The relationship between sleep quality, inappropriate medication use and frailty among older adults in aged care homes in Malaysia
Autoři:
Suresh Kumar aff001; Pei Se Wong aff001; Syed Shahzad Hasan aff002; Therese Kairuz aff003
Působiště autorů:
Department of Pharmacy Practice, International Medical University, Kuala Lumpur, Malaysia
aff001; Department of Pharmacy, University of Huddersfield, Huddersfield, West Yorkshire, United Kingdom
aff002; School of Biological Sciences and Pharmacy, University of Newcastle, Newcastle, New South Wales, Australia
aff003
Vyšlo v časopise:
PLoS ONE 14(10)
Kategorie:
Research Article
prolekare.web.journal.doi_sk:
https://doi.org/10.1371/journal.pone.0224122
Souhrn
Poor sleep quality is prevalent among older adults and is compounded by frailty and polypharmacy. This descriptive, cross-sectional study examines the associations between sleep quality, inappropriate medication use and frailty. The study was conducted among 151 residents of 11 aged care homes in three states in Malaysia; convenience sampling was used. Subjective sleep quality was assessed using the Pittsburgh Sleep Quality Index (PSQI), and Groningen Frailty Indicator (GFI) was used to assess frailty. Medication appropriateness was assessed using Drug burden Index (DBI), Potentially Inappropriate Medications (PIMs) and Potentially Inappropriate Prescriptions (PIPs). Most of the subjects (approximately 95%) reported poor sleep quality, as measured by a cut-off of global PSQI score of ≥ 5. With a second cut-off at 10, just over half (56%) reported moderately poor sleep quality followed by 39% who had very poor sleep quality. Most (90%) denied taking medication to improve their sleep during the previous month. There was no statistically significant association between medication inappropriateness (PIMs, PIPs, DBI) and global PSQI score. However, the average number of PIM was associated significantly with sleep efficiency (a measure of the actual ‘sleep to total time spent in bed) (p = 0.037). The average number of PIP was associated with subjective sleep quality (p = 0.045) and the use of sleep medications (p = 0.001), and inversely associated with sleep disturbance (0.049). Furthermore, frailty correlated significantly with poor overall sleep quality (p = 0.032). Findings support the need for medication review to identify and reduce PIMs and optimise prescriptions to improve sleep quality and hence, related health outcomes among residents of aged care homes.
Klíčová slova:
Quality of life – Geriatrics – Frailty – Elderly – Sleep disorders – Malaysia – Sleep – Sedatives
Zdroje
1. World Population Prospects—Population Division—United Nations [Internet]. [cited 2018 Dec 5]. Available from: https://esa.un.org/unpd/wpp/
2. Department of Statistics Malaysia Official Portal [Internet]. [cited 2017 June 13 ]. Available from: https://www.dosm.gov.my/v1/index.php?r=column/cthemeByCat&cat=118&bul_id=Y3kwU2tSNVFDOWp1YmtZYnhUeVBEdz09&menu_id=L0pheU43NWJwRWVSZklWdzQ4TlhUUT09
3. Conejos Miquel MD, Sánchez Cuervo M, Delgado Silveira E, Sevilla Machuca I, González-Blazquez S, Montero Errasquin B, et al. Potentially inappropriate drug prescription in older subjects across health care settings. Eur Geriatr Med. 2010 Feb 1;1(1):9–14.
4. American Geriatrics Society 2015 Updated Beers Criteria for Potentially Inappropriate Medication Use in Older Adults. J Am Geriatr Soc. 2015 Nov;63(11):2227–46. doi: 10.1111/jgs.13702 26446832
5. O’Mahony D, O’Sullivan D, Byrne S, O’Connor MN, Ryan C, Gallagher P. STOPP/START criteria for potentially inappropriate prescribing in older people: version 2. Age Ageing. 2015 Mar;44(2):213–8. doi: 10.1093/ageing/afu145 25324330
6. O’Mahony D, Gallagher P, Ryan C, Byrne S, Hamilton H, Barry P, et al. STOPP & START criteria: A new approach to detecting potentially inappropriate prescribing in old age. Eur Geriatr Med. 2010 Feb 1;1(1):45–51.
7. Ng BJ, Le Couteur DG, Hilmer SN. Deprescribing Benzodiazepines in Older Patients: Impact of Interventions Targeting Physicians, Pharmacists, and Patients. Drugs Aging. 2018 Apr 28;
8. Westbury JL, Gee P, Ling T, Brown DT, Franks KH, Bindoff I, et al. RedUSe: reducing antipsychotic and benzodiazepine prescribing in residential aged care facilities. Med J Aust. 2018;208(9):398–403. 29747564
9. Bourgeois J, Elseviers MM, Van Bortel L, Petrovic M, Vander Stichele RH. Sleep quality of benzodiazepine users in nursing homes: a comparative study with nonusers. Sleep Med. 2013 Jul;14(7):614–21. doi: 10.1016/j.sleep.2013.03.012 23692988
10. Neikrug AB, Ancoli-Israel S. Sleep disturbances in nursing homes. J Nutr Health Aging. 2010 Mar;14(3):207–11. 20191255
11. Tsai Y-F, Wong TK, Ku Y-C. Self-care management of sleep disturbances and risk factors for poor sleep among older residents of Taiwanese nursing homes. J Clin Nurs. 2008 May;17(9):1219–26. doi: 10.1111/j.1365-2702.2007.02020.x 18266847
12. Australian Journal of Advanced Nursing, The—Sleep quality in the elderly either living at home or in a nursing home (APAFT)—Informit [Internet]. [cited 2018 Dec 5]. Available from: https://search.informit.com.au/documentSummary;dn=654809692561530;res=IELAPA
13. Draugalis JR, Plaza CM. Best Practices for Survey Research Reports Revisited: Implications of Target Population, Probability Sampling, and Response Rate. Am J Pharm Educ [Internet]. 2009 Dec 17;73(8). Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2828303/
14. Lwanga SK, Lemeshow S, Organization WH. Sample size determination in health studies: a practical manual. Dťermination de la taille d’ un čhantillon dans les ťudes sanomťriques: manuel pratique [Internet]. 1991 [cited 2017 Dec 17]; Available from: http://www.who.int/iris/handle/10665/40062
15. Buysse DJ, Reynolds CF, Monk TH, Berman SR, Kupfer DJ. The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research. Psychiatry Res. 1989 May;28(2):193–213. doi: 10.1016/0165-1781(89)90047-4 2748771
16. Backhaus J, Junghanns K, Broocks A, Riemann D, Hohagen F. Test-retest reliability and validity of the Pittsburgh Sleep Quality Index in primary insomnia. J Psychosom Res. 2002 Sep;53(3):737–40. doi: 10.1016/s0022-3999(02)00330-6 12217446
17. Carpenter JS, Andrykowski MA. Psychometric evaluation of the Pittsburgh Sleep Quality Index. J Psychosom Res. 1998 Jul;45(1):5–13. doi: 10.1016/s0022-3999(97)00298-5 9720850
18. Psychometric properties of the Persian version of the Pittsburgh Sleep Quality Index addendum for PTSD (PSQI-A) | SpringerLink [Internet]. [cited 2018 Dec 6]. Available from: https://link.springer.com/article/10.1007/s11325-008-0233-3
19. Grandner MA, Kripke DF, Yoon I-Y, Youngstedt SD. Criterion validity of the Pittsburgh Sleep Quality Index: Investigation in a non-clinical sample. Sleep Biol Rhythms. 2006 Jun 1;4(2):129–36. doi: 10.1111/j.1479-8425.2006.00207.x 22822303
20. Carlson LE, Garland SN. Impact of mindfulness-based stress reduction (MBSR) on sleep, mood, stress and fatigue symptoms in cancer outpatients. Int J Behav Med. 2005 Dec 1;12(4):278–85. doi: 10.1207/s15327558ijbm1204_9 16262547
21. Chuurmans H, Steverink N, Lindenberg S, Frieswijk N, Slaets JPJ. Old or Frail: What Tells Us More? J Gerontol Ser A. 2004 Sep 1;59(9):M962–5.
22. Peters LL, Boter H, Buskens E, Slaets JPJ. Measurement Properties of the Groningen Frailty Indicator in Home-Dwelling and Institutionalized Elderly People. J Am Med Dir Assoc. 2012 Jul 1;13(6):546–51. doi: 10.1016/j.jamda.2012.04.007 22579590
23. Hasan SS, Kow CS, Thiruchelvam K, et al. An evaluation of the central nervous system medication use and frailty among residents of aged care homes in Malaysia. Neuroepidemiology 2017;49(1–2):82–90. doi: 10.1159/000480433 28892805
24. Hanlon JT, Schmader KE, Samsa GP, Weinberger M, Uttech KM, Lewis IK, et al. A method for assessing drug therapy appropriateness. J Clin Epidemiol. 1992 Oct;45(10):1045–51. doi: 10.1016/0895-4356(92)90144-c 1474400
25. Masnoon N, Shakib S, Kalisch-Ellett L, Caughey GE. What is polypharmacy? A systematic review of definitions. BMC Geriatr [Internet]. 2017 Oct 10;17. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5635569/
26. Hilmer SN, Mager DE, Simonsick EM, Cao Y, Ling SM, Windham BG, et al. A drug burden index to define the functional burden of medications in older people. Arch Intern Med. 2007 Apr 23;167(8):781–7. doi: 10.1001/archinte.167.8.781 17452540
27. Formulari Ubat KKM (FUKKM) | Program Perkhidmatan Farmasi [Internet]. [cited 2017 Aug 10]. Available from: https://www.pharmacy.gov.my/v2/ms/apps/fukkm
28. Search Drug Information, Interactions, Images, Dosage & Side Effects | MIMS.com Malaysia [Internet]. [cited 2017 Aug 12]. Available from: https://www.mims.com/
29. Azri MA, Dahlan A, Masuri MG, Isa KAM. Sleep Quality among Older Persons in Institutions. Procedia—Soc Behav Sci. 2016 Oct 31;234(Supplement C):74–82.
30. Rashid A, Ong EK, Yi Wong ES. Sleep quality among residents of an old folk’s home in Malaysia. Iran J Nurs Midwifery Res. 2012;17(7):512–9. 23922598
31. Hosseini H, Esfirizi MF, Marandi SM, Rezaei A. The effect of Ti Chi exercise on the sleep quality of the elderly residents in Isfahan, Sadeghieh elderly home. Iran J Nurs Midwifery Res. 2011;16(1):55–60. 22039380
32. Tel H. Sleep quality and quality of life among the elderly people. Neurol Psychiatry Brain Res. 2013 Feb 1;19(1):48–52.
33. Lo CM, Lee PH. Prevalence and impacts of poor sleep on quality of life and associated factors of good sleepers in a sample of older Chinese adults. Health Qual Life Outcomes. 2012 Jun 18;10:72. doi: 10.1186/1477-7525-10-72 22709334
34. Kwon AM, Shin C. Relation Between Health-Related Quality of Life and Sleep Quality With Adjustment for Comorbidity Among the Korean Elderly: Mixed-Effects Model With a 6-Year Follow-up Study. Asia Pac J Public Health. 2016 Apr;28(3):271–9. doi: 10.1177/1010539516628638 26826370
35. Hasan SS, Kow CS, Verma RK, Ahmed SI, Mittal P, Chong DWK. An evaluation of medication appropriateness and frailty among residents of aged care homes in Malaysia: A cross-sectional study. Medicine (Baltimore). 2017 Sep;96(35):e7929.
36. Sterke CS, van Beeck EF, van der Velde N, Ziere G, Petrovic M, Looman CWN, et al. New insights: dose-response relationship between psychotropic drugs and falls: a study in nursing home residents with dementia. J Clin Pharmacol. 2012 Jun;52(6):947–55. doi: 10.1177/0091270011405665 21628599
37. Maust DT, Kim HM, Seyfried LS, Chiang C, Kavanagh J, Schneider LS, et al. Antipsychotics, other psychotropics, and the risk of death in patients with dementia: number needed to harm. JAMA Psychiatry. 2015 May;72(5):438–45. doi: 10.1001/jamapsychiatry.2014.3018 25786075
38. Bourgeois J, Elseviers MM, Van Bortel L, Petrovic M, Vander Stichele RH. One-year evolution of sleep quality in older users of benzodiazepines: a longitudinal cohort study in belgian nursing home residents. Drugs Aging. 2014 Sep;31(9):677–82. doi: 10.1007/s40266-014-0203-3 25145751
39. Bosboom PR, Alfonso H, Almeida OP, Beer C. Use of Potentially Harmful Medications and Health-Related Quality of Life among People with Dementia Living in Residential Aged Care Facilities. Dement Geriatr Cogn Disord EXTRA. 2012 Sep 7;2(1):361–71.
40. Wilson NM, Hilmer SN, March LM, Cameron ID, Lord SR, Seibel MJ, et al. Associations between drug burden index and falls in older people in residential aged care. J Am Geriatr Soc. 2011 May;59(5):875–80. doi: 10.1111/j.1532-5415.2011.03386.x 21539525
41. Luo J, Zhu G, Zhao Q, Guo Q, Meng H, Hong Z, et al. Prevalence and Risk Factors of Poor Sleep Quality among Chinese Elderly in an Urban Community: Results from the Shanghai Aging Study. PLoS ONE [Internet]. 2013 Nov 25;8(11). Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3839883/
42. Wu C-Y, Su T-P, Fang C-L, Yeh Chang M. Sleep quality among community-dwelling elderly people and its demographic, mental, and physical correlates. J Chin Med Assoc JCMA. 2012 Feb;75(2):75–80. doi: 10.1016/j.jcma.2011.12.011 22340741
43. Becker NB, Jesus SN, João KADR, Viseu JN, Martins RIS. Depression and sleep quality in older adults: a meta-analysis. Psychol Health Med. 2017 Sep;22(8):889–95. doi: 10.1080/13548506.2016.1274042 28013552
44. Chapman JB, Lehman CL, Elliott J, Clark JD. Sleep quality and the role of sleep medications for veterans with chronic pain. Pain Med Malden Mass. 2006 Apr;7(2):105–14.
45. Hägg M, Houston B, Elmståhl S, Ekström H, Wann-Hansson C. Sleep quality, use of hypnotics and sleeping habits in different age-groups among older people. Scand J Caring Sci. 2014 Dec;28(4):842–51. 25562100
46. Llorca P-M, Lançon C, Hartry A, Brown TM, DiBenedetti DB, Kamat SA, et al. Assessing the burden of treatment-emergent adverse events associated with atypical antipsychotic medications. BMC Psychiatry. 2017 13;17(1):67.
47. Byerly MJ, Weber MT, Brooks DL, Snow LR, Worley MA, Lescouflair E. Antipsychotic medications and the elderly: effects on cognition and implications for use. Drugs Aging. 2001;18(1):45–61. doi: 10.2165/00002512-200118010-00004 11232738
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