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preLekára.sk / Odborné časopisy / PLOS One / 2019 - 11

On the accuracy of displacement-based wave intensity analysis: Effect of vessel wall viscoelasticity and nonlinearity

Authors: Jingyi Kang aff001;  Arian Aghilinejad aff001;  Niema M. Pahlevan aff001
Authors place of work: Department of Aerospace and Mechanical Engineering, University of Southern California, Los Angeles, CA, United States of America aff001;  Keck School of Medicine, University of Southern California, Los Angeles, CA, United States of America aff002
Published in the journal: PLoS ONE 14(11)
Category: Research Article
doi: https://doi.org/10.1371/journal.pone.0224390

Summary

Recent studies showed that wave intensity analysis (WIA) provides clinically valuable information about local and global cardiovascular function. Wave intensity (WI) is computed as the product of the pressure change and the velocity change during short time intervals. The major limitation of WIA in clinical practice is the need for invasive pressure measurement. Since vessel wall displacement can be measured non-invasively, the usage of WI will be expanded if the vessel wall dilation is used instead of pressure in derivation of WI waveform. Our goal in this study is to investigate the agreement between wall displacement-based WI and the pressure-based WI for different vessel wall models including linear elastic, nonlinear and viscoelastic cases. The arbitrary Eulerian Lagrangian finite element method is employed to solve the coupled fluid-structure interaction (FSI). Our computational models also include two types of vascular disease-related cases with geometrical irregularities, aneurysm and stenosis. Our results show that for vessels with linear elastic wall, the displacement-based WI is almost identical to the pressure-based WI. The existence of vessel irregularities does not impact the accuracy of displacement-based WI. However, in a viscoelastic wall where there is a phase difference between pressure and vessel wall dilation, displacement-based WI deviated from pressure-based WI. The error associated with this phase difference increased nonlinearly with increasing viscosity. This results in a maximum error of 6.8% and 7.13% for a regular viscoelastic vessel wall and an irregular viscoelastic vessel wall, respectively. A separate analysis has also been performed on the agreement of backward and forward running waves extracted from a decomposition of the displacement-based and pressure-based WI. Our findings suggest that displacement-based WI is a reliable method of WIA for large central arteries that do not show viscoelastic behaviors. This can be clinically significant since the required information can be measured non-invasively.

Keywords:

Reflection – Stenosis – Arteries – Aorta – Aneurysms – Deformation – Viscosity – Fluid flow

Introduction

It is well accepted that arterial waveform analysis provides clinically valuable information about local and global cardiovascular function. Due to the complex dynamic interactions of hemodynamic waves (e.g., pressure and flow), extracting clinically reliable information about the state of health or disease remains a significant challenge to modern medicine [1]. Pressure and flow pulse waves in large arteries are composed of forward running waves originated by the ventricle and backward running (reflected) waves created by the vascular network. Understanding the physics of these forward and backward waves is necessary for extracting physiological information relevant to clinical practice. Several methods such as Fourier (impedance) methods and wave intensity analysis (WIA) have been introduced for decomposing hemodynamic waves in the arterial system into their forward and backward components. The Fourier analysis method (impedance method), in particular, relies on the normal periodicity of the cardiac cycle to compute the hemodynamic impedance in the frequency domain [2]. Therefore, this method is not useful for many applications in which the timeline of certain events is important [3]. This method additionally assumes a linear relation between the pressure and flow rate at each harmonic frequency.

WIA was introduced by Parker and Jones as an alternative time domain method for separating forward and backward waves based on the method of characteristics—without needing to assume linearity or periodicity since it relies on the solution of conservation equations in the time domain [4]. In this method, wave intensity (WI) is computed as the product of the blood pressure change and the velocity change during short time intervals [5]. A positive value of WI indicates that forward-traveling waves predominate while a negative value indicates that backward-traveling waves predominate. WIA can also be used to compute physiologically relevant indices such as local pulse wave velocity [6]. Since WI is in units of power per area (an index of energy per unit area carried by waves), the WIA method can determine wave directionality as well as the magnitude of the energy transferred by the waves [5]. WIA has been used in hemodynamic studies throughout the cardiovascular circulatory network including the ascending aorta [7], carotid arteries [8], pulmonary circulation [9], and coronary arteries [10], and has demonstrated promising abilities in providing clinical insights useful for early diagnosis in cardiovascular diseases.

Although the WIA can provide valuable information in clinical study and cardiovascular research, this method requires simultaneous measurement of both pressure and flow waves at the same location (which makes it clinically challenging). In current clinical practice, simultaneous pressure and velocity measurements can be obtained invasively using sensor-tipped guidewires [11] (e.g., ComboWire, Volcano Inc). In general, invasive procedures are more expensive, may cause patient discomfort/pain, and have a higher risk of clinical complications. Therefore, non-invasive evaluation of WI [12] is prudent to expand the clinical utility and efficacy of this method. Already, blood velocity can be easily measured non-invasively with imaging modalities such as echocardiograms and phase contrast (PC) magnetic resonance imaging (MRI). The non-invasive version of WIA can use the diameter change of the vessel wall instead of invasively measured blood pressure waves. This technique has been explored in order to evaluate important hemodynamic indices such as pulse wave velocity [13] or WI [14]. As an example, Khir et al. have shown the separation of WI into its forward and backward directions using the non-invasively measured diameter of a flexible tube’s wall and the corresponding flow velocity [12]. However, it is well-known that blood vessels exhibit complex and viscoelastic properties that are attributed to the smooth muscle cells. This viscoelasticity may introduce a phase difference between the pressure and wall deformation [15] which may subsequently introduce an error in the non-invasive evaluation of WI.

Our goal in this study is to investigate the agreement between non-invasive wall displacement-based WI and the pressure-based WI. Computational fluid dynamics (CFD) with Fluid-Solid interaction (FSI) has been employed to simulate pressure and flow waves in various vessel models. In the mammalian cardiovascular system, arteries can be roughly divided into two types: i) proximal large arteries that show linear elastic behavior (under normal conditions) and ii) distal small arteries that demonstrate viscoelastic and nonlinear (stress-strain) behavior [16]. In this study, the wall models have included linearly elastic, non-linear, and viscoelastic arterial walls. Additionally, we have examined the accuracy of displacement-based WIA for cases with downstream geometrical irregularities such as aneurysm (relevant to abdominal aortic aneurysm) and stenosis (relevant to atherosclerosis). The systematic research work conducted here provides the fundamental groundwork for utilizing the non-invasive displacement-based WIA technique to measure the clinically relevant quantities such as WI.

Materials and methods

Physical model

In order to comprehensively investigate the WI in different arteries, we have considered two cases: (1) vessel walls with no viscoelastic behavior representing large central arteries such as aorta and carotid artery, and (2) vessel walls with considerable degree of viscoelasticity representing the small and muscular arteries. The generalized Maxwell model was considered for the viscoelastic wall (Fig 1). In this model, a linear spring μ0 is connected in parallel to n terms of Maxwell elements, where each element is composed of a linear spring and a viscous dashpot [17]. In the ith Maxwell element, the spring has an elastic modulus μi and the dashpot has a viscous coefficient ηi. The σ and ε in Fig 1 are the stress and strain for the whole system, respectively [18]. Specifically, we utilized the first two terms of generalized Maxwell viscoelastic model which consisted of an elastic part with Young’s modulus E1, the viscous part with Young’s modulus E2, and the damping coefficient of the dashpot η.

Fig. 1.
Schematic representation of the Generalized Maxwell model on the left (A) and the standard solid viscoelastic model on the right (B).

The extension tube boundary model [19] was used as the outflow boundary model to acquire physiologically relevant solutions for pressure, diameter, and velocity waves. This outflow boundary model can capture the compliance, resistance, and wave reflections of the downstream vasculature [19], and it consists of a straight elastic tube connected to a rigid contraction tube (Fig 2). We first studied a simple case of a straight vessel with uniform thickness and a circular cross-section (Fig 2A). Following this case, vessel models with geometrical irregularities (sudden dilation or constriction) were investigated to evaluate the accuracy of the displacement-based WIA in the presence of vascular diseases such as stenosis and aneurysm (Fig 2B and 2C). The same outflow boundary model was used in all these cases.

Fig. 2.
(A) Straight vessel connected to the outflow boundary condition, (B) Abdominal aortic aneurysm and (C) Stenosis cases connected to the same outflow boundary to capture the effect of truncated downstream vasculature.

The geometrical and outflow parameters of the vessel models (see Fig 2) are provided in Table 1. The geometric data, such as the radius and the length of the bulge in aneurysm and stenosis cases, are chosen within the average psychological range [20]. To characterize the viscoelasticity of the vessel wall, the relaxation modulus (E(t)) is utilized in response to strain loading for the Maxwell-type standard solid viscoelastic material model. This dynamic modulus includes the effects of E1 and E2 as shown in Fig 1B. In all simulations, blood is assumed to be a incompressible and Newtonian fluid with the properties shown in Table 1.

Tab. 1. Parameters employed for computational modeling.
Parameters employed for computational modeling.

Theoretical considerations

Prior to introducing our computational model, it is beneficial to consider an analytical model for vessel wall displacement with standard solid viscoelastic model. The constitutive relationship (stress-strain) can be considered as [15]

where a1, m, b1 are constants and a1 = η / E1, m = E2, b1 = η (E1+ E2) / E1.

The relaxation modulus E(t), in response to strain loading for Maxwell-type standard solid viscoelastic material model, is then given by

where E∞ = E2, E0 = E1 +E2, and the relaxation time is defined as τ0 = η / E1. Hence, the dynamic modulus in response to harmonic strain excitation of the standard solid viscoelastic model can be expressed as [21, 22]

Using the above viscoelastic model, the displacement-strain relation can be derived from the momentum balance of the arterial wall as

where u is wall displacement vector, σ is wall stress tensor, and f is body force vector. In order to facilitate the calculation, the above equation can be written in the cylindrical coordinate system. Since the vessel is symmetric, the radial equation of motion in a cylindrical vessel (in the absence of external body forces) with the assumption of the incompressibility of the vessel wall is given by [23]

For the cases considered in this work, this equation is subjected to the boundary condition given by

Here, t and r denote time and radial coordinates respectively, ρs is the vessel wall density, ur is the radial displacement of the wall, σrr is the radial stress, σθθ is the circumferential stress, p(t) is the pressure, Rin(t) is the inner radius of the vessel wall, and Rout(t) is the outer diameter of the vessel wall. Since the arterial wall is thin and has small asymmetrical deformations, it can be treated as a membrane [21, 24]. In the thin-walled theory for the blood vessel, the axial strain can be calculated by employing Hooke’s law for an isotropic medium as

where μ is the Poisson ratio. In addition, from the membrane assumption, the corresponding radial and axial stresses are

In circumferential direction, we have

Thus

where r0 is the radius of the aorta wall before deformation, and ur is the wall displacement in radial direction. It can be assumed that the flow waveform is periodic so that all variables can be expressed in terms of different harmonics of the fundamental frequency. Without loss of generality, a single harmonic of the pressure wave can be considered as the sinusoidal function given by

Because of the linearity of Eqs (1) and (4), the stress and strain also have the same frequency of oscillation as the pressure. In the complex form (which greatly simplifies the analysis), the pressure, stress and strain can be written respectively as

Here, “Re” denotes the real part, and “^” denotes the complex amplitude. Substituting Eqs (12–14) into Eq (1) and rearranging terms gives

where E^ is the complex young’s modulus for the relaxation function, σ^ and ε^ are the complex stress and strain. Combining Eq (15) with wall motion Eqs (7–10), governing Eq (5) and the boundary condition (6), the displacement expression in complex form can be written as [25]

For the Maxwell-type standard solid viscoelastic model, we have τ1 = η / E1, τ 2 = η (E1+ E2) / E1E2, E = E2/(E1+ E2). Hence, according to Eq (16), even for the simple harmonic of the pressure waveform, there will be a complex relationship between the pressure and vessel wall displacement in the presence of the viscoelasticity. This complexity motivates the need for the development of mathematical frameworks or numerical simulations, as described in what follows, for further analyzing the problem.

Numerical model

Governing equations

An arbitrary Lagrangian-Eulerian (ALE) formulation is used for the analysis of the fluid flow with moving boundaries. The ALE formulation can directly be coupled with the Lagrangian formulation in the solid domain [26]. To solve the pressure and flow fields in the fluid domain, Navier-Stokes equations for the homogenous, incompressible and Newtonian fluid are employed. For coupling the fluid-solid interface, the fundamental conditions of displacement compatibility with respect to a no-slip condition and traction equilibrium are applied as [27]

where V→=(vy,vz) is the flow velocity vector, p is the static pressure, ρf is the fluid density, μ is the dynamic viscosity, W→ is the velocity of the arbitrary Lagrangian-Eulerian (ALE) frame, Fb→ is the body force, Vf and us˙ are the velocity of the fluid and structure at the interface respectively, σf is the fluid stress tensor, and σs is the solid stress tensor. For the solid domain, we consider two cases:

Elastic wall condition

The dynamic motion of the wall can be calculated by the Lagrangian form of the balance of the momentum equations as [28]

where σij is the stress tensor, Fi is the external force, ui is the displacement vector, and ρs is the wall density. The stress tensor can be expressed as [29]
where λ and μ are Lame parameters, and λ=Eυ(1−υ)(1−2υ),μ=G=E2(1+υ). Note that the bulk modulus which describes the volumetric elasticity of the material can also be calculated by K=E3(1−2υ).

In order to examine the vessel wall displacement in a non-linear regime, we have utilized the nonlinear elastic stress-strain data input in tabular for, extracted from Fig 3. This material model is useful for large displacement and small strain analysis.

Fig. 3. Stress-Strain data used for nonlinear case analysis.
Stress-Strain data used for nonlinear case analysis.
The red curve indicates the output stress-strain region.

Viscoelastic wall condition

Considering large deformation but small strain theory, the mechanical behavior for an inotropic and quasi-linear viscoelastic material can be expressed in tensor notation as [30]

where t is the time, Sij=σij−13δijσkk is the deviatoric stress, σij is the stress, δij is the Kronecker delta, eij=εij−13δijεkk is the deviatoric strain, εij is the strain, and G(t) and K(t) are shear and bulk modulus respectively. To solve the above convolution integrals, the full-time history of the deformation and material variables must be considered—a challenging task. Alternatively, we can characterize the viscoelastic behavior of the material as relaxation functions that are described by exponential series [31]. This method takes advantage of recursive equations for evaluation hereditary integrals (Eqs (23 and 24)). Considering the generalized Maxwell model, we can express the shear and bulk modulus by Prony series expansions as
where N is the number of chains in the Maxwell model, G∞ and K∞ are the steady-state shear and bulk modulus respectively, Gi and Ki are the coefficients, and ϑi and γi are the relaxation times in the Prony series expansions. Since we are using a standard viscoelastic model in this study, we consider only the first chain (N = 1) in the Prony series for the material properties. With the viscoelastic material properties in hand (evaluated by Eqs (25 and 26)), we can numerically compute the discretized convolution integrals of Eqs (23) and (24).

Boundary conditions

At the inlet, a physiological flow waveform (similar to [19, 32]) with a flat velocity profile is imposed and scaled to give a cardiac output (CO) of 4.6 L/min. In the fluid domain, a constant normal traction of Pend = 10.5mmHg is imposed at the end of outflow boundary model, while in the solid domain, zero normal traction is imposed on the outer surface of the straight vessel and outflow boundary [19]. To simulate the effect of truncated vasculature, an extension tube boundary model was used for the outflow boundary condition at the terminal of the abdominal aorta. This boundary model extends the computational model with a straight elastic tube connected to a contracted rigid tube. The parameters of the outflow boundary condition model are given in Table 1, where the contraction ratio is the ratio of the radius of the rigid boundary tube (after the contraction) to the original radius (before the contraction) [33]. In all simulations, CO, the parameters of the outflow boundary condition, and the shape of the inflow wave were kept constant.

Wave intensity analysis

WIA is based on the method of characteristics which has been used in analogous problems in gas dynamics. In this method, the hyperbolic system of one-dimensional equations of motion in z and t is transformed into a system of ordinary differential equations along the two families of the characteristics defined as dzdt=U±c, where U is the average velocity over the cross section and c=Aρ∂A∂P is the speed of propagation [5]. Following an impermeable assumption for the wall, the Riemann invariants can be defined on the characteristic lines as

Solving for dP and dU, their corresponding product can be derived as

where dI is defined as the WI in units of power per unit area (e.g. W/m2). Based on Eq (28), the contribution of the forward running wave (dR+) to the WI is always positive, while the contribution of the backward running wave (dR−) to the WI is always negative. Therefore, if dI>0, the forward waves are dominant; and if dI <0, the backwards (reflected) waves are dominant. This allows one to easily determine wave propagation at each time. If the incremental waves are assumed to be additive, the WI can be further decomposed into purely forward (+) and purely reflected (-) waves [34] as

As can be noted from Eqs (29) and (30), simultaneous increments of pressure and flow (velocity) are needed to compute WI. Our focus in this study is to compare the pressure-based WI waveform (obtained based on the pressure and velocity) with the displacement-based WI (obtained from velocity and vessel wall displacement). Based on Eq (16), we can rewrite the wall displacement as

where R^ is the amplitude for the vessel wall displacement, and φ is the phase difference between the vessel wall displacement and pressure harmonic. We can further assume that vessel wall displacement amplitude (R^) and pressure inside the tube (P) are correlated by the proportionality coefficient in the short time interval (which depends on the wall modulus of elasticity, inner and outer diameter, and viscoelasticity parameter of the wall (τ1,τ2)). Hence, we can introduce an alternative parameter similar to the WI, defined to be dID, which is the product of the increment in diameter and the flow given by
where k^ is the proportionality coefficient. In order to compare the above parameter with the WI that is defined based on the pressure and flow, we can further non-dimensionalize these two parameters by dividing each one over the maximum value in the cycle. From this, we can compare the waveform obtained based on these two variables at each site. The non-dimensionalized variables are denoted with asterisks: DI*D for dimensionless displacement-based WI and DI*P for dimensionless pressure-based WI.

Computational model

In order to solve the equations of solids and fluids numerically, an ALE finite element method with the two-way coupling scheme of fluid-structure interaction is employed at each time step [29]. The fluid domain is modeled with 17,416 total number of four-node 3D axisymmetric elements, while the solid domain is modeled with 2,420 total number of nine-node 2D axisymmetric elements. The linearized equation of the coupled system was solved with the direct or non-iterative solution technique [35]. A Newton-Raphson iteration scheme was used for the time integration with a time step of 0.00125s. Further simulations with different time steps and grid sizes confirm that these results are independent of spatial and temporal discretization. For the same spatial discretization, the pressure wave solutions for time steps of 0.000625s and 0.00125s reveal a maximum relative error at the middle of the straight vessel of less than 3%. Similarly, for the same time step, doubling the number of spatial elements reveals a maximum relative error of less than 3%. The commercial package ADINA 9.4 (ADINA R&D, Inc., MA) is used to run all simulations. Each simulation is started at rest with no loading condition, and the simulation is carried out to at least 10 cycles in order to ensure that the mean pressure reaches an oscillating steady state condition.

Results

Regular vessel wall condition

Elastic wall condition

Based on Eq (31), φ is the phase difference between the propagated pressure and vessel wall displacement (which depends on the wall material behavior). Utilizing the standard viscoelastic wall model introduced in Eq (5), the vessel wall displacement in response to a harmonic of pressure was described in Eq (16). Therefore, the phase difference between the pressure and vessel wall displacement can be given by

All the parameters on the right-hand side of Eq (28) are real and positive values. However, note that Eq (33) is derived for a single pressure harmonic in a linear standard viscoelastic case.

It is not clear if different pressure harmonics interact linearly with each other in a viscoelastic wall under physiological conditions. Therefore, we compared the pressure-based WI (invasive in practice) with displacement-based WI (non-invasive in practice) numerically using the CFD-FSI model described in method section. Fig 4 shows the pressure and the vessel wall displacement waveforms from of our numerical simulation that demonstrates convergence to a steady-state oscillatory condition. WI results for the linear and nonlinear elastic cases are demonstrated in Fig 5.

Fig. 4.
(A) The vessel wall displacement and (B) pressure reaches a steady state condition in elastic wall condition.
Fig. 5.
Comparison of the WI that is defined based on the pressure versus the one that is defined based on the diameter for (A) a linear elastic wall, and (B) a nonlinear hyper elastic wall conditions. DI*D is the dimensionless displacement-based WI and DI*P is the dimensionless pressure-based WI (see the text for details).

Fig 6 shows the decomposition of both the displacement-based and pressure-based wave intensities into forward and backward running waves (see Eq (28)). Since the goal is to compare the shape of the displacement-based and the pressure-based wave intensity components, we have not scaled the forward and backward running waves and hence report their absolute amplitudes.

Fig. 6.
Forward (red) and backward (blue) running components of the wave intensity for the displacement-based wave intensity (A) and pressure-based wave intensity (B) under the elastic wall condition.

Viscoelastic wall condition

Fig 7 demonstrates the pressure and the vessel wall displacement waveforms from of our numerical simulation of a viscoelastic wall that demonstrates convergence to a steady-state oscillatory condition. As shown in this figure, there are clear differences between the extracted vessel wall displacement profile and the pressure profile (e.g., the relative height of the dicrotic notch).

Fig. 7.
(A) Vessel wall displacement and (B) pressure reach steady state conditions in viscoelastic wall conditions. Steady state (C) Vessel wall displacement and (D) pressure during one cardiac cycle.

WI results for viscoelastic vessel wall condition cases are demonstrated in Fig 8. Results of different wall viscosities (within the physiological range) are demonstrated in Fig 8B. The root mean square error (RMSE) for all cases (wall viscosities: 1000Pa·s, 3000Pa·s, 6000Pa·s, 9000Pa·s and 12000Pa·s) are shown in Table 2. Note that the RMSE is defined as RMSE=1n∑t=1net2, where n is number of points within a cardiac cycle and et=|DID*−DIP*|.

Fig. 8.
(A) Comparison of the WI that is defined based on the pressure versus the one that is defined based on the diameter for viscoelastic wall condition. (B) The calculated error between the two wave intensities for different vessel wall viscosities.
Tab. 2. RMSE and the peak ratios for the regular vessel wall.
RMSE and the peak ratios for the regular vessel wall.

Ratios of WI peaks are demonstrated in Table 2. The 'peakRD+' is defined as the ratio of the first positive peak over the second positive peak for the displacement-based WI. The 'peakRD-' is defined as the ratio of the first positive peak to the first negative peak for the displacement-based WI. The 'peakPD+' is defined as the ratio of the first positive peak to the second positive peak for the pressure-based WI. The 'peakPD-' is defined as the ratio of the first positive peak to the first negative peak for pressure-based WI.

Fig 9 shows the decomposition of the displacement-based and pressure-based wave intensities into forward and backward running waves for the viscoelastic wall condition with a wall viscosity of 6000Pa·s.

Fig. 9.
Forward (red) and backward (blue) running components of the wave intensity for the displacement-based wave intensity (A) and pressure-based wave intensity (B) under the viscoelastic wall condition with wall viscosity of 6000 Pa.s.

Irregular vessel wall condition

Elastic wall condition

Fig 10 shows the results at point A and point B (see Fig 2) in a linear elastic vessel wall with downstream irregular geometric features in the form of an aneurysm (Fig 10A) or a stenosis (Fig 10B).

Fig. 10.
Comparison of the WI that is defined based on the pressure versus the one that is defined based on the diameter for elastic wall condition for (A) aneurysm, and (B) stenosis cases.

Viscoelastic wall condition

Results of displacement-based WI (DID*) and pressure-based WI (DIP*) of a viscoelastic aneurysmal vessel is shown Fig 11A. The point-by-point absolute error (et) between DID* and DIP* at different levels of wall viscosity (1000 Pa·s <η<12000 Pa·s) during a complete cardiac cycle is depicted in Fig 11B.

Fig. 11.
(A) Comparison of the WI that is defined based on the pressure versus the one that is defined based on the diameter for viscoelastic wall condition in the aneurysm case. (B) Calculated error between the two wave intensities for different vessel wall viscosities.

In the presence of an aneurysm, Fig 12 shows the decomposition of the displacement-based and pressure-based wave intensities into forward and backward running waves for the viscoelastic wall condition with a wall viscosity of 6000Pa·s.

Fig. 12.
Forward (red) and backward (blue) running components of the wave intensity for the displacement-based wave intensity (A) and pressure-based wave intensity (B) under the viscoelastic wall condition with wall viscosity of 6000 Pa.s in the presence of aneurysm.

Fig 13A shows the results of DID* and (DIP*) for a viscoelastic stenotic vessel. Fig 13B demonstrates the point-by-point error (et) between DID* and DIP* at different levels of wall viscosity (1000 Pa·s <η<12000 Pa·s) during a complete cycle.

Fig. 13.
(A) Comparison of the WI that is defined based on the pressure versus the one that is defined based on the diameter for viscoelastic wall conditions in the stenosis case. (B) Calculated error between the two wave intensities for different vessel wall viscosities.

In the presence of stenosis, Fig 14 shows the decomposition of the displacement-based and pressure-based wave intensities into forward and backward running waves for the viscoelastic wall condition with a wall viscosity of 6000Pa·s.

Fig. 14.
Forward (red) and backward (blue) running components of the wave intensity for the displacement-based wave intensity (A) and pressure-based wave intensity (B) under the viscoelastic wall condition with wall viscosity of 6000 Pa.s in the presence of stenosis.

The RMSE (between DID* and DIP*) over the full cardiac cycle and the different peak ratios of WI waveforms for all viscoelastic vessels with geometrical irregularities—aneurysm or stenosis—are provided in Table 3.

Tab. 3. RMSE and the peak ratios for the irregular vessel wall in the presence of aneurysm and stenosis.
RMSE and the peak ratios for the irregular vessel wall in the presence of aneurysm and stenosis.

Discussion

In this study, we examined the impact of vessel wall nonlinearity and viscoelasticity on the accuracy of the displacement-based WI (which can be measured non-invasively in clinical practice using imaging modalities) compared with the original pressure-based formulation of WI (which requires invasive measurement in clinical practice). We have used computational vessel models utilizing an Arbitrary Lagrangian-Eulerian Finite Element method in order to facilitate our study. It has been shown recently by Segers et al. [36] that wave reflections play a prominent role in conducting wave analysis and determining the characteristic parameters (such as pulse wave velocity) from the combination of pressure, velocity, or cross-sectional waveforms. To account for the effects of wave reflection, an extension tube boundary model has been utilized in our simulations to capture the compliance, resistance, and wave reflections of the downstream vasculature.

The error associated with displacement-based WI (compared with the pressure-based WI) is the result of the phase difference (φ) between the pressure and vessel wall dilation. Based on the theoretical analysis of a single pressure harmonic (Eq 33), it can be concluded that the effect of viscoelastic behavior of the vessel wall is not considerable as long as viscoelastic time relaxation coefficients (τ1 and τ2) are negligible. Since the dependency of φ on τi (i = 1 and 2) is nonlinear (see Eq 33), there will be a subsequent nonlinear and complex relationship between the error of DID* and the degree of viscoelasticity (e.g. η) when τi (i = 1 and 2) become considerable.

Results from numerical simulations of a linearly elastic vessel wall demonstrate that the pressure-based WI (DI*P) is identical to displacement-based WI (DI*D). As shown in Fig 5 for nonlinear and non-viscoelastic wall vessels, there is no phase lead or lag between DI*P and DI*D. However, the WI peak ratios of DI*P and DI*D are different in vessels with nonlinear stress-strain relationships (even in the absence of viscoelasticity). Results of vessels with viscoelastic wall properties, on the other hand, demonstrate that there is a phase difference between the DI*P and DI*D waveforms (Fig 8A). This phase difference results in errors between DI*P and DI*D (et), as shown in Fig 8B. In general, the error grows with increasing η. However, the error displays a nonlinear dependency with increasing viscosity (see Fig 8B and Table 2) as predicted by the aforementioned analytical model. In Table 2, the errors between DI*P and DI*D waveforms for different viscoelastic cases are reported as RMSE. The results from our straight viscoelastic vessel wall model suggest that the maximum corresponding error associated with displacement-based WI is bounded around 6.8%. One of the main advantages of WIA is the ability to decompose the wave at any time and location into its forward and backward running components (see Eq (28)). Forward waves in the vasculature are mostly caused by the heart, and backward waves are the result of reflections. This decomposition reveals more aspects of the wave dynamics when the forward and backward waves are of similar magnitude (so that the net wave intensity is small even though the waves can be large). The results from Figs 6 and 9 show that the backward and forward waves from displacement-based WI in elastic and viscoelastic cases have the same features as the backward and forward waves from a pressure-based WI.

The timings of WI peaks contain information about the physics of waves in the vascular network and provide insight into the underlying cardiovascular pathology and pathophysiology [10, 37–39]. For example, in the case of aortic WI analysis, the first peak corresponds to the initial compression caused by a left ventricle contraction (positive peak), the second peak corresponds to the reflection of the initial contraction (negative peak), and the third peak corresponds to the dominant forward wave at the end of systole (which is again positive). Therefore, it is of great clinical importance to be aware of the order of the non-invasive displacement-based WI error in capturing peaks. As shown in Table 2, the peak ratio for DI*P and DI*D are similar. However, the error associated with the ratio of the first positive peak to the second positive peak is much smaller than the error in the ratio of the first positive peak to the first negative peak.

In order to encourage more widespread deployment of displacement-based WIA, we considered two types of vascular disease-related geometrical irregularities: aneurysm and stenosis. These two cases impose opposite effects on wave reflection; an aneurysm act as an open-end reflection site, but stenosis operates as a closed-end reflection site. The first type, an aneurysm, is defined as a permanent localized dilation of a vessel (similar in dimension to an adult human aorta) with at least a 50 percent increase in the diameter compared with the expected normal diameter [40]. Although most aneurysms are asymptomatic, they are observable with MRI or other non-invasive measurement techniques [41]. MRI or echo imaging of an aneurysm provides information about the size, but it does not provide reliable information about the stability or rupture risk of an aneurysm. Recent studies have shown that the pulsatile hemodynamics play a significant role in risk evaluation of an aneurysm [42, 43]. The second type of irregularity considered, a stenosis, is a localized narrowing in the arterial lumen that is typically the result of atherosclerosis [44]. Our analysis shows that the DI*P and DI*D waveforms are almost identical if the vessel wall is purely elastic, though there exist negligible differences that might be associated with simplifications in the numerical model. Similarly to the straight vessel condition, there is a phase difference and lag effect between the DI*P and DI*D for viscoelastic cases as demonstrated in Figs 11 and 13. As the viscous effect increases (η increases), the error will grow in general. However, the error shows nonlinear fluctuation with increasing viscosity (see Fig 11, Fig 13 and Table 3). Similar to the straight vessel case, this is also in agreement with the analytical model of Eq (33). As demonstrated in Table 3 for the viscoelastic vessels with irregular wall conditions, the maximum corresponding error associated with displacement-based WI is around 7.13%. In addition, for both the aneurysm and stenosis cases, the displacement-based WI and the pressure-based WI have been decomposed into their forward and backward running components (Figs 12 and 14). For the aneurysm case, the shape of the forward and backward running components is almost identical for the displacement-based and pressure-based wave intensities. For the stenosis case, although the shape of the forward running wave is almost identical for the displacement-based and pressure-based wave intensities, there is some disagreement for the backward running waves between the displacement-based and pressure-based wave intensities. This can be attributed to the nature of stenotic irregularities, resulting in the presence of the closed-end reflection site in the vessel. However, the effect of this disagreement on the total magnitude of the measured WI is not significant for the displacement-based and pressure-based wave intensities. Lastly, it should be noted that similarly to the straight viscoelastic vessel case, the error associated with the ratio of the first positive peak over the second positive peak (between the DI*P and DI*D) is much smaller than the error in the ratio of the first positive peak over the first negative peak (see Table 3).

So far, WIA has expanded our knowledge in arterial physiology and pathophysiology in the systemic circulation [45], cerebral vasometer tone [46], and pulmonary circulation [47]. Lots of effort has been made regarding the coronary WIA [48], myocardial infarction [49] and ischaemic heart disease [50]. In addition, the WI decomposition into the forward running and backward running waves has provided further information into cardiovascular physiology and the direction of the blood into the coronary arteries [51]. However, the current requirement of having invasive measurements of pressure and flow is a limitation for WI applications. The systematic research work conducted here provides a fundamental groundwork for expanding the usage of the non-invasive displacement-based WIA technique into the broader clinical environment.

Limitation of the study

With regards to the CFD model, blood was assumed to be an incompressible Newtonian fluid and the truncated vasculature was modelled with an extension tube boundary model. These are reasonable assumptions in that they don’t affect the conclusion of this manuscript. Regarding the boundary conditions, we have imposed a flat velocity profile at the inlet of the straight vessel to simulate the pulsatile flow behavior in the system. Although the fluid in this study is a viscous flow, the flat velocity profile has more features in common with the entry flow regime than the fully developed parabolic flow profile. In addition, as the wave characteristics in this study are measured far from the inlet, the influence of the flow profile beyond the inlet boundary is negligible. Hence, this boundary condition should provide accurate results for this study. Lastly, in this study, we have only considered the simplified geometry of straight vessels in and, therefore, the curvatures and bifurcations have been excluded. The complexity of the geometry may provide subtle changes of the pressure and diameter wave; however, this will have minimal impact on the behavior that has led to the overall conclusion of our findings.

Conclusion

Our results suggest that for large arteries demonstrating linear elastic behavior (such as the carotid artery or the aorta), the displacement-based WI is almost identical to the pressure-based WI. This is clinically significant since displacement-based WI can be measured non-invasively (as opposed to the pressure-based WI, which requires invasive measurement techniques). Our results indicate that the existence of vessel wall abnormalities such as an aneurysm or stenosis does not impact the accuracy of displacement-based wave intensity. Our results additionally indicate that wall viscoelasticity creates a phase difference between pressure and vessel wall dilation that results in a deviation of displacement-based WI when compared with pressure-based WI. This is the source of error between DI*P and DI*D and, as predicted by the analytical model, this error increases nonlinearly with increasing viscosity. However, at maximum, this viscoelasticity error is only 6.8% for the regular vessel wall (straight) and 7.13% for the irregular vessel wall (in the presence of aneurysm and stenosis) for the cases considered in this manuscript. In addition, our results show that the error associated with the ratio of the first positive peak over the second positive peak (between the DI*P and DI*D) is much smaller than the error in the ratio of the first positive peak over the first negative peak for both regular and irregular vessel cases. Hence the results of this study ultimately suggest that, although utilizing displacement-based WI introduces errors into WI analysis for vessels with viscoelastic behavior (which mainly exist in only small-size vessels), these errors are small and are an acceptable compromise in order to enable measurements of WI non-invasively (which is of great clinical importance).

Supporting information

S1 File [zip]
Raw simulation data for wave intensity analysis.

Zdroje

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Článek Structural mechanism for regulation of DNA binding of BpsR, a Bordetella regulator of biofilm formation, by 6-hydroxynicotinic acid
Článek How does open innovation lead competitive advantage? A dynamic capability view perspective
Článek Bull efficiency using dairy genetic traits
Článek Improved cortical boundary registration for locally distorted fMRI scans
Článek Extractive single document summarization using binary differential evolution: Optimization of different sentence quality measures
Článek Measuring the tilt and slant of Chinese handwriting in primary school students: A computerized approach
Článek Isolation and identification of an isoflavone reducing bacterium from feces from a pregnant horse
Článek Sugar labeling: How numerical information of sugar content influences healthiness and tastiness expectations
Článek Optimally adjusted last cluster for prediction based on balancing the bias and variance by bootstrapping
Článek Quantifying normal and parkinsonian gait features from home movies: Practical application of a deep learning–based 2D pose estimator
Článek Heterogeneity of porcine bone marrow-derived dendritic cells induced by GM-CSF
Článek Can visual interpretation of NucliSens graphs reduce the need for repeat viral load testing?
Článek Manganese levels in infant formula and young child nutritional beverages in the United States and France: Comparison to breast milk and regulations
Článek Association between metabolic body composition status and risk for impaired renal function: A cross-sectional study
Článek Toddler skills predict moderate-to-late preterm born children’s cognition and behaviour at 6 years of age
Článek The bacterial community in potato is recruited from soil and partly inherited across generations
Článek Infective endocarditis and diabetes mellitus: Results from a single-center study from 1994 to 2017
Článek Patient satisfaction with HIV services in Vietnam: Status, service models and association with treatment outcome
Článek Ion concentration polarization (ICP) of proteins at silicon micropillar nanogaps
Článek The trajectory of patterns of light and sedentary physical activity among females, ages 14-23
Článek Coadministration of kla peptide with HPRP-A1 to enhance anticancer activity
Článek Measuring the complexity of directed graphs: A polynomial-based approach
Článek Estimation of maize evapotraspiration under drought stress - A case study of Huaibei Plain, China
Článek Publication rates in animal research. Extent and characteristics of published and non-published animal studies followed up at two German university medical centres
Článek Developmental conservation of microRNA gene localization at the nuclear periphery
Článek Exploring critical factors of the perceived usefulness of blended learning for higher education students
Článek Anti-Alzheimer potential, metabolomic profiling and molecular docking of green synthesized silver nanoparticles of Lampranthus coccineus and Malephora lutea aqueous extracts
Článek Protective effect of Platymiscium floribundum Vog. in tree extract on periodontitis inflammation in rats
Článek Direct transport vs secondary transfer to level I trauma centers in a French exclusive trauma system: Impact on mortality and determinants of triage on road-traffic victims
Článek Honey bee microbiome associated with different hive and sample types over a honey production season
Článek Bacterial communities in the rhizosphere, phyllosphere and endosphere of tomato plants
Článek Sildenafil citrate long-term treatment effects on cardiovascular reactivity in a SHR experimental model of metabolic syndrome
Článek Postoperative delirium after lung resection for primary lung cancer: Risk factors, risk scoring system, and prognosis
Článek The CSF-1-receptor inhibitor, JNJ-40346527 (PRV-6527), reduced inflammatory macrophage recruitment to the intestinal mucosa and suppressed murine T cell mediated colitis
Článek Using Er:YAG laser to remove lithium disilicate crowns from zirconia implant abutments: An in vitro study
Článek Antibacterial efficacy of cold atmospheric plasma against Enterococcus faecalis planktonic cultures and biofilms in vitro
Článek Mechanisms of African swine fever virus pathogenesis and immune evasion inferred from gene expression changes in infected swine macrophages
Článek Application of ensemble methods to analyse the decline of organochlorine pesticides in relation to the interactions between age, gender and time
Článek Mitogenomic diversity in Sacred Ibis Mummies sheds light on early Egyptian practices
Článek Automated detection of a nonperfusion area caused by retinal vein occlusion in optical coherence tomography angiography images using deep learning
Článek Characterisation of a novel SCCmec VI element harbouring fusC in an emerging Staphylococcus aureus strain from the Arabian Gulf region
Článek Inducible UCP1 silencing: A lentiviral RNA-interference approach to quantify the contribution of beige fat to energy homeostasis
Článek iCrotoK-PseAAC: Identify lysine crotonylation sites by blending position relative statistical features according to the Chou’s 5-step rule
Článek Emerging practices supporting diabetes self-management among food insecure adults and families: A scoping review
Článek Does aneurysm side influence the infarction side and patients´ outcome after subarachnoid hemorrhage?
Článek Raising the bar: Recovery ambition for species at risk in Canada and the US
Článek Management of locally advanced non-small cell lung cancer in the modern era: A national Italian survey on diagnosis, treatment and multidisciplinary approach
Článek Foraging strategies are maintained despite workforce reduction: A multidisciplinary survey on the pollen collected by a social pollinator
Článek Incidence of colorectal cancer in Eritrea: Data from the National Health Laboratory, 2011-2017
Článek Integrated analysis of miRNA landscape and cellular networking pathways in stage-specific prostate cancer
Článek Evaluation of the reactogenicity, adjuvanticity and antigenicity of LT(R192G) and LT(R192G/L211A) by intradermal immunization in mice
Článek Role of rhesus macaque IFITM3(2) in simian immunodeficiency virus infection of macaques
Článek Variation in the LRR region of Pi54 protein alters its interaction with the AvrPi54 protein revealed by in silico analysis
Článek Evolutionarily conserved susceptibility of the mitochondrial respiratory chain to SDHI pesticides and its consequence on the impact of SDHIs on human cultured cells
Článek Statistical determination of synergy based on Bliss definition of drugs independence
Článek The association between sleep problems and academic performance in primary school-aged children: Findings from a Norwegian longitudinal population-based study
Článek Estimating the national cost burden of in-hospital needlestick injuries among healthcare workers in Japan
Článek Assessing reliability of intra-tumor heterogeneity estimates from single sample whole exome sequencing data
Článek Dispersion of Legionella bacteria in atmosphere: A practical source location estimation method
Článek Why are undergraduate emerging adults anxious and avoidant in their romantic relationships? The role of family relationships
Článek Barriers to implementation of emergency obstetric and neonatal care in rural Pakistan
Článek Testosterone supplementation improves insulin responsiveness in HFD fed male T2DM mice and potentiates insulin signaling in the skeletal muscle and C2C12 myocyte cell line
Článek Ang-(1-7)/ MAS1 receptor axis inhibits allergic airway inflammation via blockade of Src-mediated EGFR transactivation in a murine model of asthma
Článek Factors influencing bird-building collisions in the downtown area of a major North American city
Článek Collembola laterally move biochar particles
Článek Decreased retinal thickness in patients with Alzheimer’s disease is correlated with disease severity
Článek Moving system with action sport cameras: 3D kinematics of the walking and running in a large volume
Článek Factors influencing subclinical atherosclerosis in patients with biopsy-proven nonalcoholic fatty liver disease
Článek Boundary violations and adolescent drinking: Observational evidence that symbolic boundaries moderate social influence
Článek Inadequate conflict of interest policies at most French teaching hospitals: A survey and website analysis
Článek A new resolution function to evaluate tree shape statistics
Článek Thermostat wars? The roles of gender and thermal comfort negotiations in household energy use behavior
Článek Patients undergoing surgery for lumbar spinal stenosis experience unique courses of pain and disability: A group-based trajectory analysis
Článek Lifetime prevalence of intimate partner violence against women in an urban Brazilian city: A cross-sectional survey
Článek The factors associated with being left-behind children in China: Multilevel analysis with nationally representative data
Článek High heat tolerance in plants from the Andean highlands: Implications for paramos in a warmer world
Článek Quantifying pediatric patient need for second- and third-line HIV treatment: A tool for decision-making in resource-limited settings
Článek Discovery of actionable genetic alterations with targeted panel sequencing in children with relapsed or refractory solid tumors
Článek Iodine status of non-pregnant women and availability of food vehicles for fortification with iodine in a remote community in Gulf province, Papua New Guinea
Článek Fibre and extracellular matrix contributions to passive forces in human skeletal muscles: An experimental based constitutive law for numerical modelling of the passive element in the classical Hill-type three element model
Článek The status of imported Barremian-Bedoulian flint in north-eastern Iberia during the Middle Neolithic. Insights from the variscite mines of Gavà (Barcelona)
Článek Psychology of personal data donation
Článek Radiocarbon dating and cultural dynamics across Mongolia’s early pastoral transition
Článek MARGO (Massively Automated Real-time GUI for Object-tracking), a platform for high-throughput ethology
Článek Visual detection of time-varying signals: Opposing biases and their timescales
Článek Results from a World Health Organization pilot of the Basic Emergency Care Course in Sub Saharan Africa
Článek Scientists’ opinions and attitudes towards citizens’ understanding of science and their role in public engagement activities
Článek Dacentrurine stegosaurs (Dinosauria): A new specimen of Miragaia longicollum from the Late Jurassic of Portugal resolves taxonomical validity and shows the occurrence of the clade in North America
Článek Integrated pan-cancer gene expression and drug sensitivity analysis reveals SLFN11 mRNA as a solid tumor biomarker predictive of sensitivity to DNA-damaging chemotherapy
Článek Does membrane feeding compromise the quality of Aedes aegypti mosquitoes?
Článek Morphology, phylogeny, and taxonomy of two species of colonial volvocine green algae from Lake Victoria, Tanzania
Článek Metabolomics profiles associated with HbA1c levels in patients with type 2 diabetes
Článek Exploring local realities: Perceptions and experiences of healthcare workers on the management and control of drug-resistant tuberculosis in Addis Ababa, Ethiopia
Článek Sex differences in the treatment and outcome of emergency general surgery
Článek Comorbidities and costs in HIV patients: A retrospective claims database analysis in Germany
Článek Barriers to integration of bioinformatics into undergraduate life sciences education: A national study of US life sciences faculty uncover significant barriers to integrating bioinformatics into undergraduate instruction
Článek Local unemployment changes the springboard effect of low pay: Evidence from England
Článek A comparison of body composition assessment methods in climbers: Which is better?
Článek Comparison of an in-house ‘home-brew’ and commercial ViroSeq integrase genotyping assays on HIV-1 subtype C samples
Článek Elucidating genetic variability and population structure in Venturia inaequalis associated with apple scab diseaseusing SSR markers
Článek Clustering via hypergraph modularity
Článek Indomethacin enhances anti-tumor efficacy of a MUC1 peptide vaccine against breast cancer in MUC1 transgenic mice
Článek Multistage fuzzy comprehensive evaluation of landslide hazards based on a cloud model
Článek Inducible microRNA-200c decreases motility of breast cancer cells and reduces filamin A
Článek Pharmacological signatures of the reduced incidence and the progression of cognitive decline in ageing populations suggest the protective role of beneficial polypharmacy
Článek Continuous influenza virus production in a tubular bioreactor system provides stable titers and avoids the “von Magnus effect”
Článek Complex interaction networks of cytokines after transarterial chemotherapy in patients with hepatocellular carcinoma
Článek Gender essentialism in transgender and cisgender children
Článek Insertional mutagenesis in the zoonotic pathogen Chlamydia caviae
Článek Being there: A scoping review of grief support training in medical education
Článek Does the psychological profile influence the position of promising young futsal players?
Článek Effect of self-rated health status on functioning difficulties among older adults in Ghana: Coarsened exact matching method of analysis of the World Health Organization’s study on global AGEing and adult health, Wave 2
Článek Olfactory screening of Parkinson’s Disease patients and healthy subjects in China and Germany: A study of cross-cultural adaptation of the Sniffin’ Sticks 12-identification test
Článek Molecular evolution of cytochrome C oxidase-I protein of insects living in Saudi Arabia
Článek Correlates of leisure-time sedentary behavior among 181,793 adolescents aged 12-15 years from 66 low- and middle-income countries
Článek Cost-effectiveness analysis of Mucosal Leishmaniasis diagnosis with PCR-based vs parasitological tests in Colombia
Článek Spatiotemporal analysis of historical records (2001–2012) on dengue fever in Vietnam and development of a statistical model for forecasting risk
Článek Resilience assessment of Puerto Rico’s coral reefs to inform reef management
Článek Effect of community based health education on knowledge and attitude towards iron and folic acid supplementation among pregnant women in Kiambu County, Kenya: A quasi experimental study
Článek Implementation and effectiveness of non-specialist mediated interventions for children with Autism Spectrum Disorder: A systematic review and meta-analysis
Článek A tailored cognitive behavioral program for juvenile justice-referred females at risk of substance use and delinquency: A pilot quasi-experimental trial
Článek Impact of adjusted kidney volume measured in the bench surgery on one-year renal function in kidney transplantation
Článek Machine learning algorithm validation with a limited sample size
Článek The magnitude of suicidal ideation, attempts and associated factors of HIV positive youth attending ART follow ups at St. Paul’s hospital Millennium Medical College and St. Peter’s specialized hospital, Addis Ababa, Ethiopia, 2018
Článek The nonlinear effect of financial and fiscal policies on poverty alleviation in China—An empirical analysis of Chinese 382 impoverished counties with PSTR models
Článek Impacts of risk and competition on the profitability of banks: Empirical evidence from Pakistan
Článek Molecular characterization of lung adenocarcinoma from Korean patients using next generation sequencing
Článek An expansin-like protein expands forage cell walls and synergistically increases hydrolysis, digestibility and fermentation of livestock feeds by fibrolytic enzymes
Článek Joint image compression and encryption based on sparse Bayesian learning and bit-level 3D Arnold cat maps
Článek Urticating setae of tarantulas (Araneae: Theraphosidae): Morphology, revision of typology and terminology and implications for taxonomy
Článek Live observation of the oviposition process in Daphnia magna
Článek Nodosilinea signiensis sp. nov. (Leptolyngbyaceae, Synechococcales), a new terrestrial cyanobacterium isolated from mats collected on Signy Island, South Orkney Islands, Antarctica
Článek A 3’ UTR SNP rs885863, a cis-eQTL for the circadian gene VIPR2 and lincRNA 689, is associated with opioid addiction
Článek Characterizing the Randot Preschool stereotest: Testability, norms, reliability, specificity and sensitivity in children aged 2-11 years
Článek Tributyltin chloride (TBT) induces RXRA down-regulation and lipid accumulation in human liver cells
Článek Amazon climatic factors driving terpene composition of Iryanthera polyneura Ducke in terra-firme forest: A statistical approach
Článek Differences in clinical features of cluster headache between drinkers and nondrinkers in Japan
Článek Distribution of macular ganglion cell layer thickness in foveal hypoplasia: A new diagnostic criterion for ocular albinism
Článek Polo-like kinase 1 (Plk1) inhibition synergizes with taxanes in triple negative breast cancer
Článek Effect of mechanochemical activation of natural phosphorite structure as well as phosphorus solubility
Článek Automated content analysis across six languages
Článek A deep learning reconstruction framework for X-ray computed tomography with incomplete data
Článek Integrating interconception care in preventive child health care services: The Healthy Pregnancy 4 All program
Článek The prognostic significance of tumor-infiltrating lymphocytes assessment with hematoxylin and eosin sections in resected primary lung adenocarcinoma
Článek Effectiveness of novel fabrics to resist punctures and lacerations from white shark (Carcharodon carcharias): Implications to reduce injuries from shark bites
Článek Bacillus Calmette-Guérin (BCG) therapy lowers the incidence of Alzheimer’s disease in bladder cancer patients
Článek Serial block-face scanning electron microscopy reveals neuronal-epithelial cell fusion in the mouse cornea
Článek Salt or fish (or salted fish)? The Bronze Age specialised sites along the Tyrrhenian coast of Central Italy: New insights from Caprolace settlement
Článek Pragmatic language dysfunction in systemic lupus erythematosus patients: Results from a single center Italian study
Článek Association between cerebral atrophy and osteoporotic vertebral compression fractures
Článek Latitudinal gradient of cyanobacterial diversity in tidal flats
Článek Gene expression based survival prediction for cancer patients—A topic modeling approach
Článek Understanding allergic multimorbidity within the non-eosinophilic interactome
Článek The association between psychological distress and angina pectoris: A population-based study
Článek Comparative analysis on Facebook post interaction using DNN, ELM and LSTM
Článek Cerebellum-mediated trainability of eye and head movements for dynamic gazing
Článek Psychological and physiological effects of applying self-control to the mobile phone
Článek Omecamtiv mecarbil lowers the contractile deficit in a mouse model of nebulin-based nemaline myopathy
Článek Genome-wide SNP analyses reveal population structure of Portunus pelagicus along Vietnam coastline
Článek Modulating transcription through development of semi-synthetic yeast core promoters
Článek Left-handed metamaterial bandpass filter for GPS, Earth Exploration-Satellite and WiMAX frequency sensing applications
Článek Cost-effectiveness analysis of PSA-based mass screening: Evidence from a randomised controlled trial combined with register data
Článek A good tennis player does not lose matches. The effects of valence congruency in processing stance-argument pairs
Článek Validation of the group tasks uncertainty model (MITAG) in a German sample
Článek Parent psychological wellbeing in a single-family room versus an open bay neonatal intensive care unit
Článek Optimizing the procedure of grain nutrient predictions in barley via hyperspectral imaging
Článek In-situ time resolved spectrographic measurement using an additively manufactured metallic micro-fluidic analysis platform
Článek Race disparity in blood sphingolipidomics associated with lupus cardiovascular comorbidity
Článek Characterization of the placental transcriptome through mid to late gestation in the mare
Článek Indirect violence exposure and mental health symptoms among an urban public-school population: Prevalence and correlates
Článek Diagnostic ability of multifocal electroretinogram in early multiple sclerosis using a new signal analysis method
Článek Predictors of never having a mammogram among Chinese, Vietnamese, and Korean immigrant women in the U.S.
Článek The impact of hepatic steatosis on portal hypertension
Článek How do and could clinical guidelines support patient-centred care for women: Content analysis of guidelines
Článek Study of the epidemiological behavior of malaria in the Darien Region, Panama. 2015–2017
Článek School-based obesity prevention for busy low-income families—Organisational and personal barriers and facilitators to implementation
Článek Neighborhood crime, disorder and substance use in the Caribbean context: Jamaica National Drug Use Prevalence Survey 2016
Článek Significance of the lobe-specific emphysema index to predict prolonged air leak after anatomical segmentectomy
Článek Modeling of inter-organizational coordination dynamics in resilience planning of infrastructure systems: A multilayer network simulation framework
Článek Manipulating the odds: The effects of Machiavellianism and construal level on cheating behavior
Článek Early recognition of anorexia through patient-generated assessment predicts survival in patients with oesophagogastric cancer
Článek Identifying publications in questionable journals in the context of performance-based research funding
Článek ITGAM is a risk factor to systemic lupus erythematosus and possibly a protection factor to rheumatoid arthritis in patients from Mexico
Článek Nurses’ and patients’ experiences and preferences of the ankle-brachial pressure index and multi-site photoplethysmography for the diagnosis of peripheral arterial disease: A qualitative study
Článek Cluster tendency assessment in neuronal spike data
Článek Voluntary medical male circumcision for HIV prevention among adolescents in Kenya: Unintended consequences of pursuing service-delivery targets
Článek Primary care in five European countries: A citizens’ perspective on the quality of care for children
Článek High Order Profile Expansion to tackle the new user problem on recommender systems
Článek Psychometric properties of the Korean version of the Health Literacy on Social Determinants of Health Questionnaire (K-HL-SDHQ)
Článek Flood hazard mapping and assessment in data-scarce Nyaungdon area, Myanmar
Článek Methods for the identification of farm escapees in feral mink (Neovison vison) populations
Článek Transcriptional analysis of amino acid, metal ion, vitamin and carbohydrate uptake in butanol-producing Clostridium beijerinckii NRRL B-598
Článek Long-term vancomycin use had low risk of ototoxicity
Článek Overcoming platinum resistance in ovarian cancer by targeting pregnancy-associated plasma protein-A
Článek Exploration of muscle loss and metabolic state during prolonged critical illness: Implications for intervention?
Článek Pan-caspase inhibitor F573 mitigates liver ischemia reperfusion injury in a murine model
Článek Efficacy of interleukin 10 gene hydrofection in pig liver vascular isolated ‘in vivo’ by surgical procedure with interest in liver transplantation
Článek Molecular characteristics of segment 5, a unique fragment encoding two partially overlapping ORFs in the genome of rice black-streaked dwarf virus
Článek Early economic evaluation of MRI-guided laser interstitial thermal therapy (MRgLITT) and epilepsy surgery for mesial temporal lobe epilepsy
Článek GLADS: A gel-less approach for detection of STMS markers in wheat and rice
Článek Anterior tooth-use behaviors among early modern humans and Neandertals
Článek Incidence patterns of orofacial clefts in purebred dogs
Článek Capacity of the medullary cavity of tibia and femur for intra-bone marrow transplantation in mice
Článek Association of thoracic spine deformity and cardiovascular disease in a mouse model for Marfan syndrome
Článek Predicting atrial fibrillation in primary care using machine learning
Článek M3VR—A multi-stage, multi-resolution, and multi-volumes-of-interest volume registration method applied to 3D endovaginal ultrasound
Článek A developmental trajectory supporting the evaluation and achievement of competencies: Articulating the Mastery Rubric for the nurse practitioner (MR-NP) program curriculum
Článek Mobile medication manager application to improve adherence with immunosuppressive therapy in renal transplant recipients: A randomized controlled trial
Článek Default Mode Network structural alterations in Kocher-Monro trajectory white matter transection: A 3 and 7 tesla simulation modeling approach
Článek Phylogenetic revision of Gymnotidae (Teleostei: Gymnotiformes), with descriptions of six subgenera
Článek Population genetic analysis of 36 Y-chromosomal STRs yields comprehensive insights into the forensic features and phylogenetic relationship of Chinese Tai-Kadai-speaking Bouyei
Článek Prevention of suicidal behaviour: Results of a controlled community-based intervention study in four European countries
Článek An assessment of khat consumption habit and its linkage to household economies and work culture: The case of Harar city
Článek Fixation of genetic variation and optimization of gene expression: The speed of evolution in isolated lizard populations undergoing Reverse Island Syndrome
Článek One simple claudication question as first step in Peripheral Arterial Disease (PAD) screening: A meta-analysis of the association with reduced Ankle Brachial Index (ABI) in 27,945 subjects
Článek Direct cost of health care for individuals with community associated Clostridium difficile infections: A population-based cohort study
Článek Association between serum homocysteine level and cognitive function in middle-aged type 2 diabetes mellitus patients
Článek A qualitative research synthesis of contextual factors contributing to female overweight and obesity over the life course in sub-Saharan Africa
Článek Hidden noise in immunologic parameters might explain rapid progression in early-onset periodontitis
Článek The role of stigma in the acceptance and disclosure of HIV among recently diagnosed men who have sex with men in Australia: A qualitative study
Článek Detection of Schistosoma japonicum and Oncomelania hupensis quadrasi environmental DNA and its potential utility to schistosomiasis japonica surveillance in the Philippines
Článek Does age influence the quality of life in children with atopic dermatitis?
Článek Questioning the lasting effect of galvanic vestibular stimulation on postural control
Článek Identification of a novel monocytic phenotype in Classic Hodgkin Lymphoma tumor microenvironment
Článek Characterization of 20 complete plastomes from the tribe Laureae (Lauraceae) and distribution of small inversions
Článek Binding and dynamics of melatonin at the interface of phosphatidylcholine-cholesterol membranes
Článek Recent climate-driven ecological change across a continent as perceived through local ecological knowledge
Článek Nonalcoholic fatty liver disease is an early predictor of metabolic diseases in a metabolically healthy population
Článek Occurrence and multilocus genotyping of Giardia duodenalis from post-weaned dairy calves in Sichuan province, China
Článek Retinoic acid-stimulated ERK1/2 pathway regulates meiotic initiation in cultured fetal germ cells
Článek Gender disparities in scientific production: A nationwide assessment among physicians in Peru
Článek Effect of F1 and F2 generations on genetic variability and working steps of doubled haploid production in maize
Článek Mitochondrial dysfunction in rheumatoid arthritis: A comprehensive analysis by integrating gene expression, protein-protein interactions and gene ontology data
Článek A caspase-6-cleaved fragment of Glial Fibrillary Acidic Protein as a potential serological biomarker of CNS injury after cardiac arrest
Článek A handy method to remove bacterial contamination from fungal cultures
Článek The self-care profiles and its determinants among adults with hypertension in primary health care clinics in Selangor, Malaysia
Článek The mutational landscape of quinolone resistance in Escherichia coli
Článek Exploring the influence of self-perceptions on the relationship between motor competence and identity in adolescents
Článek Study on the damage characteristics of gas-bearing shale under different unloading stress paths
Článek EPILAT-IRA Study: A contribution to the understanding of the epidemiology of acute kidney injury in Latin America
Článek 16S rDNA droplet digital PCR for monitoring bacterial DNAemia in bloodstream infections
Článek Three-dimensional (3D) brain microphysiological system for organophosphates and neurochemical agent toxicity screening
Článek Diversity of endocervical microbiota associated with genital Chlamydia trachomatis infection and infertility among women visiting obstetrics and gynecology clinics in Malaysia
Článek Health impact of hepatic-venous-occlusive disease in a small town in Ethiopia—Case study from Tahtay koraro district in Tigray region, 2017
Článek Development of a novel automatable fabrication method based on electrospinning co electrospraying for rotator cuff augmentation patches
Článek Development of a quantitative PCR assay for the detection and enumeration of a potentially ciguatoxin-producing dinoflagellate, Gambierdiscus lapillus (Gonyaulacales, Dinophyceae)
Článek Association of clinical factors with survival outcomes in laryngeal squamous cell carcinoma (LSCC)
Článek Seasonal oyster harvesting recorded in a Late Archaic period shell ring
Článek Population preferences for breast cancer screening policies: Discrete choice experiment in Belarus
Článek Respiratory health and inflammatory markers - Exposure to respirable dust and quartz and chemical binders in Swedish iron foundries
Článek Trends and predictors of mother-to-child transmission of HIV in an era of protocol changes: Findings from two large health facilities in North East Nigeria
Článek Elevated Ki-67 (MIB-1) expression as an independent predictor for unfavorable pathologic outcomes and biochemical recurrence after radical prostatectomy in patients with localized prostate cancer: A propensity score matched study
Článek Genome-wide identification and gene expression analysis of SOS family genes in tuber mustard (Brassica juncea var. tumida)
Článek Carvedilol improves glucose tolerance and insulin sensitivity in treatment of adrenergic overdrive in high fat diet-induced obesity in mice
Článek Institutional differences in USMLE Step 1 and 2 CK performance: Cross-sectional study of 89 US allopathic medical schools
Článek Molecular epidemiological characteristics of dengue virus carried by 34 patients in Guangzhou in 2018
Článek Heteroplasmy in the complete chicken mitochondrial genome
Článek Candida blood stream infections observed between 2011 and 2016 in a large Italian University Hospital: A time-based retrospective analysis on epidemiology, biofilm production, antifungal agents consumption and drug-susceptibility
Článek Sixty years since the creation of Lake Kariba: Thermal and oxygen dynamics in the riverine and lacustrine sub-basins
Článek Association of uric acid in serum and urine with subclinical renal damage: Hanzhong Adolescent Hypertension Study
Článek Appropriate management of acute gastroenteritis in Australian children: A population-based study
Článek The plasma metabolome of women in early pregnancy differs from that of non-pregnant women
Článek Effectiveness of four types of neuraminidase inhibitors approved in Japan for the treatment of influenza
Článek More than just availability: Who has access and who administers take-home naloxone in Baltimore, MD
Článek Evaluating the cross-cultural validity of the Dutch version of the Social Exclusion Index for Health Surveys (SEI-HS): A mixed methods study
Článek Diminuendo al bottom—Clarifying the semantics of music notation by re-modeling
Článek Structural analysis of the manganese transport regulator MntR from Bacillus halodurans in apo and manganese bound forms
Článek Serum uromodulin is associated with the severity of clinicopathological findings in ANCA-associated glomerulonephritis
Článek Male support for cervical cancer screening and treatment in rural Ghana
Článek ADAPTS: Automated deconvolution augmentation of profiles for tissue specific cells
Článek Comparison of shape quantification methods for genomic prediction, and genome-wide association study of sorghum seed morphology
Článek An attempt to identify the issues underlying the lack of consistent conceptualisations in the field of student mathematics-related beliefs
Článek Video abstracts and plain language summaries are more effective than graphical abstracts and published abstracts
Článek Trophic structure of the macrofauna associated to deep-vents of the southern Gulf of California: Pescadero Basin and Pescadero Transform Fault
Článek Incomplete insertion of pedicle screws in a standard construct reduces the fatigue life: A biomechanical analysis
Článek Cost savings associated with timely treatment of botulism with botulism antitoxin heptavalent product
Článek Effects of light and nitrogen availability on photosynthetic efficiency and fatty acid content of three original benthic diatom strains
Článek Early signal detection of adverse events following influenza vaccination using proportional reporting ratio, Victoria, Australia
Článek Bioinformatic analysis of a novel Echinococcus granulosus nuclear receptor with two DNA binding domains
Článek Genome-wide identification and characterization, phylogenetic comparison and expression profiles of SPL transcription factor family in B. juncea (Cruciferae)
Článek Hypoxia inhibits TNF-α-induced TSLP expression in keratinocytes
Článek Conceptualising alcohol consumption in relation to long-term health conditions: Exploring risk in interviewee accounts of drinking and taking medications
Článek Elevated interleukin-25 and its association to Th2 cytokines in systemic lupus erythematosus with lupus nephritis
Článek Thrombocytopenia and thrombocytosis are associated with different outcome in atrial fibrillation patients on anticoagulant therapy
Článek Involvement of extracellular vesicles in the macrophage-tumor cell communication in head and neck squamous cell carcinoma
Článek Comparison of Humphrey Field Analyzer and imo visual field test results in patients with glaucoma and pseudo-fixation loss
Článek Out-of-pocket expenditure and catastrophic health expenditure for hospitalization due to injuries in public sector hospitals in North India
Článek Concurrent validity and discriminative ability of Dutch performance-based motor tests in 5 to 6 years old children
Článek Cumulative viral load as a predictor of CD4+ T-cell response to antiretroviral therapy using Bayesian statistical models
Článek Can General Practitioners manage mental disorders in primary care? A partially randomised, pragmatic, cluster trial
Článek Self-serving incentives impair collective decisions by increasing conformity
Článek Mutation and immune profiling of metaplastic breast cancer: Correlation with survival
Článek The clinicopathological significance of Thrombospondin-4 expression in the tumor microenvironment of gastric cancer
Článek Propofol-based total intravenous anesthesia did not improve survival compared to desflurane anesthesia in breast cancer surgery
Článek Association between ossification of the posterior longitudinal ligament and ossification of the nuchal ligament in the cervical spine
Článek Effects of Debaryomyces hansenii treatment on intestinal mucosa microecology in mice with antibiotic-associated diarrhea
Článek Molecular validation of clinical Pantoea isolates identified by MALDI-TOF
Článek A novel wheat lodging resistance evaluation method and device based on the thrust force of the stalks
Článek Evolution of high tooth replacement rates in theropod dinosaurs
Článek Outpatient facility-based order variation in combined imaging
Článek Ethnic-racial identity affirmation: Validation in Aboriginal Australian children
Článek Non-intubated anesthesia in patients undergoing video-assisted thoracoscopic surgery: A systematic review and meta-analysis
Článek Tissue-type plasminogen activator selectively inhibits multiple toll-like receptors in CSF-1-differentiated macrophages
Článek Changes of serum pentraxin-3 and hypersensitive CRP levels during pregnancy and their relationship with gestational diabetes mellitus
Článek Synergistic immuno-modulatory activity in human macrophages of a medicinal mushroom formulation consisting of Reishi, Shiitake and Maitake
Článek Investigating reindeer pastoralism and exploitation of high mountain zones in northern Mongolia through ice patch archaeology
Článek Diversity pattern of Plasmodium knowlesi merozoite surface protein 4 (MSP4) in natural population of Malaysia
Článek Protein synthesis rates of muscle, tendon, ligament, cartilage, and bone tissue in vivo in humans
Článek “What gets measured better gets done better”: The landscape of validation of global maternal and newborn health indicators through key informant interviews
Článek Contactless monitoring of heart and respiratory rate in anesthetized pigs using infrared thermography
Článek Molecular characterisation of genital human papillomavirus among women in Southwestern, Nigeria
Článek The impact of “male clinics” on health-seeking behaviors of adult men in rural Kenya
Článek Gene expression microarray public dataset reanalysis in chronic obstructive pulmonary disease
Článek Utility of the new cobas HCV test for viral load monitoring during direct-acting antiviral therapy
Článek Impact of negative tuberculin skin test on growth among disadvantaged Bangladeshi children
Článek Streptococcal phosphotransferase system imports unsaturated hyaluronan disaccharide derived from host extracellular matrices
Článek Maternal diet modulates placental nutrient transporter gene expression in a mouse model of diabetic pregnancy
Článek Effects of an incremental theory of personality intervention on the reciprocity between bullying and cyberbullying victimization and perpetration in adolescents
Článek The clot thickens: Autologous and allogeneic fibrin sealants are mechanically equivalent in an ex vivo model of cartilage repair
Článek Reproducibility, stability, and accuracy of microbial profiles by fecal sample collection method in three distinct populations
Článek Cooperation with autonomous machines through culture and emotion
Článek Variation in hybridogenetic hybrid emergence between populations of water frogs from the Pelophylax esculentus complex
Článek Breast cancer in Tanzanian, black American, and white American women: An assessment of prognostic and predictive features, including tumor infiltrating lymphocytes
Článek Intramolecular tautomerization of the quercetin molecule due to the proton transfer: QM computational study
Článek A global overview of cassava genetic diversity
Článek Whole body periodic acceleration in normal and reduced mucociliary clearance of conscious sheep
Článek Identifying resurrection genes through the differentially expressed genes between Selaginella tamariscina (Beauv.) spring and Selaginella moellendorffii Hieron under drought stress
Článek Impact of hemodialysis on the concentrations of sodium and potassium during infusion of sodium thiosulfate using an In Vitro hemodialysis model
Článek Minimal effects of oyster aquaculture on local water quality: Examples from southern Chesapeake Bay
Článek Suboptimal infant and young child feeding practices in rural Boucle du Mouhoun, Burkina Faso: Findings from a cross-sectional population-based survey
Článek High salinity tolerance of invasive blue catfish suggests potential for further range expansion in the Chesapeake Bay region
Článek From waste to food: Optimising the breakdown of oil palm waste to provide substrate for insects farmed as animal feed
Článek Quantitative assessment of interstitial lung disease in Sjögren’s syndrome
Článek Comparative efficacy of tenofovir and entecavir in nucleos(t)ide analogue-naive chronic hepatitis B: A systematic review and meta-analysis
Článek Reference ranges for ultrasonographic renal dimensions as functions of age and body indices: A retrospective observational study in Taiwan
Článek Finding phrases: On the role of co-verbal facial information in learning word order in infancy
Článek Mathematical modeling reveals the factors involved in the phenomena of cancer stem cells stabilization
Článek Effects of forest management and roe deer impact on a mountain forest development in the Italian Apennines: A modelling approach using LANDIS-II
Článek Evaluation of comprehensive improvement for mild and moderate soil salinization in arid zone
Článek Efficacy, acceptability and feasibility of daily text-messaging in promoting glycaemic control and other clinical outcomes in a low-resource setting of South Africa: A randomised controlled trial
Článek Magnitude and associated factors of postpartum depression among women in Nekemte town, East Wollega zone, west Ethiopia, 2019: A community-based study
Článek Comparison of continuous wave and cold lateral condensation filling techniques in 3D printed simulated C-shape canals instrumented with Reciproc Blue or Hyflex EDM
Článek Effect of caffeine on neuromuscular function following eccentric-based exercise
Článek AtUBL5 regulates growth and development through pre-mRNA splicing in Arabidopsis thaliana
Článek The gut microbiome of freshwater Unionidae mussels is determined by host species and is selectively retained from filtered seston
Článek Alcohol consumption and survival after breast cancer diagnosis in Japanese women: A prospective patient cohort study
Článek Selection of reference genes for normalization of cranberry (Vaccinium macrocarpon Ait.) gene expression under different experimental conditions
Článek The household economic costs associated with depression symptoms: A cross-sectional household study conducted in the North West province of South Africa
Článek Increased cell size, structural complexity and migration of cancer cells acquiring fibroblast organelles by cell-projection pumping
Článek Acute low- compared to high-load resistance training to failure results in greater energy expenditure during exercise in healthy young men
Článek Impact of body mass index and metabolically unhealthy status on mortality in the Japanese general population: The JMS cohort study
Článek Characterization of two thermophilic cellulases from Talaromyces leycettanus JCM12802 and their synergistic action on cellulose hydrolysis
Článek Ecohydrology of urban trees under passive and active irrigation in a semiarid city
Článek Cyclosporine A eyedrops with self-nanoemulsifying drug delivery systems have improved physicochemical properties and efficacy against dry eye disease in a murine dry eye model
Článek LFastqC: A lossless non-reference-based FASTQ compressor
Článek Highly accurate prediction of flammability limits of chemical compounds using novel integrated hybrid models
Článek Nonsteroidal anti-inflammatory drugs and acetaminophen ameliorate muscular mechanical hyperalgesia developed after lengthening contractions via cyclooxygenase-2 independent mechanisms in rats
Článek A popular Indian clove-based mosquito repellent is less effective against Culex quinquefasciatus and Aedes aegypti than DEET
Článek Yeasts affect tolerance of Drosophila melanogaster to food substrate with high NaCl concentration
Článek The effect of climate change on cholera disease: The road ahead using artificial neural network
Článek Grit (effortful persistence) can be measured with a short scale, shows little variation across socio-demographic subgroups, and is associated with career success and career engagement
Článek Micro-dislodgement during transcatheter aortic valve implantation with a contemporary self-expandable prosthesis
Článek Improving the antimicrobial efficacy against resistant Staphylococcus aureus by a combined use of conjugated oligoelectrolytes
Článek Kin discrimination and outer membrane exchange in Myxococcus xanthus: Experimental analysis of a natural population
Článek Inflammatory cell infiltrates, hypoxia, vascularization, pentraxin 3 and osteoprotegerin in abdominal aortic aneurysms – A quantitative histological study
Článek Effects of virtual reality rehabilitation training on gait and balance in patients with Parkinson's disease: A systematic review
Článek Serum miR-33a is associated with steatosis and inflammation in patients with non-alcoholic fatty liver disease after liver transplantation
Článek Association between housing tenure and self-rated health in Japan: Findings from a nationwide cross-sectional survey
Článek Investigation of biochemical and physiological parameters of the newborn Saiga antelope (Saiga tatarica) in Gansu Province, China
Článek One-year follow-up of changes in refraction and aberrations induced by corneal incision
Článek Evaluation of upper limb superficial venous percussion as a sign of anatomical location and venous permeability. A comparative study of superficial venous percussion to ultrasound findings on non-renal patients and on chronic kidney disease patients
Článek An assessment of the Dutch experience with health insurers acting as healthcare advisors
Článek Perception of potential harm and benefits of HIV vaccine trial participation: A qualitative study from urban Tanzania
Článek Veterans with Gulf War Illness exhibit distinct respiratory patterns during maximal cardiopulmonary exercise
Článek Deep brain stimulation restores the glutamatergic and GABAergic synaptic transmission and plasticity to normal levels in kindled rats
Článek Metformin strongly affects transcriptome of peripheral blood cells in healthy individuals
Článek Cranberry extracts promote growth of Bacteroidaceae and decrease abundance of Enterobacteriaceae in a human gut simulator model
Článek Long-term retention on antiretroviral therapy among infants, children, adolescents and adults in Malawi: A cohort study
Článek Histochemical quantification of collagen content in articular cartilage
Článek Optogenetically transduced human ES cell-derived neural progenitors and their neuronal progenies: Phenotypic characterization and responses to optical stimulation
Článek Ion torrent high throughput mitochondrial genome sequencing (HTMGS)
Článek Outpatient antibiotic prescription rate and pattern in the private sector in India: Evidence from medical audit data
Článek Acute Influenza A virus outbreak in an enzootic infected sow herd: Impact on viral dynamics, genetic and antigenic variability and effect of maternally derived antibodies and vaccination
Článek Prevalence and correlates of low serum calcium in late pregnancy: A cross sectional study in the Nkongsamba Regional Hospital; Littoral Region of Cameroon
Článek Home-cage monitoring ascertains signatures of ictal and interictal behavior in mouse models of generalized seizures
Článek CRISPR/Cas9 gene editing in the West Nile Virus vector, Culex quinquefasciatus Say
Článek Genetic susceptibility to angiotensin-converting enzyme-inhibitor induced angioedema: A systematic review and evaluation of methodological approaches
Článek Proton pump inhibitor use increases the risk of peritonitis in peritoneal dialysis patients
Článek Comparative distribution of extended-spectrum beta-lactamase–producing Escherichia coli from urine infections and environmental waters
Článek Sex differences in thigh muscle volumes, sprint performance and mechanical properties in national-level sprinters
Článek Maternal serum and cord blood leptin concentrations at delivery
Článek Winter nitrification in ice-covered lakes
Článek Intolerance of uncertainty fuels depressive symptoms through rumination: Cross-sectional and longitudinal studies
Článek Monitoring exercise-induced muscle damage indicators and myoelectric activity during two weeks of knee extensor exercise training in young and old men
Článek Can adoption of pollution prevention techniques reduce pollution substitution?
Článek The association between self-efficacy and self-management behaviors among Chinese patients with type 2 diabetes
Článek Poly-arginine-18 peptides do not exacerbate bleeding, or improve functional outcomes following collagenase-induced intracerebral hemorrhage in the rat
Článek Affective disorders in the elderly in different European countries: Results from the MentDis_ICF65+ study
Článek Evaluation of forearm vascular resistance during orthostatic stress: Velocity is proportional to flow and size doesn’t matter
Článek Proton pencil minibeam irradiation of an in-vivo mouse ear model spares healthy tissue dependent on beam size
Článek Maternal stress in Shank3ex4-9 mice increases pup-directed care and alters brain white matter in male offspring
Článek Aspartate aminotransferase-to-platelet ratio index (APRI): A potential marker for diagnosis in patients at risk of severe malaria caused by Plasmodium vivax
Článek Exploiting open source 3D printer architecture for laboratory robotics to automate high-throughput time-lapse imaging for analytical microbiology
Článek Long non-coding RNAs and latent HIV – A search for novel targets for latency reversal
Článek Clinical characteristics of neonatal fulminant necrotizing enterocolitis in a tertiary Children's hospital in the last 10 years
Článek Effects of neuromuscular electrical stimulation training on muscle size in collegiate track and field athletes
Článek Adaptive fuzzy flow rate control considering multifractal traffic modeling and 5G communications
Článek Evaluation of four commercial tests for detecting ceftiofur in waste milk bulk tank samples
Článek A smart tele-cytology point-of-care platform for oral cancer screening
Článek Vasopressin SNP pain factors and stress in sickle cell disease
Článek Carbonate production of Micronesian reefs suppressed by thermal anomalies and Acanthaster as sea-level rises
Článek Microbial metabolisms in an abyssal ferromanganese crust from the Takuyo-Daigo Seamount as revealed by metagenomics
Článek Incidence of chronic kidney disease hospitalisations and mortality in Espírito Santo between 1996 to 2017
Článek The impact of short-term machine perfusion on the risk of cancer recurrence after rat liver transplantation with donors after circulatory death
Článek Proteomic profiling of the thrombin-activated canine platelet secretome (CAPS)
Článek Blood metal levels and serum testosterone concentrations in male and female children and adolescents: NHANES 2011–2012
Článek The effects of prolonged single night session of videogaming on sleep and declarative memory
Článek Diversity, distribution and dynamics of large trees across an old-growth lowland tropical rain forest landscape
Článek Mapping developmental QTL for plant height in soybean [Glycine max (L.) Merr.] using a four-way recombinant inbred line population
Článek Vaginal ring acceptability and related preferences among women in low- and middle-income countries: A systematic review and narrative synthesis
Článek UM171 induces a homeostatic inflammatory-detoxification response supporting human HSC self-renewal
Článek Positive selection and precipitation effects on the mitochondrial NADH dehydrogenase subunit 6 gene in brown hares (Lepus europaeus) under a phylogeographic perspective
Článek Evaluation of Minimum Inhibitory Concentrations for 154 Mycoplasma synoviae isolates from Italy collected during 2012-2017
Článek Enhancement of antibiotics antimicrobial activity due to the silver nanoparticles impact on the cell membrane
Článek Correction: Smoking, alcohol use disorder and tuberculosis treatment outcomes: A dual co-morbidity burden that cannot be ignored
Článek Correction: Effect of corruption on perceived difficulties in healthcare access in sub-Saharan Africa
Článek Knowledge-based best of breed approach for automated detection of clinical events based on German free text digital hospital discharge letters
Článek Importance of thorough tissue and cellular level characterization of targeted drugs in the evaluation of pharmacodynamic effects
Článek Integrated value-chain and risk assessment of Pig-Related Zoonoses in Ghana
Článek Failed sperm retrieval from severely oligospermic or non-obstructive azoospermic patients on oocyte retrieval day: Emergent oocyte cryopreservation is a feasible strategy
Článek Cassava yield traits predicted by genomic selection methods
Článek Verification of hub genes in the expression profile of aortic dissection
Článek Pig farmers’ willingness to pay for management strategies to reduce aggression between pigs
Článek Metabolomic response of Euglena gracilis and its bleached mutant strain to light
Článek Diagnostic value of ASVS for insulinoma localization: A systematic review and meta-analysis
Článek Newly educated care managers’ experiences of providing care for persons with stress-related mental disorders in the clinical primary care context
Článek Real-time telemetry monitoring of oxygen in the central complex of freely-walking Gromphadorhina portentosa
Článek Qualification programmes for immigrant health professionals: A systematic review
Článek An analytical model to minimize the latency in healthcare internet-of-things in fog computing environment
Článek Grain filling of early-season rice cultivars grown under mechanical transplanting
Článek Intercalation of small molecules into DNA in chromatin is primarily controlled by superhelical constraint
Článek Correlative evidence for co-regulation of phosphorus and carbon exchanges with symbiotic fungus in the arbuscular mycorrhizal Medicago truncatula
Článek How to design a dose-finding study on combined agents: Choice of design and development of R functions
Článek Altered expression of Notch1 in Alzheimer's disease
Článek The ZJU index is a powerful surrogate marker for NAFLD in severely obese North American women
Článek Trunk velocity-dependent Light Touch reduces postural sway during standing
Článek Evaluation of cytological diagnostic accuracy for canine splenic neoplasms: An investigation in 78 cases using STARD guidelines
Článek Trade-offs in motivating volunteer effort: Experimental evidence on voluntary contributions to science
Článek Does caching strategy vary with microclimate in endangered Mt. Graham red squirrels?
Článek Assessment of energy expenditure during high intensity cycling and running using a heart rate and activity monitor in young active adults
Článek Evaluating rectal swab collection method for gut microbiome analysis in the common marmoset (Callithrix jacchus)
Článek Implementation of a screening, brief intervention and referral to treatment programme for risky substance use in South African emergency centres: A mixed methods evaluation study
Článek Can the CalproQuest predict a positive Calprotectin test? A prospective diagnostic study
Článek The calcium sensor OsCBL1 modulates nitrate signaling to regulate seedling growth in rice
Článek Acceptability of and treatment preferences for recurrent bacterial vaginosis—Topical lactic acid gel or oral metronidazole antibiotic: Qualitative findings from the VITA trial
Článek Mathematical determination of the HIV-1 matrix shell structure and its impact on the biology of HIV-1
Článek Contingent negative variation during a modified cueing task in simulated driving
Článek CAMDI interacts with the human memory-associated protein KIBRA and regulates AMPAR cell surface expression and cognition
Článek Effect of feeding patterns on growth and nutritional status of children aged 0-24 months: A Chinese cohort study
Článek A fecal sequel: Testing the limits of a genetic assay for bat species identification
Článek Measuring the impact of chronic conditions and associated multimorbidity on health-related quality of life in the general population in Hong Kong SAR, China: A cross-sectional study
Článek Short and long-term clinical effectiveness and cost-effectiveness of a late-phase community-based balance and gait exercise program following hip fracture. The EVA-Hip Randomised Controlled Trial
Článek Vaccine cold chain in general practices: A prospective study in 75 refrigerators (Keep Cool study)
Článek Brazilian norms for the Bank of Standardized Stimuli (BOSS)
Článek Distinct varieties of aesthetic chills in response to multimedia
Článek Interaction between apolipoprotein E genotype and hypertension on cognitive function in older women in the Nurses’ Health Study
Článek Correction: Resistance profile of the HIV-1 maturation inhibitor GSK3532795 in vitro and in a clinical study
Článek New formulation of the Gompertz equation to describe the kinetics of untreated tumors
Článek Development of visual perception of others’ actions: Children’s judgment of lifted weight
Článek Retrospective comparative analysis of intraocular lens calculation formulas after hyperopic refractive surgery
Článek Human vitreous concentrations of citicoline following topical application of citicoline 2% ophthalmic solution
Článek Development and validation of exhaled breath condensate microRNAs to identify and endotype asthma in children
Článek Arthroscopic release for frozen shoulder: Does the timing of intervention and diabetes affect outcome?
Článek Risk factors affecting dairy cattle protective grouping behavior, commonly known as bunching, against Stomoxys calcitrans (L.) on California dairies
Článek Acceleration of chemical shift encoding-based water fat MRI for liver proton density fat fraction and T2* mapping using compressed sensing
Článek Characterisation and microbial community analysis of lipid utilising microorganisms for biogas formation
Článek Sexuality in male partners of women with fibromyalgia syndrome: A qualitative study
Článek Exploring optimization strategies for improving explicit water models: Rigid n-point model and polarizable model based on Drude oscillator
Článek Artificial insemination with fresh, liquid stored and frozen thawed semen in dromedary camels
Článek Moving into an urban drug scene among people who use drugs in Vancouver, Canada: Latent class growth analysis
Článek Numerical study on the start and unstart phenomena in a scramjet inlet-isolator model
Článek Effects of dietary supplementation with apple peel powder on the growth, blood and liver parameters, and transcriptome of genetically improved farmed tilapia (GIFT, Oreochromis niloticus)
Článek Urban growth simulation in different scenarios using the SLEUTH model: A case study of Hefei, East China
Článek Chronic bronchitis without airflow obstruction, asthma and rhinitis are differently associated with cardiovascular risk factors and diseases
Článek Factors associated with medication adherence among people with diabetes mellitus in poor urban areas of Cambodia: A cross-sectional study
Článek Mammary microbiome of lactating organic dairy cows varies by time, tissue site, and infection status
Článek Force field generalization and the internal representation of motor learning
Článek Polyphenism of visual and chemical secondary sexually-selected wing traits in the butterfly Bicyclus anynana: How different is the intermediate phenotype?
Článek Minimal genetic differentiation of the malaria vector Nyssorhynchus darlingi associated with forest cover level in Amazonian Brazil
Článek The impact of leisure activities on older adults’ cognitive function, physical function, and mental health
Článek scafSLICR: A MATLAB-based slicing algorithm to enable 3D-printing of tissue engineering scaffolds with heterogeneous porous microarchitecture
Článek Association of serum leptin and adiponectin concentrations with echocardiographic parameters and pathophysiological states in patients with cardiovascular disease receiving cardiovascular surgery
Článek Operation of cognitive memory inhibition in adults with Down syndrome: Effects of maintenance load and material
Článek Influences on surgical antimicrobial prophylaxis decision making by surgical craft groups, anaesthetists, pharmacists and nurses in public and private hospitals
Článek Post-treatment Lyme disease symptoms score: Developing a new tool for research
Článek Expression of Concern: The Role of the RACK1 Ortholog Cpc2p in Modulating Pheromone-Induced Cell Cycle Arrest in Fission Yeast
Článek Equine bronchial fibroblasts enhance proliferation and differentiation of primary equine bronchial epithelial cells co-cultured under air-liquid interface
Článek Investigating cooperation with robotic peers
Článek Synthesis, purification and crystallization of a putative critical bulge of HAR1 RNA
Článek Prosthetic push-off power in trans-tibial amputee level ground walking: A systematic review
Článek A case study of the use of verbal reports for talent identification purposes in soccer: A Messi affair!
Článek Transgenerational deep sequencing revealed hypermethylation of hippocampal mGluR1 gene with altered mRNA expression of mGluR5 and mGluR3 associated with behavioral changes in Sprague Dawley rats with history of prolonged febrile seizure
Článek Obesity is associated with an impaired survival in lymphoma patients undergoing autologous stem cell transplantation
Článek Periodontal disease: Repercussions in pregnant woman and newborn health—A cohort study
Článek Origins of Chinese reindeer (Rangifer tarandus) based on mitochondrial DNA analyses
Článek Regional, racial, gender, and tumor biology disparities in breast cancer survival rates in Africa: A systematic review and meta-analysis
Článek How effective are films in inducing positive and negative emotional states? A meta-analysis
Článek 3D nanostructural characterisation of grain boundaries in atom probe data utilising machine learning methods
Článek An outbreak of tuberculosis in a middle school in Henan, China: Epidemiology and risk factors
Článek Initial clinical radiological findings and staging to predict prognosis of primary hepatic angiosarcoma: A retrospective analysis
Článek A new early Eocene deperetellid tapiroid illuminates the origin of Deperetellidae and the pattern of premolar molarization in Perissodactyla
Článek Longevity and marginal bone loss of narrow-diameter implants supporting single crowns: A systematic review
Článek Impact of UVC-sustained recirculating air filtration on airborne bacteria and dust in a pig facility
Článek Cold-related Florida manatee mortality in relation to air and water temperatures
Článek Conceptual fluency in inductive reasoning
Článek Clinical outcomes and treatment patterns among Medicare patients with nonvalvular atrial fibrillation (NVAF) and chronic kidney disease
Článek Improvements in the learnability of smartphone haptic interfaces for visually impaired users
Článek Role of the malic enzyme in metabolism of the halotolerant methanotroph Methylotuvimicrobium alcaliphilum 20Z
Článek Cyclic loading test study on a new cast-in-situ insulated sandwich concrete wall
Článek Natural compounds as angiogenic enzyme thymidine phosphorylase inhibitors: In vitro biochemical inhibition, mechanistic, and in silico modeling studies
Článek Analysis of virulence potential of Escherichia coli O145 isolated from cattle feces and hide samples based on whole genome sequencing
Článek Pre-clinical medical student reflections on implicit bias: Implications for learning and teaching
Článek Prognostic significance of non-sustained ventricular tachycardia on stored electrograms in pacemaker recipients
Článek Determinants of preterm birth among mothers who gave birth at public hospitals in the Amhara region, Ethiopia: A case-control study
Článek Real-world evidence of the effectiveness of ombitasvir-paritaprevir/r ± dasabuvir ± ribavirin in patients monoinfected with chronic hepatitis C or coinfected with human immunodeficiency virus-1 in Spain
Článek Unique transcriptomic landscapes identified in idiopathic spontaneous and infection related preterm births compared to normal term births
Článek Restrained expansion of the recall germinal center response as biomarker of protection for influenza vaccination in mice
Článek Arabidopsis TRM5 encodes a nuclear-localised bifunctional tRNA guanine and inosine-N1-methyltransferase that is important for growth
Článek Achievement of weight loss in patients with overweight during dietetic treatment in primary health care
Článek Autophagy deficiency exacerbates colitis through excessive oxidative stress and MAPK signaling pathway activation
Článek The impacts of parity on lung function data (LFD) of healthy females aged 40 years and more issued from an upper middle income country (Algeria): A comparative study
Článek Reorganization of spatial configurations in visual working memory: A matter of set size?
Článek Unravelling travellers’ route choice behaviour at full-scale urban network by focusing on representative OD pairs in computer experiments
Článek Evaluating the higher-order structure of the Profile of Emotional Competence (PEC): Confirmatory factor analysis and Bayesian structural equation modeling
Článek HIV prevalence and correlated factors among male clients of female sex workers in a border region of China
Článek Next generation sequencing and RNA-seq characterization of adipose tissue in the Nile crocodile (Crocodylus niloticus) in South Africa: Possible mechanism(s) of pathogenesis and pathophysiology of pansteatitis
Článek Association between advanced maternal age and maternal and neonatal morbidity: A cross-sectional study on a Spanish population
Článek Ethnic differences in the prevalence, socioeconomic and health related risk factors of knee pain and osteoarthritis symptoms in older Malaysians
Článek Increasing knowledge of HIV status in a country with high HIV testing coverage: Results from the Botswana Combination Prevention Project
Článek Friends with benefits: The effects of vegetative shading on plant survival in a green roof environment
Článek Comparison of the fecal, cecal, and mucus microbiome in male and female mice after TNBS-induced colitis
Článek Identifying candidate diagnostic markers for early stage of non-small cell lung cancer
Článek Complex alternative splicing of human Endonuclease V mRNA, but evidence for only a single protein isoform
Článek Correction: KML001 Induces Apoptosis and Autophagic Cell Death in Prostate Cancer Cells via Oxidative Stress Pathway
Článek Unique developmental trajectories of risk behaviors in adolescence and associated outcomes in young adulthood
Článek Enhanced fibrinolysis detection in a natural occurring canine model with intracavitary effusions: Comparison and degree of agreement between thromboelastometry and FDPs, D-dimer and fibrinogen concentrations
Článek Overexpression of Saussurea involucrata dehydrin gene SiDHN promotes cold and drought tolerance in transgenic tomato plants
Článek Foxtail millet (Setaria italica (L.) P. Beauv) CIPKs are responsive to ABA and abiotic stresses
Článek Autonomous drone hunter operating by deep learning and all-onboard computations in GPS-denied environments
Článek Heterogeneity Diffusion Imaging of gliomas: Initial experience and validation
Článek Frequency cluster formation and slow oscillations in neural populations with plasticity
Článek DHP23002 as a next generation oral paclitaxel formulation for pancreatic cancer therapy
Článek Diagnostic accuracy of SOX11 immunohistochemistry in mantle cell lymphoma: A meta-analysis
Článek Analytical solution to swing equations in power grids
Článek Pathways to conspiracy: The social and linguistic precursors of involvement in Reddit’s conspiracy theory forum
Článek Spatiotemporally random and diverse grid cell spike patterns contribute to the transformation of grid cell to place cell in a neural network model
Článek Empathic concern and personal distress depend on situational but not dispositional factors
Článek Who is more susceptible to job stressors and resources? Sensory-processing sensitivity as a personal resource and vulnerability factor
Článek Cost-effectiveness of integrating postpartum antiretroviral therapy and infant care into maternal & child health services in South Africa
Článek A substitution mutation in a conserved domain of mammalian acetate-dependent acetyl CoA synthetase 2 results in destabilized protein and impaired HIF-2 signaling
Článek One step at a time: Physical activity is linked to positive interpretations of ambiguity
Článek Calreticulin regulates vascular endothelial growth factor-A mRNA stability in gastric cancer cells
Článek Evaluation of various methods of selection of B. subtilis strains capable of secreting surface-active compounds
Článek Association between US Pharmacopeia (USP) monograph standards, generic entry and prescription drug costs
Článek Molecular characterisation of the synovial fluid microbiome in rheumatoid arthritis patients and healthy control subjects
Článek On sorption hysteresis in wood: Separating hysteresis in cell wall water and capillary water in the full moisture range
Článek Inbreeding, Allee effects and stochasticity might be sufficient to account for Neanderthal extinction
Článek Reliability and construct validity of the stepping-forward affordance perception test for fall risk assessment in community-dwelling older adults
Článek Socioeconomic determinants of nutritional status among ‘Baiga’ tribal children In Balaghat district of Madhya Pradesh: A qualitative study
Článek Study on characteristics of fire plume in building facade window under lateral blow
Článek ‘When you talk to someone in a bad way or always put her under pressure, it is actually worse than beating her’: Conceptions and experiences of emotional intimate partner violence in Rwanda and South Africa
Článek Effects of 6-mercaptopurine in pressure overload induced right heart failure
Článek The association between haemoglobin levels in the first 20 weeks of pregnancy and pregnancy outcomes
Článek Implementation and evaluation of an antimicrobial stewardship programme in companion animal clinics: A stepped-wedge design intervention study
Článek Factors associated with persistently high-cost health care utilization for musculoskeletal pain
Článek Nitrogen and chlorophyll status determination in durum wheat as influenced by fertilization and soil management: Preliminary results
Článek Effect of repeated in vivo microCT imaging on the properties of the mouse tibia
Článek Coupling environment and physiology to predict effects of climate change on the taxonomic and functional diversity of fish assemblages in the Murray-Darling Basin, Australia
Článek Hematology and plasma biochemistries in the Blanding’s turtle (Emydoidea blandingii) in Lake County, Illinois
Článek CRISPR-Cas influences the acquisition of antibiotic resistance in Klebsiella pneumoniae
Článek Phosphorylation-dependent activity-based conformational changes in P21-activated kinase family members and screening of novel ATP competitive inhibitors
Článek Antidepressant prescriptions, discontinuation, depression and perinatal outcomes, including breastfeeding: A population cohort analysis
Článek Why men with a low-risk prostate cancer select and stay on active surveillance: A qualitative study
Článek Imported severe malaria and risk factors for intensive care: A single-centre retrospective analysis
Článek Combined treatment (image-guided thrombectomy and endovascular therapy with open femoral access) for acute lower limb ischemia: Clinical efficacy and outcomes
Článek Low-latency single channel real-time neural spike sorting system based on template matching
Článek Quantifying the scale effect in geospatial big data using semi-variograms
Článek Paper-and-pencil versus computerized administration mode: Comparison of data quality and risk behavior prevalence estimates in the European school Survey Project on Alcohol and other Drugs (ESPAD)
Článek Regression adjusted colocalisation colour mapping (RACC): A novel biological visual analysis method for qualitative colocalisation analysis of 3D fluorescence micrographs
Článek Ostrich eggshell bead diameter in the Holocene: Regional variation with the spread of herding in eastern and southern Africa
Článek Spatial and temporal variations in female size at maturity of a Southern Rock Lobster (Jasus edwardsii) population: A likely response to climate change
Článek Inactive USP14 and inactive UCHL5 cause accumulation of distinct ubiquitinated proteins in mammalian cells
Článek Training rhesus macaques to take daily oral antiretroviral therapy for preclinical evaluation of HIV prevention and treatment strategies
Článek Left ventricular structural and functional changes in Friedreich ataxia – Relationship with body size, sex, age and genetic severity
Článek Magnitude and factors associated with anemia among pregnant women attending antenatal care in Bench Maji, Keffa and Sheka zones of public hospitals, Southwest, Ethiopia, 2018: A cross -sectional study
Článek Effectiveness of telerehabilitation in the management of adults with stroke: A systematic review
Článek Hydrogen sulphide-induced hypometabolism in human-sized porcine kidneys
Článek Correction: Comparison of the molecular properties of retinitis pigmentosa P23H and N15S amino acid replacements in rhodopsin
Článek Retraction: Regulation of gastric smooth muscle contraction via Ca2+-dependent and Ca2+-independent actin polymerization
Článek Evaluation of neutral oral contrast agents for assessment of the small bowel at abdominal staging CT
Článek Blood type and breed-associated differences in cell marker expression on equine bone marrow-derived mesenchymal stem cells including major histocompatibility complex class II antigen expression
Článek Induced abortion and future use of IVF treatment; A nationwide register study
Článek Psychosocial determinants of sustained maternal functional impairment: Longitudinal findings from a pregnancy-birth cohort study in rural Pakistan
Článek Measurement of finger joint angle using stretchable carbon nanotube strain sensor
Článek Determinants of mortality among patients with drug-resistant tuberculosis in northern Nigeria
Článek Drugs modulating stochastic gene expression affect the erythroid differentiation process
Článek Efficacy of UB0316, a multi-strain probiotic formulation in patients with type 2 diabetes mellitus: A double blind, randomized, placebo controlled study
Článek Prognostic value of des-γ-carboxy prothrombin in patients with hepatocellular carcinoma treated with transarterial chemotherapy: A systematic review and meta-analysis
Článek Avermectin induces the oxidative stress, genotoxicity, and immunological responses in the Chinese Mitten Crab, Eriocheir sinensis
Článek Antibiotic use in mandarin production (Citrus reticulata Blanco) in major mandarin-producing areas in Thailand: A survey assessment
Článek Application of CPI cutoff value based on parentage testing of duos and trios typed by four autosomal kits
Článek Correction: Good and Bad in the Hands of Politicians: Spontaneous Gestures during Positive and Negative Speech
Článek Adolescents with worse levels of oral health literacy have more cavitated carious lesions
Článek Effective methods for the inactivation of Francisella tularensis
Článek Detection of early-stage Alzheimer’s pathology using blood-based autoantibody biomarkers in elderly hip fracture repair patients
Článek Correlation between internal pudendal artery stenosis and erectile dysfunction in patients with suspected coronary artery disease
Článek Analysis of HER2 genomic binding in breast cancer cells identifies a global role in direct gene regulation
Článek Population productivity of shovelnose rays: Inferring the potential for recovery
Článek Correction: Long-term clinical outcomes in a cohort of patients with solitary plasmacytoma treated in the modern era
Článek Effects of tetracycline on myocardial infarct size in obese rats with chemically-induced colitis
Článek Mineral absorption is an enriched pathway in a brain region of restless legs syndrome patients with reduced MEIS1 expression
Článek Changes in weight and body composition across five years at university: A prospective observational study
Článek Adeno-associated virus-mediated expression of human butyrylcholinesterase to treat organophosphate poisoning
Článek Effects of insulin signaling on mouse taste cell proliferation
Článek Patient-level cost of home- and facility-based child pneumonia treatment in Suba Sub County, Kenya
Článek TAP: A static analysis model for PHP vulnerabilities based on token and deep learning technology
Článek Cost-effectiveness of QuantiFERON-TB Gold In-Tube versus tuberculin skin test for diagnosis and treatment of Latent Tuberculosis Infection in primary health care workers in Brazil
Článek Multifaceted intervention for the prevention and management of musculoskeletal pain in nursing staff: Results of a cluster randomized controlled trial
Článek Changes over time in creatinine clearance and comparison of emergent adverse events for HIV-positive adults receiving standard doses (300 mg/day) of lamivudine-containing antiretroviral therapy with baseline creatinine clearance of 30–49 vs ≥50 mL/min
Článek Population dynamics of foxes during restricted-area culling in Britain: Advancing understanding through state-space modelling of culling records
Článek Impacts of experimental advisory exit speed sign on traffic speeds for freeway exit ramp
Článek In-hospital outcomes and 30-day readmission rates among ischemic and hemorrhagic stroke patients with delirium
Článek Monitoring quality indicators for the Xpert MTB/RIF molecular assay in Ethiopia
Článek Delivering genes across the blood-brain barrier: LY6A, a novel cellular receptor for AAV-PHP.B capsids
Článek Correction: Using remote sensing to detect whale strandings in remote areas: The case of sei whales mass mortality in Chilean Patagonia
Článek Comparison of the inoculum size effects of antibiotics on IMP-6 β-lactamase-producing Enterobacteriaceae co-harboring plasmid-mediated quinolone resistance genes
Článek Contrast-enhanced computed tomography findings of canine primary renal tumors including renal cell carcinoma, lymphoma, and hemangiosarcoma
Článek Non-invasive in vivo imaging of UCP1 expression in live mice via near-infrared fluorescent protein iRFP720
Článek Overexpression of pink1 or parkin in indirect flight muscles promotes mitochondrial proteostasis and extends lifespan in Drosophila melanogaster
Článek Fiber stiffness, pore size and adhesion control migratory phenotype of MDA-MB-231 cells in collagen gels
Článek Comparison of two experimental ARDS models in pigs using electrical impedance tomography
Článek Are primary school children attending full-day school still engaged in sports clubs?
Článek Stroke risks in women with dysmenorrhea by age and stroke subtype
Článek Changes in patterns of mortality rates and years of life lost due to firearms in the United States, 1999 to 2016: A joinpoint analysis
Článek In vitro modeling of Batrachochytrium dendrobatidis infection of the amphibian skin
Článek Development and validation of LC-MS/MS method for imatinib and norimatinib monitoring by finger-prick DBS in gastrointestinal stromal tumor patients
Článek Correction: Habitat disturbance and the organization of bacterial communities in Neotropical hematophagous arthropods
Článek Characterisation of early metazoan secretion through associated signal peptidase complex subunits, prohormone convertases and carboxypeptidases of the marine sponge (Amphimedon queenslandica)
Článek Time trends between 2002 and 2017 in correlates of self-reported sitting time in European adults
Článek Performance of patient acuity rating by rapid response team nurses for predicting short-term prognosis
Článek Changes in HbA1c during the first six years after the diagnosis of Type 2 diabetes mellitus predict long-term microvascular outcomes
Článek Correction: Antimicrobial resistance genotypes and phenotypes of Campylobacter jejuni isolated in Italy from humans, birds from wild and urban habitats, and poultry
Článek Correction: Mental health and quality of life outcomes in family members of patients with chronic critical illness admitted to the intensive care units of two Brazilian hospitals serving the extremes of the socioeconomic spectrum
Článek Correction: Establishing an infrastructure for collaboration in primate cognition research
Článek Correction: The impact of public health insurance on health care utilisation, financial protection and health status in low- and middle-income countries: A systematic review
Článek Health provider and service-user experiences of sensory modulation rooms in an acute inpatient psychiatry setting
Článek Comparison of potential drug-drug interactions with metabolic syndrome medications detected by two databases
Článek The Polish version of the Cultural Intelligence Scale: Assessment of its reliability and validity among healthcare professionals and medical faculty students
Článek Selection of optimal reference genes for qRT-PCR analysis of shoot development and graviresponse in prostrate and erect chrysanthemums
Článek Metastasis risk prediction model in osteosarcoma using metabolic imaging phenotypes: A multivariable radiomics model
Článek Defining hospital community benefit activities using Delphi technique: A comparison between China and the United States
Článek Establishment of the experimental procedure for prediction of conjugation capacity in mutant UGT1A1
Článek A robust multi-objective optimization framework to capture both cellular and intercellular properties in cardiac cellular model tuning: Analyzing different regions of membrane resistance profile in parameter fitting
Článek Sea star wasting disease demography and etiology in the brooding sea star Leptasterias spp.
Článek Diagnostic plasma miRNA-profiles for ovarian cancer in patients with pelvic mass
Článek Genetic diversity and drug resistance of HIV-1 among infected pregnant women newly diagnosed in Luanda, Angola
Článek I’ve been robbed! – Can changes in floral traits discourage bee pollination?
Článek Visualising statistical models using dynamic nomograms
Článek Assessing the capacity of Malawi’s district and central hospitals to manage traumatic diaphyseal femoral fractures in adults
Článek Diagnostic performance of basal cortisol level at 0900-1300h in adrenal insufficiency
Článek The Mastery Rubric for Bioinformatics: A tool to support design and evaluation of career-spanning education and training
Článek Microdissection and whole chromosome painting confirm karyotype transformation in cryptic species of the Lariophagus distinguendus (Förster, 1841) complex (Hymenoptera: Pteromalidae)
Článek Quality of Kangaroo Mother Care services in Ethiopia: Implications for policy and practice
Článek Gemcitabine potentiates the anti-tumour effect of radiation on medullary thyroid cancer
Článek iTRAQ-based high-throughput proteomics analysis reveals alterations of plasma proteins in patients infected with human bocavirus
Článek The detection of a non-anemophilous plant species using airborne eDNA
Článek Perception and control of low cable operation forces in voluntary closing body-powered upper-limb prostheses
Článek Neoadjuvant chemotherapy plus surgery versus concurrent chemoradiotherapy in stage IB2-IIB cervical cancer: A systematic review and meta-analysis
Článek Randomized methods to characterize large-scale vortical flow networks
Článek Disentangling the coexistence strategies of mud-daubing wasp species through trophic analysis in oases of Baja California peninsula
Článek Front-of-pack nutritional labels: Understanding by low- and middle-income Mexican consumers
Článek Distress in patients with end-stage renal disease: Staff perceptions of barriers to the identification of mild-moderate distress and the provision of emotional support
Článek Pathways to antibiotics in Bangladesh: A qualitative study investigating how and when households access medicine including antibiotics for humans or animals when they are ill
Článek DOC export is exceeded by C fixation in May Creek: A late-successional watershed of the Copper River Basin, Alaska
Článek Behavioral observation of prosocial behavior and social initiative is related to preschoolers’ psychopathological symptoms
Článek Evaluating the impact of citations of articles based on knowledge flow patterns hidden in the citations
Článek Correction: Economic sanctions and academia: Overlooked impact and long-term consequences
Článek Correction: A novel association between relaxin receptor polymorphism and hematopoietic stem cell yield after mobilization
Článek Expression of Concern: Cooperativity of Oncogenic K-Ras and Downregulated p16/INK4A in Human Pancreatic Tumorigenesis
Článek Price dispersion of generic medications
Článek Sex differences in body composition but not neuromuscular function following long-term, doxycycline-induced reduction in circulating levels of myostatin in mice
Článek The emotion regulation effect of cognitive control is related to depressive state through the mediation of rumination: An ERP study
Článek Comparison of SMS-EPI and 3D-EPI at 7T in an fMRI localizer study with matched spatiotemporal resolution and homogenized excitation profiles
Článek Left ventricular mass normalization for body size in children based on an allometrically adjusted ratio is as accurate as normalization based on the centile curves method
Článek Correction: Combining biophysical parameters, spectral indices and multivariate hyperspectral models for estimating yield and water productivity of spring wheat across different agronomic practices
Článek Correction: Flowers as viral hot spots: Honey bees (Apis mellifera) unevenly deposit viruses across plant species
Článek 'Small small quarrels bring about happiness or love in the relationships’: Exploring community perceptions and gendered norms contributing to male perpetrated intimate partner violence in the Central Region of Ghana
Článek The performance of practitioners conducting facial comparisons on images of children across age
Článek Increased amounts and stability of telomeric repeat-containing RNA (TERRA) following DNA damage induced by etoposide
Článek Patients with limitation or withdrawal of life supporting care admitted in a medico-surgical intermediate care unit: Prevalence, description and outcome over a six-month period
Článek Correction: Diverse radiofrequency sensitivity and radiofrequency effects of mobile or cordless phone near fields exposure in Drosophila melanogaster
Článek Predicting the performance of TV series through textual and network analysis: The case of Big Bang Theory
Článek Risk of temperature, humidity and concentrations of air pollutants on the hospitalization of AECOPD
Článek Mixed methods grant applications in the health sciences: An analysis of reviewer comments
Článek Renal abnormalities among children with sickle cell conditions in highly resource-limited setting in Ghana
Článek Size matters: How reaching and vergence movements are influenced by the familiar size of stereoscopically presented objects
Článek Willingness to receive institutional and community-based eldercare among the rural elderly in China
Článek An improved deep learning method for predicting DNA-binding proteins based on contextual features in amino acid sequences
Článek Beyond executive functions, creativity skills benefit academic outcomes: Insights from Montessori education
Článek A LAMP assay for the rapid and robust assessment of Wolbachia infection in Aedes aegypti under field and laboratory conditions
Článek Nonarteritic anterior ischemic optic neuropathy is associated with cerebral small vessel disease
Článek Fiber-tract localized diffusion coefficients highlight patterns of white matter disruption induced by proximity to glioma
Článek The fight against polio through the NO-DO newsreels during the Francoism period in Spain
Článek Ocean sound levels in the northeast Pacific recorded from an autonomous underwater glider
Článek Cost-consequence analysis of influenza vaccination among the staff of a large teaching hospital in Rome, Italy: A pilot study
Článek The relationship among the progression of inflammation in umbilical cord, fetal inflammatory response, early-onset neonatal sepsis, and chorioamnionitis
Článek How medical professional students view older people with dementia: Implications for education and practice
Článek An enhanced nonparametric EWMA sign control chart using sequential mechanism
Článek Land use change, carbon stocks and tree species diversity in green spaces of a secondary city in Myanmar, Pyin Oo Lwin
Článek Is there a difference in women’s experiences of care with medication vs. manual vacuum aspiration abortions? Determinants of person-centered care for abortion services
Článek Maternal complications in pregnancy and childbirth for women with epilepsy: Time trends in a nationwide cohort
Článek Adsorption of oxytetracycline on kaolinite
Článek Interdisciplinary stratified care for low back pain: A qualitative study on the acceptability, potential facilitators and barriers to implementation
Článek The role of resource transfer in positive, non-additive litter decomposition
Článek The impact of language on the interpretation of resuscitation clinical care plans by doctors. A mixed methods study
Článek Quantum dots reveal heterogeneous membrane diffusivity and dynamic surface density polarization of dopamine transporter
Článek Genomic analysis of Shiga toxin-producing Escherichia coli from patients and asymptomatic food handlers in Japan
Článek The heavy metals lead and cadmium are cytotoxic to human bone osteoblasts via induction of redox stress
Článek Anatomical, taxonomic, and phylogenetic reappraisal of a poorly known ghost knifefish, Tembeassu marauna (Ostariophysi: Gymnotiformes), using X-ray microcomputed tomography
Článek Matrix-assisted laser desorption/ionization time of flight mass spectrometry identification of Vibrio (Listonella) anguillarum isolated from sea bass and sea bream
Článek Recommendations of older adults on how to use the PROM ‘TOPICS-MDS’ in healthcare conversations: A Delphi study
Článek The winner takes it all—Competitiveness of single nodes in globalized supply networks
Článek Hamsters in the city: A study on the behaviour of a population of common hamsters (Cricetus cricetus) in urban environment
Článek Correction: Liquid biopsies for omics-based analysis in sentinel mussels
Článek Size matters! Association between journal size and longitudinal variability of the Journal Impact Factor
Článek Drug resistance and epidemiology characteristics of multidrug-resistant tuberculosis patients in 17 provinces of China
Článek A model-based framework for chronic hepatitis C prevalence estimation
Článek Adding rewards to regulation: The impacts of watershed conservation on land cover and household wellbeing in Moyobamba, Peru
Článek Clinical determinants of social media use in individuals with schizophrenia
Článek Arsenic and nutrient absorption characteristics and antioxidant response in different leaves of two ryegrass (Lolium perenne) species under arsenic stress
Článek An evolution of socioeconomic related inequality in teenage pregnancy and childbearing in Malawi
Článek A single plasmid based CRISPR interference in Synechocystis 6803 – A proof of concept
Článek Structural vulnerability to narcotics-driven firearm violence: An ethnographic and epidemiological study of Philadelphia’s Puerto Rican inner-city
Článek Temporal trends in intracerebral hemorrhage: Evidence from the Austrian Stroke Unit Registry
Článek Prevalence and risk factors for multi-drug resistant Escherichia coli among poultry workers in the Federal Capital Territory, Abuja, Nigeria
Článek Prediction of disease-related metabolites using bi-random walks
Článek Clinical use, efficacy, and durability of maraviroc for antiretroviral therapy in routine care: A European survey
Článek Biomarker discovery in inflammatory bowel diseases using network-based feature selection
Článek The Cinderella Complex: Word embeddings reveal gender stereotypes in movies and books
Článek Exoproteome profiling of Trypanosoma cruzi during amastigogenesis early stages
Článek Reproducible phenotype alteration due to prolonged cooling of the pupae of Polyommatus icarus butterflies
Článek Nutritional treatment with an immune-modulating enteral formula alleviates 5-fluorouracil-induced adverse effects in rats
Článek Pharmacy-based predictors of non-adherence, non-persistence and reinitiation of antihypertensive drugs among patients on oral diabetes drugs in the Netherlands
Článek Systematic review of the accuracy of plasma preparation tubes for HIV viral load testing
Článek Circadian clock regulates the shape and content of dendritic spines in mouse barrel cortex
Článek “Anybody can make kids; it takes a real man to look after your kids”: Aboriginal men’s discourse on parenting
Článek Correction: A 1D computer model of the arterial circulation in horses: An important resource for studying global interactions between heart and vessels under normal and pathological conditions
Článek Maternal interpregnancy weight change and premature birth: Findings from an English population-based cohort study
Článek Correction: Identifying performance benchmarks and determinants for reproductive performance and calf survival using a longitudinal field study of cow-calf herds in western Canada
Článek Prognostic value of the model for end-stage liver disease excluding INR score (MELD-XI) in patients with adult congenital heart disease
Článek Treatment of Urethral Pain Syndrome (UPS) in Sweden
Článek Migration and political polarization in the U.S.: An analysis of the county-level migration network
Článek Epidemiology and complications of late-onset sepsis: an Italian area-based study
Článek The relationship between women’s experience of intimate partner violence and other socio-demographic factors, and under-5 children’s health in South Africa
Článek Association between trunk and gluteus muscle size and long jump performance
Článek Multimorbidity and complex multimorbidity in Brazilian rural workers
Článek Correction: Interspecific Phylogenic Relationships within Genus Melilotus Based on Nuclear and Chloroplast DNA
Článek Insulin-like growth factor (IGF)-II- mediated fibrosis in pathogenic lung conditions
Článek Wolf diet and prey selection in the South-Eastern Carpathian Mountains, Romania
Článek In vitro activity of aryl-thiazole derivatives against Schistosoma mansoni schistosomula and adult worms
Článek Sample size issues in multilevel logistic regression models
Článek Seed germination ecology of Ageratum houstonianum: A major invasive weed in Nepal
Článek Experiences of lifestyle change among women with gestational diabetes mellitus (GDM): A behavioural diagnosis using the COM-B model in a low-income setting
Článek Pharmacologic management of HCV treatment in patients with HCV monoinfection vs. HIV/HCV coinfection: Does coinfection really matter?
Článek The association between cigarette smoking and serum thyroid stimulating hormone, thyroid peroxidase antibodies and thyroglobulin antibodies levels in Chinese residents: A cross-sectional study in 10 cities
Článek Mouse movement measures enhance the stop-signal task in adult ADHD assessment
Článek Ecosystem functioning in urban grasslands: The role of biodiversity, plant invasions and urbanization
Článek Correction: KETOS: Clinical decision support and machine learning as a service – A training and deployment platform based on Docker, OMOP-CDM, and FHIR Web Services
Článek Does craniofacial morphology affect third molars impaction? Results from a population-based study in northeastern Germany
Článek Hyperconnectivity during screen-based stories listening is associated with lower narrative comprehension in preschool children exposed to screens vs dialogic reading: An EEG study
Článek Weight loss is associated with improved quality of life among rural women completers of a web-based lifestyle intervention
Článek Long-term high-grain diet altered the ruminal pH, fermentation, and composition and functions of the rumen bacterial community, leading to enhanced lactic acid production in Japanese Black beef cattle during fattening
Článek Beyond detoxification: Pleiotropic functions of multiple glutathione S-transferase isoforms protect mice against a toxic electrophile
Článek Golgi reassembly and stacking protein 65 downregulation is required for the anti-cancer effect of dihydromyricetin on human ovarian cancer cells
Článek SSR marker development in Clerodendrum trichotomum using transcriptome sequencing
Článek Risk factors for the carriage of Streptococcus infantarius subspecies infantarius isolated from African fermented dairy products
Článek Development of an intervention tool for precision oral self-care: Personalized and evidence-based practice for patients with periodontal disease
Článek Personal values in adolescence and psychological distress in adults: A cross-sectional study based on a retrospective recall
Článek Overactive bladder and bladder pain syndrome/interstitial cystitis in primary Sjögren’s syndrome patients: A nationwide population-based study
Článek Clinical utility of combined preimplantation genetic testing methods in couples at risk of passing on beta thalassemia/hemoglobin E disease: A retrospective review from a single center
Článek Hip stress distribution - Predictor of dislocation in hip arthroplasties. A retrospective study of 149 arthroplasties
Článek Mortality, morbidity, and cardiac surgery in Injection Drug Use (IDU)-associated versus non-IDU infective endocarditis: The need to expand substance use disorder treatment and harm reduction services
Článek Pup mortality in New Zealand sea lions (Phocarctos hookeri) at Enderby Island, Auckland Islands, 2013-18
Článek In vitro endothelial cell migration from limbal edge-modified Quarter-DMEK grafts
Článek Liquid Chromatography/Mass Spectrometry based serum metabolomics study on recurrent abortion women with antiphospholipid syndrome
Článek Gut carriage of antimicrobial resistance genes among young children in urban Maputo, Mozambique: Associations with enteric pathogen carriage and environmental risk factors
Článek Prepubertal nutrition alters Leydig cell functional capacity and timing of puberty
Článek Reliability of the Swedish version of the Evidence-Based Practice Attitude Scale assessing physiotherapist’s attitudes to implementation of evidence-based practice
Článek Mitochondrial alarmins are tissue mediators of ventilator-induced lung injury and ARDS
Článek Complete Chloroplast Genomes of Vachellia nilotica and Senegalia senegal: Comparative Genomics and Phylogenomic Placement in a New Generic System
Článek Retraction: Over-Expression of Superoxide Dismutase Ameliorates Cr(VI) Induced Adverse Effects via Modulating Cellular Immune System of Drosophila melanogaster
Článek Effect of pre-season training phase on anthropometric, hormonal and fitness parameters in young soccer players
Článek Exosomes from conditioned media of bone marrow-derived mesenchymal stem cells promote bone regeneration by enhancing angiogenesis
Článek Outcome of patients with heart failure after transcatheter aortic valve implantation
Článek Fatty acid profile of Romanian’s common bean (Phaseolus vulgaris L.) lipid fractions and their complexation ability by β-cyclodextrin
Článek Appropriate empirical antibiotic therapy and mortality: Conflicting data explained by residual confounding
Článek Treatment of corneal endothelial damage in a rabbit model with a bioengineered graft using human decellularized corneal lamina and cultured human corneal endothelium
Článek Telbivudine on IgG-associated hypergammaglobulinemia and TGF-β1 hyperactivity in hepatitis B virus-related liver cirrhosis
Článek Correction: Axial variation of deoxyhemoglobin density as a source of the low-frequency time lag structure in blood oxygenation level-dependent signals
Článek Correction: Mobile health-based physical activity intervention for individuals with spinal cord injury in the community: A pilot study
Článek Retraction: Placental expression of CD100, CD72 and CD45 is dysregulated in human miscarriage
Článek Correction: Use of IoT sensing and occupant surveys for determining the resilience of buildings to forest fire generated PM2.5
Článek Correction: The modulation of facial mimicry by attachment tendencies and their underlying affiliation motives in 3-year-olds: An EMG study
Článek Correction: Cognitive impairment in multiple sclerosis: An exploratory analysis of environmental and lifestyle risk factors
Článek Discovering novel disease comorbidities using electronic medical records
Článek Glutathione contributes to efficient post-Golgi trafficking of incoming HPV16 genome
Článek Epidemiology and antimicrobial resistance of methicillin-resistant Staphylococcus aureus isolates colonizing pigs with different exposure to antibiotics
Článek Social information use in adolescents: The impact of adults, peers and household composition
Článek Public practices on antibiotic use: A cross-sectional study among Qatar University students and their family members
Článek Effects of Topper Training on psychosocial problems, self-esteem, and peer victimisation in Dutch children: A randomised trial
Článek Comparative studies of two generations of NanoString nCounter System
Článek General practitioners’ perceptions of delayed antibiotic prescription for respiratory tract infections: A phenomenographic study
Článek Can altered magnetic field affect the foraging behaviour of ants?
Článek Parasitic infections and medical expenses according to Health Insurance Review Assessment claims data in South Korea, 2011–2018
Článek A prospective observational study of on-treatment plasma homocysteine levels as a biomarker of toxicity, depression and vitamin supplementation lead-in time pre pemetrexed, in patients with non-small cell lung cancer and malignant mesothelioma
Článek A strategy to identify protein-N-myristoylation-dependent phosphorylation reactions of cellular proteins by using Phos-tag SDS-PAGE
Článek Expression profile of sonic hedgehog signaling-related molecules in basal cell carcinoma
Článek Seasonal alternation of the ontogenetic development of the moon jellyfish Aurelia coerulea in Maizuru Bay, Japan
Článek Reliability of measurement of active trunk movement in wheelchair basketball players
Článek Chinese SLE Treatment and Research group (CSTAR) registry: Clinical significance of thrombocytopenia in Chinese patients with systemic lupus erythematosus
Článek Does source credibility matter for point-of-decision prompts? A quasi-experimental field study to increase stair use
Článek Male-pattern baldness and incident coronary heart disease and risk factors in the Heinz Nixdorf Recall Study
Článek Quality and utilization patterns of maternity waiting homes at referral facilities in rural Zambia: A mixed-methods multiple case analysis of intervention and standard of care sites
Článek Determining an optimal pool size for testing beef herds for Johne’s disease in Australia
Článek Correction: Change in larval fish assemblage in a USA east coast estuary estimated from twenty-six years of fixed weekly sampling
Článek APOE-knockout in rabbits causes loss of cells in nucleus pulposus and enhances the levels of inflammatory catabolic cytokines damaging the intervertebral disc matrix
Článek Testing Species Assignments in Extant Terebratulide Brachiopods: A Three-dimensional Geometric Morphometric Analysis of Long-Looped Brachidia
Článek A daily diary study on maladaptive daydreaming, mind wandering, and sleep disturbances: Examining within-person and between-persons relations
Článek Improved chemotherapy modeling with RAG-based immune deficient mice
Článek Effect of tracheal antimicrobial peptide on the development of Mannheimia haemolytica pneumonia in cattle
Článek The internal realities of individuals with type 2 diabetes  – a functional framework of self-management practices via Grounded Theory approach
Článek Role of platelet parameters in early detection and prediction of severity of preeclampsia: A comparative cross-sectional study at Ayder comprehensive specialized and Mekelle general hospitals, Mekelle, Tigray, Ethiopia
Článek eIF4E and 4EBP1 are prognostic markers of head and neck squamous cell carcinoma recurrence after definitive surgery and adjuvant radiotherapy
Článek Smoking and other determinants of bone turnover
Článek Oxygen delivery, oxygen consumption and decreased kidney function after cardiopulmonary bypass
Článek School engagement of children in early grades: Psychometric, and gender comparisons
Článek Correction: A review of the elusive bicolored iris Snouted Treefrogs (Anura: Hylidae:Scinax uruguayus group)
Článek Perceived attractiveness of Czech faces across 10 cultures: Associations with sexual shape dimorphism, averageness, fluctuating asymmetry, and eye color
Článek Discovery of stable and prognostic CT-based radiomic features independent of contrast administration and dimensionality in oesophageal cancer
Článek Correction: Population-based dementia prediction model using Korean public health examination data: A cohort study
Článek Location, location, location: Close ties among older continuing care retirement community residents
Článek Correction: ISED: Constructing a high-resolution elevation road dataset from massive, low-quality in-situ observations derived from geosocial fitness tracking data
Článek Correction: Use of validated objective methods of locomotion characteristics and weight distribution for evaluating the efficacy of ketoprofen for alleviating pain in cows with limb pathologies
Článek Monitoring fine root growth to identify optimal fertilization timing in a forest plantation: A case study in Northeast Vietnam
Článek Metabolic costs of spontaneous swimming in Sprattus sprattus L., at different water temperatures
Článek Enterovirus 71 vaccine acceptance among parents of children < 5 years old and their knowledge of hand, foot and mouth disease, Chongqing, China, 2017
Článek Correction: Transcriptome profiling of mouse brain and lung under Dip2a regulation using RNA-sequencing
Článek Genetic diversity and antiretroviral resistance-associated mutation profile of treated and naive HIV-1 infected patients from the Northwest and Southwest regions of Cameroon
Článek Maximum parsimony interpretation of chromatin capture experiments
Článek Multiple innate antibacterial immune defense elements are correlated in diverse ungulate species
Článek Incidence and characteristics of ventricular tachycardia in patients after percutaneous coronary revascularization of chronic total occlusions
Článek Estimating measures of latent variables from m-alternative forced choice responses
Článek Clade F AAVHSCs cross the blood brain barrier and transduce the central nervous system in addition to peripheral tissues following intravenous administration in nonhuman primates
Článek First evidence of hepatitis E virus infection in a small mammal (yellow-necked mouse) from Croatia
Článek The inhibitory effects of polypyrrole on the biofilm formation of Streptococcus mutans
Článek Self-reported adverse drug effects and associated factors among H. pylori infected patients on standard triple therapy: Prospective follow up study
Článek Upregulation of ERK phosphorylation in rat dorsal root ganglion neurons contributes to oxaliplatin-induced chronic neuropathic pain
Článek Characterization of the relationship between neutron production and thermal load on a target material in an accelerator-based boron neutron capture therapy system employing a solid-state Li target
Článek Remote heart rate monitoring - Assessment of the Facereader rPPg by Noldus
Článek Seroprevalence of rubella virus antibodies among pregnant women in the Center and South-West regions of Cameroon
Článek Effectiveness of steam sterilization of reusable medical devices in primary and secondary care public hospitals in Nepal and factors associated with ineffective sterilization: A nation-wide cross-sectional study
Článek Relevance of HTLV-1 proviral load in asymptomatic and symptomatic patients living in endemic and non-endemic areas of Argentina
Článek Ritualized aggressive behavior reveals distinct social structures in native and introduced range tawny crazy ants
Článek The value of kinetic glomerular filtration rate estimation on medication dosing in acute kidney injury
Článek Screening and characterization of long noncoding RNAs involved in the albinism of Ananas comosus var. bracteatus leaves
Článek Visual attention to emotional faces in adolescents with social anxiety disorder receiving cognitive behavioral therapy
Článek A Q fever outbreak associated to courier transport of pets
Článek Antibodies against measles and rubella virus among different age groups in Thailand: A population-based serological survey
Článek Molecular diet analysis of Anguilliformes leptocephalus larvae collected in the western North Pacific
Článek Correction: The relationship between context, structure, and processes with outcomes of 6 regional diabetes networks in Europe
Článek Correction: The C-reactive protein/albumin ratio as an independent predictor of mortality in patients with severe sepsis or septic shock treated with early goal-directed therapy
Článek Interleukin 21 (IL-21) regulates chronic allograft vasculopathy (CAV) in murine heart allograft rejection
Článek Semantic computational analysis of anticoagulation use in atrial fibrillation from real world data
Článek The implementation of HTA in medicine pricing and reimbursement policies in Indonesia: Insights from multiple stakeholders
Článek International experiences during United States ophthalmology residency training: Current structure of international experiences and perspectives of faculty mentors at United States training institutions
Článek Questionable utility of digoxin in left-ventricular assist device recipients: A multicenter, retrospective analysis
Článek Genotyping and outcomes of presumptive second line ART failure cases switched to third line or maintained on second line ART in Mumbai, India
Článek A mathematical model of honey bee colony dynamics to predict the effect of pollen on colony failure
Článek Airway microbiome composition correlates with lung function and arterial stiffness in an age-dependent manner
Článek An odorant receptor from Anopheles gambiae that demonstrates enantioselectivity to the plant volatile, linalool
Článek Factors associated with full immunization of children 12–23 months of age in Ethiopia: A multilevel analysis using 2016 Ethiopia Demographic and Health Survey
Článek Additional evidence that the rat renal interstitium contracts in vivo
Článek Factors affecting acceptance of at-birth point of care HIV testing among providers and parents in Kenya: A qualitative study
Článek Removal efficiency of central vacuum system and protective masks to suspended particles from dental treatment
Článek Psychological well-being and distress in patients with generalized anxiety disorder: The roles of positive and negative functioning
Článek Conventional rotator cuff versus all-suture anchors—A biomechanical study focusing on the insertion angle in an unlimited cyclic model
Článek Are viral-infections associated with Ménière’s Disease? A systematic review and meta-analysis of molecular-markers of viral-infection in case-controlled observational studies of MD
Článek An evaluation of genetic causes and environmental risks for bilateral optic atrophy
Článek Comparative vector competence of the Afrotropical soft tick Ornithodoros moubata and Palearctic species, O. erraticus and O. verrucosus, for African swine fever virus strains circulating in Eurasia
Článek Effects of the solubility of yeast cell wall preparations on their potential prebiotic properties in dogs
Článek Carbogen gas-challenge BOLD fMRI in assessment of liver hypoxia after portal microcapsules implantation
Článek Socioeconomic determinants of cancer screening utilisation in Latin America: A systematic review
Článek Development of an easy-to-use questionnaire assessing critical care nursing competence in Japan: A cross-sectional study
Článek Towards successful business process improvement – An extension of change acceleration process model
Článek Correction: Dietary polyphenols as a safe and novel intervention for modulating pain associated with intervertebral disc degeneration in an in-vivo rat model
Článek Correction: Phylogenetic analysis of hepatitis C virus among HIV/ HCV co-infected patients in Nigeria
Článek Correction: Relationship between self-disclosure to first acquaintances and subjective well-being in people with schizophrenia spectrum disorders living in the community
Článek Impact of ATM rs1801516 on late skin reactions of radiotherapy for breast cancer: Evidences from a cohort study and a trial sequential meta-analysis
Článek Involvement of human and canine MRP1 and MRP4 in benzylpenicillin transport
Článek Soil organic matter rather than ectomycorrhizal diversity is related to urban tree health
Článek Clinical risk assessment in early pregnancy for preeclampsia in nulliparous women: A population based cohort study
Článek The relation between circulating levels of vitamin D and parathyroid hormone in children and adolescents with overweight or obesity: Quest for a threshold
Článek Behavioural evidence for segments as subordinate units in Chinese spoken word production: The form-preparation paradigm revisited
Článek Correction: Measuring the impact of an interdisciplinary learning project on nursing, architecture and landscape design students’ empathy
Článek Analysis of the characteristics of chemotherapy-resistant renal cell carcinomas based on global transcriptional analysis of their tissues and cell lines
Článek The characteristics and treatment patterns of patients with Parkinson’s disease in the United States and United Kingdom: A retrospective cohort study
Článek Sex differences in youth elite swimming
Článek Unconventional SCCmec types and low prevalence of the Panton-Valentine Leukocidin exotoxin in South African blood culture Staphylococcus aureus surveillance isolates, 2013-2016
Článek Prosocial perceptions of taxation predict support for taxes
Článek Correction: Clonality analysis of pulmonary tumors by genome-wide copy number profiling
Článek Improved oxygenation following methylprednisolone therapy and survival in paediatric acute respiratory distress syndrome
Článek Normative values for relative schoolbag weight in primary school children aged 6-14 from Czech Republic: A pilot study
Článek Correction: Intensive longitudinal modelling predicts diurnal activity of salivary alpha-amylase
Článek Correction: SNV discovery and functional candidate gene identification for milk composition based on whole genome resequencing of Holstein bulls with extremely high and low breeding values
Článek Monoclonal antibody anti-PBP2a protects mice against MRSA (methicillin-resistant Staphylococcus aureus) infections
Článek Diurnal variations of amplitude of accommodation in different age groups
Článek HHIP overexpression inhibits the proliferation, migration and invasion of non-small cell lung cancer
Článek Infusion of HIV-1 Nef-expressing astrocytes into the rat hippocampus induces enteropathy and interstitial pneumonitis and increases blood–brain-barrier permeability
Článek Correlation analysis of cold-related gene expression with physiological and biochemical indicators under cold stress in oil palm
Článek Student engagement and wellbeing over time at a higher education institution
Článek Gender-based differences in platelet function and platelet reactivity to P2Y12 inhibitors
Článek Influence of season and social context on male giant panda (Ailuropoda melanoleuca) vocal behaviour
Článek Development of an intravaginal ring for the topical delivery of Aurora kinase A inhibitor, MLN8237
Článek Differential phosphorylation determines the repressor and activator potencies of GLI1 proteins and their efficiency in modulating the HPV life cycle
Článek Polymorphisms of FDPS, LRP5, SOST and VKORC1 genes and their relation with osteoporosis in postmenopausal Romanian women
Článek Depression increases the risk of rotator cuff tear and rotator cuff repair surgery: A nationwide population-based study
Článek Interleukin-38 interacts with destrin/actin-depolymerizing factor in human keratinocytes
Článek Correction: Fast, quantitative, murine cardiac 19F MRI/MRS of PFCE-labeled progenitor stem cells and macrophages at 9.4T
Článek Persistent post-discharge opioid prescribing after traumatic brain injury requiring intensive care unit admission: A cross-sectional study with longitudinal outcome
Článek Genome-wide histone modification profiling of inner cell mass and trophectoderm of bovine blastocysts by RAT-ChIP
Článek Aerobic exercise increases post-exercise exogenous protein oxidation in healthy young males
Článek Selection for tandem stop codons in ciliate species with reassigned stop codons
Článek Research ethics in inter- and multi-disciplinary teams: Differences in disciplinary interpretations
Článek Correction: Analyzing data from the digital healthcare exchange platform for surveillance of antibiotic prescriptions in primary care in urban Kenya: A mixed-methods study
Článek Correction: People making deontological judgments in the Trapdoor dilemma are perceived to be more prosocial in economic games than they actually are
Článek LFRET, a novel rapid assay for anti-tissue transglutaminase antibody detection
Článek Effects of isotemporal substitution of sedentary behavior with light-intensity or moderate-to-vigorous physical activity on cardiometabolic markers in male adolescents
Článek Topical estrogen application to wounds promotes delayed cutaneous wound healing in 80-week-old female mice
Článek Correction: An international randomised placebo-controlled trial of a four-component combination pill (“polypill”) in people with raised cardiovascular risk
Článek Correction: Evaluation of lung toxicity risk with computed tomography ventilation image for thoracic cancer patients
Článek Retraction: Pathological Roles of Interleukin-22 in the Development of Recurrent Hepatitis C after Liver Transplantation
Článek Correction: Elevational Distribution and Ecology of Small Mammals on Tanzania's Second Highest Mountain
Článek Correction: Decreased breast cancer-specific mortality risk in patients with a history of thyroid cancer
Článek Correction: Fecal microbiota dysbiosis in macaques and humans within a shared environment
Článek Correction: The center of pressure and ankle muscle co-contraction in response to anterior-posterior perturbations
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PLOS One

2019 Číslo 11
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Aktuální možnosti diagnostiky a léčby litiáz
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Autori: MUDr. Tomáš Ürge, PhD.
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