African-American and Caucasian participation in postmortem human brain donation for neuropsychiatric research
Autoři:
Amy Deep-Soboslay aff001; Michelle I. Mighdoll aff001; Andrew E. Jaffe aff001; Stephen B. Thomas aff003; Mary M. Herman aff004; Jonathan Sirovatka aff004; Jewell P. King aff004; David R. Fowler aff005; Dawn Zulauf aff005; Constance DiAngelo aff006; Thomas M. Hyde aff001; Joel E. Kleinman aff001
Působiště autorů:
Lieber Institute for Brain Development, Baltimore, Maryland, United States of America
aff001; Johns Hopkins University, School of Public Health, Department of Mental Health, Baltimore, Maryland, United States of America
aff002; University of Maryland, School of Public Health, Department of Health Policy & Management, Center for Health Equity, College Park, Maryland, United States of America
aff003; Human Brain Collection Core, NIMH, NIH, Bethesda, Maryland, United States of America
aff004; Office of the Chief Medical Examiner of the State of Maryland, Baltimore, Maryland, United States of America
aff005; Office of the Chief Medical Examiner of Virginia, Northern District, Manassas, Virginia, United States of America
aff006; Johns Hopkins University, School of Medicine, Department of Psychiatry and Behavioral Sciences, Baltimore, Maryland, United States of America
aff007; Johns Hopkins University, School of Medicine, Department of Neurology, Baltimore, Maryland, United States of America
aff008
Vyšlo v časopise:
PLoS ONE 14(10)
Kategorie:
Research Article
prolekare.web.journal.doi_sk:
https://doi.org/10.1371/journal.pone.0222565
Souhrn
Increased African-American research participation is critical to the applicability and generalizability of biomedical research, as population diversity continues to increase both domestically and abroad. Yet numerous studies document historical origins of mistrust, as well as other barriers that may contribute to resistance in the African-American community towards participation in biomedical research. However, a growing body of more recent scientific evidence suggests that African-Americans value research and are willing to participate when asked. In the present study, we set out to determine factors associated with research participation of African-American families in postmortem human brain tissue donation for neuropsychiatric disorders as compared with Caucasian families, from same-day medical examiner autopsy referrals. We retrospectively reviewed brain donation rates, as well as demographic and clinical factors associated with donation in 1,421 consecutive referrals to three medical examiner’s offices from 2010–2015. Overall, 69.7% of all next-of-kin contacted agreed to brain donation. While Caucasian families consented to donate brain tissue at a significantly higher rate (74.1%) than African-American families (57.0%) (p<0.001), African-American brain donation rates were as high as 60.5% in referrals from Maryland. Neither African-American nor Caucasian donors differed significantly from non-donors on any demographic or clinical factors ascertained, including age, sex, diagnosis of the donor, or in the relationship of the next-of-kin being contacted (p>0.05). However, Caucasian donors were significantly older, had more years of education, were more likely to be referred for study due to a psychiatric diagnosis, more likely to have comorbid substance abuse, and more likely to have died via suicide, as compared with African-American donors (p<0.05). When African-American participants are identified and approached, African-American families as well as Caucasian families are indeed willing to donate brain tissue on the spot for neuropsychiatric research, which supports the belief that African-American attitudes towards biomedical research may be more favorable than previously thought.
Klíčová slova:
Medicine and health sciences – Alzheimer's disease – Brain – Autopsy – Suicide – Brain diseases – African American people – Telephones
Zdroje
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