas: Association of Classification Type, Disease Stage, Tumor Subtype, Mitotic Rate, and Treatment With Survival. Vet Pathol. 2013;50: 738–748. doi: 10.1177/0300985813478210 23444036
59. Valli VE. Chapter 2—Normal and Benign Reactive Hematopoietic Tissues—Spleen. Veterinary Comparative Hematology. First Edit. Blackwell Publishing; 2007. pp. 47–76.
60. Sabattini S, Lopparelli RM, Rigillo A, Giantin M, Renzi A, Matteo C, et al. Canine Splenic Nodular Lymphoid Lesions: Immunophenotyping, Proliferative Activity, and Clonality Assessment. Vet Pathol. 2018;55: 645–653. doi: 10.1177/0300985818777035 29807508
61. Patten SG, Boston SE, Monteith GJ. Outcome and prognostic factors for dogs with a histological diagnosis of splenic hematoma following splenectomy: 35 cases (2001–2013). Can Vet J. 2016;57: 842–846. 27493283
Článok vyšiel v časopise
PLOS One
2019 Číslo 11
- Metamizol jako analgetikum první volby: kdy, pro koho, jak a proč?
- Nejasný stín na plicích – kazuistika
- Masturbační chování žen v ČR − dotazníková studie
- Úspěšná resuscitativní thorakotomie v přednemocniční neodkladné péči
- Dlouhodobá recidiva a komplikace spojené s elektivní operací břišní kýly
Najčítanejšie v tomto čísle
- A daily diary study on maladaptive daydreaming, mind wandering, and sleep disturbances: Examining within-person and between-persons relations
- A 3’ UTR SNP rs885863, a cis-eQTL for the circadian gene VIPR2 and lincRNA 689, is associated with opioid addiction
- A substitution mutation in a conserved domain of mammalian acetate-dependent acetyl CoA synthetase 2 results in destabilized protein and impaired HIF-2 signaling
- Molecular validation of clinical Pantoea isolates identified by MALDI-TOF